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Science China(Life Sciences) 2017年第12期60卷 1392-1395页

作者： Xiaoman Wei mingyue chen Jie Cui CAS Key Laboratory of Special Pathogens and Biosafety Center for Emerging Infectious DiseasesWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Ever since the first human infection with H7N9 avian influenza virus（AIV）was reported in China in March 2013,there have been five H7N9 AIV pandemics in ***5 began earlier than the previous four waves,spr... 详细信息

关键词： Bayesian evolutionary infectious disease

A novel pathway and seeded polymerizations of aggregates at the thermodynamic state for an amido-anthraquinone compound

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Organic Chemistry Frontiers 2022年第5期9卷 1254-1260页

作者： Houchen Wang mingyue chen Yuanyuan Zhu Yu Li Han Zhang Tiesheng Shi College of Chemistry Chemical Engineering and Materials ScienceZaozhuang UniversityZaozhuang 277160China

Monomers undergo supramolecular polymerizations via diverse pathways conferring pathway complexity;deciphering the complexity has been an intriguing and fundamental subject of various studies.

关键词： polymerization thermodynamic complexity

White-light emitting single-phase phosphor La_3Si_6N_(11):Dy^(3+),Tb^(3+):Color tunable emission, thermal stability and energy transfer process

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Journal of Rare Earths 2019年第4期37卷 350-355页

作者： Yuanhong Liu Yuan Xue Ronghui Liu mingyue chen Guantong chen Chunpei Yan Xia Zhang Yu'nan Zhou Wei Gao Xiaole Ma National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous Metals Grirem Advanced Materials Co.Ltd.

A novel white-light emitting single-phase phosphor La_3 Si_6 N_(11):Dy^(3+),exhibiting two emission peaks centering at 475 and 575 nm, was prepared via conventional solid-state reactions. The structure and morphology of La_3 Si_6 N_(11):Dy^(3+)/Tb^(3+) were investigated by X-ray diffraction(XRD) and scanning electron microscopy(SEM). The emission colors can be tuned from white to yellow-green through increasing the Tb^(3+) concentration in La_3 Si_6 N_(11):Dy^(3+),Tb^(3+), The mechanism of energy transfer(ET) from Dy^(3+) to Tb^(3+) is confirmed according to the excitation,emission spectra and decay lifetimes curve. The temperaturedependent luminescence measurements of La_(2.83)Si_6 N_(11):0.1 Dy^(3+),0.07 Tb^(3+) were also performed, and a good thermal stability is shown, suggesting superior properties for the application as white lightemitting diodes(w-LEDs) phosphor.

关键词： Single-phase White emission Energy transfer Rare earths

Plowing-Extrusion Processes and Performance of Functional Surface Structures of Copper Current Collectors for Lithium-Ion Batteries

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Nanomanufacturing and Metrology 2022年第4期5卷 336-353页

作者： Chun Wang Wei Yuan Yu chen Bote Zhao Yong Tang Shiwei Zhang Xinrui Ding Jun He Songmao chen Baoyou Pan mingyue chen School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510640China School of Environment and Energy South China University of TechnologyGuangzhou510006China

Most copper current collectors for commercial lithium-ion batteries(LIBs)are smooth copper foils,which cannot form a stable and effective combination with electrode *** are likely to deform or fall off after long-term operation,resulting in a sharp decline in battery *** is worse is that this condition inevitably causes internal short circuits and thus brings about security *** this study,a process route of fabricating the functional surface structures on the surface of a copper collector for LIBs by twice-crisscross micro-plowing(TCMP)is proposed,which provides a new idea and an efficient method to solve the above problems from the perspective of *** finite element simulation of TCMP combined with the cutting force test and morphological characterization is conducted to verify the forming mechanism of the surface structures on a copper sheet and its relationship with the processing *** influence of several key processing parameters on the surface characteristics of the copper sheet is comprehensively explored.A series of functions is tested to obtain the optimal parameters for performance improvement of the current *** show that the structured copper sheet with the cutting distance of 250μm,cutting depth of 80μm,and cutting crossing angle of 90°enables the best surface features of the current collector;the contact angle reaches 0°,the slurry retention rate is up to 89.2%,and the friction coefficient reaches *** battery using the as-prepared structured copper sheet as the current collector produces a specific capacity of 318.6 mAh/g after 50 cycles at a current density of 0.2 C,which is 132.7%higher than the one based on a smooth *** capacity reversibility of the sample with the new current collector is much better than that of the traditional samples,yielding a lower impedance.

