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Bioactive Materials 2023年第6期24卷 463-476页

作者： Pei wang Jiayingzi Wu Haiyan Yang Hengke Liu Tianyu Yao Chang Liu Yan Gong mingsong wang Guangyu Ji Peng Huang Xiansong wang Department of Thoracic Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen518060China Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai200240China

Diabetes mellitus,an epidemic with a rapidly increasing number of patients,always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization,decreased angiogenesis and increased reactive oxygen species(ROS)in the microenvironment.Herein,a poly(lactic-co-glycolic acid)(PLGA)-based microneedle patch loaded with magnesium hydride(MgH_(2))(MN-MgH_(2))is manufactured for defeating diabetic wounds.The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH_(2) that can generate hydrogen(H_(2))and magnesium ions(Mg^(2+))after reaction with body fluids.The released H_(2) reduces the production of ROS,transforming the pathological microenvironment induced by diabetes mellitus.Meanwhile,the released Mg^(2+)promotes the polarization of pro-healing M2 macrophages.Consequently,cell proliferation and migration are improved,and angiogenesis and tissue regeneration are enhanced.Such intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H_(2) and Mg^(2+)locally and sustainably.

关键词： Microneedle patch Magnesium hydride Hydrogen Magnesium ion Diabetic wound healing

Electrospun Cu-doped In_(2)O_(3) hollow nanofibers with enhanced H2S gas sensing performance

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Journal of Advanced Ceramics 2022年第3期11卷 427-442页

作者： Yu ZHANG Shuai HAN Mingyuan wang Siwei LIU Guiwu LIU Xianfeng MENG Ziwei XU mingsong wang Guanjun QIAO School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSchool of Electrical Science and EngineeringSoutheast UniversityNanjing 210096China

One-dimensional nanofibers can be transformed into hollow structures with larger specific surface area, which contributes to the enhancement of gas adsorption. We firstly fabricated Cu-doped In_(2)O_(3) (Cu-In_(2)O_(3)) hollow nanofibers by electrospinning and calcination for detecting H2S. The experimental results show that the Cu doping concentration besides the operating temperature, gas concentration, and relative humidity can greatly affect the H2S sensing performance of the In_(2)O_(3)-based sensors. In particular, the responses of 6%Cu-In_(2)O_(3) hollow nanofibers are 350.7 and 4201.5 to 50 and 100 ppm H2S at 250 ℃, which are over 20 and 140 times higher than those of pristine In_(2)O_(3) hollow nanofibers, respectively. Moreover, the corresponding sensor exhibits excellent selectivity and good reproducibility towards H2S, and the response of 6%Cu-In_(2)O_(3) is still 1.5 to 1 ppm H2S. Finally, the gas sensing mechanism of Cu-In_(2)O_(3) hollow nanofibers is thoroughly discussed, along with the assistance of first-principles calculations. Both the formation of hollow structure and Cu doping contribute to provide more active sites, and meanwhile a little CuO can form p–n heterojunctions with In_(2)O_(3) and react with H2S, resulting in significant improvement of gas sensing performance. The Cu-In_(2)O_(3) hollow nanofibers can be tailored for practical application to selectively detect H2S at lower concentrations.

关键词： electrospinning Cu-doped In_(2)O_(3) hollow nanofibers H2S detection

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Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4783-4815页

作者： Haoran Ji Chuang Hu Xuhui Yang Yuanhao Liu Guangyu Ji Shengfang Ge Xiansong wang mingsong wang Department of Thoracic Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 20o011China Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

dissemination to distant sites through a series of mechanisms,and it has been proved that lymph node metastasis(LNM)is an essential prognostic indicator in many different types of cancer.

关键词： metastasis cancer. Lymph

Spin-orbit-locked hyperbolic polariton vortices carrying reconfigurable topological charges

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eLight 2022年第1期2卷 143-153页

作者： mingsong wang Guangwei Hu Saroj Chand Michele Cotrufo Yohannes Abate Kenji Watanabe Takashi Taniguchi Gabriele Grosso Cheng‑Wei Qiu Andrea Alù Photonics Initiative Advanced Science Research CenterCity University of New YorkNew York CityNY 10031USA Department of Electrical and Computer Engineering National University of SingaporeSingapore 116083Singapore Department of Physics and Astronomy The University of GeorgiaAthensGA 30602USA Research Center for Functional Materials National Institute for Materials ScienceTsukubaIbaraki 305‑0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukubaIbaraki 305‑0044Japan Physics Program Graduate CenterCity University of New YorkNew YorkNY 10016USA

