检索结果-南通市图书馆

Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV

Infectious Microbes & Diseases 2024年第2期6卷 85-92页

作者： Jingying Pan Xiaodi Zhang Danrong Shi Xuebin Tian Lijun Xu Xiangyun Lu mingqing dong Peng Yao Zhaoyi Pan Nanping Wu Hangping Yao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infectious Disease Zhejiang Qingchun HospitalZhejiang UniversityHangzhouChina Jinan Microecological Biomedicine Shandong Laboratory JinanChina

Both HIV infection and antiretroviral therapy(ART)affect the oral *** successful treatment with ART in people living with HIV(PLWH),which leads to a significant decline in viral loads and immune reconstitution,is associated with changes in or recovery of the oral microbiome remains ***,we performed a cross-sectional study of 118 PLWH receiving regular ART and 40 healthy controls(HCs).Among the 118 PLWH,18 immunological nonresponders(INRs;<200 CD4^(+)T cells/μL)and 30 immunological responders(IRs;≥500 CD4^(+)T cells/μL)were *** oral microbiota composition of all participants was analyzed using 16S rRNA gene sequencing of throat swab *** abundance of bacterial genera was compared between IRs and INRs,and Pearson correlations between bacterial abundance and peripheral blood immune cell counts were *** INR group showed lower alpha diversity than the IR and HC groups,which displayed similar alpha *** genera Alloprevotella,Prevotella and Neisseria were more abundant in PLWH than in HCs,whereas the genera Rothia,Streptococcus and Fusobacterium were more abundant in HCs than in *** genus Rothia was more abundant in the INR group,whereas Prevotella,Alloprevotella,Porphyromonas and Haemophilus were more abundant in the IR *** genera Rothia and Alloprevotella were negatively and positively associated with CD4^(+)T cell counts,***,an increased abundance of Rothia in the oral microbiome is associated with unfavorable outcomes regarding immune reconstitution in PLWH receiving regular ART,whereas Prevotella,Alloprevotella,Porphyromonas and Haemophilus are associated with favorable outcomes.

关键词： HIV oral microbiome antiretroviral therapy immunological nonresponders immunological responders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tanshinone IIA attenuates hypoxic pulmonary arterial hypertension via modulating KV channels

Tanshinone IIA attenuates hypoxic pulmonary arterial hyperte...

引用

中国微循环学会2014年全国学术会议

作者： Manling Liu Min Wei Yi Liu mingqing dong Wansong Zheng Ying Luo Pengtao Zhao Haiying dong Wen Niu Dunquan Xu Zhiqiang Yan Zhichao Li Department of Pathology and Pathophysiology Fourth Military Medical University Lung Injury and Repair Center Fourth Military Medical University Department of Information Tangdu HospitalFourth Military Medical University Department of Neurosurgery Tangdu HospitalFourth Military Medical University

The voltage-gated K+（KV）channels play an essential role in the etiology of chronic hypoxic pulmonary arterial hypertension（CH-PAH）.Tanshinone IIA（TIIA）,a major active component of Salvia miltiorrhiza Bunge（***）,has many biological protective *** the present study,we investigated whether KV channels were responsible for the protective effect of TIIA on *** acute hypoxia experiments,the effects of TIIA（10-5 M）or 4-aminopyridine（4-AP,1mM）on intrapulmonary artery（IPA）rings isolated from healthy rats were *** then the IKV currents of pulmonary artery smooth muscle cells（PASMCs）isolated from healthy rats were determined in the absence or presence of TIIA（5ug/ml or 25ug/ml）or 4-AP（1mM）.In chronic hypoxia experiments,rats were challenged by intermittent hypoxia exposure for 4 weeks with or without TIIA（10 mg/kg）***,the hemodynamic data and the pathomorphological changes of pulmonary arteries were ***2.1 and Kv1.5 in pulmonary arteries were tested by Western blotting and RT-PCR,*** were detached from chronic hypoxia exposure rats to evaluate the IKV *** showed that TIIA markedly attenuated acute hypoxia-induced IPA rings vasoconstriction and recovered the down-regulation of IKV currents in ***,TIIA significantly restrained chronic hypoxia-induced the right ventricular systolic pressures（RVSP）and right ventricle（RV）hypertrophy,inhibited pulmonary artery wall remodeling,accompanied with modulating the expression of Kv2.1 and Kv1.5,and reversing the down-regulation of IKV *** is thus an attractive potential therapy for CH-PAH.

