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Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin mingyao Tian Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

Shading Fault Detection Method for Household Photovoltaic Power Stations Based on Inherent Characteristics of Monthly String Current Data mapping

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1370-1382页

作者： Wenting ma mingyao ma Hai Wang Zhixiang Zhan Rui Zhang Jun Wang National and Local Joint Engineering Laboratory for Renewable Energy Access to Grid Technology Hefei University of TechnologyHefei 230009China Murdoch University Murdoch 6150Australia. Sungrow Smart maintenance Technology Co. Ltd.Hefei 230088China.

The poor outdoor operating conditions of household photovoltaic(PV)make the power station prone to various faults.However,the dispersion of household PV installations often increases the difficulty and cost of operation and maintenance(O&M).Although the remote monitoring and fault detection of a PV power station can be realized by the use of operation data,the particularity of a household power station also brings many problems to fault detection.In this study,we propose a shading fault detection method of household PV power based on inherent characteristics of monthly string current data mapping.The ideal current peak obtained by a new fitting method is used to normalize string current data.The current probability density function(PDF)at each time point is estimated by kernel density estimation(KDE).Through the normalized current data corresponding to the maximum probability density,the inherent characteristics of the strings are obtained,such that whether the strings have shading can be judged and the shading degree can then be evaluated.Not only are no additional sensors needed to collect environmental data,such as irradiation and temperature,but also simulating the detailed parameters of the power station is not required.The interference caused by meteorological factors can thus be eliminated,which can be easily used in old power stations and newly constructed power stations.The effectiveness and performance of the proposed shading fault detection method is verified by experimental data collected from the actual household PV power station.Index Terms-Data fitting,fault detection,household photovoltaic(PV),kernel density estimation(KDE),shading degree.

关键词： Terms-Data fitting fault detection household photovoltaic(PV) kernel density estimation(KDE) shading degree.

Vector Control Strategy of a T-type Three-level Converter Driving a Switched Reluctance Motor

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Chinese Journal of Electrical Engineering 2019年第4期5卷 15-21页

作者： mingyao ma Zhuangzhi Wang Qingqing Yang Shuying Yang Xing Zhang National and Local Joint Engineering Laboratory of Renewable Energy Access to Grid Technology Hefei University of TechnologyHefei 230009China

A novel 12 voltage vector control strategy for switched reluctance motors(SRM)with a T-type three-level converter is proposed in this study.Based on a causal analysis of torque ripple under the control of conventional six voltage vectors,six new voltage vectors are added for further reduction of torque ripple.An optimized control rule is adopted based on the division method of the 12 new voltage vectors.A zero-voltage vector is used to adjust the duration of the 12 voltage vectors,the time of which is varied at different parts of the vector sectors according to the torque error.In addition,the windings are connected in a delta configuration,therefore,the number of connections between the converter and SRM is reduced.Finally,the results of maTLAB/Simulink and RT-LAB are presented to verify the validity of the proposed scheme.

关键词： Switched reluctance motor(SRM) T-type three-level converter vector control

一种基于分数阶微积分的CCM Boost变换器准在线无源参数的数字孪生辨识方法

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中国电机工程学报 2024年第6期44卷 2340-2349,I0022页

作者：马铭遥韩添侠陈强王鼎奕徐君可再生能源接入电网技术国家地方联合工程实验室(合肥工业大学) 安徽省合肥市230009 阳光电源股份有限公司安徽省合肥市230088

由于具有高性价比、准确性和数字化等优点,数字孪生已成为电力电子变换器故障趋势判断和预知维护的先进技术。针对当前电力电子变换器所建立的数字孪生模型尚未考虑实际电感、电容的分数阶特性的问题,基于分数阶微积分构建电力电子电路... 详细信息

由于具有高性价比、准确性和数字化等优点,数字孪生已成为电力电子变换器故障趋势判断和预知维护的先进技术。针对当前电力电子变换器所建立的数字孪生模型尚未考虑实际电感、电容的分数阶特性的问题,基于分数阶微积分构建电力电子电路的预估-校正数字孪生模型,应用基于粒子群优化(particle swarm optimization,PSO)算法的孪生参数辨识方法对不同分数阶阶次下的电感值(L)和电容值(C)进行辨识,并计算出等效串联电阻。通过与现有方法对比,该方法不仅提高了实际电感和实际电容的辨识精度,还能辨识出不同阶次下与不同C下的分数阶参数。最后,搭建不同L和C及分数阶阶次的连续导通模式Boost变换器物理样机,并考虑不同工况条件与不同辨识次数等因素来进行实验验证。实验结果验证了所提模型与方法的有效性。

关键词：数字孪生分数阶 Boost变换器参数辨识粒子群优化

In-situ Health Monitoring of IGBT Modules of an On-line Medium-voltage Inverter System Using Industrial Internet of Things

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CSEE Journal of Power and Energy Systems 2020年第3期6卷 638-648页

作者： mingyao ma Bing Ji Jinsong Han Jianing Wang Mingyue Zhan Nianwen Xiang Heifei University of Technology HeifeiChina University of Leicester LeicesterU.K

Requirements of the Internet of things for the network includes the ability to monitor the equipment and devices.Nowadays,the reliability of a power electronics converter has raised concerns of both academia and industry.In particular,power semiconductor devices are continuously exposed to excessive stress while being designed with high power handling capability and are considered as the most fragile component in power converters suffering from a high failure rate.Aiming to find an effective monitoring method which is also helpful for the Internet of Things and improve the reliability of a three-level neutral-point-clamped power inverter,an in-situ health monitoring method is proposed by harnessing the inverter operational characteristics and degradation sensitive electrical parameters to address the IGBT wire bonding faults.The zero voltage state provides an inherent redundant feature that allows for a power switch to be diagnosed during its normal operation in a neutralpoint-clamped power inverter.The proposed prognostic approach obtains both the wire bonding failure features and junction temperature from the terminals of an IGBT module,which is regarded as non-invasive on-line health monitoring.The system performance can be affected by the designated testing point and testing window,which is discussed and experimentally validated.The proposed technique allows unhealthy wire bonding in IGBT modules online monitoring during the operational period of the inverter.And the proposed in-situ health monitoring of IGBT modules can be used for the industrial Internet of things.