The topological features of optical vortices have been opening opportunities for free-space and on-chip photonic technologies,e.g.,for multiplexed optical communications and robust information transport.In a parallel but disjoint effort,polar anisotropic van der Waals nanomaterials supporting hyperbolic phonon polaritons(HP2s)have been leveraged to drastically boost light-matter interactions.So far HP2 studies have been mainly focusing on the control of their amplitude and scale features.Here we report the generation and observation of mid-infrared hyperbolic polariton vortices(HP2Vs)associated with reconfigurable topological charges.Spiral-shaped gold disks coated with a flake of hexagonal boron nitride are exploited to tailor spin-orbit interactions and realise deeply subwavelength HP2Vs.The complex interplay between excitation spin,spiral geometry and HP2 dispersion enables robust reconfigurability of the associated topological charges.Our results reveal unique opportunities to extend the application of HP2s into topological photonics,quantum information processing by integrating these phenomena with single-photon emitters,robust on-chip optical applications,sensing and nanoparticle manipulation.

关键词： Hyperbolic polariton vortex Light-matter interactions Spin-orbit interaction Topological charge Reconfigurability

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多频COTDR系统的相位解调优化方法

光学学报 2024年第1期44卷 325-332页

作者：谢浪吴明松王粤晖杨子逸饶云江吴宇电子科技大学信息与通信工程学院光纤传感与通信教育部重点实验室四川成都611731

提出一种基于多频优化分集(MFOD)算法的相位解调技术,搭建了环移多频相干光时域反射(MF-COTDR)系统,实验探究了MFOD算法对信号解调性能的提升效果。结果表明,MFOD算法不仅能够较好地还原相位信息,相较于传统的相位解调算法有超过9 dB的... 详细信息

提出一种基于多频优化分集(MFOD)算法的相位解调技术,搭建了环移多频相干光时域反射(MF-COTDR)系统,实验探究了MFOD算法对信号解调性能的提升效果。结果表明,MFOD算法不仅能够较好地还原相位信息,相较于传统的相位解调算法有超过9 dB的平均信噪比(SNR)提升,实现了33.3 pε/Hz1/2的最小应变分辨率。此外,通过实验验证了基于MFOD算法的MF-COTDR系统对不同频率振动信号的响应性能,实验结果说明该系统具有良好的线性响应能力。

关键词：光纤光学分布式光纤传感相位敏感光时域反射仪相位解调

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多螺旋输送机在煤化工卸煤装置中的应用

山东化工 2024年第11期53卷 181-184页

作者：黄明松王正上海智英化工技术有限公司杭州分公司浙江杭州311215

在煤化工装置中,设置于储煤场地坑内的卸煤装置普遍存在运行稳定性差、密封性能不好以及所需地坑深度较大的问题,导致建设成本高,生产环境差。为解决以上问题,根据煤的物料特性,对多螺旋输送机进行了选型设计计算,将其作为卸煤设备,应... 详细信息

在煤化工装置中,设置于储煤场地坑内的卸煤装置普遍存在运行稳定性差、密封性能不好以及所需地坑深度较大的问题,导致建设成本高,生产环境差。为解决以上问题,根据煤的物料特性,对多螺旋输送机进行了选型设计计算,将其作为卸煤设备,应用于储煤场卸煤装置中,有效降低了卸煤装置安装高度,提高了卸煤装置的运行稳定性,并减少了煤粉的泄露。对降低卸煤装置的生产建设成本、改善工作人员生产作业环境作用显著。

关键词：煤化工储煤场地下煤坑卸煤设备多螺旋输送机

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基于碳承载力对河南省能源消费碳排放及其驱动因素的研究

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土壤 2024年第2期56卷 439-447页

作者：陶勤王世航徐胜祥杨震赵明松王奇邓良安徽理工大学空间信息与测绘工程学院安徽淮南232001 中国科学院南京土壤研究所南京210008 安徽省地质测绘技术院合肥230022

基于河南省近20年的能源消费碳排放数据和陆地生态系统碳承载力数据,对近年来研究区碳排放量情况进行了分析,并采用LMDI因素分解模型和Tapio脱钩模型对碳排放驱动因素以及与经济耦合情况进行了探讨。结果表明:(1)2000—2020年,河南省碳... 详细信息

