检索结果-南通市图书馆

Linear Electron-Phonon Interaction in Organic Spectral Hole-Burning Materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 1993年第10期10卷 634-637页

作者： tian mingzhen LUO Baozhu LI Wenlian HUANG Shihua YU Jiaqi YANG Kaihai Cliangchun Institu te of Physics AcademiaSinicaChangchun 130021 Rese&rch Center Liaoning Normal UniversityDalian 116022

The linear electron-phonon interaction in polymethylmethacrylate(PMMA)doped with electron donor zinc-tetraphenylbenzoporphyrin(ZnTPBP)and acceptor p-hydroxybenzsAdhyde(PHBA)t or p-aininoacetophenone(PAAP)was investigated by photon-gated spectral hole-burning(PHB),The aim is to study the factors that&ffed the linear elec iron-ph on on coupling and the thermal stability of spectral holes in the organic film samples.

关键词： spectral Electron donor

拓宽路基差异沉降主控因素分析及地基处理选择依据研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

市政技术 2024年第4期42卷 110-115,133页

作者：王勇田明震张宁王岩梓王川娄术荣济南市交通工程质量与安全中心山东济南250014 山东大学齐鲁交通学院山东济南250061 山东高速集团有限公司山东济南250013 山东高速潍坊发展有限公司山东潍坊261000

以山东省某高速公路路基改扩建项目为例,采用FLAC有限差分软件模拟了路基拓宽施工及工后沉降过程,研究了路基拓宽宽度、路基填筑高度、路基填料模量、新旧路基模量比、路基土体黏聚力和路基土体内摩擦角6种因素对拓宽路基差异沉降的影响... 详细信息

以山东省某高速公路路基改扩建项目为例,采用FLAC有限差分软件模拟了路基拓宽施工及工后沉降过程,研究了路基拓宽宽度、路基填筑高度、路基填料模量、新旧路基模量比、路基土体黏聚力和路基土体内摩擦角6种因素对拓宽路基差异沉降的影响,并通过正交分析法确定了拓宽路基差异沉降的主控影响因素。研究结果表明,路基拓宽宽度、路基填筑高度和新旧路基模量比为拓宽路基差异沉降的主控因素;重点针对新旧路基模量比对拓宽路基差异沉降的影响开展了单因素分析,提出了主次加固区概念,并分析提出了地基处理方案选择依据。研究结论对于公路拓宽路基差异沉降的控制有着重要参考价值。

关键词：路基拓宽差异沉降主控因素地基处理

维普期刊数据库博看期刊

Detecting and monitoring of water inrush in tunnels and coal mines using direct current resistivity method:A review

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2015年第4期7卷 469-478页

作者： Shucai Li Bin Liu Lichao Nie Zhengyu Liu mingzhen tian Shirui Wang Maoxin Su Qian Guo Geotechnical and Structural Engineering Research Center Shandong University

Detecting, real-time monitoring and early warning of underground water-bearing structures are critically important issues in prevention and mitigation of water inrush hazards in underground engineering. Direct current （DC） resistivity method is a widely used method for routine detection, advanced detection and real-time monitoring of water-bearing structures, due to its high sensitivity to groundwater. In this study, the DC resistivity method applied to underground engineering is reviewed and discussed, including the observation mode, multiple inversions, and real-time monitoring. It is shown that a priori information constrained inversion is desirable to reduce the non-uniqueness of inversion, with which the accuracy of detection can be significantly improved. The focused resistivity method is prospective for advanced detection;with this method, the flanking interference can be reduced and the detection dis-tance is increased subsequently. The time-lapse resistivity inversion method is suitable for the regions with continuous conductivity changes, and it can be used to monitor water inrush in those regions. Based on above-mentioned features of various methods in terms of benefits and limitations, we propose a three-dimensional （3D） induced polarization method characterized with multi-electrode array, and introduce it into tunnels and mines combining with real-time monitoring with time-lapse inversion and cross-hole resistivity method. At last, the prospective applications of DC resistivity method are discussed as follows：（1） available advanced detection technology and instrument in tunnel excavated by tunnel boring machine （TBM）, （2） high-resolution detection method in holes, （3） four-dimensional （4D） monitoring technology for water inrush sources, and （4） estimation of water volume in water-bearing structures.

关键词： Direct current (DC) resistivity methodTechnical statusLatest progressUnderground engineeringWater inrushRoutine detectionAdvanced detectionReal-time monitoring

维普期刊数据库

A Blockchain-Based Access Control Scheme for Reputation Value Attributes of the Internet of Things

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第1期78卷 1297-1310页

作者： Hongliang tian Junyuan tian College of Electrical Engineering Northeast Electric Power UniversityJilin132012China

The Internet of Things(IoT)access controlmechanism may encounter security issues such as single point of failure and data *** address these issues,a blockchain-based IoT reputation value attribute access control scheme is ***,writing the reputation value as an attribute into the access control policy,and then deploying the access control policy in the smart contract of the blockchain system can enable the system to provide more fine-grained access control;Secondly,storing a large amount of resources fromthe Internet of Things in Inter Planetary File System(IPFS)to improve system throughput;Finally,map resource access operations to qualification tokens to improve the performance of the access control *** simulation experiments based on the Hyperledger Fabric *** simulation experimental results,it can be seen that the access control system can achieve more fine-grained and dynamic access control while maintaining high throughput and low time delay,providing sufficient reliability and security for access control of IoT devices.

关键词： Blockchain IoT access control Hyperledger Fabric

Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第1期35卷 24-30页

作者： tian Jing ZHANG Wei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Electromagnetic Space Security Chengdu 610036China

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial *** the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation *** cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range *** principle is presented,and the validity is proven by simulation results.

关键词： adaptive radar beamforming training sample selection non-homogeneous detector electronic jamming jamming suppression

维普期刊数据库

Transformer and GAN-Based Super-Resolution Reconstruction Network for Medical Images

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第1期29卷 197-206页

作者： Weizhi Du Shihao tian Arts&Sciences College Washington University in St.LouisSt.LouisMO 63130USA Department of Electric and Computing Engineering Cornell UniversityIthacaNY 14850USA

Super-resolution reconstruction in medical imaging has become more demanding due to the necessity of obtaining high-quality images with minimal radiation dose,such as in low-field magnetic resonance imaging(MRI).However,image super-resolution reconstruction remains a difficult task because of the complexity and high textual requirements for diagnosis *** this paper,we offer a deep learning based strategy for reconstructing medical images from low resolutions utilizing Transformer and generative adversarial networks(T-GANs).The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture ***,we weighted the combination of content loss,adversarial loss,and adversarial feature loss as the final multi-task loss function during the training of our proposed model *** comparison to established measures like peak signal-to-noise ratio(PSNR)and structural similarity index measure(SSIM),our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly.

关键词： super-resolution image reconstruction Transformer generative adversarial network(GAN)

Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu Yanyan Lin mingzhen Bai Jia Yao Chongfei Huang Long Gao Ningning Mi Haidong Ma Liang tian Ping Yue Yong Zhang Jinduo zhang Yanxian Ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo Meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids

CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu Wang Yinmei tian tian tian Yuanyuan Guo Hu Zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2

Capturing metal clusters at the strong-interaction region to reverse Ostwald ripening

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2024年第4期67卷 1363-1364页

作者： Shuheng tian Ding Ma Beijing National Laboratory for Molecular Sciences New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

High-temperature interactions induce sintering of metal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deactivation necessitates costly catalyst replacement, notably impacting metals like copper in hydrogenation and reforming reactions [2].

关键词： catalyst reforming irreversible

维普期刊数据库