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Association of interpregnancy interval and risk of adverse pregnancy outcomes in woman by different previous gestational ages

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Chinese Medical Journal 2024年第1期137卷 87-96页

作者： Peiran Chen Yi Mu Zheng liu Yanping Wang Xiaohong li li Dai Qi li mingrong li Yanxia Xie Juan liang Jun Zhu National Office for Maternal and Child Health Surveillance of China West China Second University HospitalSichuan UniversityChengduSichuan 610066China Department of Obstetrics West China Second University HospitalSichuan UniversityChengduSichuan 610066China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengduSichuan 610066China

Background:With an increasing proportion of multiparas,proper interpregnancy intervals(IPIs)are urgently ***,the association between IPIs and adverse perinatal outcomes has always been *** study aimed to explore the association between IPIs and adverse outcomes in different fertility policy periods and for different previous gestational ***:We used individual data from China’s National Maternal Near Miss Surveillance System between 2014 and *** Poisson models with restricted cubic splines were *** adverse outcome was analyzed separately in the overall model and stratified *** stratified models included different categories of fertility policy periods(2014-2015,2016-2017,and 2018-2019)and infant gestational age in previous pregnancy(livery[VD]and 1.10[1.03,1.19]for cesarean section[CS]),low Apgar scores and small for gestational age(SGA),and a decreased risk of diabetes mellitus in pregnancy,preeclampsia or eclampsia,and gestational hypertension.A long IPI(≥60 months)was associated with an increased risk of preterm birth(OR[95%CI]:1.18[1.11,1.26]for VD and 1.39[1.32,1.47]for CS),placenta previa,postpartum hemorrhage,diabetes mellitus in pregnancy,preeclampsia or eclampsia,and gestational *** policy changes had little effect on the association of IPIs and adverse maternal and neonatal *** estimated risk of preterm birth,low Apgar scores,SGA,diabetes mellitus in pregnancy,and gestational hypertension was more profound among women with previous term births than among those with preterm births or pregnancy ***:For pregnant women with shorter or longer IPIs,more targeted health care measures during pregnancy should be formulated according to infant gestational age in

关键词： Interpregnancy interval Fertility policy Gestational age Preterm birth Gestational hypertension Diabetes mellitus in pregnancy

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高原地区医学科普图书的创作思考和实践

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卫生职业教育 2024年第15期42卷 18-22页

作者：李明蓉马亚伟乐文月王颖雅安职业技术学院四川雅安625000 四川工商职业技术学院四川都江堰611830

在健康中国和乡村振兴战略背景下,通过分析高原地区医学科普图书创作必要性和当前医学科普图书不足的情况,结合创作实践从目标受众的特点、人文关怀的实现、科普创作体式、科普图示、科普语篇的实现方式等方面阐释高原地区医学科普图书... 详细信息

在健康中国和乡村振兴战略背景下,通过分析高原地区医学科普图书创作必要性和当前医学科普图书不足的情况,结合创作实践从目标受众的特点、人文关怀的实现、科普创作体式、科普图示、科普语篇的实现方式等方面阐释高原地区医学科普图书的创作要点。科普医学急救知识的同时讲述中国基层医生的故事,让群众了解医务工作者,促进医患关系和谐,助推乡村振兴,促进民族融合。

关键词：高原地区医学科普图书创作要点

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Temporal Trends of Maternal Mortality Due to Obstetric Hemorrhage in Chinese Mainland: Evidence from the Population-Based Surveillance Data Between 2000 and 2019

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Maternal-Fetal Medicine 2022年第3期4卷 169-178页

作者： Yi Mu Jun Zhu Yanping Wang Jiani Zhang mingrong li Peiran Chen Yanxia Xie Juan liang Xiaodong Wang National Office for Maternal and Child Health Surveillance of China West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China.

