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Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang Pan Yihuang chen Qiong Liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Free radical reactions

基于16S rDNA高通量测序技术分析湖北黑头羊瘤胃细菌的多样性

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黑龙江畜牧兽医 2019年第19期 46-50,178页

作者：索效军杨前平陶虎熊琪李晓锋陈明新张年湖北省农业科学院畜牧兽医研究所武汉430064 动物胚胎工程及分子育种湖北省重点实验室武汉430064

为了解湖北黑头羊瘤胃细菌多样性及群落结构,选择体重(35±2)kg、安装有永久性瘤胃瘘管的12月龄湖北黑头羊羯羊15只,正常饲喂20 d后采集瘤胃液样品,提取样品总DNA后对细菌16S rDNA序列的V4区进行PCR扩增,利用Illumina MiSeq PE300平台... 详细信息

为了解湖北黑头羊瘤胃细菌多样性及群落结构,选择体重(35±2)kg、安装有永久性瘤胃瘘管的12月龄湖北黑头羊羯羊15只,正常饲喂20 d后采集瘤胃液样品,提取样品总DNA后对细菌16S rDNA序列的V4区进行PCR扩增,利用Illumina MiSeq PE300平台对扩增子进行高通量测序,并采用QIIME等软件对测序序列进行生物信息学分析。结果表明:15个样本共获得高质量有效序列51 762条,基于97%相似性共归为851个操作分类单位(OTU);α-多样性指数表明Chao1、Ace指数分别为509.39,502.40,Shannon、Simpson指数分别为6.23,0.958 2;经过物种注释和统计,15个门、24个纲、24个目、34个科以及87个属被鉴定;拟杆菌门(Bacteroidetes,66.94%)、厚壁菌门(Firmicutes,23.41%)、柔膜菌门(Tenericutes,3.19%)为优势门,拟杆菌纲(Bacteroidia,66.09%)、梭菌纲(Clostridia,20.74%)为优势纲,拟杆菌目(Bacteroidales,66.09%)、梭菌目(Clostridiales,20.74%)、厌氧原体目(Anaeroplasmatales,2.75%)为优势目,普雷沃氏菌科(Prevotellaceac,43.88%)、理研菌科(Rikenellaceac,12.33%)、毛螺旋菌科(Lachonospiraceae,10.47%)为优势科,普雷沃代菌属1(Prevotella1,35.37%)、普雷沃氏菌科未分类属(unclassified,17.73%)、理菌属RC9(RikenellaceaeRC9gutgroup,12.00%)为优势菌属。说明湖北黑头羊瘤胃细菌多样性较低,最优势菌门为拟杆菌门,厚壁菌门次之;普雷沃氏菌属1是湖北黑头羊瘤胃中最优势细菌属。

关键词：湖北黑头羊瘤胃细菌多样性 16S rDNA MiSeq测序

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling chen Danyang chen Gaigai Li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

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Li取代对LAS系微晶玻璃核化行为的影响

陶瓷学报 2006年第1期27卷 53-57页

作者：宋芳芳郭兴忠杨辉韩陈陈明形浙江大学纳米科学与技术中心 310027 温州康尔微晶器皿有限公司 325800

以Li2O-Al2O3-SiO2三元系(LAS)微晶玻璃为研究对象,采用DTA、XRD等测试技术研究了不同Li2O含量LAS玻璃的核化行为,分析了Li取代对LAS玻璃核化行为的影响。研究结果表明,随着Li含量的降低,LAS系玻璃的相转变温度、析晶峰温度逐步增大,最... 详细信息

以Li2O-Al2O3-SiO2三元系(LAS)微晶玻璃为研究对象,采用DTA、XRD等测试技术研究了不同Li2O含量LAS玻璃的核化行为,分析了Li取代对LAS玻璃核化行为的影响。研究结果表明,随着Li含量的降低,LAS系玻璃的相转变温度、析晶峰温度逐步增大,最佳核化温度逐渐升高,最佳核化时间没有明显的变化。

关键词：锂铝硅微晶玻璃核化

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon chen chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

高pH胁迫对小龙虾的急性毒性和SOD活性的影响

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湖南文理学院学报（自然科学版） 2024年第2期36卷 40-44页

作者：韩庆陈明鑫邵立业夏虎湖南文理学院生命与环境科学学院湖南常德415000

pH是衡量水质的一项重要指标,水体pH过高或过低均会对水生生物构成危害。为了解水体pH对小龙虾的影响,为小龙虾养殖生产提供依据,本研究从pH 8–12以1.0为幅度设置5个梯度,分别记录24、48、72、96 h小龙虾的死亡数量来统计死亡率,在得出... 详细信息

pH是衡量水质的一项重要指标,水体pH过高或过低均会对水生生物构成危害。为了解水体pH对小龙虾的影响,为小龙虾养殖生产提供依据,本研究从pH 8–12以1.0为幅度设置5个梯度,分别记录24、48、72、96 h小龙虾的死亡数量来统计死亡率,在得出96 h LC50的基础上(9.71),设置对照组(pH 7.6)和实验组(pH 9.7)2个pH处理组,开始96 h高pH胁迫,于胁迫后0、2、8、24、96 h分别取样测定血液中SOD活性。结果表明,小龙虾在pH 8–12的5个梯度中各时间点的死亡情况不同,pH为8时,各时间点均无小龙虾死亡;pH为9时,24 h无小龙虾死亡;但随时间增长死亡率升高;pH为10时,小龙虾死亡率在24 h为16.50%,96 h增加到53.00%;pH为11时,小龙虾死亡率在24 h到达64.00%,48 h为100%;pH为12时,24 h死亡率为100%。对照组小龙虾血液中的SOD活性随时间变化不显著,各实验组小龙虾血液中的SOD活性随时间增加而降低,实验组与对照组之间0–8 h时无显著差异,24 h和96 h时差异显著(P<0.05)。

关键词：小龙虾 pH 半致死浓度酶活力 SOD