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Unsupervised spectral feature selection algorithms for high dimensional data

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Frontiers of Computer Science 2023年第5期17卷 27-40页

作者： mingzhao wang Henry HAN Zhao HUANG Juanying XIE School of Computer Science Shaanxi Normal UniversityXi’an 710119China Department of Computer Science School of Engineering&Computer ScienceBaylor UniversityWacoTX 76798USA

It is a significant and challenging task to detect the informative features to carry out explainable analysis for high dimensional data,especially for those with very small number of *** selection especially the unsupervised ones are the right way to deal with this challenge and realize the ***,two unsupervised spectral feature selection algorithms are proposed in this *** group features using advanced Self-Tuning spectral clustering algorithm based on local standard deviation,so as to detect the global optimal feature clusters as far as *** two feature ranking techniques,including cosine-similarity-based feature ranking and entropy-based feature ranking,are proposed,so that the representative feature of each cluster can be detected to comprise the feature subset on which the explainable classification system will be *** effectiveness of the proposed algorithms is tested on high dimensional benchmark omics datasets and compared to peer methods,and the statistical test are conducted to determine whether or not the proposed spectral feature selection algorithms are significantly different from those of the peer *** extensive experiments demonstrate the proposed unsupervised spectral feature selection algorithms outperform the peer ones in comparison,especially the one based on cosine similarity feature ranking *** statistical test results show that the entropy feature ranking based spectral feature selection algorithm performs *** detected features demonstrate strong discriminative capabilities in downstream classifiers for omics data,such that the AI system built on them would be reliable and *** is especially significant in building transparent and trustworthy medical diagnostic systems from an interpretable AI perspective.

关键词： feature selection spectral clustering feature ranking techniques entropy cosine similarity

三种β-取代茚三酮的合成及显现汗潜手印的研究

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刑事技术 2024年第2期49卷 128-134页

作者：张岩峰郭先超马荣梁孙振文耿松王铭兆四川警察学院刑事技术系智能警务四川省重点实验室四川泸州646000 四川省成都市金堂县公安局成都610499 公安部鉴定中心痕迹科学与技术公安部重点实验室北京100038 公安部刑事侦查局刑事技术处北京100741

本文基于傅克酰基化取代反应合成了三种茚三酮类似物:β-甲氧基茚三酮、β-硝基茚三酮、β-甲基茚三酮,比较并研究相同配方下三种β-取代茚三酮在不同纸张上显现汗潜手印的效果,并分别与茚三酮进行比较,分析其优劣。结果显示,三种β-取... 详细信息

本文基于傅克酰基化取代反应合成了三种茚三酮类似物:β-甲氧基茚三酮、β-硝基茚三酮、β-甲基茚三酮,比较并研究相同配方下三种β-取代茚三酮在不同纸张上显现汗潜手印的效果,并分别与茚三酮进行比较,分析其优劣。结果显示,三种β-取代茚三酮的显现液基本可显示不同纸张上的新鲜指纹,但β-硝基茚三酮对于陈旧指纹的显现效果较差,且显现液本身为棕褐色,显示出的指纹纹线为黑褐色,故视觉感官上稍劣于其他两者;β-甲氧基茚三酮和β-甲基茚三酮的效果均与茚三酮相当,灵敏度略高于茚三酮,显色后的稳定性高于茚三酮。研究表明,β-位取代基的变化能够改变茚三酮类化合物显现手印的效果,给电子基团的修饰能够提高该类化合物的手印显现性能,化合物本身的荧光性能与实际的指纹显现效果并不直接相关。

关键词：手印显现渗透/半渗透客体 β-取代茚三酮

Adaptable Invisibility Management Using Kirigami-Inspired Transformable Metamaterials

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Research 2021年第1期2021卷 1034-1044页

作者： He-Xiu Xu mingzhao wang Guangwei Hu Shaojie wang Yanzhao wang Chaohui wang Yixuan Zeng Jiafang Li Shuang Zhang Wei Huang Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China Institute of Flexible Electronics Northwestern Polytechnical UniversityXi’an 710072China Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore 117583 Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)Beijing 100081China School of Physics Beijing Institute of TechnologyBeijing 100081China Department of Physics University of Hong KongHong KongChina Department of Electronic&Electrical Engineering University of Hong KongHong KongChina