Objective:To analyze the temporal trends of maternal mortality ratio(MMR)due to obstetric hemorrhage and its specific causes in Chinese mainland from 2000 to 2019,to identify whether the rate of change has accelerated or slowed down during this period,and to find the prior cause of obstetric hemorrhage that needs to be intervened in the ***:Individual information on maternal deaths and total number of live births from 336 surveillance sites across 31 provinces in Chinese mainland was collected from the National Maternal and Child Health Surveillance System between 2000 and *** death was defined according to the World Health Organization’s *** final underlying cause of death was confirmed by the national review and was coded according to International Classification of *** trends for changes in characteristics of maternal deaths were assessed using linear or logistic models with the year treated as a continuous *** MMR and 95%confidence intervals(CI)for regions or causes were estimated by Poisson’s *** regression was used to assess the accurate temporal ***:The national MMR due to obstetric hemorrhage was 18.4 per 100,000 live births(95%CI:15.0–22.2)in *** peaked in 2001(22.1 per 100,000 live births,95%CI:18.3–26.4)and was lowest in 2019(1.6 per 100,000 live births,95%CI:1.0–2.3).For specific regions,the MMR due to obstetric hemorrhage in rural areas and western regions both experienced a slight rise,followed by a rapid decline,and then a slow *** specific causes,no change point was found in joinpoint analysis of the national MMR caused by placenta previa,postpartum uterine atony,and retained placenta(the annual percent change was12.0%,10.5%,and21.0%,respectively).The MMR caused by postpartum hemorrhages(PPH)significantly declined by 8.0%(95%CI:1.9–13.6)per year from 2000 to *** annual percent change of MMR caused by PPH accelerated further to25.0%between 2007

关键词： Maternal mortality Obstetric haemorrhage Temporal trend Annual percent change China

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Biotin-modified Galactosylated Chitosan-gene Carrier in Hepatoma Cells Targeting Delivery

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 522-531页

作者：程明荣张锋李清王华 Department of General Surgery Nanxiang Branch of Ruijin HospitalShanghai 201802China Minhang District Pujin Community Health Service Center Shanghai 201112China Hepatobiliary Surgery Center Tongji Hospital Affiliated to Tongji UniversityShanghai 200065China

Our previous studies have successfully grafted biotin and galactose onto chitosan(CS)and synthesized biotin modified galactosylated chitosan(Bio-GC).The optimum N/P ratio of Bio-GC and plasmid DNA was 3:*** this N/P ratio,the transfection efficiency in the hepatoma cells was the highest with a slow release ***-GC nanomaterials exhibit the protective effect of preventing the gene from nuclease degradation,and can target the transfection into hepatoma cells by combination with galactose and biotin *** transfection rate was inhibited by the competition of galactose and ***-GC nanomaterials were imported into cells’cytoplasm by their receptors,followed by the imported exogenous gene transfected into the ***-GC nanomaterials can also cause inhibitory activity in the hepatoma cells in the model of orthotopic liver transplantation in mice,by carrying the gene through the blood to the hepatoma *** together,bio-GC nanomaterials act as gene vectors with the activity of protecting the gene from DNase degradation,improving the rate of transfection in hepatoma cells,and transporting the gene into the cytoplasm in vitro and in ***,they are efficient hepatoma-targeting gene carriers.

关键词： gene vector hepatocellular carcinoma nanoparticles sustained release gene therapy

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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(life Sciences) 2024年第8期67卷 1697-1714页

作者： Huan Wu Yanman Zhang Yuqian li Shuya Sun Jintao Zhang Qingsong Xie Yue Dong Shushu Zhou Xuan Sha Kuokuo li Jinyi Chen Xin Zhang Yang Gao Qunshan Shen Guanxiong Wang Xiaomin Zha Zongliu Duan Dongdong Tang Chuan Xu Hao Geng mingrong Lv Yuping Xu Ping Zhou Zhaolian Wei Rong Hua Yunxia Cao Mingxi liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and Genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke

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论企业原材料采购过程中的质量控制

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中国市场 2008年第10期 128-129页

作者：李明荣桂林航天工业高等专科学校工商管理系

采购优质的生产原材料是企业生产高质量产品的前提和基础。本文从原材料实行分类管理,分类评价、选择合格的供应商,加强入库前的验收控制,严格仓储管理等方面,讨论了企业采购原材料过程中如何进行质量控制的方法。

关键词：原材料采购过程质量控制

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Chinese expert consensus on diagnosis and treatment of anal intraepithelial neoplasia

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Gynecology and Obstetrics Clinical Medicine 2024年第1期4卷 3-10页

作者： Yanyun li Hongwei Zhang Qing Cong Mingzhu li Hui Bi Yun Zhao Zhixue You Qi Zhou li Geng mingrong Qie Fanghui Zhao linhong Wang Beihua Kong Ding Ma Long Sui lihui Wei Hospital and Institute of Obstetrics and Gynecology Fudan UniversityShanghaiChina Department of Obstetrics and Gynecology Peking University People's HospitalBeijingChina Department of Obstetrics and Gynecology Peking University First HospitalBejingChina Department of Obstetrics and Gynecology Jiangsu Province People's Hospital and Nanjing Medical University First Affiliated HospitalNanjingJiangsuChina Chongqing University Cancer Hospital ChongqingChina Department of Obstetrics and Gynecology Peking University Third HospitalBeijingChina Sichuan University West China Second University Hospital ChengduSichuanChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Obstetrics and Gynecology Qilu Hospital of Shandong UniversityJinanShandongChina Department of Obstetrics and Gynecology Tongji HospitalTongji Medical Cllege of HUSTWuhanChina

Anal high-grade squamous intraepithelial lesion(HSIL)refers to the precancerous lesions of anal squamous cell carcinoma(ASCC).Anal cancer is often asymptomatic in its early stage.

