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Bidirectional regulation of Ca^(2+) in exo–endocytosis coupling

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Science China(Life Sciences) 2018年第12期61卷 1583-1585页

作者： Qian Song mingzhu huang Bianbian Wang Xinjiang Kang Changhe Wang Center for Mitochondrial Biology and Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology and Frontier Institute of Science and Technology Xi'an Jiaotong University College of Life Sciences Liaocheng University DOE-Key Lab of Medical Electrophysiology Institute of Cardiovascular Research Southwest Medical University

Vesicular exocytosis is a key process involved in neurotransmitter release,whereas vesicle recycling is critical for the homeostasis of plasma membrane structures and the maintenance of ***^2+ regulates several fundamental cellular processes(Zhu et al.,2016,Xiong and Zhu,2016).Especially,Ca^2+ influx plays a dual role of triggering vesicular exocytosis and modulating compensatory endocytosis in neurons and endocrine cells.

关键词： Vesicular exocytosis key process

DEEP GROUND STATES RELATED TO Fe IN GaAs_(1-x)P_(x) ALLOY SYSTEM

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Chinese Physics Letters 1987年第9期4卷 405-408页

作者： GU Yiming huang mingzhu WANG Keling University of Science and Technology of China Hefei

A theory suggested by Vogl et *** extended to the iron-doped GaAs_(1-x)P_(x) alloy *** deep ground states(including acceptor(Fe/Fe)levels,donor(Fe/Fe)levels,local charges and spin densities)are predicted for different composition *** calculated results show good agreement with the relevant experimental data and reveal their variation trends.

关键词： alloy

Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase Ⅱ clinical trial

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Cancer Biology & Medicine 2023年第9期20卷 682-688页

作者： Xiaoying Zhao Zhiyu Chen Xiaowei Zhang Xiaodong Zhu Wen Zhang Lixin Qiu Chenchen Wang mingzhu huang Zhe Zhang Wenhua Li Lei Yang Weijian Guo Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Shanghai Medical College Fudan UniversityShanghai 200032China Department of Medical Oncology Nantong Tumor HospitalNantong 226006China

Objective:Paclitaxel(P)is a standard second-line chemotherapy in the treatment of advanced gastric *** study compared the clinical outcome of a paclitaxel plus raltitrexed(RP)regimen as second-line treatment in metastatic gastric cancer(MGC)***:An open,randomized,multi-center phase Ⅱ clinical trial was conducted involving 148 patients who were randomly assigned and treated with RP[raltitrexed(3 mg/m^(2)on day 1)and paclitaxel(135 mg/m^(2)on day 1 every 3 weeks)]or P[paclitaxel(135 mg/m^(2)on day 1 every 3 weeks)]as 2nd-line *** primary endpoint was progression-free survival(PFS).The secondary endpoints were the overall response rate(ORR),overall survival(OS),and ***:PFS had a tendency to be prolonged with RP compared to P(2.7 months vs.1.7 months;P=0.148).OS was also prolonged with RP compared to P(10.2 months vs.6.1 months;P=0.140).The ORR was equal in the RP and P groups(6.8%and 4.0%;P=0.72).The disease control rate(DCR)in the RP and P groups was 56.2%and 36.0%,*** 3-4 treatment-related adverse events occurred in 36.2%(RP)and 28.2%(P)of *** grade 3-4 toxicities for RP and P were neutropenia(11.0%and 4.0%),anemia(1.4%and 4.0%),and thrombocytopenia(1.4%and 5.3%),and all grades of peripheral neurotoxicity(12.3%vs.17.3%).All grades of hepatic toxicity were demonstrated for the RP and P groups based on elevated aminotransferase levels(27.4%and 14.1%).Subgroup analysis shows if MGC was combined with ascites or peritoneal involvement,the OS of the RP regimen was longer(P=0.05).Conclusions:Second-line palliative chemotherapy with RP was shown to prolong the PFS and OS,especially among patients with ascites or peritoneal involvement,which warrants confirmation using larger sample studies.

关键词： Gastric adenocarcinoma raltitrexed paclitaxel second-line palliative chemotherapy

SARS-CoV-2-specific CD4^(+)T cells are associated with long-term persistence of neutralizing antibodies

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1773-1782页

作者： Zhongfang Wang Xiaoyun Yang Xinyue Mei Yumin Zhou Zhiqiang Tang Guichang Li Jiaying Zhong Mengqiu Yu mingzhu huang Xiaoling Su Bijia Lin Pengxing Cao Ji Yang Pixin Ran State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina The Second People’s Hospital of Changde HunanChina School of mathematics and Statistics University of MelbourneMelbourneVICAustralia

Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing antibodies in infected or vaccinated people and how vaccines protect against other SARS-CoV-2 variants is critical for assessing public vaccination ***,we measured different plasm antibody levels 2 and 12 months after disease onset,including anti-RBD,anti-N,total neutralizing antibodies,and two neutralizing-antibody *** found that total neutralizing antibodies declined more slowly than total anti-RBD and anti-N IgG.

关键词： antibodies neutral assessing

Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study

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Chinese Journal of Cancer Research 2019年第2期31卷 339-348页

作者： Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun mingzhu huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang Department of Medical Oncology Fudan University Shanghai Cancer CenterDepartment of Oncology Shanghai Medical College Fudan University

Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment ***: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials.

