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基于Web of Science和CNKI数据库对鲤鱼研究进展的文献计量学分析

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畜牧兽医杂志 2023年第4期42卷 21-29,34页

作者：姚明星宋清川于惠霞莫昊霖王立新张明李杨西北农林科技大学动物科技学院陕西杨凌712100

为了解全球鲤鱼研究的发展情况,本文采用文献计量法,对Web of Science核心合集数据库和CNKI中国学术期刊全文数据库收录的1999~2021年相关论文进行专题检索,使用“鲤鱼”作为搜索词。数据通过Excel 2016、GraphPad Prism v8.4.0和VOSvie... 详细信息

为了解全球鲤鱼研究的发展情况,本文采用文献计量法,对Web of Science核心合集数据库和CNKI中国学术期刊全文数据库收录的1999~2021年相关论文进行专题检索,使用“鲤鱼”作为搜索词。数据通过Excel 2016、GraphPad Prism v8.4.0和VOSviewer软件进行可视化。结果显示,通过Web of Science平台共检索到鲤鱼SCI论文12401篇,其中国内论文2487篇。从CNKI中文学术期刊全文数据库中检索到5817篇中文论文。据统计,自2006年以来,我国鲤鱼研究领域的研究总体呈上升趋势,论文数量居国际首位。中国拥有强大的研究机构、一流的农业大学和处于研究技术前沿的研究人员。近年来,水产与渔业科学、海洋与淡水生物学、环境科学与生态学是三个热门研究方向。此外,生态学、病理生理学、毒理学等学科的研究也有了一定的发展。但论文质量较差,需要紧跟鲤鱼领域的国际研究形势,进一步提升论文水平。总体而言,中国正在走向世界前列,鲤鱼研究潜力巨大。

关键词：中国知网鲤鱼文献计量学

Discovery of the first potent proteolysis targeting chimera(PROTAC) degrader of indoleamine 2,3-dioxygenase 1

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1943-1953页

作者： mingxing Hu Weilin Zhou Yijie Wang Dongping yao Tinghong Ye Yuqin yao Bin Chen Gongping Liu Xifei Yang Wei Wang Yongmei Xie State Key Laboratory of Biotherapy and Cancer Center Department of Laboratory MedicineWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610041China Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Innovation Center of Neuroregeneration Nantong UniversityNantong 226019China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Centre for Disease Control and PreventionShenzhen 518055China

Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple *** 2,3-dioxygenase 1(IDO1),an immune checkpoint,plays an important role in tumor immune escape through the regulation of multiple immune cells and has been regarded as an attractive target for cancer *** Targeting Chimeras(PROTAC)technology has emerged as a new model for drug research and development for its advantageous ***,we reported the application of PROTAC technology in targeted degradation of IDO 1,leading to the discovery of the first IDO1 PROTAC degrader 2 c,which induced significant and persistent degradation of IDO1 with maximum degradation(Dmax)of 93%in HeLa ***-blot based mechanistic studies indicated that IDO 1 was degraded by 2 c through the ubiquitin proteasome system(UPS).Label-free real-time cell analysis(RTCA)indicated that 2 c moderately improved tumorkilling activity of chimeric antigen receptor-modified T(CAR-T)***,these data provide a new insight for the application of PROTAC technology in tumor immune-related proteins and a promising tool to study the function of IDO1.

关键词： IDO1 PROTAC Protein degradation Ubiquitin proteasome system Tumor immune escape

Preparation of anti-canine interleukin-31 receptor alpha polyclonal antibody and evaluation of its therapeutic efect in canine atopic dermatitis

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Animal Diseases 2024年第3期4卷 207-216页

作者： Qiuhua Li Yanyan Qu Li yao Ning Ma mingxing Ding Yi Ding College of Veterinary Medicine Huazhong Agricultural UniversityWuhanChina

