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Crystal structure of the C-terminal domain of the ε subunit of human translation initiation factor eIF2B

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Protein & Cell 2010年第6期1卷 595-603页

作者： Jia Wei Minze Jia Cheng Zhang mingzhu wang Feng Gao Hang Xu Weimin Gong National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences Graduate University of Chinese Academy of SciencesBeijing 100049China

Eukaryotic translation initiation factor eIF2B,the guanine nucleotide exchange factor(GEF)for eIF2,catalyzes conversion of eIF2·GDP to eIF2·*** eIF2B is composed of five subunits,α,β,γ,δandε,within which theεsubunit is responsible for catalyzing the guanine exchange *** we present the crystal structure of the C-terminal domain of human eIF2Bε(eIF2Bε-CTD)at 2.0-Å*** structure resembles a HEAT motif and three charge-rich areas on its surface can be *** compared to yeast eIF2Bε-CTD,one area involves highly conserved AA boxes while the other two are only partially *** addition,the previously reported mutations in human eIF2Bε-CTD,which are related to the loss of the GEF activity and human VWM disease,have been *** on the structure,most of such mutations tend to destabilize the HEAT motif.

关键词： eukaryotic translation initiation factor 2B(eIF2B) guanine nucleotide exchange factor(GEF) crystal structure HEAT motif vanishing white matter(VWM)

LEGENDRE-GAUSS-RADAU SPECTRAL COLLOCATION METHOD FOR NONLINEAR SECOND-ORDER INITIAL VALUE PROBLEMS WITH APPLICATIONS TO WAVE EQUATIONS

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Journal of Computational Mathematics 2024年第1期42卷 217-247页

作者： Lina wang Qian Tong Lijun Yi mingzhu Zhang Department of Mathematics Shanghai Normal UniversityShanghai 200234China School of Science Henan University of EngineeringZhengzhou 451191China

We propose and analyze a single-interval Legendre-Gauss-Radau(LGR)spectral collocation method for nonlinear second-order initial value problems of ordinary differential *** design an efficient iterative algorithm and prove spectral convergence for the single-interval LGR collocation *** more effective implementation,we propose a multi-interval LGR spectral collocation scheme,which provides us great flexibility with respect to the local time steps and local approximation ***,we combine the multi-interval LGR collocation method in time with the Legendre-Gauss-Lobatto collocation method in space to obtain a space-time spectral collocation approximation for nonlinear second-order evolution *** results show that the proposed methods have high accuracy and excellent long-time *** comparison between our methods and several commonly used methods are also provided.

关键词： Legendre-Gauss-Radau collocation method Second-order initial value problem Spectral convergence Wave equation

城乡建设碳达峰碳中和区域探索与实践——以锡东新城“双碳”先导区为例

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建设科技 2024年第13期 37-42页

作者：王明威袁廷朋张路薇唐文超王明珠江苏超柏建设科技有限公司常州213000 无锡锡东新城商务区管理委员会无锡214000

本文以锡东新城城乡建设碳达峰碳中和先导区为例,探讨该类片区实现城乡建设碳达峰碳中和发展模式。从介绍国家、省、市碳达峰战略入手,以锡东新城城乡建设碳达峰碳中和先导区2028年碳达峰、2049年碳中和为实施目标,针对其建设发展模式... 详细信息

本文以锡东新城城乡建设碳达峰碳中和先导区为例,探讨该类片区实现城乡建设碳达峰碳中和发展模式。从介绍国家、省、市碳达峰战略入手,以锡东新城城乡建设碳达峰碳中和先导区2028年碳达峰、2049年碳中和为实施目标,针对其建设发展模式进行论述,探索总结城乡建设碳达峰碳中和先导区发展经验,并指出现存问题及挑战。

关键词：新城建设碳达峰碳中和发展模式

基于中医问诊信息的上海地区肥胖高血压的中医证候分类模型

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世界科学技术-中医药现代化 2024年第2期26卷 453-461页

作者：侯春蕾芦波桂明泰姚磊周训杰李建华王明珠符德玉上海中医药大学附属岳阳中西医结合医院上海200437

目的肥胖高血压证候识别模型相关研究较少,本研究基于隐结构模型分析上海地区肥胖高血压中医证候特点,为临床辨证提供依据。方法本研究收集427例上海地区肥胖高血压患者的中医问诊信息,结合频数分析及专家意见,筛选主要症状,采用双重爬... 详细信息

