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基于EEMD-HW-GBDT模型的零售商品销量多步预测

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工业工程与管理 2024年第1期29卷 133-141页

作者：霍佳震徐骏陈铭洲同济大学经济与管理学院上海200092

零售商品库存控制单位(stock keeping unit,SKU)级别的销量时间序列具有较强的非平稳性和非线性,其多步预测困难。为了解决上述问题,提出了一种基于集合经验模态分解(ensemble empirical mode decomposition,EEMD)、霍尔特-温特斯(Holt-... 详细信息

零售商品库存控制单位(stock keeping unit,SKU)级别的销量时间序列具有较强的非平稳性和非线性,其多步预测困难。为了解决上述问题,提出了一种基于集合经验模态分解(ensemble empirical mode decomposition,EEMD)、霍尔特-温特斯(Holt-Winters,HW)以及梯度提升树(gradient boosting decision tree,GBDT)的销量预测模型。该模型分为3个阶段:第1阶段利用HW模型进行区域-全商品层级销量预测,并通过移动平均比例法得到SKU级别预测结果;第2阶段利用EEMD处理原始时间序列和HW模型产生的预测值序列以降低数据的非平稳性及拓展输入特征;第3阶段集成基于HW预测分量和内外部特征构建的多个梯度提升树,得到预测结果。采用国内某零售企业的销售数据进行验证。结果表明,EEMD-HW-GBDT模型对零售商品销量多步预测问题具有良好的预测性能,在MAE、RMSE和WMAPE指标方面均优于其他7个基准对比模型。

关键词：销量预测多步预测 EEMD HW GBDT

电梯控制电源及安全控制回路故障诊断与排除方法的探讨

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通信电源技术 2024年第11期41卷 216-218页

作者：陈柳栋陈铭洲广州市交通运输职业学校广东广州510440

电梯的安全运行离不开两条核心保障线,即控制电源回路和安全控制回路。其中,控制电源回路提供稳定可靠的电力供应,是电梯所有电气系统和电子设备正常工作的基础。而安全控制回路作为电梯运行过程中的重要安全保障,负责监控电梯运行的各... 详细信息

电梯的安全运行离不开两条核心保障线,即控制电源回路和安全控制回路。其中,控制电源回路提供稳定可靠的电力供应,是电梯所有电气系统和电子设备正常工作的基础。而安全控制回路作为电梯运行过程中的重要安全保障,负责监控电梯运行的各种状态,确保电梯在安全范围内运行。文章旨在深入剖析电梯控制电源回路与安全控制回路中常见的电气故障类型,并探究这些故障的起因、诊断手段以及排除方法。通过详细分析电梯控制回路和安全回路的故障案例,总结出一套行之有效的回路故障诊断与排除方法,为电梯技术人员提供一定的维修参考。

关键词：控制电源回路安全控制回路故障诊断与排除

Sumoylation of Human Parainfluenza Virus Type 3 Phosphoprotein Correlates with A Reduction in Viral Replication

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Virologica Sinica 2021年第3期36卷 438-448页

作者： Qi cheng Wenjing Huai Xiaoyan Wu mingzhou chen State Key Laboratory of Virology Modem Virology Research CenterCollege of Life SciencesWuhan UniversityWuhan 430072China

Human parainfluenza virus type 3(HPIV3), a member of the Paramyxoviridae family, can cause lower respiratory disease in infants and young children. The phosphoprotein(P) of HPIV3 is an essential cofactor of the viral RNA-dependent RNA polymerase large protein(L). P connects nucleocapsid protein(N) with L to initiate genome transcription and *** influences many important pathways of the target proteins, and many viral proteins are also themselves sumoylated. In this study, we found that the P of HPIV3 could be sumoylated, and mutation of K492 and K532 to arginine(PK492 R/K532 R) failed to be sumoylated within P, which enhances HPIV3 minigenome activity. Biochemical studies showed that PK492 R/K532 Rhad no effect on its interactions with N, formation of homo-tetramers and formation of inclusion ***, we found that incorporation of K492 R/K532 R into a recombinant HPIV3(rHPIV3-PK492 R/K532 R) increased viral production in culture cells, suggesting that sumoylation attenuates functions of P and down-regulates viral replication.

