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Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway

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Neural Regeneration Research 2013年第34期8卷 3203-3215页

作者： Xiaojie Liu Zhigang Mei Jingping Qian Yongbao Zeng mingzhi wang Medical College of China Three Gorges University

Puerarin, a major isoflavonoid derived from the Chinese medical herb radix puerariae （Gegen）, has been reported to inhibit neuronal apoptosis and play an anti-inflammatory role in focal cerebral ischemia model rats. Recent findings regarding stroke pathophysiology have recognized that anti-inflammation is an important target for the treatment of ischemic stroke. The cholinergic anti-inflammatory pathway is a highly robust neural-immune mechanism for inflammation control. This study was to investigate whether activating the cholinergic anti-inflammatory pathway can be involved in the mechanism of inhibiting the inflammatory response during puerarin-induced cerebral ischemia/reperfusion in rats. Results showed that puerarin pretreatment （intravenous injection） re- duced the ischemic infarct volume, improved neurological deficit after cerebral ischemia/reperfusion and decreased the levels of interleukin-1β, interleukin-6 and tumor necrosis factor-a in brain tissue. Pretreatment with puerarin （intravenous injection） attenuated the inflammatory response in rats, which was accompanied by janus-activated kinase 2 （JAK2） and signal transducers and activators of transcription 3 （STAT3） activation and nuclear factor kappa B （NF-KB） inhibition. These observa- tions were inhibited by the alpha7 nicotinic acetylcholine receptor （a7nAchR） antagonist a-bungarotoxin （a-BGT）. In addition, puerarin pretreatment increased the expression of a7nAchR mRNA in ischemic cerebral tissue. These data demonstrate that puerarin pretreatment strongly protects the brain against cerebral ischemia/reperfusion injury and inhibits the inflammatory re- sponse. Our results also indicated that the anti-inflammatory effect of puerarin may partly be medi- ated through the activation of the cholinergic anti-inflammatory pathway.

关键词： neural regeneration cerebral ischemia/reperfusion inflammation cholinergic anti-inflammatory pathway alpha7 nicotinicacetylcholine receptors nuclear factor kappa B janus-activated kinase 2 signal transducers and activators of transcription 3 grants-supported paper neuroregeneration

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Fabrication of onion-like carbon from nanodiamond by annealing

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Science China(Technological Sciences) 2009年第12期52卷 3683-3689页

作者： Qin Zou mingzhi wang YanGuo Li YuCheng Zhao LiangHua Zou State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China

Onion-like carbon (OLC) was synthesized by annealing nanodiamond in low vacuum of 1 Pa and at annealing temperatures from 500°C to 1400°C. The high-resolution transmission electron microscope (HRTEM) images, X-ray diffraction (XRD) and Raman spectrum of the OLC showed that there was no OLC when the annealing temperature was lower than 900°C. Moreover, the fragment amorphous carbon existed on the surfaces of the nanodiamond particles. At the annealing temperature of 900°C, the OLC particles began appearing and the size of the OLC particles was smaller than 5 nm. When the annealing temperature was increased from 900°C to 1400°C, the nanodiamond was transformed into OLC gradually. At the annealing temperature of 1400°C, all the nanodiamond particles were transformed into OLC completely. The OLC exhibited similarity to the original nanodiamond particles in shape. A mechanism for the OLC synthesis by annealing was provided. The graphitization started at the surfaces of the nanodiamond particles. The formation process of the OLC includes formation of graphite fragments, connection and curvature of graphite sheets between diamond (111) planes and closure of the graphite layers.

关键词： onion-like carbon(OLC) nanodiamond annealing fabrication

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电子束熔丝增材制造Ti-6Al-4V钛合金研究进展

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中国材料进展 2024年第10期43卷 912-923页

作者：王明志胡嘉南辛社伟张思远刘志博张家豪杨义王皞上海理工大学材料与化学学院上海200093 中国科学院金属研究所师昌绪先进材料创新中心辽宁沈阳110016 中国科学技术大学材料科学与工程学院安徽合肥230026 西北有色金属研究院陕西西安710016

电子束熔丝增材制造技术因其电子束能量密度高、所处真空环境等优势,逐渐成为金属增材制造领域的研究热点之一。回顾了电子束熔丝增材制造技术的发展历程及现状,介绍了一种新型电子束熔丝增材制造技术——同轴送丝电子束熔丝增材制造。... 详细信息