Canine atopic dermatitis(CAD)is a prevalent genetically susceptible infammatory and pruritic allergic skin condition afecting not only the health of dogs but also the quality of life of their ***-31(IL-31)and interleukin-31 receptor alpha(IL-31RA)are essential for the development of pruritus in primates and ***,it is expected that inhibiting IL-31RA will be an efective approach to alleviate *** purpose of the study was to produce anti-canine IL-31RA polyclonal antibodies(anti-IL-31RA pAbs)and evaluate their efcacy in inhibiting house dust mite(HDM)-evoked pruritic *** were immunized with antigens formed by IL-31RA recombinant short peptides coupled to BSA to produce anti-IL-31RA *** CAD model was developed by using HDM allergen stimulation,and the efects of IL-31RA pAbs on the reduction of pruritus in CAD model dogs were *** Canine Atopic Dermatitis Extent and Severity Index(CADESI)-4 and pruritus Visual Analog Scale(pVAS)were utilized to evaluate pruritic responses,and skin tissue samples were collected from the inguinal area for pathological assessment of skin infammatory cell *** results showed that anti-IL-31RA pAbs with high titers(1:128,000)and specifcity were efectively *** the CAD model group,the severity of skin damage,pruritus score,infammatory cell infltration and level of infammatory factors were considerably ***-IL-31RA pAbs relieved pruritic behavior and dermatitis in dogs compared to placebo-treated *** conclusion,anti-IL-31RA pAbs efectively suppressed CAD in vivo and are anticipated to be an efective novel treatment for pruritic skin disorders such as CAD.

关键词： IL-31RA Atopic dermatitis Polyclonal antibody Canine

Progress on major genes for high fecundity in ewes

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Frontiers of Agricultural Science and Engineering 2014年第4期1卷 282-290页

作者： Qiuyue LIU Zhangyuan PAN Xiangyu WANG Wenping HU Ran DI Yaxing yao mingxing CHU Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China

The existence of major genes affecting fecundity in sheep flocks throughout the world has been *** major genes whose mutations can increase ovulation rate have been discovered,and all related to the transforming growth factorβ(TGF-β)*** mutant FecB of bone morphogenetic protein receptor 1B(BMPR1B)has an additive effect on ovulation *** mutations(Fec^(XI),Fec^(XH),Fec^(XG),Fec^(XB),Fec^(XL),Fec^(XR))of bone morphogenetic protein 15(BMP15)related with fertility have been identified that share the same *** the mutants can increase ovulation rate in heterozygotes and cause complete sterility in *** ewes with two new mutations(FecX^(Gr),FecX^(O))of BMP15 had increased ovulation rate without causing *** are five mutations in growth differentiation factor 9(GDF9)associated with sheep prolificacy where FecG^(E) and FecG^(F) have additive an effect on ovulation rate and litter *** newly identifiedβ-1,4-N-acetylgalactosaminyltransferase 2(B4GALNT2)gene of FecL is proposed as a new mechanism of ovulation rate regulation in *** is an X-linked maternally imprinted gene which increases ovulation *** addition,several putative major genes need to be *** review is focused on the identification of the mutations and mechanisms whereby the major genes affecting ovulation rate.

关键词： major gene ovulation rate sheep reproduction

Subtle structure tailoring of metal-free triazine luminogens for highly efficient ultralong organic phosphorescence

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Chinese Chemical Letters 2019年第11期30卷 1935-1938,F0003页

作者： Xuan Wang Nan Gan mingxing Gu Kun Ling Chaoqun Ma Huili Ma Wei yao Yujian Zhang Huifang Shi Zhongfu An Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergistic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(Nanjing Tech)Nanjing 211816China Department of Materials Chemistry Huzhou UniversityHuzhou 313000China Shanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi'an 710072China

Ultralong organic phosphorescent materials have invoked considerable attention for their great potential in sensing,data encryption,information anti-counterfeiting and so ***,effective ways to achieve highly efficient ultralong organic phosphorescence(UOP)in metal-free organic materials remain a great ***,we designed three isomers based on asymmetric triazines with various bromine substituted ***,phosphorescence efficiency of p-BrAT in solid state can reach up to 9.7%with a long lifetime of 386 ms,which was one of the highest efficient UOP materials reported so *** calculations further demonstrated that para-substitution exhibited the most effective radiative transition for triplet *** results will provide an effective approach to achieving highly efficient UOP materials.

关键词： Ultralong organic phosphorescence(UOP) Isomerism Crystal engineering H-aggregation Intermolecular interactions

Polymorphism-Dependent Dynamic Ultralong Organic Phosphorescence

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Research 2020年第1期2020卷 1501-1509页

作者： mingxing Gu Huifang Shi Kun Ling Anqi Lv Kaiwei Huang Manjeet Singh He Wang Long Gu Wei yao Zhongfu An Huili Ma Wei Huang Institute of Flexible Electronics(IFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China

Developing ultralong organic phosphorescence(UOP)materials with smart response to external stimuli is of great interest in photonics applications,whereas the manipulation of molecular stacking on tuning such dynamic UOP is still a formidable ***,we have reported two polymorphs with distinct photoactivated dynamic UOP behavior based on a pyridine derivative for the first *** experiment revealed that the dynamic UOP behavior including photoactivation and deactivation feature is highly dependent on irradiation intensity and environmental ***,given the unique dynamic UOP feature,these phosphors have been successfully applied to phosphorescence-dependent molecular logic gate and timing data *** result not only paves a way to design smart functional materials but also expands the scope of the applications on organic phosphorescence materials.

