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Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1205-1220页

作者： Yanrong Ma Fenglin Ran mingyan xin Xueyan Gou xinyi Wang xinan Wu The First School of Clinical Medicine Lanzhou UniversityLanzhou730000China School of Pharmacy Lanzhou UniversityLanzhou730000China

Renal tubular secretion mediated by organic anion transporters(OATs)and the multidrug resistanceassociated protein 4(MRP4)is an important means of drug and toxin ***,there are no biomarkers to evaluate their *** aim of this study was to identify and characterize an endogenous biomarker of the renal tubular OATs-MRP4 ***-six uremic toxins were selected as candidate compounds,of which kynurenic acid was identified as a potential biomarker by assessing the protein-binding ratio and the uptake in OAT1-,OAT3-,and MRP4-overexpressing cell ***1/3 and MRP4 mediated the transcellular vectorial transport of kynurenic acid in *** kynurenic acid concentration was dramatically increased in rats treated with a rat OAT1/3(rOAT1/3)inhibitor and in rOAT1/3 double knockout(rOAT1/3^(-/-))rats,and the renal concentrations were markedly elevated by the rat MRP4(rMRP4)*** acid was not filtered at the glomerulus(99%of albumin binding),and was specifically secreted in renal tubules through the OAT1/3-MRP4 channel with an appropriate affinity(Km)(496.7 mM and 382.2 mM for OAT1 and OAT3,respectively)and renal clearance half-life(t1/2)in vivo(3.7±0.7 h).There is a strong correlation in area under the plasma drug concentration-time curve(AUC0et)between cefmetazole and kynurenic acid,but not with creatinine,after inhibition of *** addition,the phase of increased kynurenic acid level is earlier than that of creatinine in acute kidney injury *** results suggest that albumin-bound kynurenic acid is an appropriate endogenous biomarker for adjusting the dosage of drugs secreted by this channel or predicting kidney injury.

关键词： Transporter Biomarker Kynurenic acid Renal tubular excretion

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The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats

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Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 519-529页

作者： Yanrong Ma mingyan xin Yuanjie Wen Huan Wang Guoqiang Zhang Jianye Dai xin-An Wu School of Pharmacy Lanzhou UniversityLanzhou 730000China Department of Pharmacy the First Hospital of Lanzhou UniversityLanzhou 730000China

The liver is an important organ for drugs disposition,and thus how to accurately evaluate hepatic clearance is essential for proper drug ***,there are many limitations in drug dosage adjustment based on liver function and pharmacogenomic *** this study,we evaluated the ability of endogenous glycochenodeoxycholate-3-sulfate(GCDCA-S)and 4β-hydroxycholesterol(4β-HC)plasma levels to evaluate organic anion-transporting polypeptide(Oatps)-mediated hepatic uptake and Cyp3 a-meidated metabolism of atorvastatin(ATV)in *** concentration of ATV and its metabolites,2-OH ATV and 4-OH ATV,was markedly increased after a single injection of rifampicin(RIF),an inhibitor of ***,plasma GCDCA-S levels were also *** a single injection of the Cyp3 a inhibitor ketoconazole(KTZ),plasma ATV concentrations were significantly increased and 2-OH ATV concentrations were decreased,consistent with the metabolism of ATV by Cyp3 ***,plasma 4β-HC was not affected by KTZ treatment despite it being a Cyp3 a metabolite of *** repeated oral administration of RIF,plasma concentrations of ATV,2-OH ATV and 4-OH ATV were markedly increased and the hepatic uptake ratio of ATV and GCDCA-S was *** did not affect plasma concentrations of ATV,2-OH ATV and 4-OH ATV,but significantly decreased the metabolic ratio of total and 4-OH ***,the plasma level and hepatic metabolism of 4β-HC were not changed by *** inhibition of hepatic uptake of GCDCA-S by RIF was fully reversed after a 7-d washout of *** concentration and hepatic uptake ratio of GCDCA-S were correlated with the plasma level and hepatic uptake of ATV in rats with ANIT-induced liver injury,*** results demonstrate that plasma GCDCA-S is a sensitive probe for the assessment of Oatps-mediated hepatic uptake of ***,Cyp3 a-mediated metabolism of ATV was not predicted by plasma 4β-HC levels in rats.