关键词： Human parainfluenza virus type 3(HPIV3) Phosphoprotein Sumoylation Replication Viral replication

Viral Regulation of RNA Granules in Infected Cells

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Virologica Sinica 2019年第2期34卷 175-191页

作者： Qiang Zhang Nishi R. Sharma Zhi-Ming Zheng mingzhou chen State Key Laboratory of Virology and Modern Virology Research Center College of Life Sciences Wuhan UniversityWuhan 430072 China Tumor Virus RNA Biology Section RNA Biology Laboratory National Cancer Institute National Institutes of Health Frederick MD 21702 USA

RNA granules are cytoplasmic, microscopically visible, non-membrane ribo-nucleoprotein structures and are important posttranscriptional regulators in gene expression by controlling RNA translation and stability. TIA/G3BP/PABP-specific stress granules(SG) and GW182/DCP-specific RNA processing bodies(PB) are two major distinguishable RNA granules in somatic cells and contain various ribosomal subunits, translation factors, scaffold proteins, RNA-binding proteins, RNA decay enzymes and helicases to exclude m RNAs from the cellular active translational pool. Although SG formation is inducible due to cellular stress, PB exist physiologically in every cell. Both RNA granules are important components of the host antiviral defense. Virus infection imposes stress on host cells and thus induces SG formation. However, both RNA and DNA viruses must confront the hostile environment of host innate immunity and apply various strategies to block the formation of SG and PB for their effective infection and multiplication. This review summarizes the current research development in the field and the mechanisms of how individual viruses suppress the formation of host SG and PB for virus production.

关键词： Stress granules (SG) P-bodies (PB) RNA virus - DNA virus

The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/ budding

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Protein & Cell 2022年第2期13卷 120-140页

作者： Linjuan Wu Dongning Jin Dan Wang Xuping Jing Peng Gong Yali Qin mingzhou chen State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhan 430072China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China

Ebola virus(EBOV)is an enveloped negative-sense RNA virus and a member of the filovirus ***(NP)expression alone leads to the formation of inclusion bodies(IBs),which are critical for viral RNA *** matrix protein,VP40,not only plays a critical role in virus assembly/budding,but also can regulate transcription and replication of the viral ***,the molecular mechanism by which VP40 regulates viral RNA synthesis and virion assembly/budding is ***,we show that within IBs the N-terminus of NP recruits VP40 and is required for VLP-containing NP ***,we find four point mutations(L692A,P697A,P698A and W699A)within the C-terminal hydrophobic core of NP result in a stronger VP40–NP interaction within IBs,sequestering VP40 within IBs,reducing VP40–VLP egress,abolishing the incorporation of NC-like structures into VP40–VLP,and inhibiting viral RNA synthesis,suggesting that the interaction of N-terminus of NP with VP40 induces a conformational change in the C-terminus of ***,the C-terminal hydrophobic core of NP is exposed and binds VP40,thereby inhibiting RNA synthesis and initiating virion assembly/budding.

关键词： Ebola virus nucleoprotein matrix protein two-stage interaction RNA synthesis nucleocapsid assembly/budding

The nonstructural protein 2C of Coxsackie B virus has RNA helicase and chaperoning activities

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Virologica Sinica 2022年第5期37卷 656-663页

作者： Ziyu chen Xiaobei Xiong Yiyang Li Muhan Huang Yujie Ren Di Wu Yang Qiu mingzhou chen Ting Shu Xi Zhou State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan430072China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100081China

RNA-remodeling proteins,including RNA helicases and chaperones,play vital roles in the remodeling of structured *** viral replication,viruses require RNA-remodeling proteins to facilitate proper folding and/or re-folding the viral RNA *** B3(CVB3)and Coxsackieviruses B5(CVB5),belonging to the genus Enterovirus in the family Picornaviridae,have been reported to cause various infectious diseases such as hand-foot-and-mouth disease,aseptic meningitis,and viral ***,little is known about whether CVB3 and CVB5 encode any RNA remodeling *** this study,we showed that 2C proteins of CVB3 and CVB5 contained the conserved SF3 helicase A,B,and C motifs,and functioned not only as RNA helicase that unwound RNA helix bidirectionally in an NTP-dependent manner,but also as RNA chaperone that remodeled structured RNAs and facilitated RNA strand annealing independently of *** addition,we determined that the NTPase activity and RNA helicase activity of 2C proteins of CVB3 and CVB5 were dependent on the presence of divalent metallic *** findings demonstrate that 2C proteins of CVBs possess RNA-remodeling activity and underline the functional importance of 2C protein in the life cycle of CVBs.

