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有机无机复合锂离子电池固态电解质专利分析

储能科学与技术 2024年第3期13卷 1096-1105页

作者：孙明明国家知识产权局专利局专利审查协作天津中心天津300304

随着新能源汽车产业的飞速发展,传统液态电解质已经不能满足市场需求,固态电解质因其安全和能量密度优势已经成为未来发展的理想方向。然而由于无机电解质界面性能差和聚合物电解质材料离子电导率低的固有缺陷,严重阻碍了其实际应用,兼... 详细信息

随着新能源汽车产业的飞速发展,传统液态电解质已经不能满足市场需求,固态电解质因其安全和能量密度优势已经成为未来发展的理想方向。然而由于无机电解质界面性能差和聚合物电解质材料离子电导率低的固有缺陷,严重阻碍了其实际应用,兼具无机电解质离子电导率高、力学性能好以及有机电解质柔韧性好且不与锂金属反应的复合体系固态电解质已经成为当前研究热点。为了解有机无机复合锂离子电池固态电解质发展态势,本文基于智慧芽Patsnap专利数据库检索结果,总结了全球及中国专利申请数量变化趋势和法律状态,对比了专利主要来源国和主要申请人情况,梳理了技术手段和技术效果之间的关系,重点从有机、无机、添加剂等材料组成,物理共混、三维、多层等复合方式以及特定制备工艺三个维度总结分析了专利技术发展情况。研究发现,我国在有机无机复合锂离子电池固态电解质专利布局方面具有数量优势,但目前申请人较为分散,且技术保护更多限于材料本身,建议加强合作交流,以及对上下游产业的整体技术保护,技术发展方向方面,高无机相用量的三维复合体系具有更佳的综合性能,但从产业化角度,聚合物填充无机颗粒体系可能发展得更快。

关键词：锂离子电池有机无机复合固态电解质专利

Selectively reductive amination of levulinic acid with aryl amines to N-substituted aryl pyrroles

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Green Energy & Environment 2023年第2期8卷 438-443页

作者： Cailing Wu Mengjie Lou mingming sun Huiyong Wang Zhiyong Li Jikuan Qiu Jianji Wang Zhimin Liu Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals School of Chemistry and Chemical EngineeringKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Normal UniversityXinxiangHenan453000China Beijing National Laboratory for Molecular Sciences Key Laboratory of ColloidInterface and ThermodynamicsCAS ResearchInstitute of ChemistryChinese Academy of SciencesBeijing100190China

Synthesizing nitrogen(N)-containing molecules from biomass derivatives is a new strategy for production of this kind of chemicals.Herein,for the first time we present the synthesis of N-substituted aryl pyrroles via reductive amination/cyclization of levulinic acid(LA)with primary aromatic amines and hydrosilanes(e.g.,PMHS)over Cs F,and a series of N-substituted aryl pyrroles could be obtained in good to excellent yields at 120○C.The mechanism investigation indicates that the reaction proceeds in two steps:the cyclization between amine and LA occurs first to form intermediate 5-methyl-N-alkyl-1,3-dihydro-2H-pyrrolones and their isomeride(B),and then the chemo-and region-selective reduction of intermediates take place to produce the final products.This approach for synthesis of N-substituted aryl pyrroles can be performed under mild and green conditions,which may have promising applications.

关键词： Biomass Levulinic acid Reductive amination Pyrrole

Solution-processed all-inorganic lead halide perovskite/layered double hydroxides superlattices

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Science China Chemistry 2024年

作者： Deyu Li mingming Zhang Lulu Wei Shubing Tian Mingze sun Kang Liu Jixiang Xu Lei Wang Jun Xing Key Laboratory of Eco-chemical Engineering Ministry of Education College of Chemistry and Molecular Engineering Qingdao University of Science & Technology College of Sino-German Science and Technology Qingdao University of Science & Technology