关键词： materials. smart behavior

Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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Chinese Chemical Letters 2024年第2期35卷 305-310页

作者： Hongda Zhu Kai Ma Rui Ruan Chaobo Yang Aqin Yan Jing Li Qi Yu Hongmei Sun mingxing Liu Hongmei Zheng Jing Gao Xiaofang Guan Zhu Dai yao Sun Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province) Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of TechnologyWuhan 430068China Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China National Key Laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science Ministry of EducationQingdao University of Science and TechnologyQingdao 266000China

Immune checkpoint inhibitors(ICIs)therapy targeting programmed cell death ligand 1(PD-L1)and programmed death protein 1(PD-1)had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer(TNBC).However,the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of ***,the immunomodulator epigallocatechin gallate palmitate(PEGCG)and the immunoadjuvant metformin(MET)self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction,which encapsulated the therapeutic agents doxorubicin(DOX)-loaded PEGCG-MET micelles(PMD)and combined with ICIs(anti-PD-1 antibody)as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive *** results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo,compared with DOX or anti-PD-1 antibody for the therapy of *** micelles might be a potential candidate,which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.

关键词： Immunotherapy Tumor-targeted Self-assembled micelles Metformin Reducing PD-L1 expression TNBC

Elastic organic crystals with ultralong phosphorescence for flexible anti-counterfeiting

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npj Flexible Electronics 2021年第1期5卷 169-174页

作者： Kaiwei Huang Lulu Song Kun Liu Anqi Lv Manjeet Singh Kang Shen Jing Shen Jiamin Wang Hongchen Wang Huifang Shi Huili Ma mingxing Gu Gengzhi Sun Wei yao Zhongfu An Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)NanjingPeople’s Republic of China Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Polytechnical University(NPU)Xi’anChina

Ultralong organic phosphorescence(UOP)crystals have attracted increased attention due to the distinct photophysical property of a long-lived ***,organic crystals are generally brittle,leading to a serious problem for their application in flexible ***,we report three types of elastic organic crystals(EOCs)with ultralong phosphorescence via introducing halogen atoms(Cl,Br,I)intoπ-conjugated phosphorescent ***,the crystal containing iodine atoms displayed both excellent elasticity(ε=3.01%)and high phosphorescent efficiency(Φ_(Ph)=19.1%)owing to the strong halogen *** advantage of its highly efficient UOP and excellent elasticity,we successfully used a DCz4I crystal for anti-counterfeiting *** findings may provide guidance for the development of elastic crystals with afterglow and expand the scope of potential applications on flexible materials.

关键词： materials elasticity crystal

The Climatic-induced Net Carbon Sink by Terrestrial Biosphere over 1901-1995

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Advances in Atmospheric Sciences 2001年第6期18卷 1192-1206页

作者：杨昕王明星黄耀 Chinese Academy of Sciences Inst. of Atmospheric Physics Beijing China

The spatial and temporal variability of land carbon flux over the past one hundred years was investi- gated based on an empirical model directry calculating soil respiration rate. Our model shows that during 1901-1995, about 44-89 PgC (equals to 0.5, 0.9 PgC/ yr respectively) were absorbed by terrestrial biosphere. The simulated net ecosystem productivity (NEP) after the 1930s was close to the estimated value of u missing C sink' from deconvolution analysis. Most of the total carbon sink happened during 1951 -1985 with the estimated value of 33-50 PgC Three major sinks were located in the tropics (10°S-10°N), North- ern mid-latitudes (30°-60°N) and Southern subtropics (10°-40°S). During 1940s-mid-1970s, carbon sinks by terrestrial ecosystem increased with time, and decreased after the mid-1970s. These may be due to the ch anging of climate condition, as during the 1940s-1970s, temPerature decreased and precipitation increased, while after the mid-1970s, an opposite climate situation occurred with evident increasing in temperature and decreasing in precipitation. Usually, warmer and dryer climate condition is not favor for carbon absorption by biosphere and even induces net carbon release from soil, while cooler and wetter condition may induce more carbon sink. Our model results show that the net carbon flux is particularly dependent on moisture / precipitation effect despite of temperature effect, The changing of climate in the past century may be a possible factor inducing increases in carbon sink in addition to CO2 and N fertilizer.

关键词： Climate Terrestrial biosphere Missing carbon sink Model