基于河南省近20年的能源消费碳排放数据和陆地生态系统碳承载力数据,对近年来研究区碳排放量情况进行了分析,并采用LMDI因素分解模型和Tapio脱钩模型对碳排放驱动因素以及与经济耦合情况进行了探讨。结果表明:(1)2000—2020年,河南省碳排放量呈现“先急后缓”的增长状态,在2012年后增加量开始减少并逐渐趋于稳定。(2)整体上,经济产出效应和人口规模效应对碳排放起促进作用;与之相反,能源消费强度效应和能源消费结构效应抑制了碳排放,经济产出效应的影响在减少,能源消费强度效应的影响在增加。(3)由Tapio脱钩模型分析得出,河南省碳排放与经济增长之间以弱脱钩为主,脱钩指数逐年减小,逐步向强脱钩状态迈进。总体上,2000—2020年河南省碳排放情况得到了很好的控制,合理规划土地利用、提高新能源的消费比重、降低能源消费强度对该地区节能减排具有重要意义。

关键词：能源消费碳排放 LMDI因素分解模型 Tapio脱钩模型

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The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1984-1992页

作者： Lihui Li Wenjuan Zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang Yunjing Zhang Wenlian Chen Changsheng Dong Yanmei Zhang mingsong wang Wenyi Wei Lijun Jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Laboratory Medicine Huadong HospitalAffiliated to Fudan UniversityShanghaiChina Xinhua Hospital Shanghai Jiaotong UniversityShanghaiChina Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell migration.However,the regulatory mechanism of TNFAIP1 degradation remains largely elusive.In the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)complex.More importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and degradation.Mechanistically,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in cells.As such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this effect.Finally,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of patients.Taken together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration.

关键词： TNFAIP1 CRL complex

Rethinking Data Center Networks:Machine Learning Enables Network Intelligence

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Journal of Communications and Information Networks 2022年第2期7卷 157-169页

作者： Bo Li Ting wang Peng Yang mingsong Chen Mounir Hamdi Shanghai Key Laboratory of Trustworthy Computing the Engineering Research Center of Soft-ware/Hardware Co-design Technology and Applicationthe Ministry of EducationEast China Normal UniversityShanghai 200062China College of Science and Engineering Hamad Bin Khalifa UniversityDoha 999043Qatar

To support the needs of ever-growing cloudbased services,the number of servers and network devices in data centers is increasing exponentially,which in turn results in high complexities and difficulties in network optimization.Machine learning(ML)provides an effective way to deal with these challenges by enabling network intelligence.To this end,numerous creative ML-based approaches have been put forward in recent years.Nevertheless,the intelligent optimization of data center networks(DCN)still faces enormous challenges.To the best of our knowledge,there is a lack of systematic and original investigations with in-depth analysis on intelligent DCN.To this end,in this paper,we investigate the application of ML to DCN optimization and provide a general overview and in-depth analysis of the recent works,covering flow prediction,flow classification,and resource management.Moreover,we also give unique insights into the technology evolution of the fusion of DCN and ML,together with some challenges and future research opportunities.

关键词： data center network intelligent optimiza-tion machine learning network intelligence

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兼吸式移动床生物质热解炭化装置设计与试验

农业机械学报 2024年第6期55卷 325-331,364页

作者：宋威孟海波陈明松王泽阳葛芸妤武继宁丛宏斌青岛农业大学机电工程学院青岛266109 农业农村部规划设计研究院农业农村部农业废弃物能源化利用重点实验室北京100125

针对目前内热式移动床生物质热解炭化试验研究平台条件不足的问题,开发了一种内加热兼吸式移动床热解炭化装置,模拟连续式热解炭化工艺,设计了供气系统、出炭系统、产物收集系统、气体净化系统、温度监控系统,以稻壳作为原料,开展了上... 详细信息

针对目前内热式移动床生物质热解炭化试验研究平台条件不足的问题,开发了一种内加热兼吸式移动床热解炭化装置,模拟连续式热解炭化工艺,设计了供气系统、出炭系统、产物收集系统、气体净化系统、温度监控系统,以稻壳作为原料,开展了上吸和下吸式热解炭化试验,研究了停留时间和吸气方式对内热式热解炭化产物的影响。结果表明,随着停留时间的增加,上吸和下吸内热式热解炭化变化趋势基本相同,挥发分和固定碳含量均呈下降趋势,灰分含量增加,磷及氮元素含量均下降,氧元素含量上升,氢元素变化趋势不明显,热值分别从20.7MJ/kg和22MJ/kg下降到14.6MJ/kg和15.2MJ/kg;比表面积分别从0.73m^(2)/g和0.78m^(2)/g上升到3.84m^(2)/g和3.95m^(2)/g,生物炭孔隙结构得到了发展。该系统结构合理,运行稳定可靠,密封效果良好,可有效控制进气方式、进气量、保温炭化时间等试验因素。为内加热炭化工艺参数试验研究提供了重要支撑。

关键词：生物质热解炭化上下兼吸

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