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Id2 epigenetically controls CD8^(+)T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

Cellular & Molecular Immunology 2024年第3期21卷 292-308页

作者： Yiming Li mingwei han Haolin Wei Wan Huang Zhinan Chen Tianjiao Zhang Meirui Qian Lin Jing Gang Nan Xiuxuan Sun Shuhui Dai Kun Wang Jianli Jiang Ping Zhu Liang Chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’anShaanxi 710032China State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases GanzhouJiangxi341000Xi’anShaanxi 710032China School of Medicine Shanghai UniversityShanghai 200444China

CD8^(+)T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6^(+)progenitor exhausted(Tex^(prog))and Tim-^(3+)terminally exhausted(Tex^(term))*** of DNA binding protein 2(Id2)has been shown to play important roles in T-cell development and CD8^(+)T-cell ***,the role of Id2 in CD8^(+)T-cell exhaustion is ***,we found that Id2 transcriptionally and epigenetically regulates the generation of Texprog cells and their conversion to Texterm *** deletion of Id2 dampens CD8^(+)T-cell-mediated immune responses and the maintenance of stem-like CD8^(+)T-cell subpopulations,suppresses PD-1 blockade and increases tumor ***,through its HLH domain,Id2 binds and disrupts the assembly of the Tcf3-Tal1 transcriptional regulatory complex,and thus modulates chromatin accessibility at the Slamf6 promoter by preventing the interaction of Tcf3 with the histone lysine demethylase ***,Id2 increases the abundance of the permissive H3K4me2 mark on the Tcf3-occupied E-boxes in the Slamf6 promoter,modulates chromatin accessibility at the Slamf6 promoter and epigenetically regulates the generation of Slamf6+Texprog *** LSD1 inhibitor GSK2879552 can rescue the Id2 knockout phenotype in tumor-bearing *** of LSD1 increases the abundance of Slamf6^(+)Tim-3^(−)Tex^(prog) cells in tumors and the expression level of Tcf1 in Id2-deleted CD8+T *** study demonstrates that Id2-mediated transcriptional and epigenetic modification drives hierarchical CD8^(+)T-cell exhaustion,and the mechanistic insights gained may have implications for therapeutic intervention with tumor immune evasion.

关键词： Id2 T-cell exhaustion Epigenetic modification Immune evasion

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多ROS移动小车同步定位构图与自主避障方法研究与实现

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现代信息科技 2024年第10期8卷 183-187,193页

作者：何瑞李继韩铭伟胡彬萨逸娜王孟瑜北方工业大学信息学院北京100144 北方工业大学伦敦布鲁内尔学院北京100144

单个ROS移动小车已无法完成多类型场景的快速同步定位与构图,为此需要多个ROS机器人的协同定位、构图与自主避障。选择了麦克纳姆轮的全向移动机器人作为单个ROS小车,开展了Gmapping、Hector、Karto和Cartographer四类同步定位与建图方... 详细信息

单个ROS移动小车已无法完成多类型场景的快速同步定位与构图,为此需要多个ROS机器人的协同定位、构图与自主避障。选择了麦克纳姆轮的全向移动机器人作为单个ROS小车,开展了Gmapping、Hector、Karto和Cartographer四类同步定位与建图方法研究和效果对比分析,完成了多个ROS小车的同步定位与构图实验,实验结果表明基于Gmapping方法精度最高,选择该方法实现定位与构图,在获得环境地图基础上设计了基于领航—跟随方法的多个ROS小车协同避障,并分别进行了有障碍物和无障碍物的自主避障实验,结果表明了自主避障策略的有效性。

关键词：同步定位与构图 ROS小车 SLAM Gmapping 自主避障

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Electron-electron interactions in monolayer graphene quantum capacitors

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Nano Research 2013年第8期6卷 619-626页

作者： Xiaolong Chen Lin Wang Wei Li Yang Wang Zefei Wu mingwei Zhang Yu han Yuheng He Ning Wang Department of Physics and the William Mong Institute of Nano Science and Technology Hong Kong University of Science andTechnology Hong Kong S.A.R. China

We demonstrate the effects of electron-electron （e-e） interactions in monolayer graphene quantum capacitors. Ultrathin yttrium oxide showed excellent per-formance as the dielectric layer in top-gate device geometry. The structure and dielectric constant of the yttrium oxide layers have been carefully studied. The inverse compressibility retrieved from the quantum capacitance agreed fairly well with the theoretical predictions for the e--e interactions in monolayer graphene at different temperatures. We found that electron-hole puddles played a significant role in the low-density carrier region in graphene. By considering the temperature-dependent charge fluctuation, we established a model to explain the round-off effect originating from the e-e interactions in monolayer graphene near the Dirac point.

