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PMN-MDSC:A Culprit Behind Immunosenescence and Increased Susceptibility to Clostridioides difficile Infection During Aging

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Engineering 2024年第11期42卷 59-73页

作者： Jianmin Wu Ming Zhang Hao Zhang mingxuan Sheng Jiazeng sun Fang Wu Haina Gao Lishui Chen Zhili Li Qiyu Tian Longjiao Zhu Bing Fang Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing 100191China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China School of Life Sciences Henan UniversityZhengzhou 475004China Department of Basic Medical Sciences Purdue UniversityWest LafayetteIN 47907USA Food Laboratory of Zhongyuan Louhe 462300China Department of Molecular Pathobiology New York UniversityNew YorkNY 10010USA

Susceptibility to pathogens in the elderly is heightened with age,largely because of *** an immune regulatory organ,bone marrow creates immune cells that move to other organs and tis-sues through the *** the significance of this process of this organ,there is limited research on changes in immune cell generation in the bone marrow and their effects on *** this study,the compositions of immune cells in bone marrow from young(three months)and old(24+months)mice were compared by means of mass cytometry,with further validation obtained through the reanalysis of single-cell RNA sequencing data and cell sorting via flow *** effects of differential immune cells on immunosenescence in old mice were evaluated using the Clostridium difficile(***)infection *** results showed that aged mice presented with a reduction in bone tra-beculae structure,which was accompanied by a notable increase in polymorphonuclear(PMN)-myeloid-derived suppressor cell(MDSC)*** bulk-seq and reverse transcription quantitative polymerase chain reaction(RT-qPCR)analysis,we identified differential genes associated with the immune response—specifically,the Th17 cell differentiation ***,the increase in exported PMN-MDSCs to the large intestine resulted in increased gut permeability and inflammatory damage to the colon following *** *** clearing the PMN-MDSCs in old mice using the anti-Gr-1 antibody,the symptoms induced by *** were significantly relieved,as evidenced by an inhibited IL-17 pathway in the colon and reduced gut *** conclusion,aging increases the number of PMN-MDSCs in both the generated bone marrow and the outputted intestine,which con-tributes to susceptibility to *** *** study provides a novel target for anti-aging therapy for immunosenescence,which is beneficial for improving immune function in elders.

关键词： PMN-MDSC Immunosenescence Aging Mass cytometry Clostridioides difficile

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Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

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Chinese Journal of Cancer Research 2024年第2期36卷 226-232页

作者： Jun Luo mingxuan Zhu Long Zhao Meiwen He Bei Li Yifan Liu Yuhan sun Guoqing Lyu Zhanlong Shen Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036China Department of Gastroenterological Surgery Laboratory of Surgical OncologyBeijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment ResearchPeking University People's HospitalBeijing 100044China School of Medicine the Chinese University of Hong KongShenzhen 518172China

Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more *** tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal ***, there is currently no consensus on the specific distance of distal resection margin.

关键词： Colorectal cancer distal resection margin neoadjuvant therapy

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PtNiCu nanowires with advantageous lattice-plane boundary for enhanced ethanol electrooxidation

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Nano Research 2022年第4期15卷 2877-2886页

作者： Shuna Li Yao Wang Yunrui Li Xu Fang Yujie Liu mingxuan Li Zhen Wang Yufeng Gao Haixiao sun Fei Gao Xin Zhang Xiaoping Dai State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and EnvironmentChina University of PetroleumBeijing 102249China Department of Chemistry Tsinghua UniversityBeijing 100084China Jiangsu Key Laboratory of Vehicle Emissions Control School of the EnvironmentCenter of Modern AnalysisKey Laboratory of Mesoscopic Chemistry of Ministry of Education of ChinaSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China

