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钢厂CCPP发电机组提升负荷的研究与应用

鞍钢技术 2024年第1期 37-41页

作者：郑振海张元华张明扬薛贵洋鞍钢股份有限公司鲅鱼圈钢铁分公司辽宁营口115007

为了提高CCPP发电机组负荷,根据不同环境温度采取不同的煤气热值,夏季利用空气冷却器降低空压机入口空气温度,采用水喷射系统降低燃气轮机入口燃料温度,上述措施实施后,能够降低燃烧温度,提高CCPP发电机组负荷。

关键词： CCPP发电机组负荷煤气热值空气冷却器水喷射

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晚期甲状腺髓样癌的药物治疗进展

沈阳药科大学学报 2024年第4期41卷 518-525页

作者：薛昊张铭洋郭国贤刘翥辽宁省肿瘤医院/大连理工大学肿瘤医院辽宁沈阳110044 大连医科大学附属第二医院辽宁大连116044 辽宁省检验检测认证中心辽宁沈阳110010

甲状腺髓样癌发病率低但恶性程度高,具有早期淋巴结和远端转移的倾向,预后较差。目前对于甲状腺髓样癌的有效治疗手段仍是外科手术,但对于晚期并且不能通过手术根治的甲状腺髓样癌患者,参加药物临床试验是一种有效的治疗手段。甲状腺髓... 详细信息

甲状腺髓样癌发病率低但恶性程度高,具有早期淋巴结和远端转移的倾向,预后较差。目前对于甲状腺髓样癌的有效治疗手段仍是外科手术,但对于晚期并且不能通过手术根治的甲状腺髓样癌患者,参加药物临床试验是一种有效的治疗手段。甲状腺髓样癌的发病主要原因是RET原癌基因突变,主要分为散发性和遗传性甲状腺髓样癌两大类。其中散发性甲状腺髓样癌在临床上最多见、而遗传性甲状腺髓样癌临床上较少见但具有发病年龄偏低和恶性程度更高的特点。相较于其他瘤种,目前针对晚期甲状腺髓样癌患者仍缺少有效的治疗有段,仍急需开发有效的治疗药物。本文按甲状腺髓样癌发病相关的靶点和信号通路介绍了针对晚期甲状腺髓样癌的临床研究,并简要介绍了其研究的主要结果和对应的药物相关的不良事件。

关键词：局部晚期/晚期甲状腺髓样癌靶向治疗临床试验

Continuous ice-templating of macro-porous materials with uniformly ordered architecture

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Science China Materials 2022年第11期65卷 3134-3143页

作者： Wenxing Qiu Jian zhang Guoqi Tan Kefeng Gao mingyang zhang Zengqian Liu Zhefeng zhang Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Ice-templating technique offers a viable means for constructing ordered macro-porous architectures in materials;nevertheless,it is generally limited by a low efficiency for fabrication,large difficulty for manipulation,along with the small dimension,and poor structural uniformity of icetemplated ***,a new approach was exploited for continuous ice-templating of uniformly ordered macro-porous materials based on the establishment of a large,stable temperature gradient with specific bi-directional designs at the freezing front by descending the front toward the cooling medium to accommodate its upward *** freezing rate was markedly increased with the dimension of frozen body notably enlarged as compared with the case for conventional static ice-templating *** macro-porous architecture of materials,taking zirconia ceramics as an example,was made much finer and more uniform over the entire sample,and exhibited better ordering of alignment and enhanced inter-connectivity between *** led to an improvement in the compressive strength and its stability along the height direction for ice-templated materials than those made by the static ice-templating technique at a similar *** study may facilitate the scale up of ice-templating techniques and promote the exploitation and application of new high-performance materials.

关键词： ice-templating porous materials architecture strength directional solidification

Single palladium atoms stabilized byβ-FeOOH nanorod with superior performance for selective hydrogenation of cinnamaldehyde

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Nano Research 2022年第4期15卷 3114-3121页

作者： Zhijun Li Leipeng Leng Xiaowen Lu mingyang zhang Qian Xu J.Hugh Horton Junfa Zhu Joint International Research Laboratory of Advanced Chemical Catalytic Materials&Surface Science College of Chemistry and Chemical EngineeringNortheast Petroleum UniversityDaqing 163318China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Department of Chemistry Queen′s UniversityKingstonK7L 3N6Canada

Atomically dispersed single atom catalysts represent an ideal means of converting less valuable organics into value-added chemicals of interest with high ***,we describe a facile synthetic approach to create defect-containingβ-FeOOH doped with isolated palladium atoms that bond covalently to the nearby oxygen and iron *** presence of singly dispersed palladium atoms is confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure *** single palladium atom catalyst manifests outstanding catalytic efficiency(conversion:99%;selectivity 99%;turnover frequency:2,440 h^(-1))in the selective hydrogenation of cinnamaldehyde to afford *** measurements and density functional theory(DFT)calculations elucidate the high catalytic activity and the strong metal-support interaction stem from the unique coordination environment of the isolated palladium *** findings may pave the way for the facile construction of single atom catalysts in a defect-mediated strategy for efficient organic transformations in heterogeneous catalysis.