Many real-world applications,including adaptive radar scanning and smart stealth,require reconfigurable multifunctional devices to simultaneously manipulate multiple degrees of freedom of electromagnetic(EM)waves in an on-demand ***,kirigami technique,affording versatile and unconventional structural transformation,has been introduced to endow metamaterials with the capability of controlling EM waves in a reconfigurable ***,we report for a kirigami-inspired sparse meta-architecture,with structural density of 1.5%in terms of the occupation space,for adaptive invisibility based on independent operations of frequency,bandwidth,and *** on the general principle of dipolar management via structural reconstruction of kirigami-inspired meta-architectures,we demonstrate reconfigurable invisibility management with abundant EM functions and a wide tuning range using three enantiomers(A,B,and C)of different geometries characterized by the folding angleβ.Our strategy circumvents issues of limited abilities,narrow tuning range,extreme condition,and high cost raised by available reconfigurable metamaterials,providing a new avenue toward multifunctional smart devices.

关键词： tuning visibility smart

医学整合教学模式在乳腺外科教学中的实践探讨

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大学（教学与教育） 2024年第8期 128-131页

作者：樊秀月方丹张馨王明照贵州医科大学附属医院乳腺外科贵州贵阳550025 上海财经大学浙江学院浙江金华321013

医学教育的发展需要与时俱进,适应社会需求变化。医学整合教学作为一种新型教学模式,具有重要意义。文章以医学整合教学模式在乳腺外科教学中的应用为切入点,首先析了医学整合教学模式的概念内涵,阐述了其在乳腺外科教学中应用的必要性... 详细信息

医学教育的发展需要与时俱进,适应社会需求变化。医学整合教学作为一种新型教学模式,具有重要意义。文章以医学整合教学模式在乳腺外科教学中的应用为切入点,首先析了医学整合教学模式的概念内涵,阐述了其在乳腺外科教学中应用的必要性,并且探讨了医学整合教学模式在乳腺外科教学中的具体应用,包括纵向知识整合、横向知识整合和多种教学模式的融合运用,最后指出了实施过程中可能存在的问题,针对性地提出了相应的优化策略,旨在通过医学整合教学模式的应用,促进乳腺外科教学水平的提高,培养高素质乳腺外科医学人才。

关键词：医学整合教学乳腺外科教学模式知识整合教学改革

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原地浸矿经验注液下毛细上升影响范围研究

福建冶金 2024年第1期53卷 13-18页

作者：黄豪洪本根刘文利江仰龙王明照江西理工大学资源与环境工程学院江西赣州341000 厦门钨业股份有限公司福建厦门361000 龙岩市稀土开发有限公司福建龙岩364000

离子型稀土是我国重要的战略资源,采用原地溶浸工艺开采时,容易出现毛细上升作用引起的资源损失、浸矿剂浪费和氨氮污染的问题。为了确定原地浸矿工艺现有注液条件下毛细上升的影响范围,本文立足于生产现场,通过对开采矿块山顶、山腰、... 详细信息

离子型稀土是我国重要的战略资源,采用原地溶浸工艺开采时,容易出现毛细上升作用引起的资源损失、浸矿剂浪费和氨氮污染的问题。为了确定原地浸矿工艺现有注液条件下毛细上升的影响范围,本文立足于生产现场,通过对开采矿块山顶、山腰、注液边界和注液边界外的测试点矿样进行测试化验,分别以周边注液孔孔底坐标、见矿深度和注液孔液面高度为参照物,运用描述性统计对测试点尾矿样的氨氮赋存规律进行归纳和分析,从而发现:(1)毛细上升的参照物应该选择为见矿深度;(2)毛细上升影响范围:以见矿深度为参照物,分区域设置,山顶(5.0 m)>注液边界(0.8 m)≈山腰(0.78 m)。该研究成果可以为解决毛细上升引起的资源损失和环境污染问题提供基础数据和设计依据。

关键词：离子型稀土原地浸矿毛细上升见矿深度氨氮污染

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen Liu Hui Jin Yan Chen Derong wang Haohui Yan mingzhao Wu Fang Zhao Weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