关键词： Albumin-bound paclitaxel cisplatin gemcitabine first-line therapy advanced non-small-cell lung cancer

供应链韧性影响因素研究:基于SEM与fsQCA方法

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系统工程理论与实践 2023年第9期43卷 2484-2501页

作者：马潇宇黄明珠杨朦晰北京外国语大学国际商学院北京100089 中国科学院大学经济与管理学院北京100190 中国科学院大学数字经济监测预测预警与政策仿真教育部哲学社会科学实验室(培育) 北京100190

近年来,各种安全风险事件显著增多使得大量企业的供应链遭遇冲击甚至发生中断,供应链韧性已成为学术界、产业界和政府共同关注焦点.本文从单一和多元组态视角出发,构建了供应链韧性影响因素研究模型,以622份企业的有效数据为样本,采用... 详细信息

近年来,各种安全风险事件显著增多使得大量企业的供应链遭遇冲击甚至发生中断,供应链韧性已成为学术界、产业界和政府共同关注焦点.本文从单一和多元组态视角出发,构建了供应链韧性影响因素研究模型,以622份企业的有效数据为样本,采用结构方程模型(SEM)和模糊集定性比较分析(fsQCA)方法进行了实证分析.研究发现:1)灵活性、敏捷性、重塑性、可视性、供应链合作均能够对供应链韧性产生正向影响.2)高灵活性、高敏捷性、高重塑性、高可视性、强供应链合作均无法单独构成高供应链韧性的必要条件.3)高供应链韧性存在3类驱动组态,分别是敏捷性*重塑性*供应链合作构成的高敏捷型组态、~灵活性*重塑性*可视性*供应链合作构成的高可视型组态、~灵活性*敏捷性*可视性*供应链合作和灵活性*敏捷性*可视性*重塑性构成的敏捷可视兼具型组态.高供应链韧性背后是多因素的协同作用,各因素的有效组合以“殊途同归”的方式提升供应链韧性.本研究系统性地探讨了供应链韧性影响因素,以期为企业提升供应链韧性提供理论指导和管理启示.

关键词：供应链韧性结构方程模型模糊集定性比较分析

THE DEEP LEVELS IN GaSb/AlSb(00l)SUPERLATTICES

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Chinese Physics Letters 1987年第6期4卷 253-256页

作者： huang mingzhu GU Yiming REN Shangyuan Department of Physics University of Science and Technology of ChinaHefei

The electronic states,especially the deep levels of the defects in GaSb/AlSb(001)superlattices have been *** band gap becomes larger and the donor binding energy becomes deeper with the decrease of the quantum well **... 详细信息

关键词： GaSb AlSb donor

Potential of Antibody-Dependent Cellular Cytotoxicity in Acute and Recovery Phases of SARS-CoV-2 Infection

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Infectious Diseases & Immunity 2022年第2期2卷 74-82页

作者： Tingting Cui mingzhu huang Xiaoling Su Zhengfang Lin Jiaying Zhong Xiaoyun Yang Zhongfang Wang The State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510180China

Background:Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused a global pandemic that has resulted in millions of *** researchers have reported the existence of neutralizing antibodies and viral T cell immunity against SARS-CoV-2,little is known about the presence of antibody-dependent cellular cytotoxicity(ADCC)and its role in combating SARS-CoV-2 ***:Nineteen acute COVID-19 patients at the First Affiliated Hospital of Guangzhou Medical University from January to February,2020 and 55 recovery COVID-19 patients at the Second Peoples Hospital of Changde City from February,2020 to February,2021 were recruited in this *** plasma samples were collected.A virus-specific ADCC assay was performed to study the COVID-19 plasma *** correlations between ADCC and total IgG titer,including anti-RBD,anti-N,and neutralizing antibody titer were ***:A high level of ADCC with 0.86%of IFN-g+CD107a+NK cells induced by anti RBD antibodies and with 0.54%of IFN-g+CD107a+NK cells induced by anti N antibodies was *** activity peaked at 3 weeks after disease onset with 1.16%and 0.63%of IFN-g+CD107a+NK cells induced by anti RBD and anti N antibodies respectively,declined to 0.32%and 0.32%of IFN-g+CD107a+NK cells respectively after more than 2 months,and persisted for 12 months after disease *** ADCC did not aggravate the severity of COVID-19 in terms of sequential organ failure assessment,although ADCC decreased with the age of COVID-19 ***,ADCC response is not correlated with neutralizing antibody titer or total IgG titers against S protein RBD and N protein in acute *** in recovered patients showed a significant correlation with anti RBD IgG titer(R2=0.33,P<0.001).Conclusion:Antibodies from COVID-19 patients against the N protein and S protein RBD domains could stimulate high levels of ADCC *** results provide evidence that vaccination should not only foc

关键词： Antibody-dependent cell cytotoxicity Aged immunity Anti-viral immunity SARS-CoV-2 Severity

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肿瘤干细胞传统治疗抵抗与靶向治疗

中国肿瘤临床 2009年第4期36卷 230-233页

作者：黄明主张凤春上海交通大学医学院附属仁济医院肿瘤科

近年来，不断有资料表明，肿瘤干细胞和正常干细胞具有相似的性质。肿瘤干细胞导致肿瘤的发生、复发及转移。肿瘤干细胞对传统治疗方法的抵抗是肿瘤治疗失败的主要原因。同时，肿瘤干细胞位于特定的微环境中，肿瘤干细胞与微环境的相互... 详细信息

近年来，不断有资料表明，肿瘤干细胞和正常干细胞具有相似的性质。肿瘤干细胞导致肿瘤的发生、复发及转移。肿瘤干细胞对传统治疗方法的抵抗是肿瘤治疗失败的主要原因。同时，肿瘤干细胞位于特定的微环境中，肿瘤干细胞与微环境的相互作用显著影响肿瘤的进程。本文针对肿瘤干细胞及其微环境的靶向治疗做一综述，期望为肿瘤治疗带来新的思路。

关键词：肿瘤干细胞微环境靶向治疗