关键词： Plowing-extrusion Current collector Lithium-ion batteries Functional surface structures Contact angle Specific capacity

Linsitinib (OSI‑906) modulates brain energy metabolism and seizure activity in the lithium‑pilocarpine rat model

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Acta Epileptologica 2021年第1期3卷 114-125页

作者： Guohui Jiang Shenglin Wang mingyue chen Xiaomi Ding Weiwei He Li Wang Shunxian Wang Juming Yu Xiaoming Wang Department of Neurology Affiliated Hospital of North Sichuan Medical CollegeInstitute of Neurological DiseasesNorth Sichuan Medical CollegeNanchongChina

Background:Epileptic seizure is a process of energy accumulation,bursting,and depletion accompanied by the production,spread,and termination of epileptic *** energy required for a seizure is mainly provided through mitochondrial production of *** diseases often lead to epileptic seizures,and energy depletion caused by seizures can lead to mitochondrial *** energy metabolism has become a key target for treatment of epileptic ***:The effect of OSI-906,an insulin receptor(IR)/insulin-like growth factor 1 receptor(IGF-1R)inhibitor,on behaviors and electroencephalographic activity in the lithium-pilocarpine rats were tested.18F-FDG positron emission tomography(PET)/computed tomography(CT)was performed to detect the relative whole-brain glucose uptake *** microscopy was performed to observe the ultrastructure of neuronal and mitochondrial *** changes in blood glucose at different time points before and after the intervention were tested and the effects of OSI-906 on IR/IGF-1R and downstream Akt signaling in the context of seizures were ***:The OSI-906 treatment applied 3 days before the pilocarpine-induced seizures significantly reduced the seizure severity,prolonged the seizure latency and decreased the EEG energy ***/CT revealed that 50 mg/kg of OSI-906 inhibited the 18F-FDG glucose uptake after epileptic seizures,suggesting that OSI-906,through inhibiting IR/IGF-1R and the downstream AKT signaling,may regulate the excessive energy consumption of the epileptic *** OSI-906 treatment also reduced the mitochondrial damage caused by epileptic ***:The IR/IGF-1R inhibitor OSI-906 can significantly reduce the sensitivity and severity of pilocarpineinduced seizures by inhibiting the IR/IGF-1R and the downstream Akt signaling pathway.

关键词： Epilepsy Mitochondria Energy metabolism Insulin receptor IGF-1 receptor Akt signaling

Potentials of miR-9-5p in promoting epileptic seizure and improving survival of glioma patients

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Acta Epileptologica 2022年第4期5卷 242-256页

作者： Shenglin Wang Xuzhi He Nana Bao mingyue chen Xiaomi Ding Ming Zhang Li Zhao Shunxian Wang Guohui Jiang Department of Neurology Affiliated Hospital of North Sichuan Medical CollegeNo.1 Maoyuan South RoadNanchong637000China Institute of Neurological Diseases North Sichuan Medical CollegeNanchongSichuanChina

Background Epilepsy affects over 70 million people worldwide;however,the underlying mechanisms remain ***(miRNAs)have essential functions in ***-9,a brain-specific/enriched miRNA,plays a role in various nervous system diseases and tumors,but whether miRNA-9 is involved in epilepsy and glioma-associated epilepsy remains ***,we aimed to explore the potential role of miR-9-5p in seizures and its effect on the survival of glioma patients,in order to provide new targets for the treatment of epilepsy and *** The YM500v2 database was used to validate the expression of hsa-miR-9-5p in ***,qRT-PCR was performed to investigate the expression of miR-9-5p in temporal lobe epilepsy patients and rats with lithium-pilocarpine-induced *** adeno-associated virus containing miR-9-5p was constructed to overexpress miR-9-5p in *** effects of miR-9-5p on the behavior and electroencephalographic activities of the lithium-pilocarpine rat model of epilepsy were *** analysis was used to predict the targets of miR-9-5p and explore its potential role in epilepsy and glioma-associated *** The expression of miR-9-5p increased at 6 h and 7 days after lithium-pilocarpine-induced seizures in *** of miR-9-5p significantly shortened the latency of seizures and increased seizure intensity at 10 min and 20 min after administration of pilocarpine(P<0.05).Predicted targets of miR-9-5p were abundant and enriched in the brain,and affected various pathways related to epilepsy and *** analysis revealed that overexpression of miR-9-5p significantly improved the survival of patients from with low-grade gliomas and *** involvement of miR-9-5p in the glioma-associated epileptic seizures and the improvement of glioma survival may be related to multiple pathways,including the Rho GTPases and hub genes included SH3PXD2B,ARF6,and *** miR-9-5p may p

关键词： Epilepsy Seizure Glioma miR-9-5p Survival

Ancient origin and complex evolution of porcine endogenous retroviruses

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Biosafety and Health 2020年第3期2卷 142-151页

作者： Yicong chen mingyue chen Xiaoyan Duan Jie Cui Wuhan Institute of Virology Center for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China National 111 Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation EngineeringHubei University of TechnologyWuhan 430068China

Porcine endogenous retroviruses(PERVs)are proviruses that have medical value in ***,the evolutionary process leading to the generation of modern PERVs is not well *** this study,we in silico mined 14 pig genomes and other available 304 mammalian genomes,which led to the documentation of 185 full-length PERVs or PERV-like ***,we found that lesser Egyptian jerboa(Jaculus jaculus),rock hyrax(Procavia capensis)and eight Muridae species all harbored ancestral PERV-like sequences,indicative of ancient cross-species transmission events from none-porcine species to *** also revealed that 11 genomic rearrangement events were mediated via PERVs,during the process of porcine *** conclusion,these new findings help us to understand the complex evolution of the modern PERVs.