电子束熔丝增材制造技术因其电子束能量密度高、所处真空环境等优势,逐渐成为金属增材制造领域的研究热点之一。回顾了电子束熔丝增材制造技术的发展历程及现状,介绍了一种新型电子束熔丝增材制造技术——同轴送丝电子束熔丝增材制造。结合作者课题组近几年的研究工作,针对Ti-6Al-4V钛合金的成形缺陷、显微组织及力学性能,对传统电子束熔丝增材制造技术和同轴送丝电子束熔丝增材制造技术进行了对比论述,其中同轴送丝电子束熔丝增材制造有望沉积β晶粒更细、更等轴的钛合金构件。最后结合当前研究存在的不足,对电子束熔丝增材制造的发展给出了建议。

关键词：增材制造电子束熔丝 Ti-6Al-4V 缺陷显微组织力学性能

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Phase structure and hydrogen storage properties of LaMg_(3.70)Ni_(1.18) alloy

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Rare Metals 2011年第5期30卷 458-463页

作者： LI Jinhua LIU Baozhong HAN Shumin HU Lin ZHAO Xin wang mingzhi State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China School of Materials Science and Engineering Henan Polytechnic University Jiaozuo 454000 China College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China

The phase structure and hydrogen storage properties of LaMg 3.70 Ni 1.18 alloy were investigated. The LaMg 3.70 Ni 1.18 alloy consists of main LaMg 2 Ni phase, minor La 2 Mg 17 and LaMg 3 phases. The alloy can be activated in the first hydriding/dehydriding process, and initial LaMg 2 Ni, La 2 Mg 17 , and LaMg 3 phases transfer to LaH 2.34 , Mg, and Mg 2 Ni phases after activation. The reversible hydrogen storage capacity of the LaMg 3.70 Ni 1.18 alloy is 2.47 wt.% at 558 K, which is higher than that of the LaMg 2 Ni alloy. The pressure-composition-temperature （PCT） curves display two hydriding plateaus, corresponding to the formation of MgH 2 and Mg 2 NiH 4 . However, only one dehydriding plateau is observed, owing to the synergetic effect of hydrogen desorption between MgH 2 and Mg 2 NiH 4 . The uptake time for hydrogen content to reach 99% of saturated state is less than 250 s, and 90% hydrogen can be released in 1200 s in the experimental conditions, showing fast kinetics in hydriding and dehydriding. The activation energies of the LaMg 3.70 Ni 1.18 alloy are –51.5 ± 1.1 kJ/mol and –57.0 ± 0.6 kJ/mol for hydriding and dehydriding, respectively. The hydriding/dehydriding kinetics of the LaMg 3.70 Ni 1.18 alloy is better than that of the Mg 2 Ni alloy, owing to the lower activation energy values.

关键词： hydrogen storage alloys multiphase structure hydrogen storage properties rare earths

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Decoupled deep hough voting for point cloud registration

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Frontiers of Computer Science 2024年第2期18卷 147-155页

作者： mingzhi YUAN Kexue FU Zhihao LI Manning wang Digital Medical Research Center School of Basic Medical SciencesFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention Shanghai 200032China

Estimating rigid transformation using noisy correspondences is critical to feature-based point cloud ***,a series of studies have attempted to combine traditional robust model fitting with deep *** them,DHVR proposed a hough voting-based method,achieving new state-of-the-art ***,we find voting on rotation and translation simultaneously hinders achieving better ***,we proposed a new hough voting-based method,which decouples rotation and translation ***,we first utilize hough voting and a neural network to estimate *** based on good initialization on rotation,we can easily obtain accurate rigid *** experiments on 3DMatch and 3DLoMatch datasets show that our method achieves comparable performances over the state-of-the-art *** further demonstrate the generalization of our method by experimenting on KITTI dataset.

