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Gallium-based liquid metal micro/nanoparticles for photothermal cancer therapy

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Journal of Materials Science & Technology 2023年第11期142卷 22-33页

作者： mingming Fu Yifeng shen Hao Zhou Xiaojia Liu Wenjun Chen Xing Ma School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China shenzhen Bay Laboratory Shenzhen 518055China

Gallium-based liquid metals have attracted significant interest in the biomedical field due to their unique properties such as low viscosity,good fluidity,high thermal/electrical conductivity,and good biocompatibility.Meanwhile,photothermal therapy has made great development in the field of antitumor with its advantages of low adverse effects,high specificity,and repeatable treatment.The photothermal capability possessed by gallium-based liquid metals makes them show unparalleled advantages in photothermal therapy.Liquid metal-based photothermal therapy has progressed in recent years and can perform a vital role in accurate and noninvasive antitumor therapy.Herein,a review of the major preparation methods of liquid metal micro/nanoparticles,the mechanism of liquid metal photothermal conversion,and discussions on the factors affecting the photothermal properties of liquid metals are presented.The biological applications of liquid metal photothermal therapy in synergy with other therapies are discussed,as well as the current challenges and opportunities for the clinical translation of liquid metals in biomedical applications.

关键词： Gallium-based materials Photothermal conversion principle Photothermal therapy Synergistic therapy

Dietary dihydroartemisinin supplementation alleviates intestinal inflammatory injury through TLR4/NOD/NF-kB signaling pathway in weaned piglets with intrauterine growth retardation

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Animal Nutrition 2021年第3期7卷 667-678页

作者： Yu Niu Yongwei Zhao Jintian He Yang Yun Mingming Shen Zhending Gan Lili Zhang Tian Wang College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

The aim of present study was to evaluate whether diets supplemented with dihydroartemisinin(DHA)could alleviate intestinal inflammatory injury in weaned piglets with intrauterine growth retardation(IUGR).Twelve normal birth weight(NBW)piglets and 12 piglets with IUGR were fed a basal diet(NBW-CON and IUCR-CON groups),and another 12 piglets with IUGR were fed the basal diet supplemented with DHA at 80 mg/kg(IUGR-DHA group)from 21 to 49 d of age.At 49 d of age,8 piglets with similar body weight in each group were sacrificed.The jejunal and ileal samples were collected for further analysis.The results showed that IUGR impaired intestinal morphology,increased intestinal inflamma-tory response,raised enterocyte apoptosis and reduced enterocyte proliferation and activated trans-membrane toll-like receptor 4(TLR4)/nucleotide-binding and oligomerization domain(NOD)/nuclear factor-kB(NF-kB)signaling pathway.Dihydroartemisinin inclusion ameliorated intestinal morphology,indicated by increased villus height,villus height-to-crypt depth ratio,villus surface area and decreased villus width of piglets with IUGR(P<0.05).Compared with NBW piglets,IUGR piglets supplemented with DHA exhibited higher apoptosis index and caspase-3 expression,and lower proliferation index and proliferating cell nuclear antigen expression in the intestine(P<0.05).Dihydroartemisinin supple-mentation attenuated the intestinal inflammation of piglets with IUGR,indicated by increased concen-trations of intestinal inflammatory cytokines and lipopolysaccharides(P<0.05).In addition,DHA supplementation down-regulated the related mRNA expressions of TLR4/NOD/NF-kB signaling pathway and upregulated mRNA expressions of negative regulators of TLR4 and NOD signaling pathway in the intestine of piglets with IUGR(P<0.05).Piglets in the IUGR-DHA group showed lower protein ex-pressions of TLR4,phosphorylated NF-kB(pNF-kB)inhibitorα,nuclear pNF-kB,and higher protein expression of cytoplasmic pNF-kB in the intestine than those in the IUGR-CON group(P<0.05).In conclusion

关键词： Intrauterine growth retardation Piglet Dihydroartemisinin Intestine injury Inflammation Morphology

A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis

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Nano Research 2023年第1期16卷 757-770页

作者： mingming Wang Jiaxin Yao Shihong shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology Co. Ltd.Xi’an 710069China Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Modern PhysicsNorthwest UniversityXi’an 710127China

The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone reconstruction.It is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect reconstruction.Here,a novel organic/inorganic composite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like collagen(HLC),and ZnWH nanoparticles.The scaffold had excellent mechanical properties,adjustable swelling ratio,and interconnected pore structure.In addition to its excellent biocompatibility,it could promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles could also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in hBMSCs.At the same time,the scaffold could inhibit the proliferation of bacteria.After 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone reconstruction.Therefore,these results demonstrate that the prepared novel nanocomposite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration.

