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Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

Food Science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang mingxia Ma Yumeng huang Siqing Fan Jie Peng Shiming Li Xiurong Su Yanbo Wang Chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products and School of Marine Science Ningbo UniversityNingbo 315211China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary structure.In recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing attention.This article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability improvement.The current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity evaluations.In addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical mechanism.Moreover,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability improvement.Hopefully,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

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Separation of trivalent rare earths from nitrate medium using solvent extraction with a novel extractant 2-ethylhexyl((2-ethylhexylamino)methyl)phosphonic acid

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Journal of Rare Earths 2022年第3期40卷 491-500,I0005页

作者： Yongmei Fu mingxia huang Zhulin Zhou Zhongjun Li Wuping Liao Youcai Lu Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

By introducing the amine group into the structure of P227,a novel extractant 2-ethylhexyl((2-ethylhexylamino)methyl)phosphonic acid(EEAMPA,abbreviated as HA)was synthesized for the extraction and separation of trivalent rare earths(REs)from nitrate medium.The influence factors including extractant concentration,equilibrium time,HNO_(3)concentration,separation factors,cycle regeneration,stripping acidity,and actual leach liquor of metal ions,were studied systematically.The results show that the extraction ability of EEAMPA for REs decreases with increasing acidity.A possible extraction mechanism is proposed and the extracted species as REHA_(3)(NO_(3))are confirmed by the slope analysis method.The extraction equilibrium can reach faster than P227.It shows good chemical stability and cycling regeneration.Stripping studies show that HCl is an excellent stripping agent and REs can be effectively stripped from the organic phase.

关键词： Rare eartn Extraction Separation α-aminophosphonic acid Extractant

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Essential role of the iron-sulfur cluster binding domain of the primase regulatory subunit Pri2 in DNA replication initiation

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Protein & Cell 2015年第3期6卷 194-210页

作者： Lili Liu mingxia huang Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh PA 15213 USA Department of Biochemistry and Molecular Genetics University of Colorado School of Medicine Aurora CO 80045 USA

DNA primase catalyzes de novo synthesis of a short RNA primer that is further extended by replicative DNA polymerases during initiation of DNA replication. The eukaryotic primase is a heterodimeric enzyme comprising a catalytic subunit Pril and a regulatory subunit Pri2. Pri2 is responsible for facilitating optimal RNA primer synthesis by Pril and mediating interaction between Pril and DNA polymerase o for transition from RNA synthesis to DNA elongation. All eukaryotic Pri2 proteins contain a conserved C-terminal iron-sulfur （Fe-S） cluster-binding domain that is critical for primase catalytic activity in vitro. Here we show that mutations at conserved cysteine ligands for the Pri2 Fe-S cluster markedly decrease the protein stability, thereby causing S phase arrest at the restrictive temperature. Furthermore, Pri2 cysteine mutants are defective in loading of the entire DNA pol α-primase complex onto early replication origins resulting in defective initiation. Importantly, assembly of the Fe-S cluster in Pri2 is impaired not only by mutations at the conserved cysteine ligands but also by increased oxidative stress in the sodlA mutant lacking the Cu/Zn superoxide dismutase. Together these findings highlight the critical role of Pri2＇s Fe-S cluster domain in replication initiation in vivo and suggest a molecular basis for how DNA replication can be influenced by changes in cellular redox state.

关键词： pdmase Pri2 iron-sulfur cluster,replication initiation

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Taxi origin and destination demand prediction based on deep learning:a review

Digital Transportation and Safety

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Digital Transportation and Safety 2023年第3期2卷 176-189页

作者： Dan Peng mingxia huang Zhibo Xing Department of Transportation and Geomatics Engineering Shenyang Jianzhu UniversityShenyang 110168China

Taxi demand prediction is a crucial component of intelligent transportation system research.Compared to region-based demand prediction,origin-destination(OD)demand prediction has a wide range of potential applications,including real-time matching,idle vehicle allocation,ridesharing services,and dynamic pricing,among others.However,because OD demand involves complex spatiotemporal dependence,research in this area has been limited thus far.In this paper,we first review existing research from four perspectives:topology construction,temporal and spatial feature processing,and other relevant factors.We then elaborate on the advantages and limitations of OD prediction methods based on deep learning architecture theory.Next,we discuss ongoing challenges in OD prediction,such as dynamics,spatiotemporal dependence,semantic differentiation,time window selection,and data sparsity problems,and summarize and compare potential solutions to each challenge.These findings offer valuable insights for model selection in OD demand prediction.Finally,we provide public datasets and open-source code,along with suggestions for future research directions.