Quantum wells and superlattices are key building blocks in the semiconductor industry, normally fabricated using epitaxial growth techniques, such as vapor phase epitaxy, metalorganic chemical vapor deposition and molecular beam epitaxy. However,these complicated preparation processes, as well as their high cost, limit their extensive applications. It is essential to develop a simple solution process for building superstructures. Here, we demonstrate an ion exchange strategy for synthesizing an allinorganic superlattice cesium lead bromide/layered double hydroxides(CsPbBr3/LDH) in solution. At room temperature, the perovskite ions diffuse into the interlayer of LDH and assemble into layered perovskite with various thicknesses. Compared with traditional organic-inorganic hybrid perovskite superlattice, the all-inorganic perovskite superlattice CsPbBr3/LDH has weak quantum confinement, which exhibits narrow emission line-widths of 20 nm, high quantum yields of 55%, and radiative lifetimes of several ns. Our findings offer a new route to synthesize novel perovskite superlattices and enrich the perovskite supercrystal platform for electronics, photonics and optoelectronics devices.

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Efficacy and safety of monoclonal antibodies in neuromyelitis optica spectrum disorders:A survival meta-analysis of randomized controlled trials

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 8-16页

作者： Xintong Xu Lindan Xie Lili Wei Meixuan Li Hao Wang Huanfen Zhou mingming sun Mo Yang Quangang Xu Kehu Yang Shihui Wei Medical School of Chinese PLA BeijingChina Department of Ophthalmology Chinese PLA General HospitalBeijingChina Evidence-Based Medicine Center Lanzhou UniversityLanzhouChina Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province LanzhouChina Gansu Medical Guideline Technology Center Lanzhou UniversityLanzhouChina Department of Ophthalmology Lanzhou University Second HospitalLanzhouChina

Background Monoclonal antibodies such as rituximab(RTX),eculizumab,inebilizumab,satralizumab,and tocilizumab have been found to be effective therapies for neuromyelitis optica spectrum disease(NMOSD)in several clinical randomized controlled trials.Objective The purpose of this meta-analysis of randomized controlled trials was to assess the efficacy and safety of monoclonal antibodies in the treatment of NMOSD.Methods We searched the following databases for relevant English language literature from the establishment of the database to June 2021:PubMed,Embase,Cohorane Library,the Central Register of Controlled Trials(CENTRAL),and Web of Science.Randomized controlled trials of monoclonal antibodies were the targets of the review.Results We included seven trials containing 775 patients(485 in the monoclonal antibody group and 290 in the control group).Patients in the monoclonal group(HR 0.24,95%CI:0.14 to 0.40,P<0.00001),as well as patients with seropositive AQP4-IgG(HR 0.18,95%CI:0.11 to 0.29,P<0.00001),both had a higher free recurrence rate than that in the control group.In the first year(HR 0.25,95%CI:0.09 to 0.71,P=0.009)and the second year(HR 0.32,95%CI:0.13 to 0.81,P=0.02),no relapses were documented.The average changes of the expanded disability status scale(EDSS)score decreased by 0.29(95%CI:−0.09 to 0.51,P=0.005).Upper respiratory tract infection(OR 1.52,95%CI:0.76 to 3.04,P=0.24),urinary tract infection(OR 0.79,95%CI:0.51 to 1.21,P=0.27),and headache(OR 1.30,95%CI:0.78 to 2.17,P=0.31)were three most frequent adverse reactions.Conclusions Monoclonal antibodies are particularly effective treatments in avoiding recurrence for NMOSD patients,according to this meta-analysis.The associated adverse responses are not significantly different from those seen with traditional immunosuppressants.

