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MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

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World Journal of Gastroenterology 2018年第27期24卷 2949-2973页

作者： Kenneth KW To Christy WS Tong mingxia wu William CS Cho School of Pharmacy Faculty of Medicine the Chinese University of Hong Kong Department of Clinical Oncology Queen Elizabeth Hospital

MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.

关键词： microRNA colorectal cancer multidrug resistance prognosis therapeutic target apoptosis metastasis recurrence risk stratification

Peony pollen derived nitrogen-doped activated carbon for supercapacitor application

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Chinese Chemical Letters 2020年第6期31卷 1644-1647页

作者： Yiming Liu Zhongxun An mingxia wu Anbao Yuan Hongbin Zhao Jiujun Zhang Jiaqiang Xu NEST Lab Department of PhysicsDepartment of ChemistryCollege of SciencesShanghai UniversityShanghai 200444China National Engineering Research Center for Supercapacitor for Vechicles Shanghai AOWEI Technology Development Co.Ltd.Shanghai 201203China

Peony pollen is a cheap and readily available biomass material with a relatively high protein *** this work,it was employed as an N-rich precursor to prepare the nitrogen-doped porous carbon for supercapacitor *** porous carbon microspheres were prepared through a hydrothermal method and subsequent carbonization ***,ammonium borofruoride and potassium hydroxide were employed respectively as an etchant and an activator to modify the porosity of the *** as prepared ANPPCs-700 has a super high BET specific surface area of 824.69 m^2/*** microstructure,chemical state and electrochemical properties of the product were investigated in *** prepared nitrogen-doped carbon microspheres exhibits excellent specific capacity of 209 F/g at a current density of lA/g and remained 92.5%of the initial capacitance after 5000 deep cycles at 5 A/g.

关键词： Supercapacitors Biomass Nitrogen-doped Hierarchical carbon Peony pollen

Fabrication and Characterization of TiAl Alloy by Fields Activated Sintering Technology(FAST)

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Journal of wuhan University of Technology(Materials Science) 2022年第3期37卷 470-474页

作者： ZHOU Liming wu mingxia QIN Yuan YANG Gang YANG Yi School of Mechanical Engineering Chengdu UniversityChengdu 610106China School of Mechanical Engineering Sichuan UniversityChengdu 610065China

Ti-47Al alloy was fabricated by multi-physical fields activated sintering technology(FAST).With the coupling effects of electrical and pressure fields as the dominant driving force,a nearly fulldensity(relative density:99.15%)TiAl alloy sample was *** microstructural characterizations,phase transformation at different sintering temperatures and their contributions to mechanical properties were *** results reveal that TiAl_(3)is the main phase when sintered at 600 and 700℃.When the sintering temperature reaches 800℃,the main phases are TiAl and Ti_(3)*** the increase of sintering temperature,the content of TiAl increases and that of Ti_(3)Al *** the sintering temperature reaches 1000℃,the alloy with fine and uniform microstructure and good mechanical properties can be obtained.

关键词： TiAl alloy Micro-FAST Microstructure Mechanical properties

Honeycomb-like polyaniline for flexible and folding all-solid-state supercapacitors

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Frontiers of Materials Science 2019年第2期13卷 133-144页

作者： Ge JU Muhammad Arif KHAN Huiwen ZHENG Zhongxun AN mingxia wu Hongbin ZHAO Jiaqiang XU Lei ZHANG Salma BILAL Jiujun ZHANG NEST Lab Department of Chemistry College of Sciences Shanghai University Shanghai 200444China School of Materials Science and Engineering Shanghai University Shanghai 200444 China National Engineering Research Center for Supercapacitor for Vehicles Shanghai AOWEI Technology Development Co. Ltd. Shanghai 201203 China Institute for Fuel Cell Innovation National Research Council of Canada 4250 Wesbrook Mall Vancouver Canada National Centre of Excellence in Physical Chemistry University of Peshawar 25120 Peshawar Pakistan Institute of Sustainable Energy Shanghai University Shanghai 200444 China

Porous polyaniline (PANI) was prepared through an efficient and costeffective method by polymerization of aniline in the NaCl solution at room temperature. The resulting PANI provided large surface area due to its highly porous structure and the intercrossed nanorod, resulting in good electrochemical performance. The porous PANI electrodes showed a high specific capacitance of 480 F·g^-1, 3 times greater than that of PANI without using the NaCl solution. We also make chemically crosslinked hydrogel film for hydrogel polymer electrolyte as well as the flexible supercapacitors (SCs) with PANI. The specific capacitance of the device was 234 F·g^-1 at the current density of 1 A·g^-1. The energy density of the device could reach as high as 75 W·h·kg^-1 while the power density was 0.5 kW·kg^-1, indicating that PANI be a promising material in flexible SCs.

关键词： PANI honeycomb-like nanostructure all-solid-state SC electrochemical property

烧结温度对Micro-FAST制备TiAl合金组织和性能的影响

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稀有金属材料与工程 2020年第1期49卷 337-342页

作者：秦媛杨刚杨屹吴明霞四川大学机械工程学院四川成都610065 四川大学四川成都610065

为解决TiAl合金成形困难的问题,以Ti、Al元素粉末为原料,采用Micro-FAST制备Ti-47Al合金,研究不同温度(7001050℃)对TiAl合金组织和性能的影响,并且探究了烧结过程中颗粒的迁移机制。结果表明,700℃烧结时不能形成典型组织,主要相为TiAl... 详细信息

