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Acta Pharmaceutica Sinica B 2020年第3期10卷 462-474页

作者： Han Saem Son Jiae Lee Hye In Lee Narae Kim You-Jin Jo Gong-Rak Lee Seong-Eun Hong minjeong kwon Nam Young Kim Hyun Jin Kim Jin Ha Park Soo Young Lee Woojin Jeong Department of Life Science and the Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea

Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with ***(BA)has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or ***,its role in osteoclast differentiation and function remains ***,we explored the role of BA in regulating osteoclast differentiation and elucidated the underlying *** inhibited osteoclast differentiation and strongly suppressed interleukin-1β(IL-1β)*** inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β*** reporter assay and the inhibitor study of IL-1βtranscription suggested that BA inhibited nuclear factor-κB and activator protein-1 by regulating IκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of IL-1β*** also promoted osteoblast ***,BA protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

关键词： Benzydamine Osteoclast Bone Interleukin-1β Nuclear factor-κB Activator protein-1

Development of mRNA vaccines and their prophylactic and therapeutic applications

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Nano Research 2018年第10期11卷 5173-5192页

作者： Kyuri Lee minjeong Kim Yunmi Seo Hyukjin Lee College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 13760 Republic of Korea

Nucleic acid vaccines have attracted enormous attention for resolving the limitations of conventional vaccines using live attenuated viruses. Because nucleic acid vaccines can be produced rapidly in response to the emergence of new virus strains, they are more appropriate for the control of urgent epidemic and pandemic issues. In particular, messenger RNA （mRNA） vaccines have evolved as a new type of nucleic acid vaccines in accordance with their superior protein expression and a lack of mutagenesis as compared with DNA vaccines. Using mRNA vaccines, large amounts of target proteins can be expressed in immune cells for efficient immunization. For instance, antigen-specific vaccination is a feasible option involving the expression of specific antigens in antigen-presenting cells. Immunological reactions are modulated by expressing several proteins associated with stimulation or maturation of immune cells. In addition, mRNA vaccines can stimulate innate immunity through specific recognition by pattern recognition receptors. On the basis of these remarkable properties, mRNA vaccines have been used for prophylactic and therapeutic applications. This review highlights the role of mRNA vaccines as prophylactic vaccines for prevention of future infections and as therapeutic vaccines for cancer immunotherapy. In addition to the conventional type of mRNA vaccines, RNA replicons （self-amplifying mRNA vaccines） will be described.

关键词： messenger RNA (mRNA) vaccines prophylactic vaccines self-amplifying mRNA vaccines therapeutic vaccine cancer immunotherapy

Broadband omnidirectional light detection in flexible and hierarchical ZnO/Si heterojunction photodiodes

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Nano Research 2017年第1期10卷 22-36页

作者： Seongdong Lim Doo-Seung Um minjeong Ha Qianpeng Zhang Youngsu Lee Yuanjing Lin Zhiyong Fan Hyunhyub Ko School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan Metropolitan City 44919 Republic of Korea Department of Electronic and Computer Engineering Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

The development of flexible photodetectors has received great attention for future optoelectronic applications including flexible image sensors, biomedical imaging, and smart, wearable systems. Previously omnidirectional photodetectors were only achievable by integration of a hemispherical microlens assembly on multiple photodetectors. Herein, a hierarchical photodiode design of ZnO nanowires （NWs） on honeycomb-structured Si （H-Si） membranes is demonstrated to exhibit excellent omnidirectional light-absorption ability and thus maintain high photocurrents over broad spectral ranges （365 to 1,100 nm） for wide incident angles （0° to 70°）, which enabled broadband omnidirectional light detection in flexible photodetectors. Furthermore, the stress-relieving honeycomb pattern within the photodiode micromembranes provided photodetectors with excellent mechanical flexibility （10% decrease in photocurrent at a bending radius of 3 mm） and durability （minimal change in photocurrent over 10,000 bending cycles）. When employed in semiconductor thin films, the hierarchical NW/honeycomb heterostructure design acts as an efficient platform for various optoelectronic devices requiring mechanical flexibility and broadband omnidirectional light detection.

关键词： flexible photodetector photodiode omnidirectional hierarchicalzinc oxide nanowire

Understanding the Etiology and Treatment Approaches of Schizophrenia: Theoretical Perspectives and Their Critique

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Open Journal of Psychiatry 2016年第4期6卷 253-261页

作者： minjeong Kim School of Nursing San Diego State University San Diego CA USA

This paper reviewed genetic, neurodevelopmental, and neurobiological perspectives to understand the etiology and relevant treatment approaches of schizophrenia. Although genetic and neurodevelopmental theories provide a substantial contribution to the etiology of schizophrenia, neurobiological one has its dominant stance in which it can explain causative mechanisms of schizophrenia, identify targets for treatment, and predict outcomes well. According to the neurobiology, onset and course of schizophrenia are well supported by the alterations in neurotransmitters such as dopamine or serotonin. Based on this mechanism, antipsychotics have been widely used as one of the treatment approaches for schizophrenia. By following up the degree of patients’ responses to antipsychotics, treatment outcomes could be evaluated or predicted. Although neurobiology seldom provides information about identification or prevention of risk factors about schizophrenia compared to genetic and neurodevelopmental approaches, it has well-established scientific foundations, ability to guide treatment, applicability across age and culture, and usefulness as a research framework.

