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Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system

Neural Regeneration Research 2024年第4期19卷 855-862页

作者： mingyue jin Shengming Wang Xiaodie Gao Zhenyou Zou Shinji Hirotsune Liyuan Sun Guangxi Key Laboratory of Brain and Cognitive Neuroscience Guilin Medical University Department of Genetic Disease Research Osaka Metropolitan University Graduate School of Medicine Department of Scientific Research Brain Hospital of Guangxi Zhuang Autonomous Region

α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,*** works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s *** intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent ***,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical ***,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in *** the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent *** findings indicate strong cross-talk between the two proteins in physiology and *** this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.

关键词： alpha-synuclein microtubule-associated protein neurodegenerative disease tau

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超声引导下疼痛通解治疗术治疗梨状肌综合征36例

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中国针灸 2024年第2期44卷 182-184页

作者：张鸣丛志斌王富春金明月付吉利王雪长春中医药大学附属医院电诊科吉林长春130000 长春中医药大学针灸推拿学院

目的:观察超声引导下疼痛通解治疗术治疗梨状肌综合征的临床疗效。方法:采用超声引导下疼痛通解治疗术治疗单侧梨状肌综合征患者36例。超声确定梨状肌异质回声区及坐骨神经位置,超声引导下针刺异质回声区,进行快速多角度提插,得气后再... 详细信息

目的:观察超声引导下疼痛通解治疗术治疗梨状肌综合征的临床疗效。方法:采用超声引导下疼痛通解治疗术治疗单侧梨状肌综合征患者36例。超声确定梨状肌异质回声区及坐骨神经位置,超声引导下针刺异质回声区,进行快速多角度提插,得气后再针刺坐骨神经鞘。每4 d治疗1次,共治疗3次。于治疗前及每次治疗后30 min记录患侧梨状肌异质回声区平均杨氏模量值和疼痛视觉模拟量表(VAS)评分,并评定其临床疗效。结果:治疗1、2、3次后,患者梨状肌异质回声区平均杨氏模量值、VAS评分均较治疗前降低(P<0.001),愈显率为100.0%(36/36)。结论:超声引导下疼痛通解治疗术可精准针刺梨状肌内异质回声区及坐骨神经鞘,可降低病变梨状肌异质回声区的平均杨氏模量值,减轻患者疼痛程度。

关键词：梨状肌综合征疼痛通解治疗术超声引导剪切波弹性成像

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结合太阳辐射量计算与CNN-LSTM组合的光伏功率预测方法研究

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太阳能学报 2024年第2期45卷 443-450页

作者：王东风刘婧黄宇史博韬靳明月华北电力大学自动化系保定071003

为了提高模型预测性能,提出一种综合太阳辐射模型及深度学习的光伏功率预测模型。首先,利用太阳辐射机理建立太阳辐射模型(SRM),估算出水平面上总辐射值,再由斜面辐照度转换方法计算出光伏组件所接收的斜面辐射值。其次,通过皮尔逊相关... 详细信息

为了提高模型预测性能,提出一种综合太阳辐射模型及深度学习的光伏功率预测模型。首先,利用太阳辐射机理建立太阳辐射模型(SRM),估算出水平面上总辐射值,再由斜面辐照度转换方法计算出光伏组件所接收的斜面辐射值。其次,通过皮尔逊相关分析法筛选出对光伏功率影响较大的主要因素,将斜面辐射计算值及主要影响因素作为输入,采用卷积神经网络(CNN)和长短期记忆网络(LSTM)建立光伏功率SRM-CNN-LSTM预测模型。分别利用春夏秋冬四季典型日的数据开展对比实验,结果表明:与几种其他方法相比,该文方法具有更好的预测效果。

关键词：光伏发电预测太阳辐射神经网络卷积神经网络长短期记忆网络

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The pathogenesis of chronic subdural hematoma in the perspective of neomembrane formation and related mechanisms

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BIOCELL 2024年第6期48卷 889-896页

作者： mingyue HUANG JUNFEI DAI XIANLIANG ZHONG jin WANG JIANZHONG XU BO DU School of Medicine Southern University of Science and TechnologyShenzhen518055China Department of Emergency Shenzhen People’s HospitalThe Second Clinical Medical College of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhen518055China

Chronic subdural hematoma(CSDH)is a disease characterized by capsuled blood products that progressively occupy the intracranial space,causing intracranial hypertension and compression in the *** frequently occurs in all demographics,especially in the elderly,but the pathogenesis of CSDH remains *** this review,we discuss the origin,development,and current treatment strategies of *** theﬁrst time,we analyzed the cellular and molecular compositions of hematoma membranes with a focus on neomembrane formation,a complex early-stage interactive event in hematoma *** hypothesize that in patients with CSDH,dural border cells(DBCs)might be induced to synthesize collagen or serum proteins might accumulate at the dura and arachnoid layers at the site of injury,thereby encapsulating the *** formation may trigger inﬂammatory responses after subdural hemorrhage,promotingﬁbroblast-involved extracellular matrix(ECM)deposition and aberrant angiogenesis within the outer ***,ECM deposition and angiogenesis mutually inﬂuence each other and are modulated by inﬂammatory *** illustrating the complex and interactive mechanism of neomembrane formation,we aim to provide a novel insight into CSDH pathogenesis and propose directions for future research as well as advancements in treatment strategies for this disease.

