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Understanding the Etiology and Treatment Approaches of Schizophrenia: Theoretical Perspectives and Their Critique

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Open Journal of Psychiatry 2016年第4期6卷 253-261页

作者： minjeong kim School of Nursing San Diego State University San Diego CA USA

This paper reviewed genetic, neurodevelopmental, and neurobiological perspectives to understand the etiology and relevant treatment approaches of schizophrenia. Although genetic and neurodevelopmental theories provide a substantial contribution to the etiology of schizophrenia, neurobiological one has its dominant stance in which it can explain causative mechanisms of schizophrenia, identify targets for treatment, and predict outcomes well. According to the neurobiology, onset and course of schizophrenia are well supported by the alterations in neurotransmitters such as dopamine or serotonin. Based on this mechanism, antipsychotics have been widely used as one of the treatment approaches for schizophrenia. By following up the degree of patients’ responses to antipsychotics, treatment outcomes could be evaluated or predicted. Although neurobiology seldom provides information about identification or prevention of risk factors about schizophrenia compared to genetic and neurodevelopmental approaches, it has well-established scientific foundations, ability to guide treatment, applicability across age and culture, and usefulness as a research framework.

关键词： Schizophrenia Theory Neurobiology

Philosophical and Ethical Perspectives on How We Could Know Recovery from Schizophrenia and Their Impact on Knowledge Development

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Open Journal of Psychiatry 2017年第1期7卷 31-39页

作者： minjeong kim School of Nursing San Diego State University San Diego USA

This paper discussed various philosophical and ethical perspectives on how to know recovery from schizophrenia. According to the empirical approach, recovery can be measured by objective and standardized tools which evaluate the severity of psychiatric symptoms or levels of social and vocational functioning. These measurements have minimum scores or sets of criteria of what recovery looks like, so this approach may be useful to evaluate patient’s treatment outcomes by healthcare providers. On the contrary, phenomenological approach stands qualitative research methods to understand an individual’s subjective, lived, or unique experiences while he or she lives with schizophrenia. Historical perspective holds that a point of view on recovery has been changed from negative to positive as our social perspectives for schizophrenia changes. Feminist perspective suggests that recovery can be understood by exploring female’s subjective experiences like successful marriage life or having responsibility for children. Ethical perspectives regarding the meaning of recovery were also addressed. Each philosophical and ethical perspective guides different research methodology and methods. Therefore, to employ appropriate methodology and methods, understanding philosophical and ethical backgrounds would be important.

关键词： Schizophrenia Recovery Philosophy Ethics

Co-Occurring Polysubstance Use and Physical Disease of Persons with Mental Disorders in Residential Treatment Program

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Open Journal of Nursing 2020年第12期10卷 1186-1194页

作者： minjeong kim Linda Chafetz School of Nursing San Diego State University San Diego USA School of Nursing University of California San Francisco USA

The purpose of this study was to describe the prevalence of co-occurring polysubstance use and to examine the differences in physical disease between polysubstance users and single/no substance users with mental disorders. This retrospective cross-sectional study included 1949 clinical records of psychiatric patients from 11 residential treatment programs between 2007 and 2011. Demographic variables, psychiatric diagnoses, and data on substance use and physical disease were obtained from the clinical records. Chi-square analyses were used to examine substance use difference in the prevalence of each physical disease category. This study found that the prevalence of co-occurring polysubstance use was 53.5%. Chi-square analyses identified that co-occurring polysubstance users reported more respiratory, digestive, musculoskeletal, and HIV/AIDS diseases but less endocrine diseases than single/no substance users. Therefore, integrated treatment programs for treating patients with co-occurring substance use and physical disease should be developed and expanded for this high-risk group.

