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Experimental Performance Evaluation and Artificial-Neural-Network Modeling of ZnO-CuO/EG-W Hybrid Nanofluids

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Fluid Dynamics & materials Processing 2022年第3期18卷 629-646页

作者： Yuling Zhai Long Li Zihao Xuan Mingyan Ma Hua Wang Engineering Research Center of Metallurgical Energy Conversion and Emission Reduction Ministry of EducationKunming University of Science and TechnologyYunnan650093China

The thermo-physical properties of nanofluids are highly dependent on the used base fluid.This study explores the influence of the mixing ratio on the thermal conductivity and viscosity of ZnO-CuO/EG(ethylene glycol)-W(water)hybrid nanofluids with mass concentration and temperatures in the ranges 1-5 wt.%and 25-60C,respectively.The characteristics and stability of these mixtures were estimated by TEM(transmission electron microscopy),visual observation,and absorbance tests.The results show that 120 min of sonication and the addition of PVP(polyvinyl pyrrolidone)surfactant can prevent sedimentation for a period reaching up to 20 days.The increase of EG(ethylene glycol)in the base fluid leads to low thermal conductivity and high viscosity.Thermal conductivity enhancement(TCE)decreases from 21.52%to 11.7%when EG:W is changed from 20:80 to 80:20 at 1 wt.%and 60C.A lower viscosity of the base fluid influences more significantly the TCE of the nanofluid.An Artificial Neural Network(ANN)has also been used to describe the effectiveness of these hybrid nanofluids as heat transfer fluids.The optimal number of layers and neurons in these models have been found to be 1 and 5 for viscosity,and 1 and 7 for thermal conductivity.The corresponding coefficient of determination(R^(2))was 0.9979 and 0.9989,respectively.

关键词： Hybrid nanofluids base fluid ratio viscosity thermal conductivity ANN model

Untargeted and targeted mass spectrometry reveal the effects of theanine on the central and peripheral metabolomics of chronic unpredictable mild stress-induced depression in juvenile rats

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Journal of Pharmaceutical Analysis 2023年第1期13卷 73-87页

作者： Yanru Zhu Feng Wang Jiatong Han Yunli Zhao Miao Yu Mingyan Ma Zhiguo Yu Laboratory of Pharmaceutical Analysis School of PharmacyZhejiang Pharmaceutical UniversityNingboZhejiang315100China Laboratory of Pharmaceutical Analysis School of PharmacyShenyang Pharmaceutical UniversityShenyang110016China

L-theanine has been shown to have a therapeutic effect on depression.However,whether L-theanine has an excellent preventive effect on depression in children and adolescents and what its mechanism is have not been well explained.Given the complexity of the pathogenesis of depression,this study investigated the preventive effect and mechanism of L-theanine on depression in juvenile rats by combining serum and hippocampal metabolomic strategies.Behavioral tests,hippocampal tissue sections,and serum and hippocampal biochemical indexes were studied,and the results confirmed the preventive effect of Ltheanine.Untargeted reversed-phase liquid chromatography-quadrupole-time-of-flight mass spectrometry and targeted hydrophilic interaction liquid chromatography-triple quadrupole mass spectrometry were developed to analyze the metabolism changes in the serum and hippocampus to screen for potential biomarkers related to L-theanine treatment.The results suggested that 28 abnormal metabolites in the serum and hippocampus that were considered as potential biomarkers returned to nearnormal levels after L-theanine administration.These biomarkers were involved in various metabolic pathways,mainly including amino acid metabolism and lipid metabolism.The levels of amino acids and neurotransmitters in the phenylalanine,tryptophan,and glutamic acid pathways were significantly reduced after L-theanine administration compared with chronic unpredictable mild stress-induced rats.In summary,L-theanine had a significant preventive effect on depression and achieved its preventive results on depression by regulating various aspects of the body,such as amino acids,lipids,and inflammation.This research systematically analyzed the mechanism of L-theanine in preventing depression and laid the foundation for applying L-theanine to prevent depression in children and adolescents.