关键词： Tanshinone IIA(TIIA) chronic hypoxic pulmonary arterial hypertension(CH-PAH) hypoxic pulmonary vasoconstriction(HPV) pulmonary vascular remodelling(PVR) the voltage-gated potassium ion(KV) channels

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

引用

Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

矢车菊素-3-O-葡萄糖苷(C3G)通过靶向TOPK抑制结直肠癌细胞的增殖

引用

细胞与分子免疫学杂志 2019年第12期35卷 1101-1108页

作者：王丽刘锋瑞刘亚娟高红艳董明清西安医学院第一附属医院急诊科陕西西安710077 西安北车医院内科陕西西安710086 空军军医大学基础医学院陕西西安710032

目的研究矢车菊素-3-O-葡萄糖苷(C3G)对结直肠癌增殖的影响及机制。方法采用体外结合及体外激酶实验检测C3G与T细胞淋巴因子活化杀伤细胞来源的蛋白激酶(TOPK)的结合能力及对其活性的影响;采用软琼脂试验检测C3G对结肠癌细胞克隆形成能... 详细信息

目的研究矢车菊素-3-O-葡萄糖苷(C3G)对结直肠癌增殖的影响及机制。方法采用体外结合及体外激酶实验检测C3G与T细胞淋巴因子活化杀伤细胞来源的蛋白激酶(TOPK)的结合能力及对其活性的影响;采用软琼脂试验检测C3G对结肠癌细胞克隆形成能力的影响;采用MTS法测定C3G的细胞毒性;采用大肠杆菌BL21表达GST-组蛋白H3融合蛋白;采用慢病毒感染的方法,检测C3G对沉默TOPK的结肠癌细胞克隆形成能力的影响;Western blot法检测HCT116细胞中C3G对TOPK下游分子组蛋白H3的磷酸化的水平;建立结肠癌患者癌组织异种移植小鼠模型,免疫组织化学染色法检测组蛋白H3的磷酸化水平。结果C3G在体外直接与TOPK结合并抑制TOPK活性;C3G以浓度依赖的方式抑制结肠癌细胞的增殖及克隆形成;沉默TOPK降低结肠癌细胞对C3G的敏感性;C3G以时间和浓度依赖的方式抑制TOPK下游分子组蛋白H3的磷酸化水平;另外,C3G抑制患者来源的结肠癌组织异种移植瘤小鼠体内肿瘤的生长。结论C3G通过靶向TOPK抑制结直肠癌的生长。

关键词：矢车菊素-3-O-葡萄糖苷(C3G) T细胞淋巴因子活化杀伤细胞来源的蛋白激酶(TOPK) 结直肠癌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

引用

Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan dong Wenzheng An Zihu Wang dongzhi Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

miR-144和lncRNA DNAJC3-AS1在乳腺癌组织中的表达及其在在乳腺癌细胞MCF-7化疗耐药中的作用

引用

中国肿瘤生物治疗杂志 2020年第2期27卷 177-183页

作者：景文江郭翠萍马军陈嘉琦马武董明清西安交通大学医学部附属三二〇一医院肿瘤科陕西汉中723000 汕头大学附属肿瘤医院乳腺中心广东汕头515063 空军军医大学基础医学院细胞生物学系陕西西安710032

目的:探讨miR-144及长链非编码RNA (long non-coding RNA, lncRNA)DNAJC3-AS1在乳腺癌(breat cancer, BC)组织中的表达及其对BC MCF-7细胞化疗耐药的影响。方法:选取2012年1月至2016年12月于三二〇一医院肿瘤内科收治的196例BC患者的肿... 详细信息

