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AC138128.1,an intronic lncRNA originated from ERCC1,can be a potential earlier biomarker to predict lung cancer

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AC138128.1,an intronic lncRNA originated from ERCC1,can be a...

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： mingyang xiao Tao Yu Guopei Zhang Qianye Zhang Liuli Liu xiaobo Lu Dept.of Toxicology School of Public HealthChina Medical University

Objectives Lung cancer is one of the most devastating tumors worldwide and has a high incidence and ***1 plays a key role in the occurrence and prognosis of lung ***,few studies have focused on long non-coding RNAs of ERCC1 and its *** the present study,we identified an intronic long non-coding RNA AC138128.1,originated in ERCC1,and its possibility as a novel and potential biomarker for the earlier diagnosis of lung cancer was also *** Quantitative PCR was used to detect AC138128.1 expression in tissues and *** and plasma separation of cell was to analyze the subcellular localization of *** sensitivity of cells from tissues to cisplatin was detected by cisplatin sensitivity *** AC138128.1 shows much lower expression in cancer than its para-cancer *** difference was observed in the 16 HBE,A549,and LK2 cell *** receiver operating characteristic curve suggested AC138128.1 expression is a biomarker with diagnostic *** subcellular distribution suggests that AC138128.1 is mainly expressed in the nucleus and may regulate its neighboring genes ERCC1 and *** analysis showed that AC138128.1 is related to the expression of FOSB in cancer and para-cancer *** the relationship between AC138128.1 and ERCC1 expression was observed only in tumor *** sensitivity test also reconfirmed the relationship between AC138128.1 and its neighboring *** AC138128.1 may function with its neighboring genes especially FOSB and can be a potential biomarker for the early diagnosis of lung cancer.

关键词： Lung cancer lncRNA AC138128.1 ERCC1 FOSB

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Science China Chemistry 2025年第1期68卷 273-287页

作者： Shuguang Yang Lijun Hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词： fluorescent molecular probes self-amplifying myeloperoxidase photodynamic therapy

多层螺旋CT及磁共振成像技术在心房颤动消融术中的应用

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心血管病学进展 2016年第2期37卷 147-150页

作者：罗水莲苏立重庆医科大学附属第二医院心血管内科重庆400010

射频消融已成为临床上药物难治性心房颤动主要且首选的治疗方式,但术后复发率较高仍是一个具有挑战性的问题。术前对肺静脉和左房解剖结构的准确评估以及术后对心房颤动复发的有效预测显得意义重大。随着多层螺旋CT及核磁共振成像技术... 详细信息

射频消融已成为临床上药物难治性心房颤动主要且首选的治疗方式,但术后复发率较高仍是一个具有挑战性的问题。术前对肺静脉和左房解剖结构的准确评估以及术后对心房颤动复发的有效预测显得意义重大。随着多层螺旋CT及核磁共振成像技术的不断改进完善,其临床应用价值不断的增大,对提高手术成功率起着不可替代的作用。

关键词：多层螺旋CT 磁共振成像射频消融复发预测

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分子生药学在人参研究中的应用

分子植物育种 2022年第16期20卷 5394-5399页

作者：王志成肖明阳罗云清吉林农业大学人参新品种选育与开发国家地方联合工程研究中心长春130118 吉林农业大学资源与环境学院长春130118

分子生药学作为一门新生交叉学科已在诸如药材基源鉴定、组织细胞培养、次级代谢产物生物合成途径等研究方面发挥着举足轻重的作用,尤其是在人参等贵细药材研究当中作用突出。随着人参化学成分及药理活性的拓展,从分子水平阐述物质之间... 详细信息

分子生药学作为一门新生交叉学科已在诸如药材基源鉴定、组织细胞培养、次级代谢产物生物合成途径等研究方面发挥着举足轻重的作用,尤其是在人参等贵细药材研究当中作用突出。随着人参化学成分及药理活性的拓展,从分子水平阐述物质之间的关系,必然会在未来的人参研究中发挥其更大的作用。组培技术可以从分子水平上研究人参代谢产物是如何产生的,其中的关键技术是什么,哪种诱导子可以使其化学成分积累升高,这些都为大规模获得活性物质积累了数据。此外,建立分子水平指纹图谱以判断人参参龄、辨别药材真伪;在分子水平上研究生态因子与人参的互作关系都是分子生药学在人参研究领域取得的重要成果。本综述总结以上研究基础,并对未来分子生药学在人参的研究中的作用进行展望。

