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Electrode particulate materials for advanced rechargeable batteries:A review

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Particuology 2024年第3期86卷 160-181页

作者： mingyang Ma Miao Du Yan liu Hongyan lü Jialin Yang Zelin Hao Jinzhi Guo Xinglong Wu MOE Key laboratory for UV light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin130024China Department of Chemistry Northeast Normal UniversityChangchunJilin130024China

The demand for large-scale energy storage is increasing due to the decreasing non-renewable resources and deteriorating environmental *** rechargeable batteries with high energy density and long cycle performance is an ideal choice to meet the demand of energy storage *** development of excellent electrode particles is of great significance in the commercialization of nextgeneration *** ideal electrode particles should balance raw material reserves,electrochemical performance,price and environmental *** them,the development of electrode particulate materials with excellent electrochemical properties is the top priority at *** this review,the typical researches of electrode materials are summarized in terms of crystal structure,morphology,pore structure,surface and interface ***,the structural characteristics and improvement methods of transition metal oxides,polyanionic compounds,Prussian blue and their analogues are ***,the different effects of particulate morphology,pore,surface and interface structure on the performance of electrode materials are *** designing high-performance electrode materials,preparation route should be set according to the particle properties of the materials and the synergistic effect of various optimization methods should be *** the same time,in addition to the electrode materials,other components of the rechargeable batteries,such as current collector,separator and electrolytes,should be optimized to improve the overall performance of the *** review would provide important guiding principle for designing high-performance electrode particulate materials.

关键词： Particulate properties Electrode materials Rechargeable batteries

O_(2)-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma

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Chinese Chemical letters 2024年第7期35卷 394-399页

作者： Yu Qin mingyang Huang Chenlu Huang Hannah lPerry linhua Zhang Dunwan Zhu Tianjin Key laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Molecular Sciences Research Hub Department of ChemistryWhite City CampusImperial College LondonLondon W120BZUnited Kingdom

Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential for tumor ***,two main issues hamper the antitumor performance of PDT:overexpression of glutathione(GSH)in tumors,which consumes PDT-induced reactive oxygen species(ROS),and hypoxia within the tumor *** drawbacks of PTT include uneven temperature distribution and the upregulation of the heat-shock proteins in tumors,both of which result in ineffective *** address these issues,a MnO_(2)doped nano-delivery system(HTIM-PMs)was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indocyanine green(ICG)and MnO_(2)*** surface of polymeric micelles was layered with hyaluronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cell *** internalization,HTIM-PMs showed responsiveness to the tumor microenvironment(acid pH,high glutathione,high H_(2)O_(2)).Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the MnO_(2)and *** released MnO_(2)further reduced the GSH level and promoted O_(2)generation,thus enhancing the PDT *** PTT-mediated hyperthermia accelerated blood flow,which is beneficial for O_(2)distribution,and promotes ROS *** PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of *** promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.

关键词： Photodynamic therapy Photothermal therapy Oxygen generating One-step self-assembly Stimuli-responsive nanoparticles

Clinicopathological significance and immunotherapeutic outcome of claudin 18.2 expression in advanced gastric cancer:A retrospective study

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Chinese Journal of Cancer Research 2024年第1期36卷 78-89页

作者： Changsong Qi Xiaoyi Chong Ting Zhou mingyang Ma Jifang Gong Miao Zhang Jian li Jun Xiao Xiaohui Peng Zhen liu Zonghai li lin Shen Xiaotian Zhang State Key laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China CARsgen Therapeutics Co. LtdShanghai 200231China CARsgen life Sciences Co. LtdShanghai 200131China

Objective: Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive(ClDN18.2-positive) gastric cancer(GC) vary in different clinical studies, making it difficult to optimize antiClDN18.2 therapy. We conducted a retrospective analysis to explore the association of ClDN18.2 expression with clinicopathological characteristics and immunotherapeutic outcomes in ***: A total of 536 advanced GC patients from 2019 to 2021 in the CT041-CG4006 and CT041-ST-01clinical trials were included in the analysis. ClDN18.2 expression on ≥40% of tumor cells(2+, 40%) and ClDN18.2 expression on ≥70% of tumor cells(2+, 70%) were considered the two levels of positively expressed GC. The clinicopathological characteristics and immunotherapy outcomes of GC patients were analyzed according to ClDN18.2 expression ***: ClDN18.2 was expressed in 57.6%(cut-off: 2+, 40%) and 48.9%(cut-off: 2+, 70%) of *** death-ligand 1(PD-l1) and ClDN18.2 were co-expressed in 19.8% [combined positive score(CPS)≥1, ClDN18.2(cut-off: 2+, 40%)] and 17.2% [CPS≥5, ClDN18.2(cut-off: 2+, 70%)] of ***18.2 expression positively correlated with younger age, female sex, non-gastroesophageal junction(nonGEJ), and diffuse phenotype(Pl1 expression were significantly lower in ClDN18.2-positive GC(both Pliver metastasis(Pless common in ClDN18.2-positive GC. Overall survival and immunotherapy-related progression-free survival(ir PFS) were inferior in the ClDN18.2-positive ***: ClDN18.2-positive GC is associated with poor prognosis and worse immunotherapeutic outcomes. The combination of anti-ClDN18.2 therapy, anti-PD-l1/PD-1 therapy, and chemotherapy for GC requires further investigation.

