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Efficacy of suspended moxibustion in stroke rats is associated with a change in tail temperature

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Neural Regeneration Research 2013年第12期8卷 1132-1138页

作者： Rixin chen Zhimai Lv Dangdang Huang mingren chen Fan Yi Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine The First Affiliated Hospital of Gannan Medical University Gannan Medical University Department of Health of Jiangxi Province

Suspended moxibustion-produced heat can transfer from the acupoint to other sites of the body. The suspended moxibustion should be terminated when clinical propagated sensation disappears, because this implies that the quantity of moxibustion is sufficient. We wanted to investigate if this phenomenon also occurs in experimental animals. In the present study, a rat model of stroke was established and treated with suspended moxibustion at Dazhui （DU14）for 60 minutes. Results showed that the increase in tail temperature began at 15 minutes after suspended moxibustion and decreased gradually at 40 minutes. In addition, neurological function was significantly improved in stroke rats with tail temperature increase following suspended moxibustion, and this effect was associated with significantly reduced tumor necrosis factor a and interleukin 113 mRNA. However, there was no significant difference between 40- and 60-minute suspended moxibustion. The findings indicate that elevated tail temperature began to decrease at 40 minutes after suspended moxibustion, and further suspended moxibustion was not useful in the recovery of stroke rats.

关键词： neural regeneration traditional Chinese medicine acupuncture and moxibustion suspendedmoxibustion stroke tail temperature tumor necrosis factor-alpha interleukin-1 beta grants-supported paper neuroregeneration

Neuronal apoptosis and inflammatory reaction in rat models of focal cerebral ischemia following 40-minute suspended moxibustion

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Neural Regeneration Research 2011年第15期6卷 1180-1184页

作者： Rixin chen Zhimai Lv mingren chen Xin An Dingyi Xie Jing Yi Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine Nanchang 330006 Jiangxi Province China The First Affiliated Hospital of Gannan Medical University Ganzhou 341000 Jiangxi Province China

The treatment duration of heat-sensitive moxibustion（approximately 40 minutes on average） is longer than that of traditional suspended *** present study investigated expression changes of three inflammatory and apoptosis-associated proteins（inducible nitric oxide synthase,cyclooxygenase-2 and caspase-3） in transient middle cerebral artery occlusion model rats following suspended moxibustion for 40 minutes,to explore the mechanisms underlying neuroprotective action of suspended *** results indicated that suspended moxibustion at acupoint Dazhui（DU 14） for 40 minutes reduced the cortical expression of caspase-3,cyclooxygenase-2 and inducible nitric oxide synthase proteins of transient middle cerebral artery occlusion model rats,as well as decreasing infarct volume and ameliorating the neurological deficit *** with 40 minutes of moxibustion were superior to the outcomes after suspended moxibustion for 15 minutes.

关键词： moxibustion cerebral ischemia caspase-3 cyclooxygenase-2 inducible nitric oxide synthase neural regeneration

Image formation of brain function in patients suffering from knee osteoarthritis treated with moxibustion

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Journal of Traditional Chinese Medicine 2013年第2期33卷 181-186页

作者： Hongwu Xie Fangming Xu Rixin chen Tianyou Luo mingren chen Weidong Fang Fajin Lü Fei Wu Yune Song Jun Xiong Department of Recovery with Acupuncture Hospital Affiliated to Jiangxi College of Traditional Chinese MedicineNanchang 330006China College of Traditional Chinese Medicine Chongqing Medical University Department of Radiology the First Hospital Affiliated to Chongqing Medical University

OBJECTIVES:Functional magnetic resonance imaging(fMRI) technology was used to study changes to the resting state blood flow in the brains of patients with knee osteoarthritis(KOA) before and after treatment with moxibustion at the acupoint of the left Dubi(ST 35) and to probe the cerebral mechanism underlying the effect of ***:The resting state brain function of 30 patients with left KOA was scanned with fMRI before and after treatment with *** analytic methods of fractional amplitude of low frequency fluctuation(fALFF) and regional homogeneity(ReHo) were used to observe changes in resting state brain ***:The fALFF values of the right cerebrum,extra-nucleus,left cerebellum,left cerebrum and white matter of patients after moxibustion treatment were higher than before treatment,and the fALFF values of the precentral gyrus,frontal lobe and occipital lobe were lower than before treatment(P<0.05,K≥85).The ReHo values of the thalamus,extra-nucleus and parietal lobe of patients were much higher than those before moxibustion treatment,and the ReHo values of the right cerebrum,left cerebrum and frontal lobe were lower than before treatment(P<0.05,K≥85).CONCLUSION:The influence of moxibustion on obvious changes in brain regions basically conforms to the way that pain and warmth is transmitted in the body,and the activation of sensitive systems in the body may be objective evidence of channel *** regulation of brain function by moxibustion is not in a single brain region but rather in a network of many brain regions.

