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Mechanisms of hepatocellular carcinoma progression

World Journal of Gastroenterology 2019年第19期25卷 2279-2293页

作者： Olorunseun O Ogunwobi trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin tan Grace X Ma minhhuyen t nguyen Department of Biological Sciences Hunter College of The City University of New York the Graduate Center Departments of Biology and Biochemistry The City University of New York Joan and Sanford I. Weill Department of Medicine Weill Cornell Medicine Cornell University Hunter College Center for Cancer Health Disparities Research (CCHDR) Center for Asian Health School of Medicine Temple University Department of Medicine Fox Chase Cancer Center

Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. this review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed.

关键词： Hepatocellular carcinoma Viral/non-viral hepatitis Alcohol consumption Epithelial-mesenchymal transition tumor-stromal interactions tumor microenvironment Cancer stem cells Circulating tumor cells Immunomodulation Neural regulation

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Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 891-910页

作者： N.D.nguyen t.N.nguyen Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of Engineering and technology Kien Giang UniversityChau Thanh 92000Viet Nam

this study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam *** analyses include three models for porosity distribution and two scenarios for thermal *** material properties are assessed under two conditions,i.e.,temperature dependence and temperature *** theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order *** governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev *** simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam *** findings highlight the significant influence of temperature-dependent(tD)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBt)

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Graphene-driving novel strain relaxation towards AlN film and DUV photoelectronic devices

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Light(Science & Applications) 2022年第7期11卷 1318-1319页

作者： Hieu.P.t.nguyen New Jersey Institute of technology Department of Electrical&Computer EngineeringNewarkNJ 07102USA

Graphene-driving strain-pre-store engineering enables the epitaxy of strain-free AlN film with low dislocation density for DUV-LED and the unique mechanism of strain-relaxation in QvdW epitaxy was demystified.

关键词： driving relaxation strain

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Beta-lactam antibiotic resistance among Escherichia coli isolates from patients with urinary tract infections in Vietnam:A systematic review and meta-analysis

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Asian Pacific Journal of tropical Medicine 2024年第6期17卷 243-255,I0001-I0003页

作者： Dat t nguyen Princess Margaret Cancer Centre University Health NetworkTorontoOntarioCanada

Objective:to investigate the evolving patterns of antimicrobial resistance against beta-lactam antibiotics in Escherichia coli isolates from urinary tract infection patients in Vietnam,covering the period from 2005 to ***:29 Descriptive studies published between 2010 and 2022 in English and Vietnamese were included in the *** on resistance rates to beta-lactam antibiotics,including cephalosporins and carbapenems,were extracted and *** pooled resistance rates were calculated using random-effects *** trends in resistance were assessed using linear regression ***:Among the beta-lactam antibiotics studied,Escherichia coli exhibited varying levels of resistance,with cephalosporins showing higher resistance rates compared to *** pooled resistance rates were 66%for cefotaxime,65%for ceftriaxone,54%for ceftazidime,and 56%for *** contrast,carbapenems demonstrated lower resistance rates,with weighted pooled resistance rates ranging from 3%to 4%for meropenem,ertapenem,and *** rates were also observed for amoxicillin/clavulanate(35%),ticarcillin/clavulanate(26%),and piperacillin/tazobactam(12%).Significant annual increases in resistance were noted for imipenem(0.56%,Pthis study highlights the critical issue of antimicrobial resistance in urinary tract infections in Vietnam and emphasizes the importance of prudent antibiotic use and the regular monitoring of resistance *** insights are useful for guiding healthcare professionals in optimizing treatment strategies and for policymakers in formulating evidence-based clinical guidelines to combat antibiotic resistance effectively.