关键词： Atorvastatin Hepatic disposition Glycochenodeoxycholate-3-sulfate 4β-hydroxycholesterol Oatp Cyp3a

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Changes in renal excretion pathways in rats with adenine-induced chronic renal failure

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Journal of Chinese Pharmaceutical Sciences 2021年第4期30卷 319-333页

作者： Yanrong Ma mingyan xin Juanli Wu Dangju Wang Huan Wang xin’an Wu Department of Pharmacy the First Hospital of Lanzhou UniversityLanzhou 730000 China School of Pharmacy Lanzhou UniversityLanzhou 730000 China The First Clinical Medical College of Lanzhou University Lanzhou 730000 China

Chronic renal failure(CRF)is a type of progressive chronic kidney disease with the alteration of substrates ***,changes in renal excretion pathways remain unclear in *** study aimed to evaluate the changes in renal excretion pathways of exogenous and endogenous substrates in CRF *** showed that the levels of cystatin C,creatinine,and urea nitrogen were dramatically increased in the adenine(50 or 100 mg/kg)-induced CRF *** levels of rOCT2 were dose-dependently up-regulated by adenine,and rMRP2 and rMATE1 levels were dose-dependently down-regulated,while rMRP4 was induced by adenine(50).Plasma concentrations of metformin,p-aminohippurate,and furosemide in the adenine(100)group were significantly increased compared with the control ***,plasma concentrations of metformin and p-aminohippurate were slightly changed in the adenine(50)***,urinary excretions of metformin and p-aminohippurate were *** addition,renal N1-methylnicotinamide uptakes were increased in rats treated with adenine,and renal phenyl-β-D-glucuronide and hippuric acid uptakes were induced by adenine(50).These results showed that adenine(100)-induced CRF caused the reduced function of GFR-r OCTs-r MATE1 and GFR-r OAT1/r OAT3-r MRP pathway,and oppositely the renal tubular transport pathways of rOCTs-r MATE1 and rOAT1-MRPs were induced in rats with the treatment of adenine(50).

关键词： Chronic renal failure Renal excretion pathways Transporter Adenine

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高效液相色谱法测定果汁饮料中苯甲酸、山梨酸和糖精钠含量

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食品安全导刊 2022年第11期 111-113页

作者：辛明彦浮山县综合检验检测中心山西临汾042600

目的:建立高效液相色谱-紫外检测器测定果汁饮料中苯甲酸、山梨酸及糖精钠3种食品添加剂的分析方法。方法:果汁饮料试样用纯水提取,经Acclaim^(TM) 120 C_(18)色谱柱分离,用紫外检测器测定。结果:苯甲酸、山梨酸及糖精钠在1.00~50.00 m... 详细信息

目的:建立高效液相色谱-紫外检测器测定果汁饮料中苯甲酸、山梨酸及糖精钠3种食品添加剂的分析方法。方法:果汁饮料试样用纯水提取,经Acclaim^(TM) 120 C_(18)色谱柱分离,用紫外检测器测定。结果:苯甲酸、山梨酸及糖精钠在1.00~50.00 mg/L线性良好,相关系数均大于0.999,3种添加剂的检出限均为0.005 g/kg,定量限均为0.015 g/kg,加标回收率为91.7%~109.0%,RSD为1.29%~3.36%。结论:该方法前处理简便、分析速度快、准确度高及精密度好,可用于上述3种添加剂的定性、定量检测。

关键词：高效液相色谱果汁饮料食品添加剂

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人性化设计在室内环境艺术设计中的应用探究

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鞋类工艺与设计 2023年第8期3卷 139-141页

作者：辛明燕广州涉外经济职业技术学院广东广州510540

随着人们对生活品质的要求不断提高,人性化设计逐渐成为室内环境艺术设计领域的焦点。本文结合现代室内设计的需求和特点,深入探讨人性化设计原则在不同类型室内空间中的具体应用,并选取具有代表性的案例进行分析。通过研究,旨在为室内... 详细信息

随着人们对生活品质的要求不断提高,人性化设计逐渐成为室内环境艺术设计领域的焦点。本文结合现代室内设计的需求和特点,深入探讨人性化设计原则在不同类型室内空间中的具体应用,并选取具有代表性的案例进行分析。通过研究,旨在为室内环境艺术设计领域的学者和设计师提供理论和实践参考,推动人性化设计理念在室内环境艺术设计中的普及和应用,为提升人们的生活品质做出贡献。

