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Bee Sting-Inspired Inflammation-Responsive Microneedles for Periodontal Disease Treatment

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Research 2023年第4期2023卷 23-31页

作者： Chuanhui Song Xiaoxuan Zhang minhui lu Yuanjin Zhao Department of Rheumatology and Immunology Institute of Translational MedicineThe Affliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023 China

Periodontal lesions are common and frustrating diseases that impact life *** in this aspect aim at developing local drug delivery systems with better efficacy and less ***,inspired by the sting separation behavior of bees,we conduct novel reactive oxygen species(ROS)-responsive detachable microneedles(MNs)that carry antibiotic metronidazole(Met)for controllable periodontal drug delivery and periodontitis *** from the needle-base separation ability,such MNs can penetrate through the healthy gingival to reach the gingival sulcus's bottom while offering minimal impact to oral ***,as the drug-encapsulated cores were protected by poly(lactic-co-glycolic acid)(PLGA)shells in MNs,the surrounding normal gingival tissue is not affected by Met,resulting in excellent local ***,with the ROS-responsive PLGA-thioketal-polyethylene glycol MN tips,they can be unlocked to release Met directly around the pathogen under the high ROS in the periodontitis sulcus,bringing about improved therapeutic *** on these characteristics,the proposed bioinspired MNs show good therapeutic results in treating a rat model with periodontitis,implying their potential in periodontal disease.

关键词： needle separation bringing

Developing hierarchical microneedles for biomedical applications

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Engineered Regeneration 2023年第3期4卷 316-327页

作者： minhui lu Xiaoxuan Zhang Zhiqiang luo Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China

As a new kind of microcarrier device,microneedles are featured by micrometer needle arrays with an overall size in the centimeter *** to the needle shape and the micron size,microneedles can penetrate the skin without harming nerves and blood vessels,which causes many advantages such as minimally invasive,safe and *** past few decades have witnessed a great leap in microneedles *** main materials of microneedles have changed from metal and ceramic to polymers with more complex functions,and the optimiza-tion of materials and preparation strategies has led to a greater variety of microneedle *** them,the construction or combination of smaller size structures or materials on microneedles to fabricate hierarchical mi-croneedles is a major research ***,we present the recent research progress of hierarchical microneedles for *** begin by discussing the fabrication strategies of hierarchical microneedles,including main-stream casting and coating methods based on microneedle molds and three dimensions(3D)printing *** then expand the discussion from the hierarchical microneedles with porous structure to those composited with ***,we have a discussion about the research progress of hierarchical microneedles in the area of biomarkers detection and transdermal drug delivery,as well as its future development direction.

关键词： Microneedle Porous structure Nanomaterials Drug delivery Detection

Chinese herb pollen derived micromotors as active oral drug delivery system for gastric ulcer treatment

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Bioactive Materials 2024年第2期32卷 28-36页

作者： Lijun Cai Cheng Zhao Xinyue Cao minhui lu Ning Li Yuan luo Yongan Wang Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing100850China Southeast University Shenzhen Research Institute Shenzhen518071China

Considerable efforts have been devoted to treating gastric *** in this field tend to develop drug delivery systems with prolonged gastric retention ***,we develop novel Chinese herb pollen-derived micromotors as active oral drug delivery system for treating gastric *** Chinese herb pollen-derived micromotors are simply produced by asymmetrically sputtering Mg layer onto one side of pollen *** exposed to gastric juice,the Mg layer can react with the hydrogen ions,resulting in intensive generation of hydrogen bubbles to propel the *** from the autonomous motion and unique spiny structure,our micromotors can move actively in the stomach and adhere to the surrounding ***,their special architecture endows the micromotors with salient capacity of drug loading and *** on these features,we have demonstrated that our Chinese herb pollen-derived micromotors could effective deliver berberine hydrochloride and show desirable curative effect on the gastric ulcer model of ***,these Chinese herb pollen-derived micromotors are anticipated to serve as promising oral drug delivery carriers for clinical applications.