关键词： bone repair nanocomposite scaffold zinc-whitlockite osteogenesis angiogenesis

Comparison between sepsis-induced coagulopathy and sepsis-associated coagulopathy criteria in identifying sepsis-associated disseminated intravascular coagulation

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World Journal of Emergency Medicine 2024年第3期15卷 190-196页

作者： Huixin Zhao Yiming Dong Sijia Wang Jiayuan shen Zhenju Song mingming Xue Mian Shao Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND:Disseminated intravascular coagulation(DIC)is associated with increased mortality in sepsis patients.In this study,we aimed to assess the clinical ability of sepsis-induced coagulopathy(SIC)and sepsis-associated coagulopathy(SAC)criteria in identifying overt-DIC and preDIC status in sepsis patients.METHODS:Data from 419 sepsis patients were retrospectively collected from July 2018 to December 2022.The performances of the SIC and SAC were assessed to identify overt-DIC on days 1,3,7,or 14.The SIC status or SIC score on day 1,the SAC status or SAC score on day 1,and the sum of the SIC or SAC scores on days 1 and 3 were compared in terms of their ability to identify pre-DIC.The SIC or SAC status on day 1 was evaluated as a pre-DIC indicator for anticoagulant initiation.RESULTS:On day 1,the incidences of coagulopathy according to overt-DIC,SIC and SAC criteria were 11.7%,22.0%and 31.5%,respectively.The specificity of SIC for identifying overt-DIC was significantly higher than that of the SAC criteria from day 1 to day 14(P3 had a significantly higher sensitivity(72.00%)and area under the curve(AUC)(0.69)in identifying pre-DIC than did the SIC or SAC status(sensitivity:SIC status 44.00%,SAC status 52.00%;AUC:SIC status 0.62,SAC status 0.61).The sum of the SIC scores on days 1 and 3 had a higher AUC value for identifying the pre-DIC state than that of SAC(0.79 vs.0.69,P<0.001).Favorable effects of anticoagulant therapy were observed in SIC(adjusted hazard ratio[HR]=0.216,95%confidence interval[95%CI]:0.060–0.783,P=0.018)and SAC(adjusted HR=0.146,95%CI:0.041–0.513,P=0.003).CONCLUSION:The SIC and SAC seem to be valuable for predicting overt-DIC.The sum of SIC scores on days 1 and 3 has the potential to help identify pre-DIC.

关键词： Sepsis Disseminated intravascular coagulation Sepsis-induced coagulopathy Sepsis-associated coagulopathy

数字化同群效应如何影响企业创新投入——一个有调节的中介模型

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科技进步与对策 2023年第12期40卷 23-31页

作者：滕明明申明浩广东外语外贸大学经济贸易学院广东外语外贸大学粤港澳大湾区研究院广东广州510006

数字经济时代,数字化转型能够赋能企业高质量发展。梳理数字化同群效应对企业创新投入的影响机制,以2007-2021年中国A股上市公司面板数据为样本进行实证检验,结果发现:数字化同群效应能够显著提升企业创新投入,并通过加剧行业竞争实现;... 详细信息

数字经济时代,数字化转型能够赋能企业高质量发展。梳理数字化同群效应对企业创新投入的影响机制,以2007-2021年中国A股上市公司面板数据为样本进行实证检验,结果发现:数字化同群效应能够显著提升企业创新投入,并通过加剧行业竞争实现;企业管理者能力抑制数字化同群效应对相关企业创新投入的正向效应,而融资约束会放大数字化同群效应对企业创新投入的正向影响。

