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MicroRNA-328 is associated with （non-small） cell lung cancer （NSCLC） brain metastasis and mediates NSCLC migration

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中国神经肿瘤杂志 2011年第1期9卷 38-38页

作者： Arora S Ranade AR tran NL Nasser S Sridhar S Korn RL Ross JT Dhruv H Foss KM Sibenaller Z Ryken T Gotway MB Kim S Weiss GJ Cancer and Cell Biology Division Translational Genomics Research Institute Phoenix AZ.

Brain metastasis (BM) can affect?25% of nonsmall cell lung cancer (NSCLC) patients during their lifetime. Efforts to characterize patients that will develop BM have been disappointing, microRNAs (miRNAs) regulate the expression of target mRNAs, miRNAs play a role in regulating a variety of targets and, consequently, multiple pathways, which make them a powerful tool for early detection of disease, risk assessment, and prognosis.

关键词：非小细胞肺癌 microRNA miRNA 迁移介导关联脑 mRNA

Tenon囊下麻醉中透明质酸酶对眼球运动及眼睑功能影响的随机对照试验

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 26-26页

作者： Aslam S. Sarker S.J. tran-Dang M. 廖新华 Frimley Park Hospital Portsmouth RoadCamberleySurrey GU16 7UJUnited Kingdom

Purpose:To assess the effect of hyaluronidase on eye and eyelid movements when used as an adjunct in sub-Tenon’s ***:A total of 60 patients who had sub-Tenon’s anaesthesia prior to phacoemulsification surgery were divided into two equal groups in a double-masked randomised controlled *** these,Group A had 4 ml lignocaine 2%,while Group B had 4 ml lignocaine 2% with the addition of sodium hyaluronidase 75 IU/*** motility,levator,and orbicularis oculi function were measured in all patients at 5 and 8 *** function was scored from 0(no function)to 3(complete function)while orbicularis function was scored from 0 to *** score for ocular motility was the sum in four positions of gaze,each position scoring from 0 to *** were compared using a nonparametric ***:Group B achieved significantly better ocular and lid akinesia than Group A both at 5 and 8 min with P< *** median scores for levator function at 5 and 8 min were 2 for Group A and 0 for Group *** orbicularis function,the median scores at both time intervals were 2 for Group A and 1 for Group *** ocular motility,the median score for Group A at 5 min was 3 and at 8 min was 2.5;for Group B at 5 min was 0.5 and at 8 min was ***:The addition of hyaluronidase in sub-Tenon’s anaesthesia has a significant effect in improving ocular and lid(levator and orbicularis)akinesia.

关键词：随机对照试验 Tenon 透明质酸酶眼球运动睑运动提上睑肌透明质酸钠多卡因眼轮匝肌双盲

经皮穿刺椎间盘内注射乙醇胶髓核溶解术在难治性坐骨神经痛的保守治疗的队列研究

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国际医学放射学杂志 2016年第1期 92-92页

作者： S.Touraine J.Damiano O.tran J.D.Laredo 梁静 Radiologie Ostéo-Articulaire Hpital Lariboisière

摘要目的研究保守治疗失败后经皮穿刺注射乙醇胶髓核溶解术在缓解椎间盘突出造成坐骨神经痛的治疗效果。材料与方法 42例病人保守治疗失败后,在透视引导下行经皮穿刺注射乙醇胶的手术。病人纳入标准:1根据可视疼痛模拟标尺(VAS),病人至... 详细信息

摘要目的研究保守治疗失败后经皮穿刺注射乙醇胶髓核溶解术在缓解椎间盘突出造成坐骨神经痛的治疗效果。材料与方法 42例病人保守治疗失败后,在透视引导下行经皮穿刺注射乙醇胶的手术。病人纳入标准:1根据可视疼痛模拟标尺(VAS),病人至少6周坐骨神经痛大于4/10;2依据MRI或CT检查,病人椎间盘突出小于3个月。VAS评分系统确定基线、1个月后和3个月后的疼痛程度;评估病人相关因素(年龄、性别、疼痛的持续时间)对于经皮穿刺注射乙醇胶髓核溶解术结果的影响,并评估椎间盘突出的相关因