It is generally accepted that the interface effect and surface electronic structure of catalysts have vital impact on catalytic *** and tailoring the atomic arrangement of interface structure are of great importance for ***,we proposed a simple method to synthesize etching-PtNiCu nanowires(e-PtNiCu NWs)enclosed by both(110)and(100)facets evolving from PtNiCu nanowires(PtNiCu NWs)mainly with(111)facets by selectively etching *** acetic acid etching treatment,the e-PtNiCu NWs possess high total proportions(88.3%)of(110)and(100)facets,whereas the(111)facet is dominant in PtNiCu NWs(64%)by qualitatively and quantitatively *** the structure characterizations and performance tests of ethanol electrooxidation reaction(EOR),we find that the e-PtNiCu NWs display remarkably performance for EOR,which is nearly 4.5 times and 1.5 times enhancement compared with the state-of-the-art Pt/C catalyst,as well as 2.2 and 1.4 times of PtNiCu NWs,in specific activity and mass activity,*** improved performance of e-PtNiCu NWs is attributed to synergistic catalytic effect between(110)and(100)facets that not only significantly decreases the onset potentials of adsorbed CO(CO_(ads))but also favors the oxidation of CO_(ads)on the surface of ***,thermodynamics and kinetic studies indicate that the synergistic effect of both(110)and(100)facets in e-PtNiCu NWs can decrease the activation energy barrier and facilitate the charge transfer during the *** work provides a promising approach to construct catalysts with tunable surface electronic structure towards efficient electrocatalysis.

关键词： chemical etching crystal-facet engineering synergistic effect ethanol electrooxidation CO resistibility

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基于微流控等温扩增技术的甲型H1N1流感病毒快速检测

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广西医科大学学报 2018年第4期35卷 560-563页

作者：孔文王瑞丽赵荣涛孙明璇郭旭东杨益刘婉莹郝荣章宋宏彬广西医科大学南宁530021 中国人民解放军疾病预防控制所北京100071

目的:以甲型H1N1流感病毒检测为例,建立一种简便、快速的流感病毒检测方法,为呼吸道传染病疫情防控提供技术支持。方法:整合环介导等温扩增技术(LAMP)和微流控芯片技术,建立微流控实时荧光逆转录环介导等温扩增(RT-LAMP)快速检测方法;... 详细信息

目的:以甲型H1N1流感病毒检测为例,建立一种简便、快速的流感病毒检测方法,为呼吸道传染病疫情防控提供技术支持。方法:整合环介导等温扩增技术(LAMP)和微流控芯片技术,建立微流控实时荧光逆转录环介导等温扩增(RT-LAMP)快速检测方法;针对甲型H1N1流感病毒的M基因序列中8个不同区段设计LAMP引物,根据扩增效果筛选出1套(6条)引物,并进行临床样本检测验证。结果:所建立的检测方法可实现扩增结果的荧光实时判读,能在恒定温度(65℃)30 min内完成扩增反应,检测限可达10copies/μL,仅对甲型H1N1流感病毒产生扩增曲线,对甲型H3、H5、H7、H9及乙型流感病毒均无扩增;对70份临床样本的检测结果与荧光定量PCR方法一致,特异性和灵敏度均为100%;该方法具有体系封闭、污染小、试剂用量小的优势。结论:所建立的微流控实时荧光RT-LAMP是一种快速、灵敏、特异、简便的检测甲型H1N1流感病毒的方法,便于开展现场检测。

关键词：微流控 RT-LAMP 流感病毒 H1N1 现场检测

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Pulsed LD side-pumped MgO：LN electro-optic cavity-dumped 1123 nm Nd： YAG laser with short pulse width and high peak power

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High Power Laser Science and Engineering 2018年第1期6卷 20-26页

作者： Yang Bai Bing Bai Diao Li Yanxiao sun Jianlin Li Lei Hou mingxuan Hu Jintao Bai National Key Laboratory of Photoelectric Technology and Functional Materials (Culture Base) Institute of Photonics and Photon-Technology Northwest University Xi'an 710069 China Shaanxi Engineering Technology Research Center for Solid State Lasers and Application Xi'an 710069 China Provincial Key Laboratory of Photo-electronic Technology Institute of Photonics and Photon-Technology Northwest UniversityXi'an 710069 China