关键词： Deep learning Taxi demand prediction Taxi OD demand prediction Spatiotemporal data mining Dynamic graph

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Overview of machine learning-based traffic flow prediction

Digital Transportation and Safety

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Digital Transportation and Safety 2023年第3期2卷 164-175页

作者： Zhibo Xing mingxia huang Dan Peng Department of Transportation and Geomatics Engineering Shenyang Jianzhu UniversityShenyang 110168China

Traffic flow prediction is an important component of intelligent transportation systems.Recently,unprecedented data availability and rapid development of machine learning techniques have led to tremendous progress in this field.This article first introduces the research on traffic flow prediction and the challenges it currently faces.It then proposes a classification method for literature,discussing and analyzing existing research on using machine learning methods to address traffic flow prediction from the perspectives of the prediction preparation process and the construction of prediction models.The article also summarizes innovative modules in these models.Finally,we provide improvement strategies for current baseline models and discuss the challenges and research directions in the field of traffic flow prediction in the future.

关键词： Traffic flow prediction Machine learning Intelligent transportation Deep learning

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A novel extractant bis(2-ethylhexyl)((2-ethylhexylamino)methyl) phosphine oxide for cerium(Ⅳ) extraction and separation from sulfate medium

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Journal of Rare Earths 2020年第12期38卷 1330-1336页

作者： mingxia huang Yongmei Fu Youcai Lu Wuping Liao Zhongjun Li College of Chemistry Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

By introducing the amine group into phosphorus extractant,a novel aminophosphine compound bis(2-ethylhexyl)((2-ethylhexylamino)methyl) phosphine oxide(DEHAPO,abbreviated as A) was synthesized for the extraction of cerium(Ⅳ)(Ce(Ⅳ)) from sulfate medium(H2 SO4).The influence factors including extractant concentration,H2 SO4 concentration and temperature on the Ce(Ⅳ) extraction were investigated and discussed.It is found that the extraction ability of Ce(Ⅳ),thorium(Ⅳ)(Th(Ⅳ)) and rare earths(REs(Ⅲ))(La,Gd,Yb) decreases in sulphate medium in the following order:Ce(Ⅳ)> Th(Ⅳ)> REs(Ⅲ).The extraction process is an exothermic reaction and the thermodynamic parameters were calculated.The extracted complex of Ce(HSO4)2 SO4·A in loaded organic solution was identified by the slope methods and further proved by FT-IR spectral analysis.Stripping studies indicate that Ce(IV) can be effectively stripped from the organic phase.The results of separation factors(β) and saturation loading capacity demonstrate that DEHAPO could be used to selectively extract Ce(Ⅳ) from sulphate medium with high separation efficiency and good extraction ability.

关键词： Ce(Ⅳ) Rare earths α-aminophosphine oxide Extraction Separation

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水蜜桃主要病原真菌分离鉴定及肉桂精油对其抑制作用

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食品工业科技 2024年第13期45卷 124-131页

作者：虞铭霞韦莹莹黄铮铮陈义姜舒许凤王鸿飞邵兴锋农产品质量安全危害因子与风险防控国家重点实验室宁波大学食品科学与工程学院浙江宁波315800

本文分别在2020年、2021年连续两年采集浙江省水蜜桃产区内的腐烂水蜜桃,从果实病灶组织中分离、纯化病原真菌,通过形态特征、分子生物学(rDNA-ITS序列分析)鉴定法以及致病性检测确定病原真菌的种类,并采用体外和体内试验探究肉桂精油... 详细信息

本文分别在2020年、2021年连续两年采集浙江省水蜜桃产区内的腐烂水蜜桃,从果实病灶组织中分离、纯化病原真菌,通过形态特征、分子生物学(rDNA-ITS序列分析)鉴定法以及致病性检测确定病原真菌的种类,并采用体外和体内试验探究肉桂精油对病原真菌的抑制效果。结果表明,从两年采集的腐烂桃果实中分离纯化出两株具有较强致病性的真菌,经鉴定为美澳型核果类链核盘菌(Monilinia fructicola)和匍枝根霉(Rhizopus stolonifer),分别导致桃果实的褐腐病和软腐病。肉桂精油对M. fructicola和R. stolonifer的生长均有一定的抑制作用,最小抑菌浓度分别为0.4和0.8 mL/L,M. fructicola对肉桂精油更加敏感;肉桂精油熏蒸处理水蜜桃可以降低这两种病原菌造成的病害发生率和病斑直径,表明肉桂精油能有效地控制这两种病原真菌导致的水蜜桃果实病害。

关键词：水蜜桃病原真菌肉桂精油抑菌病害防控

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不同叶果比对设施‘红美人’杂柑秋梢叶片生理生化特征的影响

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华中农业大学学报 2024年第1期43卷 133-140页

作者：王鹏金龙飞黄贝刘烽温明霞吴韶辉徐建国浙江省农业科学院柑橘研究所台州318026 国家柑橘品种改良中心浙江分中心台州318026

为探究不同叶果比(leaffruitratio,LFR)对设施柑橘秋梢叶片生理生化特征的影响,以设施栽培‘红美人’杂柑为试材,设置高(LFR=100)、中(LFR=80)、低(LFR=60)3个叶果比,测定秋梢叶片中矿质元素、碳氮代谢物、碳氮代谢的关键酶、抗氧化酶... 详细信息