关键词： Antimicrobial resistance Urinary tract infection Vietnam

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Examination of n-t_(9) conditions required by N=50,82,126 waiting points in r-process

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Communications in theoretical Physics 2021年第10期73卷 147-157页

作者： nguyen Duy Ly nguyen Ngoc Duy nguyen Kim Uyen Vinh N t Pham Faculty of Fundamental Sciences Vanlang UniversityHo Chi Minh City 700000Vietnam Department of Physics Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Physics Ho Chi Minh City University of EducationHo Chi Minh City 700000Vietnam

We examined the conditions of neutron density(n) and temperature(t9) required for the N = 50, 82,and 126 isotopes to be waiting points(WP) in the r-process. the nuclear mass based on experimental data presented in the AME2020 database(AME and AME ± Δ) and that predicted using FRDM,WS4, DZ10, and KtUY models were employed in our estimations. We found that the conditions required by the N = 50 WP significantly overlap with those required by the N = 82 ones, except for the WS4 model. In addition, the upper(or lower) bounds of the n-t9 conditions based on the models are different from each other due to the deviations in the two-neutron separation *** standard deviations in the nuclear mass of 108 isotopes in the three N = 50, 82, and 126 groups are about rms = 0.192 and 0.434 Me V for the pairs of KtUY-AME and WS4-KtUY models,respectively. We found that these mass uncertainties result in a large discrepancy in the nn-t_(9) conditions, leading to significant differences in the conditions for simultaneously appearing all the three peaks in the r-process abundance. the newly updated FRDM and WS4 calculations can give the overall conditions for the appearance of all the peaks but vice versa for their old versions in a previous study. the change in the final r-process isotopic abundance due to the mass uncertainty is from a few factors to three orders of magnitude. therefore, accurate nuclear masses of the r-process key nuclei, especially for 76 Fe,81Cu,127Rh,132Cd,192Dy, and 197tm, are highly recommended to be measured in radioactive-ion beam facilities for a better understanding of the r-process evolution.

关键词： neutron capture r-process nuclear mass isotopic abundance precise mass measurement

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Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation-associated genes

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Asian Pacific Journal of tropical Biomedicine 2021年第12期11卷 553-560页

作者： Huyen t.t.nguyen Minh t.H.nguyen thu X.nguyen Quan M.Pham Ha X.nguyen Phuong t.M.nguyen University of Science and technology of Hanoi Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and TechnologyHanoiVietnam Graduate University of Science and technology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:to investigate the osteoblastogenic activity of the ethyl acetate(EtOAc)extract of Smilax glabra Roxb roots and its major active compound ***:Astilbin was isolated from EtOAc extract using silica gel chromatography combined with fraction *** structure of astilbin was determined by analysis of the spectroscopic data in comparison with the *** method was used to detect the *** phosphatase(ALP)activity was determined by the spectrophotometric method at 405 nm using p-nitrophenyl phosphate as a *** deposition was stained with alizarin red-S,distained with cetylpyridium chloride,and quantified at 562 *** silico model for astilbin-ALP interaction was analyzed using AutoDock *** changes in expression of osteoblast differentiation related genes were determined using quantitative real-time ***:Both the EtOAc extract and astilbin had no toxicity toward osteoblast MC3t3-E1 cells at 5.0,10,25,and 50μg/*** 25μg/mL,they enhanced ALP activity and mineralization of osteoblasts up to 30%and 55%for the EtOAc extract and 22%and 41%for astilbin,*** docking analysis of astilbin-ALP interaction revealed Arg167,Asp320,His324,and His437 were key residues participating in hydrophobic interaction;meanwhile,His434 and thr436 residues were involved in hydrogen bond formation in the active site of human tissue-nonspecific ***,the expression level of genes opn,col1,osx,and runx2 were up-regulated in astilbin treated samples with the fold changes as 2.2;3.7;4.1;2.3,respectively at 10μg/mL(Pthe EtOAc extract and its major compound astilbin exhibit osteoblastogenic activity by up-regulating important markers for bone cell *** could be a new and promising osteogenic agent with dual actions for therapeutic applications.