关键词： L-theanine Depression Metabolomics Liquid chromatography-mass spectrometry

Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1205-1220页

作者： Yanrong ma Fenglin Ran mingyan Xin Xueyan Gou Xinyi Wang Xinan Wu The First School of Clinical Medicine Lanzhou UniversityLanzhou730000China School of Pharmacy Lanzhou UniversityLanzhou730000China

Renal tubular secretion mediated by organic anion transporters(OATs)and the multidrug resistanceassociated protein 4(MRP4)is an important means of drug and toxin excretion.Unfortunately,there are no biomarkers to evaluate their function.The aim of this study was to identify and characterize an endogenous biomarker of the renal tubular OATs-MRP4 channel.Twenty-six uremic toxins were selected as candidate compounds,of which kynurenic acid was identified as a potential biomarker by assessing the protein-binding ratio and the uptake in OAT1-,OAT3-,and MRP4-overexpressing cell lines.OAT1/3 and MRP4 mediated the transcellular vectorial transport of kynurenic acid in vitro.Serum kynurenic acid concentration was dramatically increased in rats treated with a rat OAT1/3(rOAT1/3)inhibitor and in rOAT1/3 double knockout(rOAT1/3^(-/-))rats,and the renal concentrations were markedly elevated by the rat MRP4(rMRP4)inhibitor.Kynurenic acid was not filtered at the glomerulus(99%of albumin binding),and was specifically secreted in renal tubules through the OAT1/3-MRP4 channel with an appropriate affinity(Km)(496.7 mM and 382.2 mM for OAT1 and OAT3,respectively)and renal clearance half-life(t1/2)in vivo(3.7±0.7 h).There is a strong correlation in area under the plasma drug concentration-time curve(AUC0et)between cefmetazole and kynurenic acid,but not with creatinine,after inhibition of rOATs.In addition,the phase of increased kynurenic acid level is earlier than that of creatinine in acute kidney injury process.These results suggest that albumin-bound kynurenic acid is an appropriate endogenous biomarker for adjusting the dosage of drugs secreted by this channel or predicting kidney injury.

关键词： Transporter Biomarker Kynurenic acid Renal tubular excretion

A mussel-induced approach to secondary functional cross-linking 3-aminopropytriethoxysilane to modify the graphene oxide membrane for wastewater purification

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Chinese Chemical Letters 2023年第1期34卷 426-434页

作者： Wenwen Tu Yucheng Liu mingyan Chen Lili ma Lingli Li Bing Yang College of Chemistry and Chemical Engineering Southwest Petroleum UniversityChengdu 610500China Research Institute of Industrial Hazardous Waste Disposal and Resource Utilization Southwest Petroleum UniversityChengdu 610500China

Graphene oxide(GO)with one-atom-thick exhibit remarkable molecule sieving properties,but its low permeance flux renders it difficult to be applied in practice as a high-permeance separation membrane.In this study,we design complex membrane from covalently crosslinked GO,polydopamine(PDA),and 3-aminopropytriethoxysilane(APTES)as building blocks to fabricate the high-permeance GO-based membrane via the vacuum filtration method.A branched crosslinking product(PDA/APTES)working as a clamp grasped the hydrophilic functional groups(hydroxyl,epoxy,carboxyl)on GO for improving the GO membrane flux.The interlayer structure of the GO membrane was optimized according to the crosslinker concentration,reaction time,initial p H,and temperature for RGO/PDA/APTES(RGPA)in this study.At the optimized reaction conditions including the crosslinker concentration of 1.4 m L/L,the temperature of 80°C,the time of 16 h,and the initial p H of 8.5 for RGPA mixture,the interlayer gallery of RGPA membrane was effectively tunes,endowing high flux ranging from 11.98 L m^(-2)h^(-1)to 1823.97 L m^(-2)h^(-1).Besides,the RGPA membrane ensured the high rejections to dye solutions such as methylene blue(MB)(>99%)and congo red(CR)(>90%).Meanwhile,the superior reusable performance of the RGPA membrane was achieved,together with the rejections for MB and CR to 96.32%and 93.1%after 4 cycles,respectively.Also,the RGPA membrane possessed superior anti-fouling performances for bovine serum albumin(BSA)aqueous solution and excellent stabilities in harsh conditions(p H 3,7 and 11).Grafting the crosslinker onto GO nanosheets exhibits the distinct advantages of achieving the high flux,high rejections to dyes,and superior reusable performance of membranes,posing a great application potential for membrane separation technology in wastewater treatment.