关键词： Moxibustion Osteoarthritis, knee Mag-netic resonance imaging Fractional amplitude oflow frequency fluctuation Regional homogeneity

Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial

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Journal of Traditional Chinese Medicine 2013年第5期33卷 584-591页

作者： Rixin chen mingren chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song Department of Acupuncture and Rehabilitation Hospital Affiliated to Jiangxi University of Traditional Chi-nese Medicine Department of Rehabilitation Guangdong Hos-pital of Combination of Traditional Chinese Medicine with Western Medicine Department of Pneumology Guangdong Hos-pital of Traditional Chinese Medicine Department of Acupuncture First Hospital of Wuhan Institute of Acupuncture and Massage Guang-zhou University of Traditional Chinese Medicine Department of Pneumology First Hospital Affili-ated to Nanchang University Department of Rehabilitation First Hospi-tal Affiliated to Chongqing Medical University Department of Acupuncture First Hospital Af-filiated to Zhejiang University of Traditional Chinese Medi-cine Department of Acupuncture Suzhou Hospital of TCM Department of Acupuncture Hospital Affiliated to Shandong University of Traditional Chinese Medicine Department of Acupuncture Guangdong Dis-abled Soldier Hospital Department of Acupuncture Nanchang Hospital of combination of Traditional Chinese Medicine with Western Medicine

OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern ***:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of *** followed up3 and 6 months after ***:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up *** addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up ***:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma.

关键词： Moxibustion Asthma Randomized controlled trial Heat sensitive Seretide

Anti-inflammatory Effect of Heat-sensitive Moxibustion via the NF-κB Signaling Pathway on Cerebral Ischemia/Reperfusion Injury in Rats

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Journal of Advances in Medicine Science 2018年第3期1卷 67-79页

作者： Aijiao Xiaoa Yisheng Xiaoa Xin OuYang Lin He mingren chen College of Basic Medical Science Jiangxi University of Traditional Chinese Medicine Nanchang Jiangxi 330004 China College of Moxibustion Jiangxi University of Traditional Chinese Medicine Nanchang Jiangxi 330004 China

Ischemic stroke is universally acknowledged as a common cause of long-term disability or even death. Suspended moxibustion, an indirect form of moxibustion, is when moxibustion is placed superficially over the skin without being in contact with it. Some researchers have used this method to treat stroke patients, but strong evidence of its therapeutic effectiveness is lacking. However, the effect of traditional suspended moxibustion has recently been improved with the development of heat-sensitive suspended moxibustion. Our previous studies showed that moxibustion for 35 min provided a more effective treatment strategy than moxibustion for 15 min, and moxibustion by 35 min with tail temperature increase had a better outcome than that without, however, the mechanism underlying the effect is not clear. In this study, we treated the stroke rats with moxibustion by 35min and divided them into non-heat sensitive moxibustion(NHSM) group and heat sensitive moxibustion (HSM) group according to difference in the tail temperature increase, then we compared the effect and investigated the mechanisms between NHSM and HSM. We found that HSM significantly decreased tail-flick latency, increased neurological function score, decreased infarct volume, reduced inflammatory cells, decreased the expression of inflammatory factor ICAM-1 and reduced the expression of NF-κB p65 and p-IKKα/β in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings revealed that HSM exerted its anti-inflammatory and neuroprotective effects from MCAO-induced injury by decreasing the expression of the NF-κB signaling pathway.

关键词： Auspended Moxibustion Heat-sensitive moxibustion Middle cerebral artery occlusion Cerebral ischemia/reperfusion injury Tail temperature Tail-flick latency Infarct volume Inflammatory cells CD11b ICAM-1 NF-κB p65 p-IKKα/β Traditional Chinese Medicine

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金融机构集聚过程的动态博弈分析

会计与经济研究 2014年第5期28卷 103-112页

作者：陈铭仁上海立信会计学院金融学院上海201620

在理性行为人收益最大化原则条件下得出了行为人空间博弈的结果——在均衡状态,限制性条件(如运输技术等)能够产生一个收敛的空间区位调整过程,最终实现空间集聚。在这个博弈集聚的过程中,外部因素存在发生作用的空间,从而说明了政策制... 详细信息

在理性行为人收益最大化原则条件下得出了行为人空间博弈的结果——在均衡状态,限制性条件(如运输技术等)能够产生一个收敛的空间区位调整过程,最终实现空间集聚。在这个博弈集聚的过程中,外部因素存在发生作用的空间,从而说明了政策制定者可以通过制定相关的政策来影响金融机构的集聚过程,进而促进金融市场的深化发展和金融中心的形成。这一空间集聚过程也可用于分析城镇化的形成和发展过程。