关键词： Gastric cancer claudin18.2 CT041 PD-l1 immunotherapy

创新作业设计助力素养提升——探究滑动摩擦力的大小和质量、重力是否有关

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物理教学 2024年第5期46卷 30-34页

作者：叶鸣扬南京师范大学附属中学树人学校江苏210011 南京师范大学教师教育学院江苏210023

教育部于2021年4月颁布了《教育部办公厅关于加强义务教育学校作业管理的通知》,其中明确提出:创新作业类型方式,根据学科特点合理布置包括科学探究在内的不同类型的作业,鼓励科学设计探究性作业和实践性作业。文章以一节观摩课中获取... 详细信息

教育部于2021年4月颁布了《教育部办公厅关于加强义务教育学校作业管理的通知》,其中明确提出:创新作业类型方式,根据学科特点合理布置包括科学探究在内的不同类型的作业,鼓励科学设计探究性作业和实践性作业。文章以一节观摩课中获取的灵感,设计一份创新型探究性作业,将《通知》要求落到实处。

关键词：作业设计滑动摩擦力

籽用美洲南瓜EMS诱变突变体库的构建及表型分析

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西北植物学报 2024年第8期44卷 1283-1294页

作者：孙明洋王萍内蒙古农业大学园艺与植物保护学院呼和浩特010011

【目的】构建籽用美洲南瓜突变体库,加快籽用美洲南瓜种质资源创新进程,对南瓜品种选育、品种改良以及遗传基础的拓宽具有重要的意义。【方法】利用1.8%诱变剂甲基磺酸乙酯(EMS)处理籽用美洲南瓜ZHl4种子15 h,然后对M_(1)和M_(2)代群体... 详细信息

【目的】构建籽用美洲南瓜突变体库,加快籽用美洲南瓜种质资源创新进程,对南瓜品种选育、品种改良以及遗传基础的拓宽具有重要的意义。【方法】利用1.8%诱变剂甲基磺酸乙酯(EMS)处理籽用美洲南瓜ZHl4种子15 h,然后对M_(1)和M_(2)代群体单株进行表型变异观察,同时对M_(2)群体变异株系ZHl4-33进行显微组织结构观察。【结果】(1)M_(2)群体中共筛选到242个突变植株,45种表型变异,变异类型涵盖了突变株的各个生长时期以及各植物器官,总的突变频率达到25.17%。(2)突变体叶片栅栏组织厚度显著高于野生型,排列紧凑,维管形成层痕迹明显;突变体茎维管束多而密集,导管直径小于野生型,髓部发达,细胞间隙较小,细胞数目有所增加。【结论】初步构建了由425个M_(2)家系所组成的籽用美洲南瓜突变体库,为籽用美洲南瓜功能基因组研究和新品种选育奠定了材料基础。

关键词：籽用美洲南瓜 EMS 表型分析突变体库显微组织结构

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RepVGG与CapsNet融合的轴承故障诊断

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振动与冲击 2024年第14期43卷 301-307页

作者：尹爱军吕明阳杨敏英陈小敏重庆大学机械与运载工程学院重庆400044 西安卫星测控中心西安710000

如何提高特征提取能力和提取特征空间信息是实现高精度故障诊断的关键。RepVGG等深层卷积神经网络忽视了特征空间信息,而CapsNet由于网络层次较浅导致特征提取能力受限。为解决上述问题,提出了RepVGG与CapsNet融合的轴承故障诊断方法。... 详细信息

如何提高特征提取能力和提取特征空间信息是实现高精度故障诊断的关键。RepVGG等深层卷积神经网络忽视了特征空间信息,而CapsNet由于网络层次较浅导致特征提取能力受限。为解决上述问题,提出了RepVGG与CapsNet融合的轴承故障诊断方法。首先获取不同测点的振动信号,通过格拉姆角差场转换成二维特征图并沿通道方向拼接;然后选取RepVGG网络作为前置卷积层,实现多维振动信号的特征提取与融合;最后由CapsNet提取特征空间信息,实现轴承故障诊断。试验结果表明,RepVGG与CapsNet融合的故障诊断方法具有优良的故障识别效果和抗噪性能。

关键词：轴承故障诊断深度学习卷积神经网络

中国北方针叶林碳通量动态变化及其影响因素分析

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气候与环境研究 2024年第3期29卷 243-252页

