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Journal of Materials Science & Technology 2016年第9期32卷 889-900页

作者： Ting pan Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou 5J0006China Guangdong Province Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China

Gelatin/Alginate hydrogels were engineered for bioplotting in tissue engineering. One major drawback of hydrogel scaffolds is the lack of adequate mechanical properties. In this study, using a bioplotter, we constructed the scaffolds with different pore architectures by deposition of gelatin/alginate hydrogels layerby-layer. The scaffolds with different crosslinking degree were obtained by post-crosslinking methods. Their physicochemical properties, as well as cell viability, were assessed. Different crosslinking methods had little influence on scaffold architecture, porosity, pore size and distribution. By contrast, the water absorption ability, degradation rate and mechanical properties of the scaffolds were dramatically affected by treatment with various concentrations of crosslinking agent （glutaraldehyde）. The crosslinking process using glutaraldehyde markedly improved the stability and mechanical strength of the hydrogel scaf- folds. Besides the post-processing methods, the pore architecture can also evidently affect the mechanical properties of the scaffolds. The crosslinked gelatin/alginate scaffolds showed a good potential to encap-sulate cells or drugs.

关键词： Bioplotting Tissue engineering Scaffolds Gelatin Alginate

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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大亚湾区横塘片区水土流失防治措施与水土保持技术综合研究

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水利技术监督 2025年第1期 99-105页

作者：潘文婷广东海纳工程管理咨询有限公司惠州分公司广东惠州516000

水土流失是城市转型工程建设过程中不可避免的问题,水土流失整改与防治是城市转型工程的前提也是重点。以广东省大亚湾区塘横片区河道改造为背景,分析了区域地质气候以及两处河道面临的主要现状问题,并根据地质地形和河道自身特点,采取... 详细信息

水土流失是城市转型工程建设过程中不可避免的问题,水土流失整改与防治是城市转型工程的前提也是重点。以广东省大亚湾区塘横片区河道改造为背景,分析了区域地质气候以及两处河道面临的主要现状问题,并根据地质地形和河道自身特点,采取分段治理的水土流失防治措施,对河道护岸、两段河道以及河道水陂进行了新的扩展加固设计,最后提出工程措施、植物措施和临时措施相结合的水土保持综合措施。作为热点城市,大亚湾区河道改造可为类似工程提供可行性设计和整改思路。

关键词：水土流失河道改造水土保持

Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： Xia-Hui pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions

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运动干预与细胞焦亡在骨关节炎中的作用

中国组织工程研究 2025年第8期29卷 1667-1675页

作者：王秋月靳攀蒲锐长江大学教育与体育学院湖北省荆州市434023 长江大学医学部湖北省荆州市434023 长江大学运动人体科学实验室湖北省荆州市434023

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞... 详细信息

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞焦亡在改善骨关节炎中的机制。方法:以“pyroptosis,osteoarthritis,chondrocyte pyroptosis,synovial cell pyroptosis,exercise”和“细胞焦亡,骨关节炎,软骨细胞焦亡,滑膜细胞焦亡,运动”为关键词,检索PubMed与中国知网数据库1992-2024年间发表的相关文献,根据纳入及排除标准选择71篇文献进行综述。结果与结论:①骨关节炎是以软骨细胞外基质降解、滑膜炎症和软骨下骨重塑等为特点的慢性退行性关节疾病,易引起骨的器质性病变、疼痛并引发功能障碍。②细胞焦亡作为一种特殊的程序性死亡机制,其特征为细胞裂解死亡释放炎症因子引发强烈的炎症反应,与骨关节炎的发生发展关系密切。细胞焦亡可导致大量炎症因子释放,进而激活核因子κB转录,增加焦亡蛋白的产生,进而加剧骨关节炎的发生发展,因此细胞焦亡可作为骨关节炎防治的新方向。③运动可通过下调焦亡蛋白信号通路和抑制相关炎症因子表达等途径抑制软骨细胞和滑膜细胞的焦亡,从而在骨关节炎防治中发挥重要作用。有氧和无氧运动可通过抑制细胞焦亡的发生延缓骨关节炎的病理进程,中等强度的有氧运动通过抑制细胞焦亡信号通路改善骨关节炎的效果较好,无氧运动可通过提高肌肉质量进而对骨关节炎产生有益效应。

关键词：细胞焦亡骨关节炎运动运动调控信号通路综述

压应力激活SOST/Wnt/β-catenin 通路诱导软骨终板细胞退变

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中国组织工程研究 2025年第5期29卷 951-957页

作者：项攀车艳军罗宗平苏州大学附属第一医院骨科研究所江苏省苏州市215006 南京医科大学附属苏州医院骨科与运动医学中心江苏省苏州市215000

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨... 详细信息

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨终板细胞,体外利用力学加载仪器对终板软骨细胞施加压应力,于压缩细胞1,3,5,7 d,采用CCK-8法测定细胞活力;Western blot、RT-qPCR及细胞免疫荧光等检查终板软骨细胞内软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)、钙化相关因子(Runx2、骨钙素)、细胞外基质降解酶及信号通路基因(硬骨素、β-catenin)等表达。结果与结论:①压应力作用下,终板软骨细胞活力会随着压应力时间、强度增加而降低;②终板软骨细胞的软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)表达下降,而钙化相关因子(Runx2、骨钙素)表达上升;③压应力能促进终板软骨细胞的细胞外基质降解,基质金属蛋白酶3、基质金属蛋白酶13表达量增加;④细胞内Wnt/β-catenin信号通路表达出现异常,其特异性抑制因子硬骨素伴随着β-catenin的异常积累而表达下降。结果说明:在压应力作用下,终板软骨细胞内硬骨素的表达下降,导致Wnt/β-catenin信号通路激活,促进软骨终板的钙化、退变与细胞外基质的降解,进而促进椎间盘退变。