关键词： point cloud registration robust model fitting deep learning hough voting

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A novel non-stoichiometric medium-entropy carbide stabilized by anion vacancies

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Journal of Materials Science & Technology 2020年第16期47卷 161-166页

作者： Chong Peng Hu Tang Yu He Xiaoqian Lu Peng jia Guoying Liu Yucheng Zhao mingzhi wang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Center for High Pressure Science and Technology Advanced Research Beijing 100190China

Recently,high-entropy ceramics have attracted considerable attentions because of comprehensive physical and chemical properties of high hardness,fracture toughness,and ***,as a newly emerging class of materials,the synthesis,performance and applications of high-entropy ceramics are subject to further ***,we reported a new non-stoichiometric TiC0.4/WC/0.5Mo2C medium-entropy carbide(MEC)with a rock-salt *** to the solid solution strengthening and twinning strengthening,the TiCO0.4/WC/0.5Mo2C sintered at 1900℃by spark plasma sintering(SPS)shows superior mechanical behaviors of microhardness(21.7 GPa),which exceeds that expected from the rule of mixture(ROM)of three individual metal carbides(19.1 GPa)and good fracture toughness(5.3 MPa m1/2).Significantly,the bulk synthesized via high-pressure and high-temperature(HPHT)sintering possesses smaller grain size and shows better comprehensive mechanical properties of microhardness(23.7 GPa)and fracture toughness(6.2 MPa m1/2).In addition,the effect of anion vacancies on the thermodynamic stability and synthesizability of TiC0.4/WC/0.5Mo2C was analyzed via quantitatively calculated *** could significantly enhance the configuratio nal entropy of mixing of the solid *** introduction of vacancy defects may expand synthetic path for entropy-stabilized ceramics,especially for multi-component high tempe rature refractory ceramics.

关键词： Anion vacancies Medium-entropy carbide Solid solution strengthening Twinning

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Developmental competence and ultrastructural changes of heat-stressed mouse early blastocysts produced in vitro

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Current Zoology 2009年第1期55卷 61-66页

作者： Pingping Qu Wenru TIAN Tao LI Zhongling JIANG Shansong GAO Zhongjie TIAN mingzhi wang College of Animal Science ＆ Veterinary Medicine Qingdao Agricultural University Qingdao 266109 Shandong China

Mouse early blastocysts were exposed to temperatures of 39℃ and 41℃ for 2 h, respectively, to determine their developmental competence and ultrastructural changes. The results showed that heat stress at 41 ℃ for 2 h, significantly reduced the percentages of expanded and hatched blastocysts, but not at 39℃ for 2 h. The average cell numbers in expanded blastocysts, which developed from early blastoeysts heat-stressed at temperatures of 39℃ and 41 ℃, were significantly reduced. The average cell numbers in hatched blastocysts subjected to heat stress were no different from those in the control group cultured at 37 ℃ . The mitochondria of the early blastocysts heat-stressed at 39℃ for 2 h, were slightly swollen, but they had recovered after culturing at 37 ℃ for 2 h. However, the mitochondria in the blastocysts heat stressed at 41 ℃ for 2 h were severely swollen, and their number increased. The ribosomes shed from the rough endoplasmic reticulum, and the number of secondary lysosomes in the plasma increased. The integrity of desmosomes was disrupted. The space between the nuclear envelope and the perivitelline membrane enlarged. The fibre fraction and the particulate fraction of nueleoli were separated. The heterochromatin in nueleoli was also increased in its quantity. There were some lamellar-shape structures and heterogeneous dense materials exhibiting in the cytoplasm. The ultrastructural changes induced by heat shock at 41 ℃ for 2 h were not reversible. In conclusion, the damage of heat stress to mitoehondria, lysosomes, ribosomes and cell nucleus, may be one of the most important factors that inhibit the normal development of mouse early blastoeysts .

关键词： Heat tress Mouse Early blastocysts Developmental competence Ultrastructure

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鱼眼型高速连接器的材料性能识别与压接特性仿真研究

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电子与封装 2024年第3期24卷 21-28页

作者：侯冰玉盛依航耿秀侠胡俊王剑王世堉王明智西安电子科技大学机电工程学院西安710071 中兴通讯股份有限公司广东深圳518000

获取高速连接器关键部位准确的力学性能参数,是开展连接器插拔过程仿真和压接可靠性优化设计的前提。针对某型号鱼眼型高速连接器关键部位的材料开展纳米压痕实验,获取了顺应针和PCB孔镀层的载荷-位移曲线。结合内点罚函数优化算法,采... 详细信息

