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Chronic Hepatitis B in Indian Americans: Lack of Screening and Poor Linkage to Care

International Journal of Clinical Medicine 2024年第4期15卷 197-209页

作者： Chul Hyun Soonsik Kim Emily Li minhee lee Mitchell K. Spinnell Joseph McMenamin Dohyun Cho The Center for Viral Hepatitis Englewood Cliffs NJ USA Korean Community Services of Metropolitan New York New York City NY USA Englewood Hospital Medical Center Englewood NJ USA Christian & Barton LLP Richmond VA USA

Background: Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality in the United States (US) and globally. CHB disproportionately affects Asian Americans and many other immigrant minority populations, primarily owing to the high prevalence of CHB in their countries of origin. India is a country with a medium-to-high prevalence of hepatitis B (HB) (>2%) and has over 40 million people infected with hepatitis B virus (HBV), with more than 115,000 deaths annually from HBV-related complications. Indian Americans are one of the largest immigrant populations in the US but remain underdiagnosed and poorly linked to clinical care. We, therefore, assessed the HBV prevalence and evaluated the linkage-to-care (LTC) among Indian Americans to develop strategic plans to reduce the impact of HBV in the US. Methods: Between April 2022 and January 2024, serologic screening and surveys were provided to 328 Indian American adults (age 20 - 80) in New York City. All participants were tested for a triple panel consisting of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core IgG antibody (anti-HBc). A survey was conducted on the subjects chronically infected with HBV regarding their histories of infection. Self-administered questionnaires were employed to evaluate demographic and epidemiologic characteristics. Results: Of 328 screened and evaluated (246 males and 82 females), 10 (3.0%) were HBV-infected, 222 (67.7%) were susceptible to HBV, and 96 (29.3%) were immune. The prevalence of chronic HBV varied between the age groups: 4.6% (age 20 - 40), 3.4% (age 41 - 60), and 1.7% (age 61 - 80). Of 10 chronically infected, only two subjects had been previously diagnosed but were not engaged in care. Conclusion: HBV disproportionately affects Asian Americans, primarily owing to immigration from parts of the world where the disease is endemic. Indian Americans belong to an intermediate-risk group, with an HBV prevalence

关键词： Hepatitis B Virus Chronic Hepatitis B Indian Americans Health Disparity Community-Based Screening Linkage-to-Care

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ACUPUNCTURE FOR DRY EYE SYNDROME AFTER REFRACTIVE SURGERY:STUDY PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL

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Journal of Integrative Medicine 2014年第3期 318-318页

作者： Hyesun Jang Sanghun lee Tae-Hun Kim Ae-Ran Kim minhee lee Jun-Hwan lee Korea Institute of Oriental Medicine College of Korean medicine Gachon University

Background: Dry eye is a frequent consequence of refractive *** has been widely used to alleviate the associated ***, the use of acupuncture for patients who suffer from dry eye syndrome following refractive surgery has its *** pilot study aims to evaluate the efficacy of acupuncture treatment in treating the signs and symptoms of dry eye after refractive ***: Forty participants will be randomly assigned to acupuncture plus usual care group or usual care control *** maintaining usual care, the acupuncture plus usual care group will undergo treatments 3 times per week for 4 weeks on 17 acupuncture *** control group will receive only usual care during the same *** primary outcome will refer to ocular surface disease index(OSDI) and examinations at 1, 3, 5, and 13 weeks.A tear-film breakup time(TBUT), the Schirmer-I test, visual analogue scale(VAS), quality of life(QOL) for selfassessment of ocular discomfort, and fluorescein-stained corneal surface digital photography will be used as secondary outcome ***-I test, TBUT, and fluorescein-stained corneal surface digital photography will be assessed at the screening and week *** will be assessed at the screening, and 1, 3, 5, and 13 *** will be evaluated at 1, 3, 5, and 13 ***: This trial will provide primary data for the clinical effectiveness and safety of acupuncture treatment for dry eye after refractive surgery.

关键词： QOL VAS

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不同肌肉组选择导出模块对组间肌电反复性的影响（英文）

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医用生物力学 2019年第4期34卷 425-433页

作者： Yushin KIM minhee KIM Bumchul YOON Sangheon lee 韩国高等科学技术研究院力学工程系大田韩国高丽大学保健大学院首尔韩国高丽大学医学研究中心康复医学科首尔韩国

目的评价组间肌电反复性对不同肌肉组选择导出模块的影响。方法记录12名参与实验者在自选速度下行走时16块肌肉的肌电图。用组内相关系数评价每个步行周期的肌肉兴奋度和肌肉模块。依据肌肉兴奋度的反复性,区分出3种类型的肌肉组。结果... 详细信息

目的评价组间肌电反复性对不同肌肉组选择导出模块的影响。方法记录12名参与实验者在自选速度下行走时16块肌肉的肌电图。用组内相关系数评价每个步行周期的肌肉兴奋度和肌肉模块。依据肌肉兴奋度的反复性,区分出3种类型的肌肉组。结果可靠肌肉组显示出较高的组内相关系数(>0.4),而全身肌肉组和混合肌肉组显示出较低的组内相关系数(<0.4)。3种类型肌肉组比较,可靠肌肉组分析得出的模块具有最好的反复性,全身肌肉组和混合肌肉组的反复性较低。结论具有较高可靠性的肌肉兴奋性能够得出较一致的模块。得出一致模块的方法非常重要,尤其是在依靠肌肉兴奋性反馈而改变的运动模式中。

关键词：肌肉兴奋度肌电图行走稳定性重复性

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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： minhee Kim Jin Hee Park Miyeon Go Nawon lee Jeongin Seo Hana lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

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Light(Science & Applications) 2022年第7期11卷 1595-1606页

作者： Geon Kim Daewoong Ahn minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong lee YongKeun Park Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Tomocube Inc. Daejeon 34109Republic of Korea Smart Healthcare&Device Research Center Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Emergency Medicine Bundang CHA HospitalSeongnam-siGyeonggi-Do 13496Korea Division of Infectious Diseases Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Laboratory Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA

The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial *** infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly *** studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to *** main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample ***,we propose a microscopy-based framework that identifies the pathogen from single to few *** framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural *** demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or *** performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical ***,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or *** believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections.

关键词： artificial neural exploit

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