关键词：人性化设计室内环境艺术设计应用探究

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Facile Synthesis of Bi2MoO6 Nanosheets@Nitrogen and Sulfur Codoped Graphene Composites for Sodium-ion Batteries

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Chemical Research in Chinese Universities 2020年第1期36卷 115-119页

作者： XU xin LI mingyan YU Ting Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University637371Singapore School of Electrical Engineering Xi'an Jiaotong UniversityXi'an 710049P.R.China

Recently,sodium-ion batteries gradually become the promising alternative to lithium-ion batteries because of cost *** this work,a kind of Bi2MoO6 nanosheets@N,S codoped graphene composite is designed and fabricated for sodium storage *** characterizations are employed to investigate its morphology,structure and chemical *** evaluated as an anode material for sodium-ion batteries,the as-prepared composite is able to display a specific capacity of 254 mA·h/g after 50 cycles at a current density of 0.2 A/g,and 186 mA·h/g at 1.6 A/g during the rate capability *** a result,the further morphology and structure optimization is still required for high performance sodium-ion batteries.

关键词： Bi2MoO6 Nanosheet Codoped graphene Composite Sodium-ion battery

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Malondialdehyde treatment reduced immunoreactivity of amandin and delayed its digestion

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Food Quality and Safety 2023年第2期7卷 277-290页

作者： xin Luo mingyan Ai Yongyan Wu Qia Wang Hongbo Song Qun Huang Jiankang Lu Production&Construction Group Key Laboratory of Special Agricultural Products Further Processing in Southern xinjiang Tarim UniversityAla'erChina College of Food Science Fujian Agriculture and Forestry UniversityFuzhouChina School of Public Health The Key Laboratory of Environmental Pollution Monitoring and Disease ControlMinistry of EducationGuizhou Medical UniversityGuiyangChina Wuhan Academy of Agricultural Sciences WuhanChina Institute for Egg Science and Technology School of Food and Biological EngineeringChengdu UniversityChengduChina Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangChina

Objectives:The secondary products of lipid oxidation are one of the main factors inducing protein *** effects of oxidation treatment with malondialdehyde(MDA)on the immunoreactivity of amandin and its digestion were *** and Methods:The rabbit IgG binding ability of amandin was analyzed by western blotting,and the changes in amandin oxidation and immunoreactivity during digestion of amandin with different degrees of oxidation were investigated in combination with an almond allergen enzyme-linked immunosorbent assay *** of linear epitopes of amandin by oxidation was investigated by liquid chromatography-tandemmass spectrometry(LC-MS/MS).Results:The results showed that the immunoreactivity of amandin was significantly reduced after 1 mmol/L MDA and 100 mmol/L MDA ***,the 1 mmol/L MDA treatment was owing to cleavage of linear epitope peptide in amandin and oxidation of the active amino *** 100 mmol/L MDA treatment was due to aggregation of amandin and significant decrease in its *** also reduced di-gestibility of amandin and significantly affected immunoreactivity during ***-MS/MS also identified four oxidation-prone methionine sites(aa 264-274,298-308,220-240,and 275-297)in gamma conglutinin ***:MDA treatment reduced the immunoreactivity of *** treatment also led to protein aggregation,which slowed down the digestion of amandin and altered the immunoreactivity of amandin during digestion.

关键词： Oxidation amandin immunoreactivity digestion LC-MS/MS

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Driving mechanism and boundary control of urban sprawl

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Frontiers of Environmental Science & Engineering 2015年第2期9卷 298-309页

作者： Dongmei JIANG Xiaoshun LI Futian QU mingyan LI Shaoliang ZHANG Yunlong GONG Xiaoping SHI xin CHEN School of Environment and Spatial Informatics China University of Mining & Technology Xuzhou 221116 China College of Public Administration Nanjing Agricultural University Nanjing 210095 China Institute of Economics Zhejiang Academy of Social Sciences Hangzhou 310025 China

