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The optimal anticoagulation strategy for COVID-19,prophylactic or therapeutic?:a meta-analysis,trial sequential analysis,and meta-regression of more than 27,000 participants

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Emergency and Critical Care Medicine 2022年第3期2卷 148-166页

作者： mingyue Guo Qi Han Jiaxuan Xing Feng Xu Jiali Wang Chuanbao Li Zechen Shan Yuan Bian Hao Wang Li Xue Qiuhuan Yuan Chang Pan Yanshan De Xingfang Wang Panpan Hao Shengchuan cao Jiaojiao Pang Yuguo Chen Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityChest Pain CenterQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Anticoagulants are promising regimens for treating coronavirus disease 2019(COVID-19).However,whether prophylactic or intermediate-to-therapeutic dosage is optimal remains under active ***:We comprehensively searched PubMed,Embase,Scopus,Web of Science,Cochrane Library,ClinicalTrials,and MedRxiv databases on April 26,*** independent researchers conducted literature selection and data extraction separately according to predetermined ***,this is the first meta-analysis on COVID-19,taking serious consideration regarding the dosage overlap between the 2 comparison groups of prophylactic anticoagulation(PA)and intermediate-to-therapeutic anticoagulation(I-TA).Results:We included 11 randomized controlled trials(RCTs)and 36 cohort studies with 27,051 COVID-19 *** analyzing all the RCTs,there was no significant difference in mortality between the PA and I-TA groups,which was further confirmed by trial sequential analysis(TSA)(odds ratio[OR]:0.93;95%confidence interval[CI]:0.71–1.22;P=0.61;TSA adjusted CI:0.71–1.26).The rate of major bleeding was remarkably higher in the I-TA group than in the PA group,despite adjusting for TSA(OR:1.73;95%CI:1.15–2.60;P=0.009;TSA adjusted CI:1.09–2.58).RCTs have supported the beneficial effect of I-TA in reducing thrombotic *** including all studies,mortality in the I-TA group was significantly higher than in the PA group(OR:1.38;95%CI:1.15–1.66;P=0.0005).The rate of major bleeding was similar to the analysis from RCTs(OR:2.24;95%CI:1.86–2.69;P<0.00001).There was no distinct difference in the rate of thrombotic events between the 2 regimen *** addition,in both critical and noncritical subgroups,I-TA failed to reduce mortality but increased major bleeding rate compared with PA,as shown in meta-analysis of all studies,as well as RCTs ***-regression of all studies suggested that there was no relationship between the treatment effect and the overall risk of mortality or maj

关键词： Anticoagulation COVID-19 Major bleeding Mortality Prophylactic Therapeutic

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赤霉素、水杨酸和乙烯利对圆锥绣球开花及生理特性的影响

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江西农业大学学报 2023年第3期45卷 605-618页

作者：王明月曹受金彭继庆中南林业科技大学林学院湖南长沙410004 中南林业科技大学生命科学与技术学院湖南长沙410004

[目的]探究植物生长调节剂对圆锥绣球花期及生理特性的影响,为圆锥绣球花期调控提供理论依据和技术途径。[方法]以‘香草草莓’圆锥绣球为材料,在花芽分化前,对叶片喷施赤霉素(GA3)、水杨酸(SA)、乙烯利(ETH)和清水(CK),记录圆锥绣球的... 详细信息

[目的]探究植物生长调节剂对圆锥绣球花期及生理特性的影响,为圆锥绣球花期调控提供理论依据和技术途径。[方法]以‘香草草莓’圆锥绣球为材料,在花芽分化前,对叶片喷施赤霉素(GA3)、水杨酸(SA)、乙烯利(ETH)和清水(CK),记录圆锥绣球的花期以及花序大小和数量,并检测不同时期叶片的内源激素、光合色素、可溶性糖和可溶性蛋白质等指标。[结果]花芽分化期,高水平的叶绿素、可溶性糖、可溶性蛋白、ABA和ZR,以及低水平的IAA和GA3有利于促进植株开花。100 mg/L SA处理能显著提高圆锥绣球花芽分化期叶绿素含量,促进可溶性糖及可溶性蛋白的积累,提高ABA/IAA、ABA/GA3、ZR/IAA、ZR/GA3的比值,有利于推进花芽分化进程以及花的发育,使圆锥绣球花期提前6 d、开花总时长延长11 d,花序长、宽和花瓣面积分别较CK增长22.76%、26.74%、27.45%;100 mg/L GA3处理使花序长、宽较CK组分别增加了7.54%、12.04%,但其始花期较对照推迟4 d,花序数量明显减少;而中高浓度SA、GA3以及所有浓度的ETH处理均导致花期推迟,花序品质不佳。[结论]圆锥绣球叶面喷施100 mg/L SA将显著促进花序生长、提早开花、增大花瓣面积和延长花期等,可在其生产上加以应用。