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绿原酸碳基材料的荧光性质及细胞毒性

化工科技 2024年第4期32卷 33-37页

作者：李悦杨欣怡何靖岚齐彬羽王明钊吉成锦成昭西安医学院药学院陕西西安710021

以绿原酸(CA)为碳源,通过溶剂热法一步合成绿原酸衍生的碳基发光材料CA-71。借助荧光光谱、细胞共聚焦成像及细胞活力实验,进行CA-71荧光性质及细胞毒性研究。结果表明,绿原酸碳基材料CA-71荧光发射光谱具有激发依赖特性,最大激发波长为... 详细信息

以绿原酸(CA)为碳源,通过溶剂热法一步合成绿原酸衍生的碳基发光材料CA-71。借助荧光光谱、细胞共聚焦成像及细胞活力实验,进行CA-71荧光性质及细胞毒性研究。结果表明,绿原酸碳基材料CA-71荧光发射光谱具有激发依赖特性,最大激发波长为400 nm,对应的发射波长为492 nm。共聚焦成像实验进一步显示,CA-71能够通透细胞膜,定位人脐静脉内皮细胞(HUVEC)内线粒体,与线粒体绿色定位染料高度定位重合,皮尔森系数为0.98。此外,25.00 mg/L的CA-71对体外HUVEC细胞24 h抑制率为(7.70±0.93)%,与等质量浓度绿原酸对HUVEC细胞的抑制率(8.24±1.18)%接近,总体呈现低毒性,但无显著性差异。

关键词：碳基材料荧光性质激发依赖共聚焦成像细胞毒性

Geometric based apple suction strategy for robotic packaging

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 12-20页

作者： Zhong wang Qingyu wang mingzhao Lou Fan Wu Yaonan Zhu Dong Hu Mingchuan Zhou Yibin Ying College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Micro-Nona Mechanical Science and Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Packaging is one of the least automated steps among all the fruit postharvest processes,which is time-consuming and ***,a robust suction strategy for robotic manipulation needs to be *** this research,a geometric-based apple suction strategy for robotic packaging was studied,including suction cup design,optimal suction region selection algorithm,and robot system *** the first place,on the basis of the geometric features of the spheroid fruit,the structure of the suction cups was designed to provide reliable suction ***,suction force measurement experiments on both acrylic balls and apples were *** on the results,the parameters of the suction cup were finally *** results also indicated that the curvature radius of the suction region is supposed to larger than that of the suction ***,a robust suction region selection algorithm was developed,which involves four steps:RGB-D information acquisition,object detection and point cloud generation,spherical fitting,and suction region ***,the above methods were integrated into a robotic packaging *** addition,on the basis of spatial-frequency domain imaging(SFDI)technology,early stage bruise was detected for *** results showed that,the proposed suction strategy and system is potential for robust robotic apple packaging.

关键词： apple suction cup robotic packaging robotic manipulation point cloud

Mitochondrial components transferred by MSC-derived exosomes promoted bone regeneration under high salt microenvironment via DRP1/Wnt signaling

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Nano Research 2024年第9期17卷 8301-8315页

作者： Yiming wang Shuai Lin Liujing Chen mingzhao Li Zilu Zhu Zimeng Zhuang Meilian Cai Han Zhang Chenyang Xing Weiran Li Ruili Yang Department of Orthodontics School and Hospital of StomatologyPeking UniversityBeijing 100081China National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China Beijing Key Laboratory of Digital Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China

Bone homeostasis relies on the dynamic balance of osteoblast mediated bone construction and osteoclast-based bone resorption processes,which has been reported to be controlled by various mineral ***,there is no direct evidence of the effect and the underlying mechanism of high salt stimulation on bone *** this study,we demonstrated that high salt stimulation promoted excessive mitochondrial fission mediated by dynamin-related protein 1 in mesenchymal stem cells,which resulted in impaired mitochondrial morphology and ***,this impairment hindered the bone formation of mesenchymal stem cells,resulting in osteopenia in ***,the impaired property of mesenchymal stem cells which was caused by high salt was controlled by dynamin-related protein 1 mediated mitochondrial fission,which inhibited the classical Wnt signaling ***,the osteogenic property of mesenchymal stem cells decreased by high salt could be restored by exosomes to transfer the mitochondrial DNA into the impaired mesenchymal stem *** study provides not only new strategies for promoting bone regeneration but also new insights into the effect and mechanism of exosome-mediated delivery.

关键词： high salt dynamin-related protein 1 mitochondrial injury exosomes bone regeneration