为解决TiAl合金成形困难的问题,以Ti、Al元素粉末为原料,采用Micro-FAST制备Ti-47Al合金,研究不同温度(7001050℃)对TiAl合金组织和性能的影响,并且探究了烧结过程中颗粒的迁移机制。结果表明,700℃烧结时不能形成典型组织,主要相为TiAl3;800℃及以上烧结时为岛状组织,主要相为大量的TiAl和少量的Ti3Al;在1050℃烧结时具有最佳的综合力学性能。烧结过程由多种扩散机制共同控制,随着烧结的进行,依次为蒸发-凝聚、体积扩散、晶界扩散和表面扩散。

关键词： Ti-47Al 烧结温度 Micro-FAST

烧结温度对Micro-FAST制备钛微型齿轮致密化的影响

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稀有金属材料与工程 2015年第6期44卷 1504-1508页

作者：吴明霞杨刚杨屹尹德强四川大学四川成都610065

将新颖的多物理场活化烧结微成形技术(Micro-FAST)引入到钛微型齿轮的制备中,研究了烧结温度对Micro-FAST制备钛微型齿轮致密化的影响。结果表明,在1200℃烧结保温4 min,体系的相对密度即可达到90.5%。Micro-FAST的烧结致密化过程大致... 详细信息

将新颖的多物理场活化烧结微成形技术(Micro-FAST)引入到钛微型齿轮的制备中,研究了烧结温度对Micro-FAST制备钛微型齿轮致密化的影响。结果表明,在1200℃烧结保温4 min,体系的相对密度即可达到90.5%。Micro-FAST的烧结致密化过程大致可分为4个阶段:预热阶段、低温保温阶段、快速升温阶段和烧结保温阶段,钛粉末的致密化过程主要发生在快速升温阶段。对烧结体系的收缩动力学曲线研究发现,在电场、力场和温度场的耦合作用下,粉末体系在450℃发生了塑性变形,在1032℃生成了局部液相。研究表明,与传统烧结法相比,多物理场活化烧结法是一种新型和高效的制备钛微型零件的良好方法。

关键词： Micro-FAST 钛微型齿轮烧结温度致密化

领域化视角下的珠三角乡村城市化再思考——以广州市旧水坑村为例

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地理科学 2016年第12期36卷 1834-1842页

作者：刘云刚仵明霞中山大学地理科学与规划学院/广东省城市化与地理环境空间模拟重点实验室广东广州510275

从领域视角看,改革开放以来出现的自下而上的乡村城市化过程即是乡村地域的重新领域化与再/去领域化过程。以广州市旧水坑村为案例,运用实地调查、访谈的方法,对乡村城市化过程中社会、市场和行政力量等领域化主体的作用机制进行了剖析... 详细信息

从领域视角看,改革开放以来出现的自下而上的乡村城市化过程即是乡村地域的重新领域化与再/去领域化过程。以广州市旧水坑村为案例,运用实地调查、访谈的方法,对乡村城市化过程中社会、市场和行政力量等领域化主体的作用机制进行了剖析。研究发现,村民代表的社会力量是乡村领域化的设计者,而行政力量、市场力量试图通过在其中构建独立领域以增强话语权。叠置的领域和差异悬殊的空间资源支配能力致使资源争夺加剧及非均衡的空间-权力结构形成,并导致村庄发展管治的混乱。因此,需要尽快构建多元主体有机组合的领域单元及均衡的领域政治体系,以实现乡村地域的可持续发展。

关键词：乡村城市化自下而上领域化广州旧水坑村

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考虑消费者信息更新的概率销售策略

运筹与管理 2024年第3期33卷 133-139页

作者：戴睿吴明霞东华大学旭日工商管理学院上海200051

概率销售模式下,部分商家不披露其产品抽中的概率信息,消费者需通过产品在线评论等收集信息以更新对抽取概率的预估,从而产生信息更新行为。此外,概率销售往往导致抽中不满意产品的消费者将产品转售。综合考虑消费者的信息更新和产品转... 详细信息

概率销售模式下,部分商家不披露其产品抽中的概率信息,消费者需通过产品在线评论等收集信息以更新对抽取概率的预估,从而产生信息更新行为。此外,概率销售往往导致抽中不满意产品的消费者将产品转售。综合考虑消费者的信息更新和产品转售行为,本文分别构建了信息披露和不披露情形下的概率销售企业策略优化模型,求解并对比了不同信息披露情形下的产品定价及零售商利润,总结了信息精度等重要因素对零售商的定价、信息披露策略以及利润的影响。结论表明,信息不披露会降低概率产品价格。此外,当消费者获得的信息精度较低或转售价格较高时,零售商倾向于不披露产品的抽取概率信息;反之,则披露信息更有利。

关键词：概率销售信息披露贝叶斯更新产品转售

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中小学教师工作—家庭冲突与社会支持的相关研究

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教育导刊（上半月） 2010年第3期3卷 33-38页

作者：秦波吴明霞重庆教育学院教师教育研究所副所长重庆南岸400067 西南大学教科所副教授博士重庆北碚400715

该研究采用吴明霞等人编制的教师工作—家庭冲突问卷和肖水源编制的社会支持评定量表,对重庆市298名城乡中小学教师的工作—家庭冲突和社会支持的现状及相互关系进行了研究。其结论是:①社会支持在年龄、教龄、受教育水平、婚姻状态和... 详细信息

该研究采用吴明霞等人编制的教师工作—家庭冲突问卷和肖水源编制的社会支持评定量表,对重庆市298名城乡中小学教师的工作—家庭冲突和社会支持的现状及相互关系进行了研究。其结论是:①社会支持在年龄、教龄、受教育水平、婚姻状态和职称等方面存在显著差异;②工作—家庭冲突在年龄、教龄等方面存在显著差异;③总体的社会支持与工作—家庭冲突负相关。同时,对利用社会支持预防和干预中小学教师工作—家庭冲突提出了建议。

关键词：中小学教师工作—家庭冲突社会支持