关键词：数字化创新投入行业竞争管理者能力同群效应

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中国古典小说的园林书写与女性空间

同济大学学报（社会科学版） 2020年第5期31卷 103-113页

作者：沈鸣鸣同济大学人文学院上海200092

在物我疏离的当代背景下,文章以中国古典小说为主要研究对象,发掘园林、文学、女性三者之间内在的逻辑关联,重视主体的审美体验及伦理诉求。文章根据女性在场的经验变化,阐释园林如何逐步获得女性心理、审美乃至伦理的支持;从叙事文学... 详细信息

在物我疏离的当代背景下,文章以中国古典小说为主要研究对象,发掘园林、文学、女性三者之间内在的逻辑关联,重视主体的审美体验及伦理诉求。文章根据女性在场的经验变化,阐释园林如何逐步获得女性心理、审美乃至伦理的支持;从叙事文学中的“逾墙”现象入手,梳理园林和女性的历史关联以及两者在文学叙事中结盟的依据;找出古典小说中园林书写渐趋女性化的途径和手法,根据两者之间共通的美学、哲学依据,得出园林和女性在价值上互证并结成价值共同体的结论。

关键词：中国古典小说园林书写女性空间

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孤岛工作面过空巷安全技术研究

机械管理开发 2023年第7期38卷 262-264页

作者：申明明霍州煤电晋北能化有限责任公司山西静乐035100

以3508孤岛工作面过空巷为研究对象,针对采面开采范围内应力集中、空巷在采动影响下围岩控制困难等问题,提出采泵送支柱方式支护空巷。根据3508孤岛工作面现场情况,确保泵送支柱充填材料类型、支柱布置方案及充填工艺,并进行工程应用。... 详细信息

以3508孤岛工作面过空巷为研究对象,针对采面开采范围内应力集中、空巷在采动影响下围岩控制困难等问题,提出采泵送支柱方式支护空巷。根据3508孤岛工作面现场情况,确保泵送支柱充填材料类型、支柱布置方案及充填工艺,并进行工程应用。现场应用后,采面在过空巷期间空巷围岩变形量较小,采面顶板及煤壁基本保持稳定,泵送支柱为采面安全过空巷创造了良好条件。

关键词：孤岛工作面采动压力充填支柱围岩控制

Study on the Fracturing Parameters and Productivity of Horizontal Wells

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Acta Geologica Sinica(English Edition) 2015年第A01期89卷 321-323页

作者： TANG mingming LU Shuangfang LIANG Hongru YAN Bihui shen Shan Research Institute of Unconventional Petroleum and Renewable Energy China University of PetroleumQingdao

1 Introduction Hydraulic fracturing refers to the parting of geo- materials due to excessively high fluid pressure. The most common application of hydraulic fracturing is enhanced oil recovery, in which increase in functional permeability of the ground is achived by the formation of permeable fracture （Mohammad, et al,2014）. Such processes are of vital importance tbr the explitation of deep geothermal reservoirs as well as for shale gas and oil reservoir （Gunther ＆ Dirk ,2015）. Currently, the most common used method to detecting the hydraulic fracturinggeometry （including location, orientation, and dimension） is micro-seismic monitoring.

关键词： HYDRAULIC fracturing PETROLEUM reservoirs BASINS (Geology) SIMULATION methods & models OIL saturation in reservoirs CHINA

Fine Geological Modeling of the Tight Oil Reservoir

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Acta Geologica Sinica(English Edition) 2015年第A01期89卷 65-66页

作者： LIANG Hongru LU Shuangfang TANG mingming YAN Bihui shen Shan Research Institute of Unconventional Petroleum and Renewable Energy China University of Petroleum QingdaoShandong 266580 China School of Geosciences China University of Petroleum Qingdao Shandong 266580 China

1 Introduction The study area of Northern Honggang is located in the Daan-Honggang terrace in the central depression of the southern Songliao basin, covering an area of 110km2. The oil field is categorized as an ultra-low permeability reservoir and the target horizon is the Fuyu oil layer. The reservoir is characterized as poor physical property, strong heterogeneity and difficultly exploitation.

关键词： GEOLOGICAL modeling POROSITY PETROLEUM reservoirs PERMEABILITY OIL saturation in reservoirs