关键词： Porcine endogenous retrovirus Evolution Origin Genomic rearrangement Cross-species transmission

西班牙大帆船“科瓦东加圣母”号被俘始末与清朝的介入

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重庆大学学报（社会科学版） 2024年第3期30卷 206-215页

作者：陈鸣悦首都师范大学历史学院北京100048

詹金斯之耳战争期间,西班牙大帆船“科瓦东加圣母”号被英国军舰“百夫长”号在菲律宾海域俘获。中国被卷入此次英西纠纷中,成为英国军舰的休整地,西班牙俘虏的释放地,西班牙人向英国复仇的目的地。学界此前较少关注中国在该事件中扮演... 详细信息

詹金斯之耳战争期间,西班牙大帆船“科瓦东加圣母”号被英国军舰“百夫长”号在菲律宾海域俘获。中国被卷入此次英西纠纷中,成为英国军舰的休整地,西班牙俘虏的释放地,西班牙人向英国复仇的目的地。学界此前较少关注中国在该事件中扮演的角色以及中、英、西三方的互动,尚未综合利用三国原始文献。该事件可以充分反映出18世纪全球联系愈加密切的背景下欧洲全面战争对中国的影响以及清朝应对国际争端的方式。中国之所以与该事件产生关联,源于18世纪中叶英国海军着力破坏西班牙在太平洋地区的贸易网络,欧洲全面战争蔓延到了更广阔的地域,符合欧洲殖民争霸的历史趋势。而中国的港口具有安全性高、物资充盈、国际贸易发达、信息交流通畅等特征,增加了中国被卷入国际冲突的可能性。在大帆船被俘前后,中国是多方力量博弈的场域。英、西两国人员基于各自帝国的利益行事,具有挑战清朝秩序的倾向,却又受其制约。清朝官员原则上不干涉境外的国际纠纷,但对管辖范围内的事务表现出了外邦不易撼动的绝对权威。他们着力维护海防稳定,同时坚持怀柔远人原则,既阻止了英、西两国船舰在中国作乱,又保障了“百夫长”号的正常补给,促成大部分西班牙俘虏的释放。需要注意的是,清朝官员对姿态强硬的英国海军作出了一定的妥协,未阻止英国人强留少量俘虏的行为,反而在奏文中过度歌颂地方政绩,一定程度上淡化了海防隐患。但总的来说,他们对保证海疆安宁、推动夷商和谐相处、弘扬大国形象起到了积极作用。

关键词： “科瓦东加圣母”号西班牙大帆船 “百夫长”号乔治·安森

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生物质表面活性剂研究进展

化学通报 2019年第8期82卷 725-730页

作者：陈渭陈明月孙哲青海师范大学化学化工学院西宁810016 西宁市教育局西宁810000

生物质表面活性剂因其原料来源广泛、可再生、无污染等优点,已成为替代石油基表面活性剂的最优选择。目前,生物质类表面活性剂主要以天然脂类、糖类、蛋白质和生物质酚类等物质为原料制备而成,因其特殊的“两亲性”结构,使其具有良好的... 详细信息

生物质表面活性剂因其原料来源广泛、可再生、无污染等优点,已成为替代石油基表面活性剂的最优选择。目前,生物质类表面活性剂主要以天然脂类、糖类、蛋白质和生物质酚类等物质为原料制备而成,因其特殊的“两亲性”结构,使其具有良好的分散、乳化、增稠、絮凝以及独特的生理等性能,在食品、医疗、日用化学品等行业有较大的应用优势。本文以表面活性剂的发展方向为出发点,综述了以生物质为基础制备表面活性剂的研究进展,展望了生物质表面活性剂的发展方向。

关键词：生物质表面活性剂糖苷氨基酸磷脂

埋嵌型镍铁合金纳米颗粒的制备及其应变场研究

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江西师范大学学报（自然科学版） 2020年第4期44卷 373-377,423页

作者：陈明月周行江西师范大学物理与通信电子学院江西南昌330022

通过脉冲激光沉积系统和快速热退火工艺,制备了在Al2O3薄膜中生长的埋嵌型镍铁合金纳米颗粒;再通过有限元分析方法,发现退火温度不仅对埋嵌型镍铁合金纳米颗粒的尺寸大小的影响非常显著,而且还会改变镍铁合金纳米颗粒所受到的应变场分布... 详细信息

通过脉冲激光沉积系统和快速热退火工艺,制备了在Al2O3薄膜中生长的埋嵌型镍铁合金纳米颗粒;再通过有限元分析方法,发现退火温度不仅对埋嵌型镍铁合金纳米颗粒的尺寸大小的影响非常显著,而且还会改变镍铁合金纳米颗粒所受到的应变场分布,使纳米颗粒的相关性能得到进一步提升.因此,探究退火温度对埋嵌型镍铁合金纳米颗粒所受到的应变场分布造成的影响有着十分重要的研究意义,同时也为镍铁合金纳米颗粒的机械性能以及软磁性能的调控方法提供了一条崭新的思路.

关键词：镍铁合金纳米颗粒有限元分析应变场分布