关键词： 2C protein Coxsackieviruses B3(CVB3) Coxsackieviruses B5(CVB5) NTPase RNA helicase RNA chaperon

关节镜下规避骺板经单一隧道使用PDS-Ⅱ线结合Endobutton钢板固定治疗儿童胫骨髁间嵴骨折的临床疗效

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微创医学 2024年第1期19卷 27-32页

作者：彭伟盛希王胜涛陈东旭陈明洲李朝旭广西壮族自治区南溪山医院关节外科与运动医学科广西桂林市541002

目的探讨关节镜下规避骺板经单一隧道使用PDS-Ⅱ线结合Endobutton钢板固定治疗儿童胫骨髁间嵴骨折的临床疗效。方法回顾性分析11例胫骨髁间嵴骨折患儿的临床资料,均在关节镜下规避骺板经单一隧道使用PDS-Ⅱ线结合Endobutton钢板固定治... 详细信息

目的探讨关节镜下规避骺板经单一隧道使用PDS-Ⅱ线结合Endobutton钢板固定治疗儿童胫骨髁间嵴骨折的临床疗效。方法回顾性分析11例胫骨髁间嵴骨折患儿的临床资料,均在关节镜下规避骺板经单一隧道使用PDS-Ⅱ线结合Endobutton钢板固定治疗。术后随访,观察骨折愈合情况及膝关节稳定性,记录膝关节Lysholm评分、功能独立性测评(FIM)量表评分、2000国际膝关节评分委员会(2000 IKDC)膝关节主观评分、疼痛视觉摸拟量表(VAS)评分,以及并发症的发生情况、膝关节功能恢复情况。结果11例患者术后随访时间为6~12个月,平均9.4个月。(1)术后第1天复查患膝X线片提示胫骨髁间嵴撕脱骨块复位满意,各切口均于2周内甲级愈合并拆线。所有患者骨折均于术后3个月骨性愈合,未发现骨折畸形愈合、肢体不等长、伤肢出现内外翻畸形等情况,膝关节活动度正常,前抽屉试验及Lachman试验阴性,膝关节稳定性良好。(2)术前、术后2周、术后3个月、末次复诊时患儿的膝关节Lysholm评分、2000 IKDC评分、FIM量表评分均依次升高,疼痛VAS评分依次降低;末次复诊时膝关节Lysholm评分基本恢复伤前水平,2000 IKDC膝关节主观评分基本达满分,大部分患者处于无痛状态。(3)术后6个月,患者膝关节优良率为100.00%。所有患者术后均未出现双下肢长度不一致、双膝关节外翻角度不一致、切口感染、内固定物移位等并发症。结论关节镜下规避骺板经单一隧道使用PDS-Ⅱ线结合Endobutton钢板固定治疗儿童胫骨髁间嵴骨折是一种微创、可靠的治疗方式,其操作简单,固定可靠,治疗效果好,同时可以避免损伤骺板等相关并发症。

关键词：儿童胫骨髁间嵴骨折规避骺板可吸收缝线 Endobutton钢板临床疗效

SARS-CoV-2 promote autophagy to suppress type I interferon response

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1661-1663页

作者： Xianfeng Hui Linliang Zhang Lei Cao Kun Huang Ya Zhao Yufei Zhang Xi chen Xian Lin mingzhou chen Meilin Jin State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanChina State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhanChina CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyWuhanChina

Dear Editor,The outbreak of SARS-CoV-2 leads global epidemic with high morbidity and ***,the pathophysiology of this deadly virus is complex and largely *** is a highly conserved homeostatic process that allows cells to recycle their *** studies provided evidence that human coronavirus infections are closely related to various cellular aspects associated with autophagy.1 Autophagy may play a crucial role in the SARS-CoV-2 viral lifecycle.

关键词： mortality interferon morbidity

STUDY ON A PRECISE ON-SPOT CALIBRATION METHOD FOR DISTRIBUTED STEREO REFERENCE POSITION-SETTING

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Chinese Journal of Mechanical Engineering 2002年第4期15卷 324-327页

作者： Wang Zhong Kou Xinyu chen mingzhou Ye ShenghuaState Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University,Tianjin 300072, ChinaXiong ChunbaoTianjin University Tianjin University State Key Laboratory of Precision Measuring Technology and Instruments 天津 300072

A high precision method used for on-spot calibration of distributed stereoreference position setting is presented. The high measuring accuracy in stereo reference calibrationis derived from using a high precision water level instrument and an accurate height verniercaliper. It settles the problem of reference calibration effectively and accurately, without usinglarge coordinate measuring machines (CMM). It is more adaptable and precise than traditionalcalibration methods applying theodolites or autocollimators. The error sources of this method areanalyzed in detail and several methods are developed to eliminate the calibration *** swallowtail-like anchor target is developed. Experiments show that the calibrationaccuracy can be limited within 0.06 mm in the range of 3～5 m and 0.03 mm with optimizing anchortarget. This method can be widely used in on-spot calibration.

关键词： position setting reference calibration water level on-spot inspection error analysis