获取高速连接器关键部位准确的力学性能参数,是开展连接器插拔过程仿真和压接可靠性优化设计的前提。针对某型号鱼眼型高速连接器关键部位的材料开展纳米压痕实验,获取了顺应针和PCB孔镀层的载荷-位移曲线。结合内点罚函数优化算法,采用反演求解的方法得到了顺应针和PCB孔镀层的力学性能参数。建立鱼眼型高速连接器插拔过程的有限元模型,将仿真结果与实验结果进行对比,验证了仿真模型的有效性。对顺应针的几何结构进行参数化表征,通过调整顺应针和PCB孔的几何参数,分析几何参数与插拔力的关系,为鱼眼型高速连接器插拔特性的优化以及可靠性分析提供了参考。

关键词：鱼眼型高速连接器纳米压痕力学性能仿真模拟组装技术

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MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation

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Chinese Science Bulletin 2013年第23期58卷 2836-2845页

作者： ZHOU JiaLiang JIANG Zhi wang ZhengWu ZOU ShiTao ZHANG YunXia CAI Wei wang mingzhi XU Min SHI DongTao CHEN WeiChang Department of Gastroenterology the First Affiliated Hospital of Soochow University Department of Oncology the Forth Affiliated Hospital of Soochow University Wuxi No.4 People's Hospital Department of Biochemistry and Molecular Biology School of Medicine Soochow University

MicroRNAs are small single-stranded RNA molecules consisting of approximately 22 nucleotides (nt), and have post-transcriptional regulatory functions. By gene chip screening, we previously showed that miR-142-3p was significantly upregulated in colorectal cancer tissue and was associated with clinicopathological features, compared with matched non-tumor tissue. In this study, we confirmed significant upregulation of miR-142-3p in 60 colorectal cancer samples and three colorectal cancer cell lines by quantitative real-time PCR (qRT-PCR). Using software and network resources, we predicted TCF7 as a target of miR-142-3p, which we confirmed with dual-luciferase assays. By RT-PCR and Western blot analysis, we found miR-142-3p negatively regulates TCF7 expression post-transcriptionally. CCK8 assays and growth curves indicated that overexpression of miR-142-3p in SW480 colorectal cancer cells potently inhibited cell proliferation in vitro. The expression of TCF7 mRNA and protein was upregulated in both colorectal cancer tissues and colorectal cancer cell lines, closely correlating with its function as an oncogene in promoting tumor cell proliferation and inhibiting apoptosis. With TCF7 as a direct target, our results suggested that miR-142-3p may be involved in the regulation of cell proliferation in colorectal cancer.

关键词：细胞增殖大肠癌实时定量RT-PCR microRNA 实时定量PCR blot分析肿瘤组织核苷酸组成

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Multi-Objective Optimization of Aluminum Alloy Electric Bus Frame Connectors for Enhanced Durability

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 735-755页

作者： Wenjun Zhou mingzhi Yang Qian Peng Yong Peng Kui wang Qiang Xiao Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha410018China School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen361024China

The widespread adoption of aluminumalloy electric buses,known for their energy efficiency and eco-friendliness,faces a challenge due to the aluminum frame’s susceptibility to deformation compared to *** issue is further exacerbated by the stringent requirements imposed by the flammability and explosiveness of batteries,necessitating robust frame *** study aims to optimize the connectors of aluminum alloy bus frames,emphasizing durability,energy efficiency,and *** research delves into Multi-Objective Coordinated Optimization(MCO)techniques for lightweight design in aluminum alloy bus body *** goal is to enhance lightweighting,reinforce energy absorption,and improve deformation resistance in connector *** typical aluminum alloy connectors were selected and a design optimization platform was built for their MCO using a variety of software and ***,through three-point bending experiments and finite element analysis on three types of connector components,we identified optimized design parameters based on deformation ***,employing Optimal Latin hypercube design(OLHD),parametric modeling,and neural network approximation,we developed high-precision approximate models for the design parameters of each connector component,targeting energy absorption,mass,and logarithmic ***,utilizing the Archive-based Micro Genetic Algorithm(AMGA),Multi-Objective Particle Swarm Optimization(MOPSO),and Non-dominated SortingGenetic Algorithm(NSGA2),we explored optimized design solutions for these joint ***,we simulated joint assembly buckling during bus rollover crash scenarios to verify and analyze the optimized solutions in three-point bending *** joint component showcased a remarkable 30%–40%mass reduction while boosting energy *** design optimization method exhibits high efficiency and *** contemporary automation technology,the design optimiza

关键词： Aluminum connectors three-point bending simulation parametric design model multi-objective collaborative optimization

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