关键词：圆锥绣球植物生长调节剂开花生理花期调控水杨酸

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重庆“四山”生态环境状况时空特征与障碍因子分析

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水土保持研究 2025年第2期32卷 353-365页

作者：谢慧君曹聪范泽英杜清江刘智尹小彤重庆市地质矿产勘查开发局南江水文地质工程地质队重庆401121 重庆市地下水资源利用与环境保护实验室重庆401121 重庆市地质矿产勘查开发局208水文地质工程地质队(重庆市地质灾害防治工程勘查设计院) 重庆400700

[目的]重庆“四山”地区是重庆重点生态功能区,开展重庆“四山”生态环境状况和障碍因子研究,对进一步保护和合理利用四山资源具有重要指导意义。[方法]基于DEM、土地利用类型、植被覆盖率和地下水水位监测站等数据基础,采用AHP-PCA熵... 详细信息

[目的]重庆“四山”地区是重庆重点生态功能区,开展重庆“四山”生态环境状况和障碍因子研究,对进一步保护和合理利用四山资源具有重要指导意义。[方法]基于DEM、土地利用类型、植被覆盖率和地下水水位监测站等数据基础,采用AHP-PCA熵权组合模型、空间自相关分析和障碍度模型等方法,分析了重庆四山地区生态环境质量时空变化特征,探讨了不同聚集模式下的生态环境质量变化趋势,量化了各影响因子对四山生态环境质量影响的障碍度。[结果](1)2014—2021年重庆四山地区生态环境质量状况较好,整体以改善趋势为主(面积占比36.24%);局部出现恶化趋势(面积占比24.20%),主要分布在人类活动频繁的槽谷地带。(2)研究区不同等级生态环境质量发生转移,生态环境质量极差和优的区域具有一定稳定性,分别有59.36%和73.22%的区域未发生变化;生态环境质量差、一般和良的区域流动性相对较大,发生转移的面积占比分别为63.69%,54.09%和43.65%。不同山脉中,明月山生态环境质量稳定性较高,中梁山生态环境质量改善趋势最小,缙云山生态环境质量存在恶化的风险较其他山脉更大。(3)聚类和异常值分析结果显示:四山生态环境质量的高值区域和低值区域具有显著的空间聚集特征(p<0.01),高—低模式下生态环境质量面临进一步恶化的可能,低—高模式下,反映出生态环境可能存在潜在受损状态。(4)重庆四山地区影响生态环境的各因子中地下水水位障碍度最大,其次为植被覆盖率、生物丰度和城镇开发强度;障碍度变化较大的为隧道建设密度、地下水水位和地表水体丰度,其中隧道建设密度障碍度增加,地下水水位和地表水体丰度障碍度降低。[结论]四山地区生态环境状况向好发展,局部生态环境质量较差,隧道建设密度对生态环境的影响增加。

关键词：生态环境质量时空变化人类活动障碍因子 AHP-PCA熵权

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The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs:A multicenter retrospective real-world study

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Current Urology 2024年第4期18卷 283-286页

作者： Zijie Xu Chujiang He Jianwei cao Jianhong Wu Dawei Wang Jun Da Dongliang Xu mingyue Tan Xiaofeng Gao Yonghan Peng Jie Chen Rong Chen Pengfei Wu Juntao Jiang Lei Chen Shujie Xia Yi Shao Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Xin Hua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Municipal Hospital Urology Specialist Alliance ShanghaiChina Department of Urology Huadong HospitalFudan UniversityShanghaiChina Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Urology Changhai HospitalNaval Medical UniversityShanghaiChina Department of Urology Shanghai Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Urology Shanghai Sixth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Urology Shanghai Tenth People's HospitalTongji University School of MedicineShanghaiChina