We report a cavity-dumped 1123 nm laser with narrow pulse width and high peak power by an Mg O: LN crystal electrooptic(EO) modulator. Based on the structural optimization design of a folded biconcave cavity using the 808 nm pulsed laser diode(LD) side-pumped ceramic Nd: YAG rod, output pulses with maximum pulse energy and peak power up to39.6 m J and 9.73 MW were obtained, corresponding to 100 Hz repetition rate and 4.07 ns pulse width. The instabilities of pulse width and pulse energy were ±1.55% and ±2.06%, respectively. At the highest repetition rate of 1 kHz, the pulse energy, pulse width, and peak power were 11.3 mJ, 5.05 ns, and 2.24 MW, respectively. The instabilities of pulse width and pulse energy were ±2.65% and ±3.47%, respectively.

关键词： cavity-dumped high peak power MgO LN EO 1123nm laser short pulse width

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Fluorescence interference structured illumination microscopy for 3D morphology imaging with high axial resolution

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Advanced Photonics 2023年第5期5卷 96-105页

作者： Yile sun Hongfei Zhu Lu Yin Hanmeng Wu mingxuan Cai Weiyun sun Yueshu Xu Xinxun Yang Jiaxiao Han Wenjie Liu Yubing Han Xiang Hao Renjie Zhou Cuifang Kuang Xu Liu Zhejiang University College of Optical Science and EngineeringState Key Laboratory of Extreme Photonics and InstrumentationHangzhouChina The Chinese University of Hong Kong Department of Biomedical EngineeringHong KongChina China Jiliang University College of Optical and Electronic TechnologyHangzhouChina Zhejiang University of Technology Institute of PharmacologyCollege of Pharmaceutical SciencesHangzhouChina ZJU-Hangzhou Global Scientific and Technological Innovation Center HangzhouChina Huazhong University of Science and Technology Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical PhotonicsAdvanced Biomedical Imaging Facility-Wuhan National Laboratory for OptoelectronicsWuhanChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina

Imaging three-dimensional,subcellular structures with high axial resolution has always been the core purpose of fluorescence ***,trade-offs exist between axial resolution and other important technical indicators,such as temporal resolution,optical power density,and imaging process *** report a new imaging modality,fluorescence interference structured illumination microscopy(FI-SIM),which is based on three-dimensional structured illumination microscopy for wide-field lateral imaging and fluorescence interference for axial ***-SIM can acquire images quickly within the order of hundreds of milliseconds and exhibit even 30 nm axial resolution in half the wavelength depth range without z-axis ***,the relatively low laser power density relaxes the requirements for dyes and enables a wide range of applications for observing fixed and live subcellular structures.

关键词： optical imaging super-resolution microscopy fluorescence interference structured illumination microscopy

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基于激光三角位移传感器的双头螺杆在机测量系统

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中国激光 2023年第14期50卷 83-92页

作者：孙梦楠董祉序徐威刘明轩孙兴伟沈阳工业大学机械工程学院辽宁沈阳110870

针对双头螺杆廓形参数难以实现高精度、高效率检测的问题,以四轴旋风铣床为载体,设计并实现了一种基于激光三角位移传感器(LTDS)的在机测量系统。为了提高系统的测量精度,基于变结构元广义形态学方法、多项式插值算法及椭圆拟合法,实现... 详细信息