关键词： Chronic subduralhematoma Inflammation Angiogenesis Extracellular matrix Hyperfibrinolysis

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Formation Mechanism of Maceral and Mineral Compositions of the“Barkinite”Liptobiolith from the jinshan Mine,Anhui Province,China

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Acta Geologica Sinica(English Edition) 2010年第3期84卷 643-653页

作者： SUN Yuzhuang ZHAO Cunliang LIN mingyue jin Kankun DING Shuli Key Laboratory of Resource Exploration Research of Hebei Province Hebei University of Engineering Handan Hebei 056038 China

In order to study the accumulation mechanism of＂barkinite＂,eight Late Permian channel benches（approximately 15-cm across and 10-cm deep） were taken from the jinshan Mine,Anhui Province,*** samples were analyzed by microscopical and geochemical *** microscopical observations indicate that the occurrence modes of＂barkinite＂in this area are different from those in other areas of *** ratios of structureless＂barkinite＂are much higher in the jinshan Mine,probably due to the flow-water and marine influenced ***, vitrinite macerals also show a strong *** vitrinite fluorescence characteristics have not been observed in the Permian＂barkinite＂coals from northern *** composition and variation of minerals in the column section also showed that the swamps in the study area were seriously influenced by seawater in the early and late stage during the peat accumulation.

关键词： macerai "barkinite" liptobiolith vitrinite mineralogy Permian coal jinshan Mine China

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Rock burst prevention based on dissipative structure theory

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International Journal of Mining Science and Technology 2012年第2期22卷 159-163页

作者： Song Dazhao Wang Enyuan Li Nan jin mingyue Xue Shipeng School of Safety Engineering China University of Mining&TechnologyXuzhou 221116China

Dynamic collapses of deeply mined coal rocks are *** order to explore new ideas for rock burst prevention,the relationship between entropy equations and dissipative structure was studied,and a concept-rock burst activity system(RAS) was proposed and its entropy was *** energy features of RAS were analyzed,and the relationship between electromagnetic radiation(EMR) intensity E and dissipated energy Ud was initially *** suggest that rock burst normally happens only when diS deS in RAS;RAS is the dissipative structure before collapse,and after which it become a new orderly structure,i.e.,a ''dead'',a statically orderly *** advanced that the effective way to prevent rock burst is to introduce entropy to the system for it keeps the system away from the dissipative structure.E and Ud of RAS are positively related,which is used as a bridge between dissipative structure theory and rock burst prevention engineering *** on this,and using the data of rock burst prevention for working face No.250205up of Yanbei coal mine,an engineering verification for the dissipative structure of RAS was carried out,which showed good results.

关键词：耗散结构理论岩爆预防有序结构防治工程 RAS 熵方程岩石破裂

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5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2153-2176页

作者： Qing Meng Jianshuang Guo Ke Lv Yang Liu jin Zhang mingyue Li Xirui Cheng Shenghua Chen Xiaoguang Huo Quan Zhang Yue Chen jing Li State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China College of Chemistry and Frontiers Science Center for New Organic Matter Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China Accendatech Company Ltd.Tianjin 300193China

Aberrant changes in the gut microbiota are implicated in many diseases,including inflammatory bowel disease(IBD).Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity,indicating that microbe-mediated modulation may be a promising strategy for preventing and treating *** fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies,novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently ***,we report the total synthesis of heudelotinone and the discovery of 5S-heudelotinone(an enantiomer)as a potent agent against experimental colitis that acts by modulating the gut microbiota.5S-Heudelotinone alters the diversity and composition of the gut microbiota and increases the concentration of short-chain fatty acids(SCFAs);thus,it regulates the intestinal immune system by reducing proinflammatory immune cell numbers,and maintains intestinal mucosal integrity by modulating tight junctions(TJs).Moreover,5S-heudelotinone(2)ameliorates colitis-associated colorectal cancer(CAC)in an azoxymethane(AOM)/dextran sulfate sodium(DSS)-induced in situ carcinoma ***,these findings reveal the potential of a novel natural product,namely,5S-heudelotinone,to control intestinal inflammation and highlight that this product is a safe and effective candidate for the treatment of IBD and CAC.

关键词： 5S-heudelotinone Total synthesis Inflammatory bowel disease Gut microbiota Short-chain fatty acids Immune system Intestinal barrier Drug discovery

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In silico off-target profiling for enhanced drug safety assessment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2927-2941页

作者： jin Liu Yike Gui jingxin Rao jingjing Sun Gang Wang Qun Ren Ning Qu Buying Niu Zhiyi Chene Xia Sheng Yitian Wang mingyue Zheng Xutong Li College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Nanjing University of Chinese Medicine Nanjing 210023China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyHangzhou 330106China

Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent ***,the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is *** off-target interactions,along with the adverse drug reactions they induce,are significant factors affecting drug *** assess the liability of candidate drugs,we developed an artificial intelligence model for the precise prediction of compound off-target interactions,leveraging multi-task graph neural *** outcomes of off-target predictions can serve as representations for compounds,enabling the differentiation of drugs under various ATC codes and the classification of compound ***,the predicted off-target profiles are employed in adverse drug reaction(ADR)enrichment analysis,facilitating the inference of potential ADRs for a *** the withdrawn drug Pergolide as an example,we elucidate the mechanisms underlying ADRs at the target level,contributing to the exploration of the potential clinical relevance of newly predicted off-target ***,our work facilitates the early assessment of compound safety/toxicity based on off-target identification,deduces potential ADRs of drugs,and ultimately promotes the secure development of drugs.

关键词： Drug safety Off-target prediction Adverse drug reactions Toxicity Molecular representation Artificial intelligence

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