关键词：空间博弈收敛过程金融机构集聚

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长蛇灸治疗类风湿关节炎:随机对照研究

中国针灸 2016年第7期36卷 694-698页

作者：张伟陈明人胡锦玉江西中医药大学附属医院针灸科南昌330006

目的：观察长蛇灸、温针灸和西药治疗类风湿关节炎的临床疗效差异并探讨其作用机制。方法：将120例患者随机分为长蛇灸组、温针灸组及西药组,每组40例。长蛇灸组予长蛇灸疗法,于大椎至腰俞穴的督脉处行药物隔姜铺灸,每月治疗1次,治疗2个... 详细信息

目的：观察长蛇灸、温针灸和西药治疗类风湿关节炎的临床疗效差异并探讨其作用机制。方法：将120例患者随机分为长蛇灸组、温针灸组及西药组,每组40例。长蛇灸组予长蛇灸疗法,于大椎至腰俞穴的督脉处行药物隔姜铺灸,每月治疗1次,治疗2个月;温针灸组穴取大椎、肝俞、脾俞、肾俞、至阳、命门、腰阳关为主,每次取4~5穴行温针灸,每穴灸3壮,隔日治疗1次,治疗2个月;西药组口服甲氨蝶呤,每次10mg,顿服,每周1次,若关节压痛度评分或关节肿胀度评分达6分,加用双氯芬酸钠,每次25mg,每日3次,共服用2个月。观察3组患者治疗前后症状评分、体征评分、疼痛视觉模拟评分（VAS）,及血清类风湿因子（RF）、血沉（ESR）、C反应蛋白（CRP）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）含量等变化。结果：3组皆可显著改善类风湿关节炎患者的症状、体征、VAS评分以及血清RF、ESR、CRP、IgM、IgG的含量（均P〈0.01）,且长蛇灸组疗效显著优于温针灸组及西药组（P〈0.05,P〈0.01）。结论：长蛇灸疗法治疗类风湿关节炎临床疗效显著,其疗效优于温针灸及西药甲氨蝶呤,可以更好地降低免疫应答,减轻疾病程度。

关键词：类风湿关节炎长蛇灸温针灸甲氨蝶呤随机对照试验

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广电主干网光缆线路健康状态评估研究

广播与电视技术 2022年第11期49卷 92-95页

作者：陈铭人浙江广联有线电视传输中心浙江310061

为了实现广电主干网光缆线路的运维分析监测,做好事前排障、事中即时维护、事后重点监管的安全保障准备,本文基于三角模糊数与层次分析法的基本理论,结合省网相关系统数据、现场实际情况,进行三重权重演算、劣化度演算,并结合专家评估数... 详细信息

为了实现广电主干网光缆线路的运维分析监测,做好事前排障、事中即时维护、事后重点监管的安全保障准备,本文基于三角模糊数与层次分析法的基本理论,结合省网相关系统数据、现场实际情况,进行三重权重演算、劣化度演算,并结合专家评估数,对全省广电主干网光缆线路健康状态进行了多层次评估。

关键词：光缆线路健康分析层次分析法三重权重演算专家评估数

凤尾草合番石榴叶治疗湿热型急性腹泻56例疗效观察

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新中医 2014年第6期46卷 75-77页

作者：陈明仁阳春市中医院广东阳春529600

目的:观察鲜品凤尾草合番石榴叶治疗湿热型急性腹泻的临床疗效。方法:将106例湿热型急性腹泻患者随机分为2组各53例,治疗组给予鲜品凤尾草合番石榴叶煎剂治疗,对照组给予补液盐及思密达治疗。疗程均为3天。结果:总有效率治疗组为92.45%... 详细信息

目的:观察鲜品凤尾草合番石榴叶治疗湿热型急性腹泻的临床疗效。方法:将106例湿热型急性腹泻患者随机分为2组各53例,治疗组给予鲜品凤尾草合番石榴叶煎剂治疗,对照组给予补液盐及思密达治疗。疗程均为3天。结果:总有效率治疗组为92.45%,对照组为64.15%,2组比较,差异有显著性意义(P<0.05)。治疗后2组症状积分均较治疗前明显下降(P<0.05);2组治疗后症状积分差值比较,治疗组大于对照组,差异有显著性意义(P<0.05)。治疗期间2组均未出现明显不良反应。结论:凤尾草合番石榴叶鲜品对急性湿热型腹泻有良好的治疗作用,值得临床推广应用。

关键词：急性腹泻湿热型鲜药凤尾草番石榴叶