关键词： Cross-linked graphene oxide Polydopamine APTES High flux membranes Dye separation

New measurements on hydrodynamics in a gas-liquid-solid expanded bed

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Particuology 2021年第5期19卷 276-284页

作者： Xiuhong Zhou Yongli ma mingyan Liu Yixian Zhu Jiaming Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300350China China Energy Longyuan Environmental Protection Co. Ltd.Beijing 100039China

The solid holdup,in a 150 mm-ID×2460 mm-height gas-liquid-solid expanded bed with air,water and glass beads(the diameter of particles is 0.6-0.8 mm)was firstly investigated based on the immersion-type online multiphase measuring instrument,and bubble behavior was studied via the BVW-2 double electrical conductivity probe.The effect of the superficial gas velocity and liquid velocity on the expanded ratio,the transition ratio,the bubble rising velocity,the gas holdup and the solid holdup was studied.It is discovered that compared with the gas velocity,the liquid velocity has stronger impact on the expanded ratio,but it is opposite for the transition ratio.The average gas holdup and solid holdup increase linearly as the superficial gas velocity goes up.Among it,the gas holdup increases greater in the center,while the solid holdup increases greater near the wall.Compared with it,when the superficial liquid velocity rises,the average gas holdup hardly changes,but the average solid holdup keeps decreasing,especially the solid holdup distributes flatter with the increase of the superficial liquid velocity.

关键词： Phase holdup Gas-liquid-solid expanded bed Immersion-type online multiphase measuring instrument BVW-2 double electrical conductivity probe

Effects of bone marrow cells transplantation for acute myocardial infarction on cardiac function,infarct size,and clinical events:a metaanalysis

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Chinese Medical Journal 2023年第20期136卷 2518-2520页

作者： Shuxia Wang Jihong Hu Genxi Dong Mingyan Ma Xuelian Chen Fengfeng Ding Public Health School Gansu University of Chinese MedicineLanzhouGansu 730000China Affiliated Hospital of Gansu University of Chinese Medicine LanzhouGansu 730000China Center of Research and Experiment Gansu University of Chinese MedicineLanzhouGansu 730000China School&Hospital of Stomatology Lanzhou University LanzhouGansu 730000China

To the Editor:Acute myocardial infarction(AMI)poses a substantial threat to human health.^([1])At present,AMI is mainly treated by reperfusion,drugs,and surgery,^([2])which only temporarily delay cell death and deterioration.Sian Harding at el^([3])suggested that myocardial transfer of specific bone marrow cells(BMCs)and progenitor cell populations may enhance recovery of systolic and diastolic function after AMI.Although a few previous meta-analysis studies of BMCs transplantation for AMI have been published,the quality of these studies was varied due to marked heterogeneity^([4,5])or because they focused on a single outcome(e.g.,cardiac function)[5]and very few evaluated the clinical evens.^([6])In addition,the effects of BMCs transplantation over different lengths of follow-up periods were unclear.In an attempt to reach more reliable conclusions,we performed an updated meta-analysis of randomized controlled trials(RCTs)and conducted subgroup analyses according to follow-up periods.

关键词： cardiac clinical myocardial

Modeling of acute cadmium toxicity in solution to barley root elongation using biotic ligand model theory

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Journal of Environmental Sciences 2016年第4期28卷 112-118页

作者： Xuedong Wang mingyan Wu Jingxing ma Xiaolin Chen Luo Hua The Key Lab of Resource Environment and GIS College of Resource Environment and TourismCapital Normal University

Protons（H^＋）as well as different major and trace elements may inhibit cadmium（Cd）uptake in aquatic organisms and thus alleviate Cd toxicity.However,little is known about such interactions in soil organisms.In this study,the independent effects of the cations calcium（Ca^2＋）,magnesium（Mg^2＋）,potassium（K^＋）,H^＋ and zinc（Zn^2＋）on Cd toxicity were investigated with 5-day long barley root elongation tests in nutrient solutions.The tested concentrations of selected cations and trace metal ions were based on the ranges that occur naturally in soil pore water.The toxicity of Cd decreased with increasing activity of Ca^2＋,Mg^2＋,H^＋and Zn^2＋,but not K^＋.Accordingly,conditional binding constants were obtained for the binding of Cd^2＋,Ca^2＋,Mg^2＋,H^＋,and Zn^2＋ with the binding ligand：log K（CdBL）5.19,logK（CaBL）2.87,logK（MgBL）2.98,logK（HBL）5.13 and logK（ZnBL）5.42,respectively.Furthermore,it was calculated that on average 29% of the biotic ligand sites needed to be occupied by Cd to induce a 50% decrease in root elongation.Using the estimated constants,a biotic ligand model was successfully developed to predict the Cd toxicity to barley root elongation as a function of solution characteristics.The feasibility and accuracy of its application for predicting Cd toxicity in soils were discussed.