目的:探讨miR-144及长链非编码RNA (long non-coding RNA, lncRNA)DNAJC3-AS1在乳腺癌(breat cancer, BC)组织中的表达及其对BC MCF-7细胞化疗耐药的影响。方法:选取2012年1月至2016年12月于三二〇一医院肿瘤内科收治的196例BC患者的肿瘤组织及其配对癌旁组织,采用q PCR法检测DNAJC3-AS1、DNAJC3及miR-144在BC组织中的相对表达量,分析其对患者生存期的影响;荧光素酶报告基因实验验证DNAJC3-AS1与miR-144的靶向结合关系;将DNAJC3-AS1过表达质粒及miR-144 mimics转染MCF-7细胞,采用q PCR验证转染效果。CCK-8实验检测过表达DNAJC3-AS1及过表达miR-144对MCF-7细胞增殖及顺铂敏感性的影响。结果:DNAJC3-AS1及其宿主基因DNAJC3在BC组织中均呈高表达(均P<0.01),且两者表达水平呈正相关(r=0.451,P<0.01),并且高表达DNAJC3-AS1和DNAJC3的患者生存期较短(均P<0.01);miR-144在BC组织中呈低表达(P<0.01),且与DNAJC3-AS1呈负相关(r=–0.524,P<0.01)。转染后细胞中DNAJC3-AS1过表达平均倍数为13.47倍(P<0.01),miR-144过表达平均倍数为20.27倍(P<0.01);生物信息学分析和荧光素酶报告实验证实DNAJC3-AS1能够与miR-144靶向结合。成功构建过表达DNAJC3-AS1和miR-14的MCF-7细胞,与对照组相比,DNAJC3-AS1过表达组细胞增殖能力显著增强(P<0.01)、对顺铂的敏感性显著降低(P<0.01),而miR-144过表达组细胞对顺铂的敏感性显著增加(P<0.01)。结论:miR-144和lncRNADNAJC3-AS1在BC组织中均高表达,miR-144可通过靶向DNAJC3-AS1从而提高BC MCF-7细胞对顺铂的敏感性。

关键词：乳腺癌化疗耐药长链非编码RNA DNAJC3-AS1 miR-144

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

全科医学专业病理生理学教学中的问题及对策

引用

中华医学教育探索杂志 2014年第6期13卷 576-579页

作者：罗颖赵澎涛董明清第四军医大学基础部病理学与病理生理学教研室西安710032

全科医学专业是针对全科医生的培养需求设立的新专业，如何做好全科医学专业学生医学专业课教学工作是教学改革中的新课题。病理生理学是医学基础和临床联系的桥梁课，也是培养医学生临床思维能力的必修课。根据军医大学全科医学专业学... 详细信息

全科医学专业是针对全科医生的培养需求设立的新专业，如何做好全科医学专业学生医学专业课教学工作是教学改革中的新课题。病理生理学是医学基础和临床联系的桥梁课，也是培养医学生临床思维能力的必修课。根据军医大学全科医学专业学生文化课基础知识差、学生来源、毕业后参加定向分配等特点，在病理生理学教学中采取“调整授课内容、突出课程重点”“灵活选择教学方法、加强师生互动”“发挥网络多媒体教学优势，开设专题病例讨论”等方法，取得较好教学效果。但如何调整病理生理学教学内容使其更适合全科医学生的培养目标，如何合理设置各门医学专业基础课的顺序等，仍是以后需进一步探索的问题。

关键词：病理生理学全科医学教学课程设计全科军医

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Hybrid Approach for Pavement Crack Detection Using Mask R-CNN and Vision Transformer Model

引用

Computers, Materials & Continua 2025年第1期82卷 561-577页

作者： Shorouq Alshawabkeh Li Wu Daojun dong Yao Cheng Liping Li Faculty of Engineering China University of GeosciencesWuhan430074China

Detecting pavement cracks is critical for road safety and infrastructure *** methods,relying on manual inspection and basic image processing,are time-consuming and prone to *** deep-learning(DL)methods automate crack detection,but many still struggle with variable crack patterns and environmental *** study aims to address these limitations by introducing the Masker Transformer,a novel hybrid deep learning model that integrates the precise localization capabilities of Mask Region-based Convolutional Neural Network(Mask R-CNN)with the global contextual awareness of Vision Transformer(ViT).The research focuses on leveraging the strengths of both architectures to enhance segmentation accuracy and adaptability across different pavement *** evaluated the performance of theMaskerTransformer against other state-of-theartmodels such asU-Net,TransformerU-Net(TransUNet),U-NetTransformer(UNETr),SwinU-NetTransformer(Swin-UNETr),You Only Look Once version 8(YoloV8),and Mask R-CNN using two benchmark datasets:Crack500 and *** findings reveal that the MaskerTransformer significantly outperforms the existing models,achieving the highest Dice SimilarityCoefficient(DSC),precision,recall,and F1-Score across both ***,the model attained a DSC of 80.04%on Crack500 and 91.37%on DeepCrack,demonstrating superior segmentation accuracy and *** high precision and recall rates further substantiate its effectiveness in real-world applications,suggesting that the Masker Transformer can serve as a robust tool for automated pavement crack detection,potentially replacing more traditional methods.

关键词： Pavement crack segmentation transportation deep learning vision transformer Mask R-CNN image segmentation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：