目的肥胖高血压证候识别模型相关研究较少,本研究基于隐结构模型分析上海地区肥胖高血压中医证候特点,为临床辨证提供依据。方法本研究收集427例上海地区肥胖高血压患者的中医问诊信息,结合频数分析及专家意见,筛选主要症状,采用双重爬山法,以Lantern 5.0软件构建肥胖高血压中医问诊信息隐结构模型,对隐变量进行综合聚类分析,分析肥胖高血压中医证候分布,建立证候分类模型。结果427例上海地区肥胖高血压患者的中医问诊信息中,出现最多的5种症状为眩晕(79.3%)、口干口渴(61.2%)、心悸怔忡(60.0%)、急躁易怒(56.9%)、头痛(54.0%),30个显变量构建隐结构模型,得到6个隐变量Y0、Y1、Y2、Y3、Y4、Y5。结论上海地区肥胖高血压患者的临床证候虚实夹杂,基于隐结构模型将该病主要证候分为肝阳上亢证、阴阳两虚证、心肾阴虚证,痰浊、血瘀为肥胖高血压重要的病理因素。隐结构模型对肥胖高血压证候分析的结果与该病的中医临床特点基本吻合,可以反映其主要病因病机。

关键词：原发性高血压肥胖隐结构模型中医证候客观化

Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2

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Protein & Cell 2015年第9期6卷 693-697页

作者： Hong wang (1) (2) mingzhu wang (1) Na Yang (1) (2) Rui-Ming Xu (1) (2) 1.National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2.University of Chinese Academy of Sciences Beijing 100049 China

The building block of eukaryotic chromatin is the nucleo- some core particle （NCP）, which is consisted of -146 bps of DNA wrapped around an octamer of core histones. A tetra- mer of histone H3 and H4 and two H2A-H2B dimers form the histone octamer （Kornberg, 1974; Luger et al., 1997; Tho- mas and Kornberg, 1975）. During DNA replication, nucleo- some disassembly and reassembly occurs at the replication fork, and histone chaperons CAF-1 and ASF1 are principally responsible for the deposition of histones H3 and H4 onto replicated DNA （Kaufman et al., 1995; Tyler et al., 1999）. ASF1 binds a heterodimeric histone H3-H4 complex through its conserved N-terminal domain （aa 1-155） and impedes the formation of the （H3-H4）2 tetramer both inside the nucleus and in the cytoplasm （English et al., 2005）.

关键词： Histone Chaperone Nucleosome Core Particle Quaternary Complex Replicative Helicase HeLa Cell Nuclear Extract

受体酪氨酸激酶AXL在肿瘤生物学中的作用研究进展

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现代肿瘤医学 2024年第1期32卷 167-171页

作者：何凯桐周阳王明珠郭婷孙轶华哈尔滨医科大学附属肿瘤医院检验科黑龙江哈尔滨150086 菏泽医学专科学校免疫学检验教研室山东菏泽274000

AXL是一种受体酪氨酸激酶(receptor tyrosine kinase,RTK),属于TAM(TYRO3-AXL-MER)家族。在生理条件下,AXL表达于人体的心脏、骨骼肌、甲状腺中。AXL通过调控多条信号通路介导了肿瘤细胞的血管生成、迁移、侵袭、增殖与转移等过程。此外... 详细信息

AXL是一种受体酪氨酸激酶(receptor tyrosine kinase,RTK),属于TAM(TYRO3-AXL-MER)家族。在生理条件下,AXL表达于人体的心脏、骨骼肌、甲状腺中。AXL通过调控多条信号通路介导了肿瘤细胞的血管生成、迁移、侵袭、增殖与转移等过程。此外,AXL在多种癌症中高表达,对于肿瘤患者的预后评价具有重要意义,并极有可能成为一种新的诊断及预后生物标志物和治疗靶点。本文就近年来AXL在肿瘤生物学中的作用研究进展进行综述。

关键词：受体酪氨酸激酶 AXL 肿瘤耐药

Functional microfluidics:theory,microfabrication,and applications

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International Journal of Extreme Manufacturing 2024年第3期6卷 140-173页

作者： mingzhu Xie Ziheng Zhan Yinfeng Li Junkai Zhao Ce Zhang Zhaolong wang Zuankai wang Interdisciplinary Research Center of Low-carbon Technology and Equipment College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082People’s Republic of China Energy Research Institute of Shandong Academy of Sciences Qilu University of Technology(Shandong Academy of Sciences)Jinan 250014People’s Republic of China Qian Xuesen Laboratory of Space Technology China Academy of Space Technology(CAST)Beijing 100094People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of China 999077People’s Republic of China