关键词： Smilax glabra Roxb Astilbin Cytotoxicity Osteogenesis Osteoblast Ethyl acetate extract

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Optimum Design for the Magnification Mechanisms Employing Fuzzy Logic-ANFIS

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Computers, Materials & Continua 2022年第12期73卷 5961-5983页

作者： Ngoc thai Huynh tien V.t.nguyen Quoc Manh nguyen Faculty of Automobile technology Industrial University of Ho Chi Minh CityHo Chi Minh City70000Vietnam Faculty of Mechanical technology Industrial University of Ho Chi Minh CityHo Chi Minh City70000Vietnam Faculty of Mechanical Engineering Hung Yen University of Technology and EducationHung Yen160000Vietnam

to achieve high work performance for compliant mechanisms of motion scope,continuous work condition,and high frequency,we propose a new hybrid algorithm that could be applied to multi-objective optimum *** this investigation,we use the tools of finite element analysis(FEA)for a magnificationmechanism to find out the effects of design variables on the magnification ratio of the mechanism and then select an optimal mechanism that could meet design requirements.A poly-algorithm including the Grey-taguchi method,fuzzy logic system,and adaptive neuro-fuzzy inference system(ANFIS)algorithm,was utilized mainly in this *** FEA outcomes indicated that design variables have significantly affected on magnification ratio of the mechanism and verified by analysis of variance and analysis of the signal to noise of grey relational *** results are also predicted by employing the tool of ANFIS in *** conclusion,the optimal findings obtained:Its magnification is larger than 40 times in comparison with the initial design,the maximum principal stress is 127.89MPa,and the first modal shape frequency obtained 397.45 ***,we found that the outcomes obtained deviation error compared with predicted results of displacement,stress,and frequency are 8.76%,3.6%,and 6.92%,respectively.

关键词： Compliant mechanism grey relational analysis taguchi method multi-objective optimization fuzzy logic system adaptive neuro-fuzzy inference system(ANFIS)

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Dietary soluble non-starch polysaccharide level and xylanase supplementation influence performance,egg quality and nutrient utilization in laying hens fed wheat-based diets

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Animal Nutrition 2021年第2期7卷 512-520页

作者： Xa H.nguyen Hong t.nguyen Natalie K.Morgan University of New England School of Environmental and Rural ScienceArmidaleNew South Wales2351Australia

the aim of this study was to evaluate the effects of dietary soluble non-starch polysaccharide(sNSP)content and xylanase supplementation on production performance,egg quality parameters,and nutrient di-gestibility in Hy-line Brown layers from 25 to 32 wk of age.A total of 144 Hy-line Brown laying hens(25 wk of age)were randomly allocated to 1 of 4 wheat-based dietary treatments in a 2×2 factorial experimental design,with 36 replicates of individual hens per *** diets were formulated to contain either a high or low sNSP level(at 13.3 or 10.8 g/kg)and were supplemented with either 0 or 12,000 BXU/kg exogenous *** were fed these treatment diets for an 8-wk period,and hen production perfor-mance,including daily egg production,average egg weight,daily egg mass,feed conversion ratio and pro-portion of dirty and abnormal eggs were measured at bird age 25 to 28 wk and 29 to 32 *** interaction between sNSP content of the diet and xylanase supplementation was observed on daily egg production from 25 to 28 wk of age(P-0.018);birds fed the high sNSP diet without xylanase had lower egg production than those fed any other *** interaction between the 2 dietary factors was also observed on hen weight gain at 29 to 32 wk of age(P=0.014),with birds fed the low sNSP diet with 12,000 BXU/kg xylanase presenting greater weight gain compared to those fed the high sNSP diet with 12,000 BXU/kg *** intake at 29 to 32 wk of age was reduced by xylanase supplementation(P=0.047).Xylanase supplemen-tation also increased yolk colour score at both 28 and 32 wk of age,and decreased yolk weight at 32 wk of age(P-0.014,0.037 and 0.013,respectively).Birds fed the low sNSP diet presented lower protein digestibility(P-0.024)than those fed the high sNSP ***,birds fed high sNSP presented higher shell reflectivity at both 28 and 32 wk of age(P-0.05 and 0.036,respectively).the influence of duration of feeding the treatment diets on egg quality was also