关键词： NMOSD Randomized controlled trials Monoclonal antibody Meta-analysis Free-relapse Adverse events

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中国式现代化建设中农民价值观的迭代跃升

西北农林科技大学学报（社会科学版） 2024年第3期24卷 39-48页

作者：吴春梅孙明明华中农业大学马克思主义学院武汉430070

中国农民价值观的迭代跃升,遵循新中国成立后的价值同质建构向改革开放后社会主义制度下的多元价值衍生、再向新时代多元基础上的价值共识诉求的转变趋势,并呈现出主体观向主体意识、利益观向公私协力、文明观向团体文明、生态观向尊重... 详细信息

中国农民价值观的迭代跃升,遵循新中国成立后的价值同质建构向改革开放后社会主义制度下的多元价值衍生、再向新时代多元基础上的价值共识诉求的转变趋势,并呈现出主体观向主体意识、利益观向公私协力、文明观向团体文明、生态观向尊重自然、道德观向现代情理的演化形态。以中国式现代化的五个基本特征为遵循,农民价值观迭代跃升的时代诉求聚焦于农民的主体观、利益观、文明观、生态观、道德观分别向自主自强、共赢共富、平等包容、和谐共生、向上向善的价值方向整体跃升。现阶段要从创新问题瞄准机制、遵循“指导-引领-人本”贯通原则、顺应“传承-借鉴-淬炼”递进理路、强化“政府-组织-农民”联动保障入手,进行系统整体推进,以实现全方位的价值跃升目标。

关键词：农民价值观迭代跃升中国式现代化建设核心价值观

基于多目标决策的矿山采石场边坡生态修复设计参数优选

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安全与环境工程 2024年第1期31卷 282-290页

作者：卢明明黄在智孙侃中交和美环境生态建设有限公司湖北武汉430030

为合理确定矿山采石场边坡生态修复设计参数,基于多目标决策的理念,首次提出一套适用于矿山采石场边坡生态修复设计参数优化的技术方案,并以广西某废弃石灰岩矿山采石场高陡岩质边坡生态修复治理工程设计为例开展实例研究,提出以削坡坡... 详细信息

为合理确定矿山采石场边坡生态修复设计参数,基于多目标决策的理念,首次提出一套适用于矿山采石场边坡生态修复设计参数优化的技术方案,并以广西某废弃石灰岩矿山采石场高陡岩质边坡生态修复治理工程设计为例开展实例研究,提出以削坡坡度、坡高和平台宽度为决策变量,建立地质安全性-生态修复效益-工程总成本多目标决策模型,利用灰色关联分析评价模型对方案进行选优,得到该边坡生态修复治理工程的最优削坡设计参数组合。结果表明:本边坡削坡设计参数的最优组合是坡度为75°、坡高为6m、平台宽度为3.5m。研究结果可为类似边坡工程的生态修复设计优化提供重要参考,具有一定的实际应用价值。

关键词：矿山采石场边坡生态修复优化设计多目标决策地形重塑

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锂离子电池固态电解质的专利分析

河南科技 2024年第9期51卷 127-133页

作者：孙明明国家知识产权局专利局专利审查协作天津中心天津300304

【目的】随着新能源汽车产业的快速发展,传统的锂离子电池液态电解液已不能满足市场需求。固态电解质能有效解决锂离子电池的安全问题,是目前新能源领域的研究重点,可以为相关企业的专利战略布局提供技术指引。【方法】以PatSnap(智慧芽... 详细信息

【目的】随着新能源汽车产业的快速发展,传统的锂离子电池液态电解液已不能满足市场需求。固态电解质能有效解决锂离子电池的安全问题,是目前新能源领域的研究重点,可以为相关企业的专利战略布局提供技术指引。【方法】以PatSnap(智慧芽)专利检索系统收录的锂离子电池固态电解质相关专利作为数据源,对专利申请发展趋势、法律状态、专利申请人进行可视化分析,并从材料、结构、工艺、专利引用次数等多个维度总结无机、聚合物、有机无机复合固态电解质的技术发展情况。【结果】无机固态电解质和有机无机复合固态电解质具有良好的应用前景,国外企业已经在无机固态电解质方向做了大量专利布局;我国有机无机复合固态电解质领域的专利布局还较少,企业的相关专利布局还较为分散。【结论】加强有机无机复合固态电解质方向的专利布局,确保电解质上下游产业全过程受到知识产权保护,同时深化产学研合作。