Microfluidic devices are composed of microchannels with a diameter ranging from ten to a few hundred ***,quite a small(10-9–10-18l)amount of liquid can be manipulated by such a precise *** the past three decades,significant progress in materials science,microfabrication,and various applications has boosted the development of promising functional microfluidic *** this review,the recent progress on novel microfluidic devices with various functions and applications is ***,the theory and numerical methods for studying the performance of microfluidic devices are briefly ***,materials and fabrication methods of functional microfluidic devices are ***,the recent significant advances in applications of microfluidic devices are highlighted,including heat sinks,clean water production,chemical reactions,sensors,biomedicine,capillaric circuits,wearable electronic devices,and ***,perspectives on the challenges and future developments of functional microfluidic devices are *** review aims to inspire researchers from various fields engineering,materials,chemistry,mathematics,physics,and more—to collaborate and drive forward the development and applications of functional microfluidic devices,specifically for achieving carbon neutrality.

关键词： capillary theory functional devices functional microfluidics

基于采灌均衡模拟的砂岩热储合理采灌井距计算方法

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地质科技通报 2024年第5期43卷 170-180页

作者：段晓飞康凤新吴晓华王明珠杨亚宾战静华陈京鹏山东省地质矿产勘查开发局第二水文地质工程地质大队山东德州253072 山东科技大学地球科学与工程学院山东青岛266590 山东省地质矿产勘查开发局八○一水文地质工程地质大队济南250014 济南大学水利与环境学院济南250022 山东省地热清洁能源探测开发与回灌工程技术研究中心山东德州253072 德州市地热清洁能源开发利用中试基地山东德州253072 德州市深层地质能节能减碳重点实验室山东德州253072

为实现地热能可持续开发利用的目标,需要明确不同采灌条件下合理的采灌井间距。为此,以鲁北馆陶组热储为研究对象,建立了层状热储开发的概念模型及数学模型,采用COMSOL Multiphysics多场耦合模拟软件建立了地热对井采灌井距计算器。通... 详细信息

为实现地热能可持续开发利用的目标,需要明确不同采灌条件下合理的采灌井间距。为此,以鲁北馆陶组热储为研究对象,建立了层状热储开发的概念模型及数学模型,采用COMSOL Multiphysics多场耦合模拟软件建立了地热对井采灌井距计算器。通过参数拟合及模拟结果对比,验证了模型的准确性;进而以软件APP编译功能为基础,以普通用户使用为导向,简化相关参数输入,建立了地热采灌井距计算APP。为适应实际生产需求,计算了不同采灌量条件下对应的合理采灌井距。计算结果表明:鲁北地区馆陶组热储采灌量分别为40,60,80,100 m^(3)/h时,不发生热突破的合理采灌井距分别为290,330,360,390 m。研究表明:(1)在鲁北层状传导型砂岩热储地区,对概念模型进行简化处理后,数值模拟计算结果可靠,可以在该地区建立合理采灌井距计算APP;(2)水热数值模拟是合理采灌井距计算的有力手段,能够确定开采量、回灌量、回灌温度、采灌井距等地热开发利用工程的关键参数,有利于实现地热资源可持续开发利用。

关键词：砂岩热储采灌工程采灌井距热突破水热耦合模拟 APP

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SURFACE METALLIZATION OF CENOSPHERES AND PRECIPITATORS BY ELECTROLESS PLATING

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China Particuology 2003年第4期1卷 156-161页

作者： Chujiang Cai Zhigang Shen mingzhu wang Shulin Ma Yushan Xing Beijing Key Laboratory for Powder Technology Research and Development Beijing University of Aeronautics and AstronauticsBeijing 100083P.R.China

This paper reports the use of a colloidal Pd0 catalysis system to metallize the surface of precipitators separated from coal fly-ash, and metals such as Cu, Ni etc. are deposited on the precipitators surface. Alternatively, according to the characteristic surface of cenospheres, an Ag coating catalysis system is adopted to first deposit Ag on the cenospheres surface, followed, if necessary, by the deposition of other metals such as Cu, Ni, etc. on the Ag coating to produce monolayer and multilayer metal-coated cenospheres. The surface characteristics and the morphologies of the metal coatings are examined in detail with scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) techniques. It can be shown that the quality of metal coatings derived from the Ag coating catalysis system, is better than that of the colloidal Pd0 catalysis system.

关键词： electroless plating precipitator cenosphere metal coating