为探究不同叶果比(leaffruitratio,LFR)对设施柑橘秋梢叶片生理生化特征的影响,以设施栽培‘红美人’杂柑为试材,设置高(LFR=100)、中(LFR=80)、低(LFR=60)3个叶果比,测定秋梢叶片中矿质元素、碳氮代谢物、碳氮代谢的关键酶、抗氧化酶活性等生理指标的变化。结果显示,LFR80和LFR100秋梢叶片的磷、钾、镁、淀粉含量较高;丙二醛、脯氨酸、抗坏血酸含量较低;β-淀粉酶、硝酸还原酶、谷氨酰胺合成酶和抗坏血酸过氧化物酶的活性较高;LFR80和LFR100秋梢叶片整体养分含量充足,受胁迫程度较低。结果表明,设施栽培‘红美人’杂柑的叶果比控制在80~100有利用于平衡营养生长和生殖生长,延缓叶片衰老,维持树势强健。

关键词：柑橘设施栽培叶果比生理生化

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Representation of the coherent state for a beam splitter operator and its applications

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Communications in Theoretical Physics 2022年第3期74卷 11-19页

作者： mingxia Zhan Fang Jia Jiali huang Huan Zhang Liyun Hu Center for Quantum Science and Technology Jiangxi Normal UniversityNanchang 330022China Institute for Military-civilian integration of Jiangxi province Nanchang 330029China

A beam splitter operator is a very important linear device in the field of quantum optics and quantum information.It can not only be used to prepare complete representations of quantum mechanics,entangled state representation,but it can also be used to simulate the dissipative environment of quantum systems.In this paper,by combining the transform relation of the beam splitter operator and the technique of integration within the product of the operator,we present the coherent state representation of the operator and the corresponding normal ordering form.Based on this,we consider the applications of the coherent state representation of the beam splitter operator,such as deriving some operator identities and entangled state representation preparation with continuous-discrete variables.Furthermore,we extend our investigation to two single and two-mode cascaded beam splitter operators,giving the corresponding coherent state representation and its normal ordering form.In addition,the application of a beam splitter to prepare entangled states in quantum teleportation is further investigated,and the fidelity is discussed.The above results provide good theoretical value in the fields of quantum optics and quantum information.

关键词： beam splitter operator coherent state representation the technique of integration within product of operator quantum teleportation

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不同水分供应条件下春玉米的适宜播期

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中国生态农业学报(中英文) 2024年第7期32卷 1170-1182页

作者：李扬王靖王培娟尹红胡琦黄明霞陈仁伟中国气象科学研究院中国农业大学资源与环境学院国家气候中心

春玉米是半干旱区重要的粮食作物,但该区降水少且年际变异大,春玉米产量低而不稳。适宜播期的选择有利于作物稳产高产,但适宜播期会随水分供应条件的变化而变化。本文以半干旱区主栽春玉米品种‘郑单958’为研究对象,使用APSIM-Maize模... 详细信息

春玉米是半干旱区重要的粮食作物,但该区降水少且年际变异大,春玉米产量低而不稳。适宜播期的选择有利于作物稳产高产,但适宜播期会随水分供应条件的变化而变化。本文以半干旱区主栽春玉米品种‘郑单958’为研究对象,使用APSIM-Maize模型探究该区分期播种试验的适宜间隔以及不同水分供应条件下[雨养、灌溉60 mm、灌溉120 mm、灌溉180 mm、灌溉240 mm、潜在条件（灌溉量308 mm）]春玉米的适宜播期范围。结果表明:1)以不同供水条件下春玉米产量的5%分位为差异阈值划分播期时,该地区春玉米分期播种试验和模拟的时间步长建议设定为4 d;2)雨养条件下,干旱年、正常年和湿润年春玉米平均产量分别为0.9 t·hm-2、2.3 t·hm-2和5.5 t·hm-2,平均水分利用效率分别为0.4 kg·m-3、0.7 kg·m-3和1.5 kg·m-3,潜在条件、灌溉240 mm、灌溉180 mm、灌溉120 mm、灌溉60 mm和雨养条件下的适宜播期范围分别为5月6日—6月2日、5月6—29日、5月10—29日、5月14—29日、5月14—25日和5月14—17日,适宜播期范围随生育期供水量的增加而提前和扩大;3)潜在条件下春玉米产量的气象决定因子是生育期辐射量,灌溉240 mm和180 mm时产量的气象决定因子分别是营养生长阶段辐射量和降水量,灌溉120 mm和60 mm及雨养条件下的产量决定因子均为生育期降水量。本文探究了春玉米的适宜播期及其随生育期供水量的变化规律,研究结果可为半干旱区春玉米适水播种提供理论参考。

关键词：春玉米播种窗口适宜播期产量保证率水分利用效率灌溉降水年型

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