关键词： Soluble NSP Xylanase Laying hen Production performance Egg quality

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Antibiofilm activity of alpha-mangostin loaded nanoparticles against Streptococcus mutans

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Asian Pacific Journal of tropical Biomedicine 2020年第7期10卷 325-332页

作者： Phuong t.M.nguyen Minh t.H.nguyen Lien t.Quach Phuong t.M.nguyen Lam L.nguyen Dong V.Quyen Institute of Biotechnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam Institute of Graduate University of Science and technology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam University of Science and technology of Hanoi Vietnam Academy of Science and Technology18-Hoang Quoc Viet RoadCau GiayHanoiVietnam

Objective:to investigate the antibiofilm activity of alphamangostin(AMG)loaded nanoparticle(nano AMG)against dental caries pathogen Streptococcus ***:AMG was isolated from the peels of Garcinia mangostana *** silica gel columns and chemically analysed by high performance liquid chromatography and nuclear magnetic *** AMG was prepared using the solvent evaporation method combined with high-speed *** nanoparticles were characterized using dynamic light scattering,field emission scanning electron microscopy(FE-SEM)and Fourier transform infrared spectroscopy(FtIR).the toxicity of nano AMG in fibroblast NIH/3 t3 cell line was determined using Mtt *** antibiofilm effect of nano AMG was determined through the evaluation of biofilm formation by Streptococcus mutans using a 96-well *** biomass was quantified using crystal *** viability was observed under confocal microscopy using LIVE/DEAD Bac Light ***,gene expression was determined by quantitative real-time PCR and membrane permeabilization activity by measuring the uptake of o-nitrophenol-β-***:Nano AMG size was in a range of 10-50 nm with a polydispersity index ofta potential value of-35.2 m *** size and the incorporation of AMG in the nanoparticles were confirmed by FE-SEM and FtIR *** IC50 values of the test agents on NIH/3 t3 cells were(9.80±0.63)μg/m L for AMG and(8.70±0.81)μg/m L for nano AMG,while no toxicity was generated from excipients used to prepare *** the early stage of biofilm formation,treatment with 6.25μmol/L nano AMG caused a reduction in biofilm biomass up to 49.1%,compared to 33.4%for *** contrast,biofilms at the late stage were more resistant to the test *** 96μmol/L(=10×MIC),nano AMG reduced only 20.7%of biofilm biomass while AMG did not showany *** of gtf B and gtf C genes involved in biofilm formation were down-regulated 3.3 and 12.5 folds,res

关键词： Alpha-mangostin Nanoparticle Antibiofilm activity Streptococcus mutans

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A combination of damage locating vector method （DLV） and differential evolution algorithm （DE） for structural damage assessment

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Frontiers of Structural and Civil Engineering 2018年第1期12卷 92-108页

作者： t. nguyen-tHOI A. tRAN-VIEt N. nguyen-MINH t. VO-DUY V. HO-HUU Division of Computational Mathematics and Engineering Institute for Computational Science Ton Duc Thang University Hochiminh City Vietnam Division of Construction Computation Institute for Computational Science Ton Duc Thang University Hochiminh City Vietnam Faculty of Civil Engineering Ton Duc Thang University Hochiminh City Vietnam

In this study, a two-stage method is presented for identifying multiple damage scenarios. In the first stage, the damage locating vector （DLV） method using normalized cumulative energy （nce） is employed for damage localization in structures. In the second stage, the differential evolution algorithm （DE） is used for damage severity of the structures. In addition, in the second stage, a modification of an available objective function is made for handing the issue of symmetric structures. to verify the effectiveness of the present technique, numerical examples of a 72-bar space truss and a one-span steel portal frame are considered. In addition, the effect of noise on the performance of the identification results is also investigated. the numerical results show that the proposed combination gives good assessment of damage location and extent for multiple structural damage cases.

关键词： damage assessment damage locating vector method (DLV) differential evolution (DE) multiple damagelocation assurance criterion (MDLAC) mode shape error function

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