关键词：溶解术椎间盘突出脊柱病经皮穿刺髓核坐骨神经痛保守治疗酒醇一元醇乙醇

Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 205-215,I0005页

作者： Tan-To Cheung Rong Liu Federica Cipriani Xiaoying Wang Mikhail Efanov David Fuks Gi-Hong Choi Nicholas L.Syn Charing C.N.Chong Fabrizio Di Benedetto Ricardo Robles-Campos Vincenzo Mazzaferro Fernando Rotellar Santiago Lopez-Ben James O.Park Alejandro Mejia Iswanto Sucandy Adrian K.H.Chiow Marco V.Marino Mikel Gastaca Jae Hoon Lee TPeter Kingham Mathieu D’Hondt Sung Hoon Choi Robert P.Sutcliffe Ho-Seong Han Chung-Ngai Tang Johann Pratschke Roberto I.Troisi Go Wakabayashi Daniel Cherqui Felice Giuliante Davit L.Aghayan Bjorn Edwin Olivier Scatton Atsushi Sugioka tran Cong Duy Long Constantino Fondevila Mohammad Abu Hilal Andrea Ruzzenente Alessandro Ferrero Paulo Herman Kuo-Hsin Chen Luca Aldrighetti Brian K.P.Goh International robotic and laparoscopic liver resection study group investigators Department of Surgery Queen Mary HospitalThe University of Hong KongHong Kong SARChina Faculty of Hepatopancreatobiliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Liver Surgery and transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscowRussia Department of Digestive Oncologic and Metabolic SurgeryInstitute Mutualiste MontsourisUniversite Paris DescartesParisFrance Division of Hepatopancreatobiliary Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoulKorea Department of Hepatopancreatobiliary and transplant Surgery Singapore General Hospital and Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong Kong SARChina HPB Surgery and Liver transplant Unit University of Modena and Reggio EmiliaModenaItaly Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de la ArrixacaIMIB-ARRIXACAMurciaSpain HPB Surgery Hepatology and Liver TransplantationFondazione IRCCS Istituto Nazionale Tumori di MilanoMilanItaly HPB and Liver transplant Unit Department of General SurgeryClinica Universidad de NavarraUniversidad de NavarraPamplonaSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Hepatobiliary and Pancreatic Surgery Unit Department of SurgeryDr.Josep Trueta HospitalIdIBGiGironaSpain Hepatobiliary Surgical Oncology Department of SurgeryUniversity of Washington Medical CenterSeattleWAUSA The Liver Institute Methodist Dallas Medical CenterDallasTXUSA AdventHealth Tampa Digestive Health InstituteTampaFLUSA Hepatopancreatobiliary Unit Department of SurgeryChangi General

Background:The use of laparoscopic(LLR)and robotic liver resections(RLR)has been safely performed in many institutions for liver tumours.A large scale international multicenter study would provide stronger evidence and insight into application of these techniques for huge liver tumours≥10 ***:this was a retrospective review of 971 patients who underwent LLR and RLR for huge(≥10 cm)tumors at 42 international centers between ***:One hundred RLR and 699 LLR which met study criteria were *** comparison between the 2 approaches for patients with huge tumors were performed using 1:3 propensity-score matching(PSM)(73 vs.219).Before PSM,LLR was associated with significantly increased frequency of previous abdominal surgery,malignant pathology,liver cirrhosis and increased median *** PSM,RLR and LLR was associated with no significant difference in key perioperative outcomes including media operation time(242 vs.290 min,P=0.286),transfusion rate rate(19.2%vs.16.9%,P=0.652),median blood loss(200 vs.300 mL,P=0.694),open conversion rate(8.2%vs.11.0%,P=0.519),morbidity(28.8%vs.21.9%,P=0.221),major morbidity(4.1%vs.9.6%,P=0.152),mortality and postoperative length of stay(6 vs.6 days,P=0.435).Conclusions:RLR and LLR can be performed safely for selected patients with huge liver tumours with excellent *** was no significant difference in perioperative outcomes after RLR or LLR.