Objective The objective of this study is to assess the effectiveness and safety of ureteroscopic lithotripsy and flexible ureteroscopy(fURS)for treating patients on anticoagulant(AC)or antiplatelet(AP)*** and Methods The study included 213 patients with urinary stones who underwent ureteroscopic lithotripsy or fURS between January 2019 and October 2022 at the Shanghai Municipal Hospital Urology Specialist *** these patients,15 received AC therapy,193 received AP therapy,and 5 received both AC and AP *** were divided into 3 groups based on the real-world management of antithrombotic drugs:the continuation group(n=62),the discontinuation group(n=91),and the discontinuation and bridge heparin group(n=60).Intraoperative and postoperative outcomes were compared among the 3 *** Age,sex,body mass index,stone location,stone size,stone side,and residual fragments were not different among the *** of the patients received blood transfusions or had thromboembolic events,emergencies for gross hematuria,significant bleeding-related complications,or unplanned secondary ureteroscopic *** mean duration of hospital stay of the continuation group(3.97 days)was significantly lower than that of the discontinuation group(5.99 days)and the discontinuation and bridge heparin group(5.75 days)(p<0.001).Conclusions Ureteroscopic lithotripsy and fURS can be performed safely and effectively in patients on AC or AP drugs,resulting in reduced duration of hospital stay.

关键词： Ureteroscopic lithotripsy Flexible ureteroscopy Anticoagulant drugs Antiplatelet drugs

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Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro

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Virologica Sinica 2020年第6期35卷 776-784页

作者： Leike Zhang Jia Liu Ruiyuan cao mingyue Xu Yan Wu Weijuan Shang Xi Wang Huanyu Zhang Xiaming Jiang Yuan Sun Hengrui Hu Yufeng Li Gang Zou Min Zhang Lei Zhao Wei Li Xiaojia Guo Xiaomei Zhuang Xing-Lou Yang Zheng-Li Shi Fei Deng Zhihong Hu Gengfu Xiao Manli Wang Wu Zhong State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100850China CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China

The recent outbreak of novel coronavirus pneumonia(COVID-19)caused by a new coronavirus has posed a great threat to public *** safe and effective antivirals is of urgent demand to cure the huge number of *** proteases are considered potential drug *** human immunodeficiency virus protease inhibitors(lopinavir/ritonavir)has been recommended in the global Solidarity Trial in March launched by World Health ***,there is currently no experimental evidence to support or against its clinical *** evaluated the antiviral efficacy of lopinavir/ritonavir along with other two viral protease inhibitors in vitro,and discussed the possible inhibitory mechanism in *** in vitro to in vivo extrapolation was carried out to assess whether lopinavir/ritonavir could be effective in *** the four tested compounds,lopinavir showed the best inhibitory effect against the novel coronavirus ***,further in vitro to in vivo extrapolation of pharmacokinetics suggested that lopinavir/ritonavir could not reach effective concentration under standard dosing regimen[marketed as Kaletraò,contained lopinavir/ritonavir(200 mg/50 mg)tablets,recommended dosage is 400 mg/10 mg(2 tablets)twice daily].This research concluded that lopinavir/ritonavir should be stopped for clinical use due to the huge gap between in vitro IC50 and free plasma ***,the structure–activity relationship analysis of the four inhibitors provided further information for de novel design of future viral protease inhibitors of SARS-CoV-2.

关键词： Respiratory pharmacology COVID-19 SARS-CoV-2 Protease inhibitor

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Chinese Compilation of Physical Activities in healthy adults aged 18-64:Categories and metabolic intensities

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Sports Medicine and Health Science 2022年第3期4卷 160-171页

作者： Junqiang Qiu Junchao Yang mingyue Lu Yuyang Chen Yanping Yang Wei cao Kun Meng Yan Chen Jun Zhang Chunyan Xu Longyan Yi Xian Guo Yang Wang Xiaolei Liu Yi Yan Hanjun Li Qin Zhuo Wenhua Zhao Lianshi Feng Barbara E.Ainsworth School of Sports Science Beijing Sport UniversityBeijing100084China Beijing Sports Nutrition Engineering Research Center Beijing100084China China Institute of Sport and Health Beijing Sport UniversityBeijing100084China China Wushu School Beijing Sport UniversityBeijing100084China National Institute of Nutrition and Health Chinese Center for Disease Control and PreventionBeijing100050China Chinese Leisure Sports Administrative Center Beijing100763China School of Kinesiology Shanghai University of SportShanghai200433China College of Health Solutions Arizona State UniversityPhoenixAZ85003USA