关键词： Mental Disorders Physical Disease Polysubstance Use

Classroom-Based Parent Interview in Psychiatric Mental Health Nursing

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Open Journal of Nursing 2020年第6期10卷 613-616页

作者： minjeong kim Michelle Grace Lee School of Nursing San Diego State University San Diego USA Graduate of the School of Nursing San Diego State University San Diego USA

A classroom-based parent interview was designed and implemented in an undergraduate psychiatric mental health nursing class to fill the gap between nursing students and parents of child or adolescent patients with mental health issues faced during clinical. The goals of this learning activity were to increase understanding of what parents experience when dealing with their child’s mental health problems and to increase student engagement and attention. The class using this learning activity consisted of three parts: 1) an assigned pre-class reading;2) a mini-lecture;and 3) a parent interview presentation. Students were pre-assigned a reading chapter and faculty-developed interview questions. During the mini-lecture, important knowledge related to mental health care of children was assessed using CourseKey software. After the mini-lecture, the parent guest speaker delivered her presentation about herself, her child’s strengths and abilities, her child’s mental health problems and their impact, and her family’s strengths based on the interview question prompts for about 30 minutes, followed by 20 minutes of a Q & A session. The set of interview questions was developed by faculty based on the competency questions of the Child Behavior Check List. Despite some limitations, this classroom-based parent interview using a flipped classroom model was found to be a meaningful learning strategy by increasing student engagement and attention, increasing retention of knowledge learned in class, and filling that gap in clinical.

关键词： Nursing Education Parent Interview Psychiatric Mental Health Nursing

Predictors of Co-Occurring Substance Use among Asian Americans in Residential Treatment Programs

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Open Journal of Psychiatry 2019年第2期9卷 153-164页

作者： minjeong kim Jinhee Lee Midori Nakajima Linda Chafetz School of Nursing San Diego State University San Diego USA School of Nursing California State University-East Bay Hayward USA University of California-San Francisco San Francisco USA

Although severe and chronic mental disorders are common among Asian Americans in residential treatment programs, little has been known about the prevalence and predictors of co-occurring substance use in this population. The purpose of this study was to examine predictors of co-occurring substance use among Asian Americans with mental disorders in residential treatment programs. This cross-sectional study included 375 clinical records of Asian Americans from residential treatment programs between 2007 and 2011. Demographic variables, principal psychiatric diagnoses, and data on alcohol, stimulant, and marijuana use were obtained from the clinical records. Separate binary logistic regression analyses were used to examine the demographic and diagnostic contributions to the risk of each type of substance use. Findings of this study indicated that the prevalence of co-occurring substance use was about 53% in Asian Americans with mental disorders. Binary logistic regression analyses revealed that male gender, older age, and depressive disorder predicted more alcohol use, but homelessness and schizophrenia predicted less alcohol use. Male gender, homelessness, and smoking predicted more stimulant use. Male gender and younger age predicted more marijuana use. Based on the findings of this study, awareness about co-occurring substance use problems of ethnic minority psychiatric clients should be increased and appropriate substance use prevention and treatment programs should be developed and provided for high-risk groups.

关键词： Asian Americans Mental Disorders Substance Use

Liquid Metal Grid Patterned Thin Film Devices Toward Absorption‑Dominant and Strain‑Tunable Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 541-553页

作者： Yuwen Wei Priyanuj Bhuyan Suk Jin Kwon Sihyun kim Yejin Bae Mukesh Singh Duy Thanh Tran minjeong Ha Kwang‑Un Jeong Xing Ma Byeongjin Park Sungjune Park Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Composites Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea School of Materials Science and Engineering and Sauvage Laboratory for Smart MaterialsHarbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055People’s Republic of China

The demand of high-performance thin-film-shaped deformable electromagnetic interference(EMI)shielding devices is increasing for the next generation of wearable and miniaturized soft *** highly reflective conductive materials can effectively shield EMI,they prevent deformation of the devices owing to rigidity and generate secondary electromagnetic pollution ***,soft and stretchable EMI shielding thin film devices with absorption-dominant EMI shielding behavior is *** devices consist of liquid metal(LM)layer and LM grid-patterned layer separated by a thin elastomeric film,fabricated by leveraging superior adhesion of aerosol-deposited LM on *** devices demonstrate high electromagnetic shielding effectiveness(SE)(SE_(T) of up to 75 dB)with low reflectance(SER of 1.5 dB at the resonant frequency)owing to EMI absorption induced by multiple internal reflection generated in the LM grid ***,the excellent stretchability of the LM-based devices facilitates tunable EMI shielding abilities through grid space adjustment upon strain(resonant frequency shift from 81.3 to 71.3 GHz@33%strain)and is also capable of retaining shielding effectiveness even after multiple strain *** newly explored device presents an advanced paradigm for powerful EMI shielding performance for next-generation smart electronics.