关键词： IGBT health monitoring temperature sensitive electrical parameter(TSEP) three-level inverters reliability

Review of Real-time Simulation of Power Electronics

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Journal of Modern Power Systems and Clean Energy 2020年第4期8卷 796-808页

作者： Fei Li Yichao Wang Fan Wu Yao Huang Yang Liu Xing Zhang mingyao ma School of Electrical Engineering and Automation Hefei University of TechnologyHefeiChina National and Local Joint Engineering Laboratory for Renewable Energy Access to Grid Technology HefeiChina

Real-time simulation of power electronics has been recognized by the industry as an effective tool for developing power electronic devices and systems.Since there is no energy transfer during the course of the usage,real-time simulation has a lot of advantages in the process of development and experimentation.From the perspective of real-time simulation,this paper focuses on the main problems in modeling accuracy,system bandwidth and stability,limitations on communication interface and energy interface,and the cost of platform construction.Finally,we provide further research directions.

关键词： Hardware-in-the-loop simulation modeling and simulation of power electronics correction method power interface algorithm numerical method

Open-circuit Fault-tolerant Control Strategy Based on Five-level Power Converter for SRM System

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CES Transactions on Electrical machines and Systems 2019年第2期3卷 178-186页

作者： mingyao ma Kexiang Yuan Qingqing Yang Shuying Yang School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

Switched reluctance motor power converters are prone to open-circuit faults because it need to withstand large voltages and currents.Due to the small number of traditional asymmetrical half bridge topology switches,it is difficult to carry out fault tolerant control when power converters has an open-circuit fault,resulting in larger output torque ripple.This paper presents a five-level power converter based on the traditional asymmetric half-bridge power converter.The five-level topology has more switching states and can work in multi-level mode.Based on the topology,different excitation and demagnetization voltages can be choose at different speeds.A fault-tolerance strategy is developed to decrease the influence of the open-circuit fault.The five-level power converter has four switches per phase,and two of them will be used in one of the operating mode.So the remaining two of the switches can be used for safe backup,enabling fault-tolerant control when an open-circuit occur.Since each phase of the five-level power converter proposed in this paper is independent of each other,a reasonable control strategy can be used to avoid the unbalance of the midpoint potential.Finally,the topology and fault-tolerant strategy proposed in this paper are verified by simulation and experiment.

关键词： Fault tolerance control Midpoint potential Open-circuit fault Power converter Torque ripple.

一种具有高容错能力的改进型LLC拓扑及其控制策略

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电源学报 2024年第3期22卷 165-171页

作者：陈庆华吴克邱荣禄王涵宇马铭遥合肥工业大学电气与自动化工程学院合肥230009

LLC谐振变换器因其功率密度高、效率高和体积小等优点被广泛应用于车载电源中,其可靠的运行能力对行驶安全和乘用体验十分关键。然而,车辆运行的复杂工况和严苛环境对功率器件的冲击巨大,一旦出现开关管故障则谐振变换器无法在保证输出... 详细信息

LLC谐振变换器因其功率密度高、效率高和体积小等优点被广泛应用于车载电源中,其可靠的运行能力对行驶安全和乘用体验十分关键。然而,车辆运行的复杂工况和严苛环境对功率器件的冲击巨大,一旦出现开关管故障则谐振变换器无法在保证输出电压不变的同时运行在谐振点附近,系统的效率和输出能力均大幅下降。为使变换器具有故障容错能力,提出一种改进型LLC拓扑及相应控制策略,可在开关发生故障后保证输出电压不受影响且变换器工作在谐振频率附近。此外,针对容错瞬态过程中谐振电容电压尖峰较大的问题,设计一种优化的Burst控制策略对其进行抑制,保证容错过程的平滑,仿真实验结果验证了所提方法的有效性。

关键词：车载变流器 LLC谐振变换器故障容错可靠性

Corrigendum to“Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration”[Journal of Genetics and Genomics(2022)49,1114-1126]

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Journal of Genetics and Genomics 2024年第5期51卷 578-578页

作者： Xi Chen Xuran Niu Yang Liu Rui Zheng Lei Yang Jian Lu Shuming Yin Yu Wei Jiahao Pan Ahmed Sayed Xueyun ma Meizhen Liu Fengxiang Jing mingyao Liu Jiazhi Hu Liren Wang Dali Li Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China The MOE Key Laboratory of Cell Proliferation and Differentiation Genome Editing Research CenterSchool of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai 200092China Biochemistry Laboratory Chemistry DepartmentFaculty of ScienceAssiut UniversityAssiut 71516Egypt Shanghai Turtle Technology Co. Shanghai 201900China

The authors regret that the grant number“21CJ1402200”in the Acknowledgments session should be replaced as“21JC1402200”.The corrected contents areprovided as follows.

关键词： CRISPR/Cas9 correction ledgment