A Chinese Compilation of Physical Activities was compiled to estimate the energy costs of physical activities(PAs)using data on adults aged 18–*** were obtained from published articles and laboratory ***,including PubMed,Embase,Scopus,Ebsco,Web of Science,Chinese National Knowledge Infrastructure,Wan Fang Data,National Science and Technology Report Service,Public Health Scientific Data were searched to collect data from inception to January 2022,on energy expenditure associated with PA in the healthy Chinese *** reviewers independently screened the literature and extracted,classified,and summarized *** were measured for 36 PAs using indirect *** descriptions of specific activities and metabolic equivalent values were provided by summarizing 241 physical activities in 13 *** first edition of the Chinese Compilation of PAs in Healthy Adults Aged 18–64(CCPA)was *** provides valuable resources for people who regularly engage in physical exercise,researchers,educators,fitness professionals,and health or commercial sectors to quickly obtain various PA MET *** the future,the energy expenditure of various PAs of different ages within the Chinese population can be measured based on the CCPA.

关键词： Compendium of physical activity Healthy Chinese adults Energy cost Metabolic equivalent

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黄酮类化合物与肠道菌群互作研究进展

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中国食品学报 2022年第6期22卷 369-381页

作者：陈斌刘洁詹敏敏吕慕雯曹庸宋明月华南农业大学食品学院广东省功能食品活性物重点实验室广州510642 北京工商大学中加食品营养与健康联合实验室北京100048

黄酮类化合物广泛存在于蔬菜和水果中,能够显著促进人体健康。肠道菌群也被证明对维持人体健康具有重要的调控作用。例如:肠道菌群紊乱会增加患炎症性肠病、肥胖和结直肠癌等慢性疾病的风险。本文综述膳食摄入的黄酮类化合物与肠道菌群... 详细信息

黄酮类化合物广泛存在于蔬菜和水果中,能够显著促进人体健康。肠道菌群也被证明对维持人体健康具有重要的调控作用。例如:肠道菌群紊乱会增加患炎症性肠病、肥胖和结直肠癌等慢性疾病的风险。本文综述膳食摄入的黄酮类化合物与肠道菌群相互作用的最新研究进展。黄酮类化合物通过促进益生菌的生长、抑制病原菌的繁殖、增加菌群的多样性以及促进菌群有益代谢物(如短链脂肪酸)的产生来发挥其生物学活性。肠道菌群影响膳食黄酮类化合物的生物转化和代谢模式,并通过产生肠道菌群介导的小分子活性代谢产物,提高黄酮类化合物的生物利用度,在一定程度上决定其生物学活性在体内的表达。

关键词：黄酮肠道菌群调控代谢相互作用

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味觉感知的人体肠-脑轴信号传导机制研究进展

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食品科学 2022年第11期43卷 197-203页

作者：赵孟斌张琦梦宋明月刘果曹庸高向阳华南农业大学食品学院广东省功能食品活性物重点实验室广东广州510642 岭南现代农业科学与技术广东省实验室广东广州510642

味觉是人类感知生物摄取能的重要环节,胃肠道亦存在味觉感知现象。本文从胃肠道味觉受体、胃肠道味觉感知通路及肠-脑轴味觉信号传导机制等方面进行了分析,胃肠道中味觉感知表明胃肠道中存在味觉受体第一家族亚型(taste receptor type 1... 详细信息

味觉是人类感知生物摄取能的重要环节,胃肠道亦存在味觉感知现象。本文从胃肠道味觉受体、胃肠道味觉感知通路及肠-脑轴味觉信号传导机制等方面进行了分析,胃肠道中味觉感知表明胃肠道中存在味觉受体第一家族亚型(taste receptor type 1 member,T1R)1、T1R2、T1R3、味觉受体第二家族亚型(taste receptors type 2,T2Rs)等味觉受体,且肠道味觉物质刺激肠内分泌细胞分泌胆囊收缩素(cholecystokinin,CCK)、肽YY(peptide YY,PYY)等脑肠肽激素,与味觉信号在神经元的传递有关;肠道中鲜味物质谷氨酸钠显著激活大脑缰核、杏仁核和下丘脑亚核的神经网络,表明肠-脑轴味觉感知是基于胃肠道受体及脑肠肽、神经元和大脑中枢神经系统之间的共同调控,从而提出肠-脑轴味觉信号传导机制假说,认为甜味受体T1R2/T1R3和鲜味受体T1R1/T1R3具有相似的信号传导通路,味觉物质作用于肠道后,与肠道中相应的味觉受体结合,激活磷脂酶-β2(phospholipase C-β2,PLC-β2),释放Ca^(2+),引起肠道内环境的变化,刺激肠内分泌细胞分泌PYY、CCK等激素,被肠神经元突触特异性识别,将味觉信号传导至大脑神经中枢;而谷氨酸代谢型受体4(metabotropic glutamate receptor 4,mGluR4)和苦味受体T2Rs信号传导通路则是通过激活磷酸二酯酶(phosphodiesterase,PDE),使细胞质内3’,5’-环腺苷酸(3’,5’-cyclic adenylic acid,cAMP)浓度降低,从而解除环核苷酸(cyclic nucleotide,cNMP)的抑制作用,从而释放Ca^(2+)。基于肠-脑轴味觉偏好,为味觉发生改变的患者开发治疗新药物、寻找新的药物靶点提供了新的方向。对肠-脑轴味觉信号传导机制的研究将为胃肠道生理的神经控制提供分子框架、精准控制人体对味觉营养物质的生理反应,并对味觉物质在肠-脑轴中的摄入、代谢、调节等及开发新的味觉感知途径提供新的理论依据。