关键词： Cadmium Biotic ligand model （BLM） Toxicity Barley

The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats

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Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 519-529页

作者： Yanrong ma mingyan Xin Yuanjie Wen Huan Wang Guoqiang Zhang Jianye Dai Xin-An Wu School of Pharmacy Lanzhou UniversityLanzhou 730000China Department of Pharmacy the First Hospital of Lanzhou UniversityLanzhou 730000China

The liver is an important organ for drugs disposition,and thus how to accurately evaluate hepatic clearance is essential for proper drug dosing.However,there are many limitations in drug dosage adjustment based on liver function and pharmacogenomic testing.In this study,we evaluated the ability of endogenous glycochenodeoxycholate-3-sulfate(GCDCA-S)and 4β-hydroxycholesterol(4β-HC)plasma levels to evaluate organic anion-transporting polypeptide(Oatps)-mediated hepatic uptake and Cyp3 a-meidated metabolism of atorvastatin(ATV)in rats.The concentration of ATV and its metabolites,2-OH ATV and 4-OH ATV,was markedly increased after a single injection of rifampicin(RIF),an inhibitor of Oatps.Concurrently,plasma GCDCA-S levels were also elevated.After a single injection of the Cyp3 a inhibitor ketoconazole(KTZ),plasma ATV concentrations were significantly increased and 2-OH ATV concentrations were decreased,consistent with the metabolism of ATV by Cyp3 a.However,plasma 4β-HC was not affected by KTZ treatment despite it being a Cyp3 a metabolite of cholesterol.After repeated oral administration of RIF,plasma concentrations of ATV,2-OH ATV and 4-OH ATV were markedly increased and the hepatic uptake ratio of ATV and GCDCA-S was decreased.KTZ did not affect plasma concentrations of ATV,2-OH ATV and 4-OH ATV,but significantly decreased the metabolic ratio of total and 4-OH ATV.However,the plasma level and hepatic metabolism of 4β-HC were not changed by KTZ.The inhibition of hepatic uptake of GCDCA-S by RIF was fully reversed after a 7-d washout of RIF.Plasma concentration and hepatic uptake ratio of GCDCA-S were correlated with the plasma level and hepatic uptake of ATV in rats with ANIT-induced liver injury,respectively.These results demonstrate that plasma GCDCA-S is a sensitive probe for the assessment of Oatps-mediated hepatic uptake of ATV.However,Cyp3 a-mediated metabolism of ATV was not predicted by plasma 4β-HC levels in rats.

关键词： Atorvastatin Hepatic disposition Glycochenodeoxycholate-3-sulfate 4β-hydroxycholesterol Oatp Cyp3a

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水中超声波脱气的效应研究

化工学报 2023年第4期74卷 1693-1702页

作者：王倩倩刘明言马永丽天津大学化工学院天津300350 化学工程联合国家重点实验室(天津大学) 天津300350

超声波脱气技术在化工、冶金、环境以及地热能利用等领域具有现实或潜在的应用价值。但是,目前对空气-水系统中超声波脱气规律的研究还相对较少。开展了空气-水系统中的超声波脱气实验研究,在不同的操作参数下,如超声波电功率、频率等,... 详细信息

超声波脱气技术在化工、冶金、环境以及地热能利用等领域具有现实或潜在的应用价值。但是,目前对空气-水系统中超声波脱气规律的研究还相对较少。开展了空气-水系统中的超声波脱气实验研究,在不同的操作参数下,如超声波电功率、频率等,研究了超声波对气体脱除的实际效果。同时将超声波技术与真空脱气技术相结合,探究其脱气效果。结果表明,在实验条件下,随着超声波频率的升高,脱气效果下降;随着超声波电功率的升高,脱气效果提升;与单独真空脱气相比,超声波与真空脱气结合时,脱气效果显著提升;在流动条件下,随着流量增加,脱气效果降低。通过KI实验和可视化方法对超声过程中的声空化现象进行了研究,研究结果可为超声波脱气的工业应用提供基础指导。

关键词：超声波气体流动真空脱气反应