Since the reform and opening-up, China＇s economy has achieved remarkable development and so does the urbanization. However, there is an unavoidable contradiction between urban sprawl and the protection of arable land and the environment. By redefining the urban sprawl boundary, this paper is to provide a solution for the conflict above on the China＇s urbanization context. The ideal boundary, moderate boundary and limit boundary are defined for urban sprawl in space. Taking Nanjing city as a case, the three urban sprawl boundaries are estimated in this paper based on the calculation of agricultural land resources value in Nanjing. The results show that 1） the integrated value of agricultural （cultivated） land resources in Nanjing is 1.55× 10^7 CNg·hm^-2, the economic value accounts for only 8.74% of the integrated value, while 91.26% of the integrated value has not revealed itself due to the existing institutional arrangements, policy distortions, and imperfect land market; 2） it is difficult to define the ideal and moderate boundaries due to the relatively low price of North Nanjing. In South Nanjing the land price is expensive and the ideal, moderate and limit boundaries are expanded to Jiangning, Qixia, and Yuhuatai; 3） the city scale of South Nanjing should be limited within 5.82 × 10^4 hm^2, which is roughly the same as the designated size of 5.81 × 10^4 hm^2 in the urban planning. It is suggested that the rational scope of urban expansion should be controlled within the moderate boundary.

关键词： urban sprawl rational expansion drivingforces boundary control Nanjing

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Simultaneous regulation on coordination environment and interfacial chemistry via taurine for stabilized Zn metal anode

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Journal of Energy Chemistry 2023年第11期86卷 343-350,I0008页

作者： xin Xu Junyi Yin Ruimin Qin Haoliang Liu Xiang Feng Minghui Wang mingyan Li Weiyu Sun Weichen Shi Bing Xiao Yaqiong Su Yonghong Cheng State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049ShannxiChina Xi'an Key Laboratory of Sustainable Energy Materials Chemistry School of Chemistry and Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an 710049ShannxiChina

Aqueous Zn-ion batteries(AZIBs)are the potential options for the next-generation energy storage scenarios due to the cost effectiveness and intrinsic ***,the industrial application of AZIBs is still impeded by a series of parasitic reactions and dendrites at zinc *** this study,taurine(TAU)is used in electrolyte to simultaneously optimize the coordination condition of the ZnSO4electrolyte and interfacial chemistry at the *** can preferentially adsorb with the zinc metal and induce an in situ stable and protective interface on the anode,which would avoid the connection between H_(2)O and the zinc metal and promote the even deposition of Zn^(2+).The resulting Zn//Zn batteries achieve more than 3000 hours long cyclic lifespan under 1 mA cm^(-2)and an impressive cumulative capacity at 5 mA cm^(-2).Moreover,Zn//Cu batteries can realize a reversible plating/stripping process over 2,400cycles,with a desirable coulombic efficiency of 99.75%(1 mA cm^(-2)).Additionally,the additive endows Zn//NH_(4)V_(4)O_(10)batteries with more stable cyclic performance and ultrafast rate *** capabilities can promote the industrial application of AZIBs.

关键词： Electrolyte Additive Coordination Environment Interfacial Chemistry Zinc Metal Anode

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葛洲坝下游胭脂鱼的繁殖生物学和人工繁殖初报

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水生生物学报 1988年第1期12卷 87-89页

作者：余志堂邓中粦蔡明艳邓昕姜华易继舫田家元中国科学院水生生物研究所水电部葛洲坝工程局中华鲟人工繁殖研究所

胭脂鱼（Myoxcyprinus asiaticus）属鲤形目，胭脂鱼科，是我国的一种珍稀鱼类。胭脂鱼科约有65种，几乎都分布于北美洲。在亚洲只有两种，而见于西伯利亚东部的亚口鱼(Catostomus catostomus)是与北美共有的一个种。唯有胭脂鱼是亚洲... 详细信息

胭脂鱼（Myoxcyprinus asiaticus）属鲤形目，胭脂鱼科，是我国的一种珍稀鱼类。胭脂鱼科约有65种，几乎都分布于北美洲。在亚洲只有两种，而见于西伯利亚东部的亚口鱼(Catostomus catostomus)是与北美共有的一个种。唯有胭脂鱼是亚洲特有的物种，因此，它在鱼类学和动物地理学上占有特殊的地位，具有重要的科学价值。

关键词：胭脂鱼初报繁殖生物学下游人工繁殖鱼类学分布动物地理学鲤形目物种

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