关键词：软骨终板软骨细胞 SOST Wnt/β-catenin 压应力椎间盘退变

Decoupling effect and driving factors of carbon footprint in megacity Wuhan,Central China

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Ecological Processes 2023年第1期12卷 330-343页

作者： Gao pan Xinhang Li Deng pan Wensheng Liu College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004People’s Republic of China Central South Academy of Inventory and Planning of NFGA Changsha 410014People’s Republic of China

Background China’s 35 largest cities,including Wuhan,are inhabited by approximately 18%of the Chinese popula-tion,and account for 40%energy consumption and greenhouse gas *** is the only sub-provincial city in Central China and,as the eighth largest economy nationwide,has experienced a notable increase in energy ***,major knowledge gaps exist in understanding the nexus of economic development and carbon footprint and their drivers in *** We studied Wuhan for the evolutionary characteristics of its carbon footprint(CF),the decoupling relation-ship between economic development and CF,and the essential drivers of *** on the CF model,we quantified the dynamic trends of CF,carbon carrying capacity,carbon deficit,and carbon deficit pressure index from 2001 to *** also adopted a decoupling model to clarify the coupled dynamics among total CF,its accounts,and eco-nomic *** used the partial least squares method to analyze the influencing factors of Wuhan’s CF and determine the main *** The CF of Wuhan increased from 36.01 million t CO_(2)eq in 2001 to 70.07 million t CO_(2)eq in 2020,a growth rate of 94.61%,which was much faster than that of the carbon carrying *** energy consumption account(84.15%)far exceeded other accounts,and was mostly contributed by raw coal,coke,and crude *** carbon deficit pressure index fluctuated in the range of 8.44-6.74%,indicating that Wuhan was in the relief zone and the mild enhancement zone during *** the same time,Wuhan was in a transition stage between weak and strong CF decoupling and economic *** main driving factor of CF growth was the urban per capita residen-tial building area,while energy consumption per unit of GDP was responsible for the CF *** Our research highlights the interaction of urban ecological and economic systems,and that Wuhan’s CF changes were mainly affected by four factors:city size,economic developm

关键词： Carbon footprint Economic development Decoupling analysis Partial least squares analysis Megacity

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Uncertainty Principles on Clifford Modules

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2537-2570页

作者： pan LIAN School of Mathematical Sciences Tianjin Normal UniversityTianjin 300387P.R.China

In this paper,we derive the optimal Cauchy–Schwarz inequalities on a class of Hilbert and Krein modules over a Clifford algebra,which heavily depend on the Clifford algebraic *** obtained inequalities further lead to very general uncertainty inequalities on these *** new phenomena arise,due to the non-commutative nature,the Clifford-valued inner products and the Krein *** into account applications,special attention is given to the Dirac operator and the Howe dual pair Pin(m)×osp(1|2).Moreover,it is surprisingly to find that the recent highly nontrivial uncertainty relation for triple observables is indeed a direct consequence of our Cauchy–Schwarz *** new observation leads to refined uncertainty relations in terms of the Wigner–Yanase–Dyson skew information for mixed states and other *** show that the obtained uncertainty inequalities on Clifford modules can be considered as new uncertainty relations for multiple observables.

关键词： Clifford algebra uncertainty principle Krein space Fischer decomposition Wigner-Yanase-Dyson skew information

Hermitian-Poisson Metrics on Flat Bundles over Complete Hermitian Manifolds

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Chinese Annals of Mathematics,Series B 2021年第4期42卷 575-582页

作者： Changpeng pan School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

In this paper,the author solves the Dirichlet problem for Hermitian-Poisson metric equation√(-1)Λ_(ω)G_(H)=λId and proves the existence of Hermitian-Poisson metrics on flat bundles over a class of complete Hermiti... 详细信息

关键词： Flat bundle Hermitian harmonic metric Hermitian-poisson metric Complete Hermitian manifolds

Progress of the Quantum Experiment Science Satellite(QUESS) Micius Project

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空间科学学报 2018年第5期38卷 604-609页

作者： pan Jianwei Department of Modern Physics and Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei 230026 CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Shanghai 201315

By using satellites, ultra-long-distance quantum communication and tests of quantum foundations could be achieved at a global scale. The Quantum Experiment Science Satellite(QUESS) in China, also called Micius, one of the scientific satellite programs in the Strategic Priority Program on space science, the Chinese Academy of Sciences, was launched on 16 August 2016. There are totally 4 scientific payloads. We give a brief overview of the quantum experiment science satellite project and present most recent science results. The main scientific goal of the quantum experiment science satellite was achieved in 2017. Here, we introduce the latest achievements in satellite-based quantum communication and large-scale tests of quantum foundations obtained by Micius.

关键词：科学卫星实验科学卫星工程中国科学院优先级测试通讯基础

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