关键词： Micromotor Chinese herb Pollen Drug delivery Gastric ulcer Wound healing

Inhibition of the maize salt overly sensitive pathway by ZmSK3 and ZmSK4

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Journal of Genetics and Genomics 2023年第12期50卷 960-970页

作者： Jianfang Li Xueyan Zhou Yan Wang Shu Song Liang Ma Qian He minhui lu Kaina Zhang Yongqing Yang Qian Zhao Weiwei Jin Caifu Jiang Yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China College of Life Sciences Qingdao Agricultural UniversityQingdaoShandong 266109China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100093China National Maize Improvement Center of China China Agricultural UniversityBeijing 100193China

Soil salinity is a worldwide problem that adversely affects plant growth and crop productivity. The salt overly sensitive (SOS) pathway is evolutionarily conserved and essential for plant salt tolerance. In this study, we reveal how the maize shaggy/glycogen synthase kinase 3-like kinases ZmSK3 and ZmSK4, orthologs of brassinosteroid insensitive 2 in Arabidopsis thaliana, regulate the maize SOS pathway. ZmSK3 and ZmSK4 interact with and phosphorylate ZmSOS2, a core member of the maize SOS pathway. The mutants defective in ZmSK3 or ZmSK4 are hyposensitive to salt stress, with higher salt-induced activity of ZmSOS2 than that in the wild type. Furthermore, the Ca^(2+) sensors ZmSOS3 and ZmSOS3-like calcium binding protein 8 (ZmSCaBP8) activate ZmSOS2 to maintain Na^(+)/K^(+) homeostasis under salt stress and may participate in the regulation of ZmSOS2 by ZmSK3 and ZmSK4. These findings discover the regulation of the maize SOS pathway and provide important gene targets for breeding salt-tolerant maize.

关键词： Salt stress Maize SOS pathway ZmSK3 ZmSK4 ZmSCaBP8

预警评估在老年患者护理不良事件管理中的作用

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中华现代护理杂志 2016年第4期22卷 519-522页

作者：芦敏慧华中科技大学同济医学院附属普爱医院护理部武汉430034

目的探讨预警评估在老年患者护理不良事件管理中的作用。方法选择2013年3-12月收治的396例未进行预警评估的老年患者作为对照组，2014年1-9月收治的377例进行了预警评估并采取不同护理措施的老年患者作为观察组；对照组根据医生开具的... 详细信息

目的探讨预警评估在老年患者护理不良事件管理中的作用。方法选择2013年3-12月收治的396例未进行预警评估的老年患者作为对照组，2014年1-9月收治的377例进行了预警评估并采取不同护理措施的老年患者作为观察组；对照组根据医生开具的护理级别实施分级护理；观察组入院后根据自制预警评估表第一时间进行预警评估，针对评分确定预警等级并采取不同护理措施。结果观察组护理不良事件发生率（0．53％，2／377）低于对照组（2．78％，11／396），差异有统计学意义（χ^2=4．618，P〈0．05）。结论在老年患者中进行预警评估管理可使护理不良事件发生率下降。

关键词：预警评估老年患者护理不良事件护理措施

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驼道悠悠——锡林郭勒草原行(下)

丝绸之路 2000年第2期 4-33页

作者：卢明辉

本部分记述了吉祥的苏鲁台敖包牧民的生活习俗、风土人情和参观班禅寺庙的详细情形。

关键词：祖国先生教委优秀文化研究所奖状指导敦煌文物敦煌艺术常书鸿

魔芋葡甘露聚糖与AMPSNa的接枝共聚物及其性能

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石油化工 2015年第4期44卷 489-493页

作者：卢敏晖姜翠玉虞建业马巍中国石化江苏油田分公司石油工程技术研究院江苏扬州225009 中国石油大学(华东)理学院山东青岛266580

以硝酸铈铵为引发剂、2-丙烯酰胺基-2-甲基丙磺酸钠(AMPSNa)为接枝改性单体,对魔芋葡甘露聚糖(KGM)进行接枝改性。考察反应温度、引发剂用量、AMPSNa浓度等因素对KGM-g-AMPSNa接枝共聚物溶胶黏度的影响以及交联剂对接枝共聚物交联及压... 详细信息