关键词： graphene e-e interaction inverse compressibility quantum capacitance charge fluctuation electron-hole puddles

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Dynamic Response of Foundations during Startup of High-Frequency Tunnel Equipment

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 821-844页

作者： Dawei Ruan mingwei Hu College of Civil and Transportation Engineering Shenzhen UniversityShenzhen518060China State Key Laboratory of Intelligent Geotechnics and Tunnelling Shenzhen UniversityShenzhen518060China Key Laboratory of Coastal Urban Resilient Infrastructures of Ministry of Education Shenzhen UniversityShenzhen518060China Underground Polis Academy Shenzhen UniversityShenzhen518060China Shenzhen Key Laboratory of Green Efficient and Intelligent Construction of Underground Metro StationShenzhen UniversityShenzhen518060China

The specialized equipment utilized in long-line tunnel engineering is evolving towards large-scale,multifunctional,and complex *** vibration caused by the high-frequency units during regular operation is supported by the foundation of the units,and the magnitude of vibration and the operating frequency fluctuate in different engineering contexts,leading to variations in the dynamic response of the *** high-frequency units yield significantly diverse outcomes under different startup conditions and times,resulting in failure to meet operational requirements,influencing the normal function of the tunnel,and causing harm to the foundation structure,personnel,and property in severe *** article formulates a finite element numerical computation model for solid elements using three-dimensional elastic body theory and integrates field measurements to substantiate and ascertain the crucial parameter configurations of the finite element *** proposing a comprehensive startup timing function for high-frequency dynamic machines under different startup conditions,simulating the frequency andmagnitude variations during the startup process,and suggesting functions for changes in frequency and magnitude,a simulated startup schedule function for high-frequency machines is created through *** into account the selection of the transient dynamic analysis step length,the dynamic response results for the lower dynamic foundation during its fundamental frequency crossing process are *** validation checks if the structural magnitude surpasses the safety threshold during the critical phase of unit startup traversing the structural resonance *** design recommendations for high-frequency units’dynamic foundations are provided,taking into account the startup process of the machine and ensuring the safe operation of the tunnel.

关键词： Tunnel equipment high-frequency units startup conditions transient dynamics dynamic response foundation design

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d-Orbital steered FeN_(4)moiety through N,S dual-site adjustation for zinc-air flow battery

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Journal of Energy Chemistry 2024年第5期92卷 8-15页

作者： Chunzhu Bao mingwei Tong Xueli Li Zhonghua Xiang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

The implementation of pristine covalent organic polymer(CO_(2)P)with well-defined structure as air electrode may spark fresh vitality to rechargeable zinc-air flow batteries(ZAFBs),but it still remains challenges in synergistically regulating their electronic states and structural porosity for the great device ***,we conquer these issues by exploiting N and S co-doped graphene with COP rich in metal-ligand nitrogen to synergistically construct an effective catalyst for oxygen reduction reaction(ORR).Among them,the N and S co-doped sites with high electronegativity properties alter the number of electron occupations in the d orbital of the iron centre and form electron-transfer bridges,thereby boosting the selectivity of the ORR-catalysed four-electron ***,the introduction of COP materials aids the formation of pore interstices in the graphene lamellae,which both adequately expose the active sites and facilitate the transport of reactive *** from the synergistic effect,as-prepared catalyst exhibits excellent half-wave potentials(E_(1/2)=912 mV)and stability(merely 8.8%drop after a long-term durability test of 50000 s).Further,ZAFBs assembled with the N/SG@CO_(2)P catalyst demonstrate exceptional power density(163.8 mW cm^(-2))and continuous charge and discharge for approximately 140 h at 10 mA cm^(-2),outperforming the noble-metal benchmarks.

关键词： Nitrogen/sulfurdual sites Metal-coordinated nitrogen sites Covalent organic polymer Oxygen reduction reaction Zn-airflow battery

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A vector sum analysis method for stability evolution of expansive soil slope considering shear zone damage softening

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3746-3759页

作者： Junbiao Yan Lingwei Kong Cheng Chen mingwei Guo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Slope stability analysis is a classical mechanical problem in geotechnical engineering and engineering *** is of great significance to study the stability evolution of expansive soil slopes for engineering construction in expansive soil *** of the existing studies evaluate the slope stability by analyzing the limit equilibrium state of the slope,and the analysis method for the stability evolution considering the damage softening of the shear zone is *** this study,the large deformation shear mechanical behavior of expansive soil was investigated by ring shear *** damage softening characteristic of expansive soil in the shear zone was analyzed,and a shear damage model reflecting the damage softening behavior of expansive soil was derived based on the damage ***,by skillfully combining the vector sum method and the shear damage model,an analysis method for the stability evolution of the expansive soil slope considering the shear zone damage softening was *** results show that the shear zone subjected to large displacement shear deformation exhibits an obvious damage softening *** damage variable equation based on the logistic function can be well used to describe the shear damage characteristics of expansive soil,and the proposed shear damage model is in good agreement with the ring shear test *** vector sum method considering the damage softening behavior of the shear zone can be well applied to analyze the stability evolution characteristics of the expansive soil *** stability factor of the expansive soil slope decreases with the increase of shear displacement,showing an obvious progressive failure behavior.