关键词： heterogeneous catalysis palladium single atom catalyst β-FeOOH nanorod coordination environment hydrogenation of cinnamaldehyde

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温度对换流变压器瞬态电场的影响分析

电器与能效管理技术 2024年第6期 17-24页

作者：李茜高有华冯小雪张铭洋沈阳工业大学辽宁沈阳110870 国家电网沈阳供电公司辽宁沈阳110023

基于传统变压器的绝缘设计并未考虑油纸绝缘的非线性特性,采用有限元法将电磁场、温度场等多物理场进行耦合仿真计算,重点研究油纸复合绝缘的电导率随温度非线性变化时,换流变压器阀侧绕组端部暂态电场分布的规律和特征,以及油、纸板电... 详细信息

基于传统变压器的绝缘设计并未考虑油纸绝缘的非线性特性,采用有限元法将电磁场、温度场等多物理场进行耦合仿真计算,重点研究油纸复合绝缘的电导率随温度非线性变化时,换流变压器阀侧绕组端部暂态电场分布的规律和特征,以及油、纸板电导率比值对阀侧电场的影响。结果表明:考虑温度电导率非线性特性时,换流变压器阀侧端部的电场分布更加集中,畸变现象更明显,且随着电导率比值的增大,阀侧绕组端部的等位线分布越来越密集,高场强值集中在阀侧绕组端部绝缘纸板之间的油隙中。所提研究为变压器绝缘设计提供技术支持。

关键词：换流变压器极性反转非线性暂态电场油纸绝缘温度影响

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Rational design of palladium single-atoms and clusters supported on silicoaluminophosphate-31 by a photochemical route for chemoselective hydrodeoxygenation of vanillin

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Nano Research 2021年第11期14卷 4347-4355页

作者： Xiaowen Lu Chunmu Guo mingyang zhang Leipeng Leng J.Hugh Horton Wei Wu Zhijun Li Joint International Research Laboratory of Advanced Chemical Catalytic Materials&Surface Science College of Chemistry and Chemical EngineeringNortheast Petroleum UniversityDaqing163318China National Center for International Research on Catalytic Technology School of Chemistry and Material ScienceHeilongjiang UniversityHarbin150080China Department of Chemistry Queen’s UniversityKingstonK7L 3N6Canada

Chemoselective hydrodeoxygenation of vanillin is of great importance in converting biomass into high value-added ***,we describe a facile photochemical route to access palladium single atoms and clusters supported on silicoaluminophosphate-31(SAPO-31)as a highly active,chemoselective,and reusable catalyst for hydrodeoxygenation of *** by aberration-corrected high-angle annular dark-field scanning transmission electron microscopy,extended X-ray absorption fine structure measurement,and CO-absorbed diffuse reflectance infrared Fourier transform spectroscopy reveal the atomically dispersed palladium single atoms and clusters are loosely bonded and randomly dispersed,without forming strong palladium-palladium metallic bonding,over the SAPO-31 *** catalyst,with a full metal availability to the reactants,exhibits exceptional catalytic activity(TOF:3,000 h^(−1),Yield:>99%)in the hydrodeoxygenation of vanillin toward 2-methoxy-4-methylphenol(MMP)under mild conditions(1 atm,80°C,30 min),along with excellent stability,scalability(up to 100-fold),and wide substrate *** superior catalytic performance can be attributed to the synergistic effect of the positively charged palladium single atoms and fully exposed clusters,as well as the strong metal-support *** work may offer a new avenue for the design and synthesis of fully exposed metal catalysts with targeted functionalities.