关键词：肠-脑轴味觉受体感知神经元

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采油采气工程技术新进展与展望

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石油勘探与开发 2022年第3期49卷 565-576页

作者：郑新权师俊峰曹刚杨能宇崔明月贾德利刘合中国石油勘探与生产分公司北京100007 中国石油勘探开发研究院北京100083

总结采油采气工程领域“十三五”期间重要进展,分析当前采油采气工程在工艺适应性、数字化建设和节能减排等方面所面临的挑战,并指出未来的发展方向。“十三五”期间分层注入、人工举升、储集层改造、排水采气、井下作业等5大主体技术... 详细信息

总结采油采气工程领域“十三五”期间重要进展,分析当前采油采气工程在工艺适应性、数字化建设和节能减排等方面所面临的挑战,并指出未来的发展方向。“十三五”期间分层注入、人工举升、储集层改造、排水采气、井下作业等5大主体技术取得重大进展,为实现老油田持续挖潜、新建产能效益动用提供了关键技术保障。当前复杂国际政治经济形势下,采油采气工程面临油气开采技术难度不断增大、数字化转型技术仍不完善、绿色低碳技术尚不成熟等3个方面严峻挑战。确立稳油增气、数字化转型、绿色低碳发展3大战略方向和实施路径,指出精细分层注入技术、高效举升工艺技术、精准储集层改造技术、长效排水采气技术及智能井下作业技术5个重点研究方向,为中国油气行业的转型升级和高质量发展提供工程技术支撑。

关键词：采油采气工程分层注入人工举升储集层改造排水采气井下作业数字化转型低碳经济

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聚磺酰胺/聚乙烯(PSA/PE)耐酸复合膜的制备及渗透汽化脱盐性能

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北京化工大学学报（自然科学版） 2022年第2期49卷 55-61页

作者：刘明悦夏建中曹兵张睿李培北京化工大学材料科学与工程学院北京100029 深圳大学先进技术研究院深圳518060

以间苯二磺酰氯(BDSC)为有机相单体、二胺和多胺类化合物为水相单体,通过界面聚合法在聚乙烯(PE)微滤膜上制备了聚磺酰胺(PSA)/PE渗透汽化复合膜。经配方和工艺优化,确定了PSA/PE复合膜的制备条件为:将聚乙烯亚胺(PEI)与间苯二胺(MPD)以... 详细信息

以间苯二磺酰氯(BDSC)为有机相单体、二胺和多胺类化合物为水相单体,通过界面聚合法在聚乙烯(PE)微滤膜上制备了聚磺酰胺(PSA)/PE渗透汽化复合膜。经配方和工艺优化,确定了PSA/PE复合膜的制备条件为:将聚乙烯亚胺(PEI)与间苯二胺(MPD)以5∶1的质量比共混作为水相单体,将PE膜直接浸润到水相中,然后浸入含有0.5%BDSC的有机相中进行界面聚合反应。测定了在优化条件下制备的PSA/PE复合膜的渗透汽化脱盐性能和耐酸性,结果表明:在料液为3.5%NaCl水溶液、温度为75℃的条件下,PSA/PE复合膜的水通量为35.1 kg/(m^(2)·h),截盐率达99.85%;在20%H_(2)SO_(4)溶液中浸泡6个月后,其脱盐性能不变,化学结构稳定。

关键词：聚磺酰胺聚乙烯界面聚合渗透汽化脱盐性能耐酸性

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