关键词： Schizophrenia Theory Neurobiology

Philosophical and Ethical Perspectives on How We Could Know Recovery from Schizophrenia and Their Impact on Knowledge Development

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Open Journal of Psychiatry 2017年第1期7卷 31-39页

作者： minjeong Kim School of Nursing San Diego State University San Diego USA

This paper discussed various philosophical and ethical perspectives on how to know recovery from schizophrenia. According to the empirical approach, recovery can be measured by objective and standardized tools which evaluate the severity of psychiatric symptoms or levels of social and vocational functioning. These measurements have minimum scores or sets of criteria of what recovery looks like, so this approach may be useful to evaluate patient’s treatment outcomes by healthcare providers. On the contrary, phenomenological approach stands qualitative research methods to understand an individual’s subjective, lived, or unique experiences while he or she lives with schizophrenia. Historical perspective holds that a point of view on recovery has been changed from negative to positive as our social perspectives for schizophrenia changes. Feminist perspective suggests that recovery can be understood by exploring female’s subjective experiences like successful marriage life or having responsibility for children. Ethical perspectives regarding the meaning of recovery were also addressed. Each philosophical and ethical perspective guides different research methodology and methods. Therefore, to employ appropriate methodology and methods, understanding philosophical and ethical backgrounds would be important.

关键词： Schizophrenia Recovery Philosophy Ethics

Co-Occurring Polysubstance Use and Physical Disease of Persons with Mental Disorders in Residential Treatment Program

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Open Journal of Nursing 2020年第12期10卷 1186-1194页

作者： minjeong Kim Linda Chafetz School of Nursing San Diego State University San Diego USA School of Nursing University of California San Francisco USA

The purpose of this study was to describe the prevalence of co-occurring polysubstance use and to examine the differences in physical disease between polysubstance users and single/no substance users with mental disorders. This retrospective cross-sectional study included 1949 clinical records of psychiatric patients from 11 residential treatment programs between 2007 and 2011. Demographic variables, psychiatric diagnoses, and data on substance use and physical disease were obtained from the clinical records. Chi-square analyses were used to examine substance use difference in the prevalence of each physical disease category. This study found that the prevalence of co-occurring polysubstance use was 53.5%. Chi-square analyses identified that co-occurring polysubstance users reported more respiratory, digestive, musculoskeletal, and HIV/AIDS diseases but less endocrine diseases than single/no substance users. Therefore, integrated treatment programs for treating patients with co-occurring substance use and physical disease should be developed and expanded for this high-risk group.

关键词： Mental Disorders Physical Disease Polysubstance Use

Classroom-Based Parent Interview in Psychiatric Mental Health Nursing

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Open Journal of Nursing 2020年第6期10卷 613-616页

作者： minjeong Kim Michelle Grace Lee School of Nursing San Diego State University San Diego USA Graduate of the School of Nursing San Diego State University San Diego USA

A classroom-based parent interview was designed and implemented in an undergraduate psychiatric mental health nursing class to fill the gap between nursing students and parents of child or adolescent patients with mental health issues faced during clinical. The goals of this learning activity were to increase understanding of what parents experience when dealing with their child’s mental health problems and to increase student engagement and attention. The class using this learning activity consisted of three parts: 1) an assigned pre-class reading;2) a mini-lecture;and 3) a parent interview presentation. Students were pre-assigned a reading chapter and faculty-developed interview questions. During the mini-lecture, important knowledge related to mental health care of children was assessed using CourseKey software. After the mini-lecture, the parent guest speaker delivered her presentation about herself, her child’s strengths and abilities, her child’s mental health problems and their impact, and her family’s strengths based on the interview question prompts for about 30 minutes, followed by 20 minutes of a Q & A session. The set of interview questions was developed by faculty based on the competency questions of the Child Behavior Check List. Despite some limitations, this classroom-based parent interview using a flipped classroom model was found to be a meaningful learning strategy by increasing student engagement and attention, increasing retention of knowledge learned in class, and filling that gap in clinical.