关键词： diagnosis squamous intraepithelial

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采用STAMP-24Model的多组织事故分析

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安全与环境学报 2024年第7期24卷 2741-2750页

作者：曾明荣秦永莹刘小航栗婧尚长岭中国安全生产科学研究院北京100012 中国矿业大学(北京)应急管理与安全工程学院北京100083 国家粮食和物资储备局储备安全和应急物资保障中心北京100834

安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事... 详细信息

安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。

关键词：安全工程系统理论事故建模与过程模型(STAMP) 24Model 多组织事故原因分析

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面向自动驾驶的多模态信息融合动态目标识别

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重庆大学学报 2024年第4期47卷 139-156页

作者：张明容喻皓吕辉姜立标李利平卢磊广东轻工职业技术学院汽车技术学院广州510000 广汽埃安新能源汽车股份有限公司研发中心广州511400 华南理工大学机械与汽车工程学院广州510641 广州城市理工学院工程研究院广州510800

研究提出一种面向自动驾驶的多模态信息融合的目标识别方法,旨在解决自动驾驶环境下车辆和行人检测问题。该方法首先对ResNet50网络进行改进,引入基于空间注意力机制和混合空洞卷积,通过选择核卷积替换部分卷积层,使网络能够根据特征尺... 详细信息

研究提出一种面向自动驾驶的多模态信息融合的目标识别方法,旨在解决自动驾驶环境下车辆和行人检测问题。该方法首先对ResNet50网络进行改进,引入基于空间注意力机制和混合空洞卷积,通过选择核卷积替换部分卷积层,使网络能够根据特征尺寸动态调整感受野的大小;然后,卷积层中使用锯齿状混合空洞卷积,捕获多尺度上下文信息,提高网络特征提取能力。改用GIoU损失函数替代YOLOv3中的定位损失函数,GIoU损失函数在实际应用中具有较好操作性;最后,提出了基于数据融合的人车目标分类识别算法,有效提高目标检测的准确率。实验结果表明,该方法与OFTNet、VoxelNet和FasterRCNN网络相比,在mAP指标白天提升幅度最高可达0.05,晚上可达0.09,收敛效果好。

关键词：自动驾驶 ResNet50 YOLOv3 数据融合注意力机制损失函数

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泥鳅幼鱼配合饲料中蛋白质、脂肪、糖类及纤维素的适宜含量研究

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饲料工业 2017年第10期38卷 15-20页

作者：杨明容李达曹岩江西生物科技职业学院江西南昌330200

采用四因素三水平L_9(3~4)正交试验设计,制成蛋白质含量为25%、30%、35%,脂肪含量为4%、8%、12%,糖含量20%、25%、30%,纤维素含量1.6%~2.0%、2.0%~2.4%、2.4%~2.8%的9种泥鳅幼鱼配合饲料,进行为期38 d的饲养试验,以探讨初始体重为(1.23... 详细信息

采用四因素三水平L_9(3~4)正交试验设计,制成蛋白质含量为25%、30%、35%,脂肪含量为4%、8%、12%,糖含量20%、25%、30%,纤维素含量1.6%~2.0%、2.0%~2.4%、2.4%~2.8%的9种泥鳅幼鱼配合饲料,进行为期38 d的饲养试验,以探讨初始体重为(1.23±0.09)g的泥鳅幼鱼配合饲料中蛋白质、脂肪、糖、纤维素的适宜含量。结果表明,各营养素对泥鳅幼鱼增重率、特定生长率、蛋白质效率的影响顺序为:蛋白质>脂肪>纤维素>糖;当配合饲料中粗蛋白质为35%,脂肪为8%,糖为25%~30%,粗纤维为1.6%~2.0%时,泥鳅幼鱼的WGR、SGR最大,PER最高,FCR最小,CF各组间无显著差异(P>0.05)。通过综合分析,在本试验条件下,蛋白质为主要营养素(P0.05),泥鳅幼鱼配合饲料中蛋白质、脂肪、糖和纤维素的适宜含量分别为35%、8%、25%~30%、1.6%~2.0%。

关键词：泥鳅配合饲料蛋白质脂肪糖纤维素需求量

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