作者：吕富成酒名扬韩立钦陈晓虹河南师范大学旅游学院河南新乡453007 河南省太行山森林生态系统野外科学观测研究站河南新乡453007 河南师范大学生命科学学院河南新乡453007

基于北方针叶林典型站点——呼中定位观测站2014~2018年不同时间尺度碳通量观测数据,探究了该生态系统长时间序列碳通量动态变化及其影响因素。结果表明:受总初级生产力(Gross Primary Productivity,GPP)和生态系统呼吸(Ecosystem Respi... 详细信息

基于北方针叶林典型站点——呼中定位观测站2014~2018年不同时间尺度碳通量观测数据,探究了该生态系统长时间序列碳通量动态变化及其影响因素。结果表明:受总初级生产力(Gross Primary Productivity,GPP)和生态系统呼吸(Ecosystem Respiration,RE)的综合作用影响,北方针叶林生态系统净碳交换量(Net Ecosystem Exchange,NEE)年际变化差异较大,在2.64~17.63 g(C)m^(-2) a^(-1)之间波动;从季节上看,在生长季(6~8月)GPP值大于RE,北方针叶林以净碳吸收为主,在非生长季,NEE与RE相等,北方针叶林为弱碳源;逐日尺度上,NEE呈倒“U”形变化特征,RE和GPP则呈“U”形特征。日尺度NEE主要受净辐射、相对湿度、气温、土壤温度等因素影响,这些环境因素构建的回归方程可以解释45.19%的NEE日变化;月尺度上NEE主要受净辐射、相对湿度、气温3个因素影响,回归方程可以解释78.42%的NEE月变化。

关键词：碳通量气候变化北方针叶林净碳交换量

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毛蕊花糖苷抑制Erastin诱导的多巴胺能神经细胞系MN9D细胞铁死亡

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中国组织工程研究 2025年第7期29卷 1408-1413页

作者：张明洋杨新玲新疆医科大学第二附属医院新疆维吾尔自治区乌鲁木齐市830028

背景:近年越来越多的研究证实多巴胺能神经元细胞铁死亡参与了帕金森病的发病,毛蕊花糖苷目前被证实具有抗氧化、抗炎和神经保护作用。目的:探讨毛蕊花糖苷对Erastin诱导的MN9D细胞铁死亡的保护效果及作用机制。方法:以MN9D细胞为研究对... 详细信息

背景:近年越来越多的研究证实多巴胺能神经元细胞铁死亡参与了帕金森病的发病,毛蕊花糖苷目前被证实具有抗氧化、抗炎和神经保护作用。目的:探讨毛蕊花糖苷对Erastin诱导的MN9D细胞铁死亡的保护效果及作用机制。方法:以MN9D细胞为研究对象,分为对照组、模型组(20μmol/l Erastin组)、Erastin+1μg/ml毛蕊花糖苷组、Erastin+5μg/ml毛蕊花糖苷组、Erastin+10μg/ml毛蕊花糖苷组。MN9D细胞在CO_(2)恒温培养箱中培养24 h,然后用不同质量浓度毛蕊花糖苷预处理8 h,再加入20μmol/l Erastin诱导24 h后,采用ElISA法检测还原型谷胱甘肽、超氧化物歧化酶、总铁离子、丙二醛水平,免疫组织化学法检测酪氨酸羟化酶的表达,Western blot法检测酪氨酸羟化酶、核因子红细胞-2相关因子2、血红素加氧酶1、谷胱甘肽过氧化物酶4蛋白表达。结果与结论:(1)与对照组相比,模型组还原型谷胱甘肽、超氧化物歧化酶水平明显减少(Pl组还原型谷胱甘肽、超氧化物歧化酶水平明显增加(Pl组酪氨酸羟化酶阳性细胞面积明显增加(Pl组酪氨酸羟化酶、核因子红细胞-2相关因子2、血红素加氧酶1、谷胱甘肽过氧化物酶4的蛋白表达明显增加(P<0.05)。结果提示:毛蕊花糖苷对Erastin诱导的MN9D细胞铁死亡具有明显的抑制作用,其机制可能通过作用于核因子红细胞-2相关因子2/血红素加氧酶1/谷胱甘肽过氧化物酶4通路实现的。

关键词：毛蕊花糖苷 Erastin MN9D细胞铁死亡核因子红细胞-2相关因子2 血红素加氧酶1 谷胱甘肽过氧化物酶4

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关注民生时事,开发课程资源——一场冻雨引发的学科教学与育人的思考

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物理教学 2024年第7期46卷 78-80页

作者：杜素峰叶鸣扬南京师范大学附属中学树人学校江苏210011 南京师范大学教师教育学院江苏210023

通过关注时事“冻雨灾害”,初探冻雨的成因及其与其他形式降水的区别,挖掘冻雨素材在物理教学与学科育人中的价值,并运用过冷水开发创新课堂演示实验。

关键词：冻雨过冷水创新实验