关键词： Nursing Education Parent Interview Psychiatric Mental Health Nursing

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近10年韩国的中国文化教育再思考

近10年韩国的中国文化教育再思考

作者： LEE minjeong（李旻贞）浙江大学

学位级别：硕士

1992年中国和韩国建交以来,两国在政治、经济、社会、文化等整个领域形成了有好的伙伴关系。中韩两国的交往越来越频繁和紧密。随着中国发展,除了语言域外,越来越多的韩国人试图了解中国文化。汉语的学习离不开中国文化的学习,汉语的教... 详细信息

1992年中国和韩国建交以来,两国在政治、经济、社会、文化等整个领域形成了有好的伙伴关系。中韩两国的交往越来越频繁和紧密。随着中国发展,除了语言域外,越来越多的韩国人试图了解中国文化。汉语的学习离不开中国文化的学习,汉语的教学离不开中国文化教学。文化教学的重要性受到了越来越多的关注。韩国也从21世纪90年代后期开始在外语教育上强调文化了解教育。但是实际上当前韩国的汉语教育,语言教学是绝对的主体,文化教学是补助的。所以本论文以现有的研究为基础梳理高中和大学的中国文化教育现状和问题。接下来进行分析韩国的中国文化教育研究现状和特点。通过探讨当代韩国的中国文化教育现状及问题,提出对策,希望能起到'他山之石,可以攻玉'的作用。

关键词：文化教学中国文化教育韩国对外汉语文化教学汉语教材的文化因素

Predictors of Co-Occurring Substance Use among Asian Americans in Residential Treatment Programs

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Open Journal of Psychiatry 2019年第2期9卷 153-164页

作者： minjeong Kim Jinhee Lee Midori Nakajima Linda Chafetz School of Nursing San Diego State University San Diego USA School of Nursing California State University-East Bay Hayward USA University of California-San Francisco San Francisco USA

Although severe and chronic mental disorders are common among Asian Americans in residential treatment programs, little has been known about the prevalence and predictors of co-occurring substance use in this population. The purpose of this study was to examine predictors of co-occurring substance use among Asian Americans with mental disorders in residential treatment programs. This cross-sectional study included 375 clinical records of Asian Americans from residential treatment programs between 2007 and 2011. Demographic variables, principal psychiatric diagnoses, and data on alcohol, stimulant, and marijuana use were obtained from the clinical records. Separate binary logistic regression analyses were used to examine the demographic and diagnostic contributions to the risk of each type of substance use. Findings of this study indicated that the prevalence of co-occurring substance use was about 53% in Asian Americans with mental disorders. Binary logistic regression analyses revealed that male gender, older age, and depressive disorder predicted more alcohol use, but homelessness and schizophrenia predicted less alcohol use. Male gender, homelessness, and smoking predicted more stimulant use. Male gender and younger age predicted more marijuana use. Based on the findings of this study, awareness about co-occurring substance use problems of ethnic minority psychiatric clients should be increased and appropriate substance use prevention and treatment programs should be developed and provided for high-risk groups.

关键词： Asian Americans Mental Disorders Substance Use

大众传媒与学校道德课程的价值观比较——以韩剧《来自星星的你》和道德教科书为考察对象

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大众传媒与学校道德课程的价值观比较——以韩剧《来自星星的你》...

作者：李旼贞（LEE minjeong）华东师范大学

学位级别：硕士

本文以韩国社会在急剧产业化的过程中所形成的新文化和新价值观为背景,通过对教科书和电视剧中所凸显出的价值观比较,来分析韩国道德教科书中的价值观与社会发展的相契程度,以此探讨道德教科书的改善方法。笔者首先查找相关文献,对文化... 详细信息

本文以韩国社会在急剧产业化的过程中所形成的新文化和新价值观为背景,通过对教科书和电视剧中所凸显出的价值观比较,来分析韩国道德教科书中的价值观与社会发展的相契程度,以此探讨道德教科书的改善方法。笔者首先查找相关文献,对文化、价值观等重要概念进行界定,再以此为基础来介绍韩国社会的文化基础和本文所重点关注的价值观类别;其次,根据韩国现行的道德教育的课程目标和内容,选择韩国天才教育出版社的初中道德教科书和电视剧《来自星星的你》作为分析对象;然后再从网络伦理与礼节、亲环境的生活、邻里关怀与合作、两性平等、生命伦理等五个方面对教科书与韩剧中的价值观进行比较分析。通过对比分析,本研究发现学校道德教育中所提倡的核心价值观和韩剧中所呈现的价值观在方向上是一致的,而表达方式则有所不同。教科书偏重认知性理解,内容比较抽象,而电视剧将价值观融于具体的生活事件当中,更加直观,同时便于人们感受与体验。然而在性别平等的价值观上,教科书和电视剧中都有强化传统固有性别偏见的倾向;在生命伦理上,教科书内容过于理想化,而电视剧的内容则比较负面,在教育内容上都有改善之处。综合全篇,本文认为,今后的韩国道德教科书可以从以下几个方面进行改善:将道德教育目标从建设理想化国家目标转移到个人的发展和价值上来,突出个体现实中可以追求的价值;道德课的重点应放在民主精神的培养上,补充多元文化的教育;教科书的内容应该给予学生们自主发现道德的意义和价值的机会,同时提供更具体的案例和生活情景,避免抽象化;帮助学生树立两性平等的价值观。

关键词：韩国道德教育价值观教科书韩剧