关键词： Laparoscopic liver resection(LLR) robotic liver resection(RLR) hepatocellular carcinoma colorectal liver metastases huge

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 60-60页

作者： Pawlikowska L. tran M.N. Achrol A.S. W.L. Young 张慧 UCSF 1001 Potrero Ave. SanFrancisco CA 94110 United States.Dr

Background and Purpose -Mutations in endoglin (ENG)-and activin-like kinase (ALK1) cause hereditary hemorrhagic telangiectasias, disorders characterized by pulmonary and brain arteriovenous malformations (BAVMs). We investigated whether polymorphisms in these genes are also associated with sporadic BAVM. Methods -A total of 177 sporadic BAVM patients and 129 controls (all subjects white) were genotyped for 2 variants in ALK1 and 7 variants in ENG. Results -The ALK1 IVS3-35A>G polymorphism was associated with BAVM: (AnyA [AA+AG] genotype: odds ratio, 2.47; 95%CI, 1.38 to 4.44; P=0.002). Two ENG polymorphisms, ENG -1742A >G and ENG 207G >A, showed a trend toward association with BAVM that did not reach statistical significance. Conclusions -A common polymorphism in ALK1 is associated with sporadic BAVM, suggesting that genetic variation in genes mutated in familial BAVM syndromes may play a role in sporadic BAVMs.

关键词：散发性 ALK1 多态性 ENG

伊马替尼(Gleevec~)诱发肝脏毒性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 46-46页

作者： Ayoub W.S. Geller S.A. tran T. F.F. Poordad 徐瑞 Hepatology and Liver transplantation Ctr. for Liver Dis. and Transplant. 8635West 3rd Street Los Angeles CA 90048 United States Dr.

Imatinib (Gleevec ), Novartis Pharmaceuticals Corp, East Hanover, NJ) is wi dely used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. To our knowledge, only one case report of histologically proven Imatinib- induced hepatotoxicity has been reported. We describe another case of hepatotoxicity in a 22- year- old woman including the histopathologic changes and the clinical course after the discontinuation of Imatinib.

关键词：伊马替尼肝脏毒性 Gleevec 组织病理学变化肝毒性胃肠道间质瘤临床病程

人类免疫缺陷病毒感染患者中的梅毒性葡萄膜炎

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 46-46页

作者： tran T.H.C. Cassoux N. Bodaghi B. P. Lehoang 曹绪胜 Department of Opthalmology Pitié -Salpê etriè re 47-83 Boulevard de l'H pital 75013 Paris France

Background: this work investigates the incidence and clinical features of syphilitic uveitis in patients infected with human immunodeficiency virus (HIV). Material and methods: We retrospectively reviewed syphilitic uveitis in patients coinfected with HIV that presented at a referral center between July 2001 and November 2003. Results: Twelve patients (20 eyes) were included. The ocular manifestations of syphilis led to the discovery of HIV-1 seropositivity in three patients. All patients were male and homosexual. One patient has been previously treated for syphilis with benzathine penicillin G. One patient presented with anterior uveitis and 11 patients had panuveitis or posterior uveitis. Necrotizing retinitis was noted in seven eyes (35% ), posterior placoid chorioretinitis in six eyes (30% ) and optic nerve involvement in five eyes (25% ). Of nine patients with available cerebrospinal fluid (CSF) studies, seven (77.8% ) had CSF abnormalities. Eleven patients were treated with intravenous penicillinG and one with intravenous ceftriaxone sodium. One patient required a second course of antibiotics to control uveitis. Ocular inflammation decreased and visual acuity improved in all nine patients for whom follow-up was available after treatment. Conclusion: Manifestations of syphilitic uveitis in HIV-infected patients are multiple, with high frequencies of posterior uveitis, posterior placoid chorioretinitis, necrotizing retinitis and optic nerve involvement. Syphilitic uveitis in HIV-infected patients seems to have a more severe course and may relapse despite high-dose intravenous penicillin therapy.