关键词：分子生药学人参组织培养人参皂苷生物合成

rDNA-ITS序列分析方法在药用植物研究中的应用

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分子植物育种 2022年第19期20卷 6397-6404页

作者：肖明阳罗云清王志成吉林农业大学中药材学院人参新品种选育与开发国家地方联合工程研究中心长春130118 吉林农业大学环境与资源学院长春130118

rDNA-ITS序列分析,是一种基于对核糖体RNA基因(Ribosomal DNA,rDNA)内转录间隔区(internal transcribed spacer,ITS)进行PCR扩增、测序的多态性序列分析方法,该方法在植物种质资源鉴定、中药材鉴定和品质评价、遗传多样性与亲缘关系等... 详细信息

rDNA-ITS序列分析,是一种基于对核糖体RNA基因(Ribosomal DNA,rDNA)内转录间隔区(internal transcribed spacer,ITS)进行PCR扩增、测序的多态性序列分析方法,该方法在植物种质资源鉴定、中药材鉴定和品质评价、遗传多样性与亲缘关系等方面具有广阔的应用前景。本研究介绍了rDNA-ITS序列分析技术的原理与技术路线,回顾了该方法在药用植物分类、品种鉴别、亲缘关系鉴定等方面的应用,提出了3条对r DNA-ITS序列分析技术的利用建议,分别为建立药用植物指纹图谱库,探索药用植物基因与生态环境因子关系以及鉴定中药材道地性分析。

关键词： rDNA-ITS 药用植物品种鉴定亲缘关系

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy

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考虑空间异质性的短距离出行方式选择研究

重庆交通大学学报（自然科学版） 2023年第3期42卷 112-118,127页

作者：何明卫肖明阳何民石庄彬刘阳昆明理工大学交通工程学院云南昆明650500

促进城市居民短距离出行方式由机动车向慢行交通转移,对缓解机动化出行造成的交通拥堵和环境污染至关重要。基于昆明市居民出行调查数据和建成环境数据,利用地理加权逻辑回归模型探究了出行者社会经济-人口属性、出行属性与建成环境对... 详细信息

促进城市居民短距离出行方式由机动车向慢行交通转移,对缓解机动化出行造成的交通拥堵和环境污染至关重要。基于昆明市居民出行调查数据和建成环境数据,利用地理加权逻辑回归模型探究了出行者社会经济-人口属性、出行属性与建成环境对短距离出行中小汽车和慢行交通方式选择的影响。研究表明:地理加权逻辑回归模型拟合结果优于全局回归逻辑模型。交叉口密度、道路网密度、人口密度、总POI密度、离退休人员和通勤出行在总体上对短距离出行中的小汽车使用起到负向影响,到CBD距离在总体上起到正向影响,但这些变量的影响具有显著的空间异质性,在不同区域表现出相反的作用。此外,男性、个体经营者、30岁以下、大专及以上、家庭收入越高的群体更倾向于在短距离出行中使用小汽车,而购物和娱乐出行更倾向采用慢行交通方式。

关键词：交通工程短距离出行地理加权逻辑回归出行方式选择空间异质性建成环境

The Hilbert expansion of the Boltzmann equation in the incompressible Euler level in a channel

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Science China Mathematics 2025年第1期68卷 39-88页

作者： Feimin Huang Weiqiang Wang Yong Wang Feng xiao Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education) School of Mathematics and StatisticsHunan Normal University

The study of the hydrodynamic limit of the Boltzmann equation with physical boundary is a challenging problem due to the appearance of the viscous and Knudsen boundary *** this paper,the hydrodynamic limit from the Boltzmann equation with the specular reflection boundary condition to the incompressible Euler equations in a channel is *** on the multi-scaled Hilbert expansion,the equations with boundary conditions and compatibility conditions for interior solutions,and viscous and Knudsen boundary layers are derived under different scaling,***,some uniform estimates for the interior solutions,and viscous and Knudsen boundary layers are *** the help of the L2-L∞framework and the uniform estimates obtained above,the solutions to the Boltzmann equation are constructed by the truncated Hilbert expansion with multiscales,and hence the hydrodynamic limit in the incompressible Euler level is justified.

关键词： Boltzmann equation incompressible Euler equations hydrodynamic limit Hilbert expansion specular reflection boundary condition viscous boundary layer Knudsen boundary layer

Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期68卷 21-25页

作者： Leyu Liu Zhaoming Xia Zeyu Wang Yinjuan Chen Hai xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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