关键词： heterogeneous catalysis photochemical reduction palladium single atoms and clusters atomic dispersion hydrodeoxygenation vanillin

铝制品加工重油污分油水基清洗剂研究及生产应用

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电镀与精饰 2024年第8期46卷 98-105页

作者：张明阳冯震耿缪元刘锋李鹏飞邱信欣李少华苏州科技大学环境科学与工程学院江苏苏州215009 苏州科锐德节能环境科技有限公司江苏苏州215011 江西嘉梦环保科技有限公司江西景德镇333314 城市生活污水资源化利用技术国家地方联合工程实验室江苏苏州215009

大量铝制品在拉伸成型过程中会涂抹拉伸油以防止产品拉伤、断裂,为清洗其表面残留的重油污,需采用含有大量表面活性剂的清洗剂。为解决传统铝制品清洗中清洗难度大、污染排放多的问题,研究了一款分油水基清洗剂。研究结果表明:该分油水... 详细信息

大量铝制品在拉伸成型过程中会涂抹拉伸油以防止产品拉伤、断裂,为清洗其表面残留的重油污,需采用含有大量表面活性剂的清洗剂。为解决传统铝制品清洗中清洗难度大、污染排放多的问题,研究了一款分油水基清洗剂。研究结果表明:该分油水基清洗剂属于低泡型清洗剂,在清洗温度50℃,清洗时间5 min,清洗剂浓度5%的条件下清洗效果最优,除油率可达99%以上,各项性能可满足行业标准JB/T 4323—2019《水基金属清洗剂》中的要求。实际生产应用结果表明,分油水基清洗剂的清洗量超过常规水基清洗剂的32倍,每清洗一百万个电池壳,能减少浓水排放量116.25 t、危废量16.25 t,对企业增效和节能减排具有深远意义。

关键词：水基清洗剂铝制品重油污除油油回用再生节能减排

A systematic strategy for screening therapeutic constituents of Schisandra chinensis(Turcz.) Baill infiltrated blood-brain barrier oriented in lesions using ethanol and water extracts:a novel perspective for exploring chemical material basis of herb medicines

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Acta Pharmaceutica Sinica B 2020年第3期10卷 557-568页

作者： Yiwen zhang Xinyan Lv Jiameng Qu Xin zhang mingyang zhang Hao Gao Qian zhang Ran Liu Huarong Xu Qing Li Kaishun Bi School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China

Schisandra chinensis,a widely used Chinese herbal medicine,was considered as central nervous system(CNS)drug for *** ethanol extracts(EES)and water extracts(WES)of it were applied ***,the difference of their efficacy and even effective material foundation of *** remains *** this study,to explore the active constituents of ***,we compared pharmacodynamics and chemical profiles in vitrolin vivo of EES/WES for the first time using multiple chemical analysis,pharmacological and data processing *** was proved that there was no significant difference in the anti-depressive effects between WES and ***,the contents of most components in vitro and in plasma were higher in EES than those in WES,which was unconvincing for their similar ***,we further explored components of *** targeted onto brain and the results showed that 5 lignans were identified with definite absorptivity respectively both in EES and WES caused by the limitation of blood-brain ***,bioinformatic analysis predicted their anti-depressive *** all,the systematic strategy screened 5 brain-targeted effective substances of *** and it was suggested that exploring the components into nidi would promote the studies on herbs effective material basis.

关键词： Schisandra chinensis Ethanol extracts Water extracts Pharmacodynamics Chemical profiles Components into nidi Effective material basis Traditional Chinese medicine

Boosting SN38-based oral chemotherapy to combine reductionbioactivated structured lipid-mimetic prodrug with ascorbic acid

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Nano Research 2022年第10期15卷 9092-9104页

作者： Helin Wang Qi Lu Yifan Miao Jiaxuan Song mingyang zhang Zixuan Wang Haotian zhang Zhonggui He Chutong Tian Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

The reduction-responsive disulfide bonds have been widely used as bioactive linkages to facilitate a rapid release of anticancer drugs into tumor ***,the activation can be hindered by the kinetics of the thiol-disulfide exchange *** with an additional reductant is a promising strategy to further boost drug ***,inspired by the specific absorption mechanism of triglyceride fat,structured lipid-mimetic oral prodrugs of 7-ethyl-10-hydroxycamptothecin(SN38)were designed to improve intestinal permeability and bypass the first-pass ***38 prodrugs were prepared into lipid formulations that could self-emulsify into nano-sized particles after entering the gastrointestinal ***,we found that the oral bioavailability of the prodrug lipid formulation could be up to 2.69-fold higher than that of the parent SN38,indicating an effective oral *** addition,the reduction-responsive disulfide bond was used as a linker,and ascorbic acid(ASC)was coadministrated to further promote the efficient release of SN38 from the *** enhanced the oral antitumor effect of the reduction-responsive oral prodrug and exhibited good *** summary,the combination of a structured lipid-mimetic prodrug and ASC was firstly demonstrated to boost the oral chemotherapy effect of the difficult-for-oral chemotherapeutics.

关键词： oral chemotherapy structured lipid-mimetic prodrug 7-ethyl-10-hydroxycamptothecin(SN38) ascorbic acid