以硝酸铈铵为引发剂、2-丙烯酰胺基-2-甲基丙磺酸钠(AMPSNa)为接枝改性单体,对魔芋葡甘露聚糖(KGM)进行接枝改性。考察反应温度、引发剂用量、AMPSNa浓度等因素对KGM-g-AMPSNa接枝共聚物溶胶黏度的影响以及交联剂对接枝共聚物交联及压裂液性能的影响。采用FTIR技术对KGM-g-AMPSNa结构进行表征。实验结果表明,合成接枝共聚物最佳的反应条件为:6.2 g KGM溶于20 m L 75%(φ)乙醇,40℃下溶胀0.5 h,AMPSNa浓度0.43 mol/L,引发剂浓度1.71 mmol/L,反应温度50℃,反应时间2.5 h,在此条件下0.6%(w)接枝共聚物溶胶的黏度为196.93 m Pa·s;采用硼砂-有机钛复配交联剂,可使接枝共聚物溶胶的交联性能、耐温性能更好;以0.6%(w)接枝共聚物溶胶和复合交联剂(5.0%(w)硼砂+0.3%(w)有机钛)构成的压裂液的耐温耐剪切性能达到100℃。

关键词：魔芋葡甘露聚糖 2-丙烯酰胺基-2-甲基丙磺酸钠接枝共聚压裂液

Interpretation and revision proposals of GB/T 29319-2012,Technical requirements for connecting photovoltaic power system to distribution network

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China Standardization 2022年第1期87卷 62-64,I0065页

作者： lu minhui Sun Wenwen He Guoqing State Grid Gansu Electric Power Company China Electric Power Research Institute

In the context of clean and Low-carbon energy transformation and new power system,China^photovoltaic power generation will usher in great *** large-scale access impacts the safe and stable operation of the power grid with increasing *** order to strengthen the support and Leading roles of the standards,it is urgent to revise the national standard GB/T 29319-2012,Technical requirements for connecting photovoltaic power system to distribution network,based on the current development trend of photovoltaic power generation and power grid transformation *** paper firstly interprets the important technical provisions of the standard,then analyzes the problems in its implementation and finally proposes some revision suggestions in terms of grid adaptability,power control and fault crossing,to facilitate safe and orderly development of photovoltaic power generation in China.

关键词： photovoltaic power generation distribution network standard guide amendments

芥酸酰胺丙基阳离子型黏弹表面活性剂的合成及其性能

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石油化工 2014年第7期43卷 811-815页

作者：袁萍毛金成陆林华马巍卢敏辉虞建业中国石化江苏油田分公司石油工程技术研究院江苏扬州225009 苏州大学材料与化学化工学部江苏苏州215123

以芥酸为原料,无溶剂条件下经两步法合成了N-(3-芥酸酰胺基)丙基-N-(3-羟基)丙基-N,N-二甲基溴化铵(产品Ⅰ)和N-(3-芥酸酰胺基)丙基-N-(3-羟基)丙基-N,N-二乙基溴化铵(产品Ⅱ)。利用FTIR、MS和两相滴定法分析了产品Ⅰ和Ⅱ的结构,并测定... 详细信息

以芥酸为原料,无溶剂条件下经两步法合成了N-(3-芥酸酰胺基)丙基-N-(3-羟基)丙基-N,N-二甲基溴化铵(产品Ⅰ)和N-(3-芥酸酰胺基)丙基-N-(3-羟基)丙基-N,N-二乙基溴化铵(产品Ⅱ)。利用FTIR、MS和两相滴定法分析了产品Ⅰ和Ⅱ的结构,并测定了活性物的含量。将产品Ⅰ和Ⅱ分别配制成黏弹性表面活性剂(VES)酸性体系,并测定体系的流变性能。表征结果显示,产品Ⅰ和Ⅱ中的活性物含量(w)分别为97%和96%;两种产品配制的VES酸性体系在170 s-1、100℃下剪切1 h后,体系黏度仍大于25 mPa·s,符合行业应用标准。产品Ⅰ和Ⅱ的分子结构中既含酰胺基和羟基,又含C21长烷基链,因此既增加了表面活性剂的亲水性,又改善了由于过长疏水链带来的疏水性。

关键词：芥酸酰胺化季胺化黏弹性表面活性剂黏度压裂液