关键词：毒性葡萄膜炎患者视网膜炎视网膜疾病

皮肤癌肉瘤附属器与表皮型型别决定肿瘤危险度的荟萃分析结果

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 27-27页

作者： tran T.A. Muller S. Chaudahri P.J. Carlson J.A. 冯义国 Department of Pathology Florida Orlando Hospital Orlando FL United States

Objective: We report four cases of cutaneous carcinosarcoma (CS)and perform a meta-analysis of the cutaneous CS literature. Results: CS occurred in elderly patients (mean of 80 years) on sun-damaged skin, and were keratotic papules of short duration. They did not recur after excision. CS exhibited basal cell carcinoma mixed with atypical fibroxanthoma cell populations. Immunophenotyping revealed vimentin+ /keratin-spindle cells and vimentin-/keratin+ epithelial cells. Three cases exhibited p53 protein expression of both carcinomatous and sarcomatous components. Literature review identified 38 cases of cutaneous CS that could be broadly classified into two distinct groups. Epidermal-derived (basal or squamous cell carcinoma epithelial component) CS arose on the sun- damaged skin of the head and neck of elderly males (mean age 72 years) and had a 70% 5- year disease- free survival. In contrast, adnexal CS (spiradenocarcinoma,porocarcinoma,proliferating tricholemmal cystic carcinoma,or matrical carcinoma)occurred in younger patients (mean age 58 years), showed recent growth in a long- standing nodule and had a 25% 5- year disease-free survival. Age less than 65 years, recent growth, long-standing skin tumor, and tumor size greater than 2 cm significantly correlated with poor outcome. Conclusions: Cutaneous CS is an aggressive skin cancer with high risk for advanced disease. Significant risk factors exist whose identification will allow for better management of CS patients.

关键词：附属器皮型癌肉瘤基底细胞癌荟萃分析黄瘤细胞无病生存期角质蛋白汗孔癌毛母质

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中越河口-老街双边边境地区蚊虫比较性调查

寄生虫与医学昆虫学报 2010年第1期17卷 61-64页

作者：孙肖红张晓龙周麟杨旭陈文年胡克林岑江王静中国检验检疫科学研究院北京100123 云南河口出入境检验检疫局云南河口661300 云南省出入境检验检疫局昆明650228 越南老街国际卫生检疫中心老街越南

为明确中越河口-老街双边边境地区蚊虫种类及其分布情况，2008年11月在云南省河口县及越南老街省老街市4个地点的畜圈，于夜间用电动诱蚊灯采集蚊虫，并对雌蚊进行分类鉴定。结果显示，在中国河口采集库蚊、按蚊、阿蚊、伊蚊、小蚊共5... 详细信息

为明确中越河口-老街双边边境地区蚊虫种类及其分布情况，2008年11月在云南省河口县及越南老街省老街市4个地点的畜圈，于夜间用电动诱蚊灯采集蚊虫，并对雌蚊进行分类鉴定。结果显示，在中国河口采集库蚊、按蚊、阿蚊、伊蚊、小蚊共5属19种678只，在越南老街采集到库蚊、按蚊、伊蚊、阿蚊、曼蚊、蓝带蚊6属20种1334只。骚扰阿蚊和三带喙库蚊是河口、老街夜间畜圈数量最多的蚊种；河口的骚扰阿蚊构成比比20年前有所增加；致倦库蚊在老街蚊虫中构成比仅次于骚扰阿蚊和三带喙库蚊，与河口不同。

关键词：蚊虫边境种群构成云南越南