关键词： Expansive soil slope Stability analysis Ring shear test Vector sum method Damage model Strain softening

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Scalable Temporal Dimension Preserved Tensor Completion for Missing Traffic Data Imputation With Orthogonal Initialization

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2188-2190页

作者： Hong Chen mingwei Lin Jiaqi Liu Zeshui Xu School of Mathematics and Statistics Fujian Normal UniversityFuzhou 350117China College of Computer and Cyber Security Fujian Normal UniversityFuzhou 350117China Business School Sichuan UniversityChengdu 610064China IEEE

Dear Editor,This letter puts forward a novel scalable temporal dimension preserved tensor completion model based on orthogonal initialization for missing traffic data(MTD)*** MTD imputation acts directly on accessing ... 详细信息

关键词： Dimension management traffic

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Synergistic effect and heterointerface engineering of cobalt/carbon nanotubes enhancing electromagnetic wave absorbing properties of silicon carbide fibers

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Nano Research 2024年第9期17卷 8479-8486页

作者： Zixiang Zhao Zheyipei Ma Zizhao Ding Yanqiong Liu mingwei Zhang Chao Jiang Institute of Powder Metallurgy Research Central South UniversityChangsha 410083China

To improve the synergistic effect between dielectric and magnetic loss is a practical and effective way in optimizing electromagnetic wave absorbing *** composites of metal particles and carbon ligands derived from metal organic frameworks have gained wide *** this study,Co particles and multiwalled carbon nanotubes(CNT)were successfully synthesized covering the surface of silicon carbide(SiC)fibers,and the morphology,interfaces and electromagnetic wave absorption performance were *** sample SiC@Co/CNT,the minimum reflection loss value can reach-70.22 dB at 11.21 GHz with the thickness of 2.12 *** effective absorbing bandwidth can reach up to 6.03 GHz with the thickness of 1.71 mm,which covers the entire Ku *** brings more interfaces between Co particles and CNTs as well as SiC fibers and Co/C *** interfacial polarization has been hugely enhanced,and the microwave absorbing properties have been *** article reports on the impedance matching of magnetic and non-magnetic components and the heterointerface engineering,which can be effective strategy and inspiration to illustrate the relationship between components,structures and functions of electromagnetic wave absorbing materials.

关键词： metal organic frameworks Co nanocrystals carbon nanotubes Schottky heterointerfaces synergistic effect

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Regulation of pseudographitic carbon domain to boost sodium energy storage

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Nano Research 2024年第6期17卷 5188-5196页

作者： Zhidong Hou mingwei Jiang Da Lei Xiang Zhang Yuyang Gao Jian-Gan Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Lab of Graphene(NPU)Xi’an 710072China

Hard carbon anode has shown extraordinary potentials for sodium-ion batteries(SIBs)owing to the cost-effectiveness and advantaged ***,the widespread application of hard carbon is still hindered by the insufficient sodium storage capacity and depressed rate property,which are mainly induced by the undesirable pseudographitic ***,we develop a molten-salt-mediated strategy to regulate the pseudographitic structure of hard carbon with suitable interlayer spacing and enlarged pseudographitic domain,which is conducive to the intercalation capacity and diffusion kinetics of sodium ***,the optimized hard carbon anode delivers a high reversible capacity of 320 mAh·g^(−1),along with superior rate property(138 mAh·g−1 at 2 A·g^(−1))and stable cyclability over 1800 ***,the in situ Raman spectroscopic study and full-cell assembly further investigate the sodium storage mechanism and practical implement of obtained hard *** work pioneers a low-cost and effective route to regulate the pseudographitic structure of hard carbon materials for advanced SIBs.

关键词： pseudographitic structure molten salt hard carbon anode sodium-ion batteries

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Dirac-geodesics with curvature term

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Science China Mathematics 2024年

作者： Qun Chen mingwei Zhang School of Mathematics and Statistics Wuhan University

Dirac-geodesics with curvature term are Dirac-harmonic maps with curvature term from onedimensional domains. In this paper, we first describe the structure of Dirac-geodesics with curvature term in surfaces and give solutions on the unit 2-sphere and the hyperbolic plane, and then we give the structure of solutions in warped product spaces. Finally, we define the heat flow of Dirac-geodesics with curvature term and prove the global existence and sub-convergence of the heat flow into any closed surfaces and space forms. Our results provide the first examples and general existence theorems of Dirac-geodesics with curvature term.

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