关键词： Absorption-dominant electromagnetic interference shielding Liquid metals Soft and stretchable electronics Thin film devices Tunable electromagnetic interference shielding

Galectin 3-binding protein(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(TGF-β1)availability and inhibits hepatocarcinogenesis

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Cancer Communications 2024年第10期44卷 1106-1129页

作者： Dae-Hwan kim minjeong Sung Myong-Suk Park Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho Ik-Joo Chung Department of Internal Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Department of Internal Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinatorial Tumor Immunotherapy MRC Center Chonnam National University Medical SchoolHwasunSouth Korea National Immunotherapy Innovation Center HwasunSouth Korea BioMedical Sciences Graduate Program Chonnam National UniversityHwasunSouth Korea Department of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine R&D Center Chonnam National UniversityHwasunSouth Korea Department of Biochemistry and Molecular Pharmacology Baylor College of MedicineHoustonTexasUSA

Background:Increased Galectin 3-binding protein(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming growth factor-β1(TGF-β1)in the emergence of these diseases,the present study tested the hypothesis that LGALS3BP regulates the TGF-β1 signaling ***:The expression levels of LGALS3BP and TGFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as RNA-sequencing,transposaseaccessible chromatin-sequencing assay,and liquid chromatography-tandem mass spectrometry proteomics,were used to identify the regulatory mechanisms for the LGALS3BP-TGF-β1 *** effects of altered TGF-β1 signaling by LGALS3BP were investigated in conditional LGALS3BP-knockin and LGALS3BP-knockout ***:In patients with MASH and HCC,the levels of LGALS3BP and TGFB1 exhibited positive *** of LGALS3BP by the inflammatory cytokine interferonαin HCC cells or ectopic overexpression of LGALS3BP in hepatocytes promoted the expression levels of *** fibrosis was observed in the livers of hepatocyte-specific LGALS3BP-knockin mice,with increased TGFB1 ***3BP directly bound to and assembled integrinαV,an integral mediator required for releasing active TGF-β1 from extracellular latent complex with the rearranged F-actin *** released TGF-β1 activated JunB transcription factor,which in turn promoted the TGF-β1 positive feedback ***3BP deletion in the hepatocytes downregulated TGF-β1 signaling and CCl4 induced ***,LGALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic TGF-β***:LGALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the TGF-β1 signaling pathway,making it a promising therapeutic target in TGF-β1-related diseases.

关键词： F-actin FAK hepatic carcinogenesis IntegrinαV Interferonα JunB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force TGF-β1

管理控制系统与创新——文献、争论与未来研究

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中国管理会计 2021年第4期 109-118页

作者： Clara Xiaoling Chen minjeong(MJ)kim 宿文迪美国伊利诺伊大学厄巴纳—香槟分校美国威斯康星大学麦迪逊分校中欧国际工商学院

本文回顾了关于管理控制系统与创新之间关系的研究,并指出了未来的研究方向。我们首先分析关于管理控制系统对企业创新作用的争论,随后论述管理会计研究者如何参与讨论并做出贡献,同时,我们回顾了近期关于管理控制系统在企业创新活动中... 详细信息

本文回顾了关于管理控制系统与创新之间关系的研究,并指出了未来的研究方向。我们首先分析关于管理控制系统对企业创新作用的争论,随后论述管理会计研究者如何参与讨论并做出贡献,同时,我们回顾了近期关于管理控制系统在企业创新活动中的作用的研究。接下来我们就管理会计研究者如何使用不同方法检验管理控制系统对创新的影响展开论述。最后,我们探讨了关于创新的一些误区并指出了未来的研究方向。

关键词：管理控制系统创新

Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

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Acta Pharmaceutica Sinica B 2020年第3期10卷 462-474页

作者： Han Saem Son Jiae Lee Hye In Lee Narae kim You-Jin Jo Gong-Rak Lee Seong-Eun Hong minjeong Kwon Nam Young kim Hyun Jin kim Jin Ha Park Soo Young Lee Woojin Jeong Department of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(BA)has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we explored the role of BA in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly suppressed interleukin-1β(IL-1β)*** inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β*** reporter assay and the inhibitor study of IL-1βtranscription suggested that BA inhibited nuclear factor-κB and activator protein-1 by regulating IκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of IL-1β*** also promoted osteoblast ***,BA protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

关键词： Benzydamine Osteoclast Bone Interleukin-1β Nuclear factor-κB Activator protein-1