关键词：锂离子电池固态电解质无机有机专利分析

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PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism

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Acta Pharmaceutica Sinica B 2023年第1期13卷 157-173页

作者： mingming sun Leilei Li Yujia Niu Yingzhi Wang Qi Yan Fei Xie Yaya Qiao Jiaqi Song Huanran sun Zhen Li Sizhen Lai Hongkai Chang Han Zhang Jiyan Wang Chenxin Yang Huifang Zhao Junzhen Tan Yanping Li Shuangping Liu Bin Lu Min Liu Guangyao Kong Yujun Zhao Chunze Zhang Shu-Hai Lin Cheng Luo Shuai Zhang Changliang Shan State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Biomedical Translational Research Institute Jinan UniversityGuangzhou 510632China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen 361102China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pathology and Institute of Precision Medicine Jining Medical UniversityJining 272067China Department of Pathology Medical SchoolDalian UniversityDalian 116622China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesHengyang Medical SchoolUniversity of South ChinaHengyang 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China Institute of Biomedical Sciences Shandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Colorectal Surgery Tianjin Union Medical Center Nankai UniversityTianjin 300121China

Metabolic reprogramming is a hallmark of cancer,including lung cancer.However,the exact underlying mechanism and therapeutic potential are largely unknown.Here we report that protein arginine methyltransferase 6(PRMT6)is highly expressed in lung cancer and is required for cell metabolism,tumorigenicity,and cisplatin response of lung cancer.PRMT6 regulated the oxidative pentose phosphate pathway(PPP)flux and glycolysis pathway in human lung cancer by increasing the activity of 6-phosphogluconate dehydrogenase(6PGD)and a-enolase(ENO1).Furthermore,PRMT6 methylated R324 of 6PGD to enhancing its activity;while methylation at R9 and R372 of ENO1 promotes formation of active ENO1 dimers and 2-phosphoglycerate(2-PG)binding to ENO1,respectively.Lastly,targeting PRMT6 blocked the oxidative PPP flux,glycolysis pathway,and tumor growth,as well as enhanced the antitumor effects of cisplatin in lung cancer.Together,this study demonstrates that PRMT6 acts as a posttranslational modification(PTM)regulator of glucose metabolism,which leads to the pathogenesis of lung cancer.It was proven that the PRMT6-6PGD/ENO1 regulatory axis is an important determinant of carcinogenesis and may become a promising cancer therapeutic strategy.

关键词： Lung cancer Metabolic reprogramming Post-translational modification PRMT6 Pentose phosphate pathway flux Glycolysis 6-Phospho-gluconate dehydrogenase a-enolase ENO1

Author correction to‘Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy’[Acta Pharmaceutica Sinica B 11(2021)3508-3526]

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Acta Pharmaceutica Sinica B 2023年第2期13卷 897-898页

作者： Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi mingming sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren Department of Emergency Shanghai Tenth People's HospitalSchool of Medicine Tongji UniversityShanghai 200072China Shanghai University School of Medicine Shanghai 200044China University of Wyoming College of Health Sciences LaramieWY 82071USA Department of Cardiovascular Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510000China Medprime Health Services LLC ParisTX 75460USA Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan Hospital Fudan UniversityShanghai 200032China Department of Cardiology Affiliated Hospital of Nantong UniversityNantong 226001China Cardiovascular Research Centre University of AlbertaEdmontonAlberta T6G 2S2Canada Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationDepartment of Endocrinology and MetabolismZhongshan Hospital Fudan UniversityShanghai 200032China Department of Laboratory Medicine and Pathology University of WashingtonSeattleWA 98195USA

The authors of the above-mentioned paper noticed an error in Fig.5a as reported.H&E staining was shown in wrong color during figure processing and DKO-LF group was accidently copied and pasted twice.Original H&E images have been replaced with the correct color with the accurate grouping information.No text content in figure legend or conclusion is affected by this error.The authors sincerely apologize for any inconvenience caused to the journal and readers.

关键词： correction journal mentioned