针对双头螺杆廓形参数难以实现高精度、高效率检测的问题,以四轴旋风铣床为载体,设计并实现了一种基于激光三角位移传感器(LTDS)的在机测量系统。为了提高系统的测量精度,基于变结构元广义形态学方法、多项式插值算法及椭圆拟合法,实现了含噪光斑图像质心的微米级提取,并进行了实验验证。为了避免最小二乘分段拟合方法在断点处不满足函数连续性和可导性的缺陷,提出了基于拉格朗日乘数法的点云信号光顺处理算法。最后根据信号重构结果实时计算廓形参数,判断加工质量。实验结果表明,设计的在机测量系统可在39.7 s内完成一个螺距的螺杆廓形参数检测,测量精度为±9μm,其中长轴、短轴、螺距的测量不确定度分别为0.72、0.69、1.65μm,显著提高了测量精度和效率。

关键词：测量螺杆转子激光位移传感器信号处理

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论国家政治决策与刑法的变革

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法学杂志 2009年第1期30卷 4-7页

作者：高铭暄孙晓中国人民大学法学院北京100872

国家政治决策和刑法的变革问题是一个既关涉政治,又关涉法律,特别是刑法的问题;是一个既宏观又微观的问题。深入考察国家政治决策和刑法变革关系发展的历史,认真分析现实中两者关系存在的问题,展望未来两者关系发展之趋势,以求裨益于我... 详细信息

国家政治决策和刑法的变革问题是一个既关涉政治,又关涉法律,特别是刑法的问题;是一个既宏观又微观的问题。深入考察国家政治决策和刑法变革关系发展的历史,认真分析现实中两者关系存在的问题,展望未来两者关系发展之趋势,以求裨益于我国政治之发展和刑法的进步,是一件非常有意义的事情。

关键词：国家政治决策刑法

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药物递送系统介导的脑胶质瘤放疗增敏

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中国药科大学学报 2024年第5期55卷 624-633页

作者：刘明萱郭赟孙涛复旦大学药学院智能化递药教育部重点实验室

脑胶质瘤是中枢神经系统常见恶性肿瘤，经常出现放疗耐受性。药物递送系统有助于放疗增敏剂的血脑屏障跨越和脑胶质瘤的靶向递送，进而增敏放疗疗效，受到越来越多的关注。本文重点总结了放疗耐受与自身DNA损伤修复机制、具有DNA和膜攻... 详细信息

脑胶质瘤是中枢神经系统常见恶性肿瘤，经常出现放疗耐受性。药物递送系统有助于放疗增敏剂的血脑屏障跨越和脑胶质瘤的靶向递送，进而增敏放疗疗效，受到越来越多的关注。本文重点总结了放疗耐受与自身DNA损伤修复机制、具有DNA和膜攻击性的活性氧自由基清除和脑胶质瘤干细胞的快速增殖的相关性，从探讨了无机纳米材料、有机复合材料和仿生递药系统等药物递送系统在解决跨屏障递送难题上的表现，总结了放疗增敏剂的跨血脑屏障和肿瘤靶向递送的递药系统设计方法，并为解决纳米递送系统临床转化问题提供了可能的方向。

关键词：脑胶质瘤药物递送系统放射耐受性放疗增敏肿瘤微环境

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论行政犯罪与行政违法行为的界分

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江海学刊 2008年第5期 132-136页

作者：高铭暄孙晓中国人民大学法学院

随着社会的发展,刑法典中的行政犯罪不断增加,行政违法行为也在不断增多。行政犯罪和行政违法行为是两种性质不同的行为,由此导致评价的不同和法律责任的不同,关涉罪与非罪的界限,因而两种行为的界分显得非常重要。应坚持保障功能和保... 详细信息

随着社会的发展,刑法典中的行政犯罪不断增加,行政违法行为也在不断增多。行政犯罪和行政违法行为是两种性质不同的行为,由此导致评价的不同和法律责任的不同,关涉罪与非罪的界限,因而两种行为的界分显得非常重要。应坚持保障功能和保护功能相协调以及公正和效率兼顾的界分原则,把握以危害程度的轻重为基础、以行为违法类型的不同为必要补充的具体界分标准,对行政犯罪与行政违法行为进行合理的界分。

关键词：行政犯罪行政违法行为界分

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