检索结果-南通市图书馆

Herb-drug enzyme-mediated interactions and the associated experimental methods： a review

Journal of Traditional Chinese Medicine 2016年第3期36卷 392-408页

作者： Li Bo Zhao Baosheng Liu Yang tang mingmin Lǚe Beiran Luo Zhiqiang Zhai Huaqiang School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100102 China Center of Scientific and Experiment Beijing niversity of Chinese Medicine Beijing 100029 China Beijing Key Laboratory of Protection and Utilization of Chinese Medicine Beijing Normal UniversityBeijing 100875 China

OBJECTIVE: To review the interactions between herbs and widely used drugs and summarize the associated experimental ***: Definite herb-drug interactions were obtained by searching Pub Med, other large overseas databases and summarizing new researches from China. We summarize some methods to assess the interaction between herbs and drugs involving microsomal, cell culture and animal experiments, and clinical trials, classifying this method as single ingredient herbs, crude herb extracts, andherbal ***: Many herbs interact with drugs through a complex cytochrome P450 and/or P-glycoprotein mechanism. Herb-induced enzyme inhibition and/or induction may result in enhanced and / or decreased plasma, tissue, urine and bile drug concentrations, leading to a change in a drug's pharmacokinetic parameters and resulting in the improper treatment of patients and potentially severe side effects. Use of an appropriate method for comprehensively assessing herb-drug interactions can minimize clinical risks. Different methods were used by researchers to assess the pharmacological changes of drugs in vivo and in vitro and the mechanisms of the interactions from microsomal, cell culture and animal experiments, and clinical trials are discussed in this ***: Co-medication with herbs can result in changes in pharmacological effects of many drugs. This review describes the assessment of single-ingredient herbs, crude herb extracts, and herbal formulae. When choosing a research method to investigate herb-drug interactions, the properties of the drugs and herbs should be considered.

关键词： Herb-drug interaction Metabolism Cytochrome P-450 enzyme system P-glycoprotein Review

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current anti-diabetes mechanisms and clinical trials using Morus alba L.

引用

Journal of Traditional Chinese Medical Sciences 2016年第1期3卷 3-8页

作者： Simin Tian mingmin tang Baosheng Zhao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100102China Center of Scientific Experiment Beijing University of Chinese MedicineBeijing 100029China

Backgrounds:Diabetes mellitus,especially type 2 diabetes,with its fast-rising prevalence,has become a global ***(Morus alba L.)leaf has been known to have hypoglycemic effects since ancient *** Asia mulberry leaf is used as tea to complement the treatment of diabetes *** methods by which mulberry leaf affects the body and its mechanism when combined with chemical agents have been studied ***:We summarize the possible mechanisms of the anti-diabetic effects of mulberry leaf based on extraction procedures,in vitro and in vivo experiments,and clinical *** also discuss the hypothesis that crosstalk and“critical nodes”may be useful for a deeper molecular understanding of the treatment and prevention of diabetes with mulberry leaf.

关键词： Mulberry leaf Anti-diabetes Molecular mechanisms Clinical trials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CMT2D neuropathy is influenced by vitamin D-mediated environmental pathway

引用

Journal of Molecular Cell Biology 2023年第4期15卷 64-67页

作者： Huaqing Liu mingmin tang Hualin Yu Tongfei Liu Qinqin Cui Linfan Gu Zhi-Ying Wu Nengyin Sheng Xiang-Lei Yang Linghui Zeng Ge Bai Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015China Department of Neurobiology and Department of Neurology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain–Machine IntegrationState Key Laboratory of Brain–Machine IntelligenceZhejiang UniversityHangzhou 311121China The Institute for Brain Science and Disease Chongqing Medical UniversityChongqing 400016China Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037USA Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

Dear Editor,Peripheral neuropathy is a group of devastating diseases affecting periphe-ral nerves and may cause symptoms such as extreme numbness,muscle weakness,and ***,there are no effective therapies for these *** progress has been made in identifying genetic causes for peripheral neuropathy owing to the advances in genetic testing in the last *** example,>100 genes have been identified to be associated with Charcot–Marie–Tooth(CMT)neuropathy,a group of disorders among the most common forms of inherited peripheral neuropathy.

关键词： neuropathy vitamin Marie

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the structure of the summer monsoon regime of East Asia

引用

Acta Oceanologica Sinica 1988年第S1期 1-13页

作者： Huang Shisong and tang mingmin Department of Atmospheric Sciences, Nanjing University, Nanjing, China

-In this paper the structure of the East Asian summer monsoon regime is unraveled through investigation of the activity of the summer monsoon of China in connection with the circulation systems of low latitudes. It is shown that the components of the summer monsoon regime of East Asia are the Tibetan high. Northwest Pacific high, Mascarene high, Australian high, India-South China Sea depression and the therefrom derived tropical convergence zone and associated ascending clouds over the South China Sea and Mei-Yu fronts and associated ascending clouds over China. It is more complicated than the structure of the Indian summer monsoon regime. The East Asian summer monsoon mainly consists of the trade curreuts from the tropical region of the North Pacific Ocean and the Somalian cross-equatorial currents from the Indian Ocean. In the entire monsoon regime the key components should be the Northwest Pacific high and the Mascarene high, and they have a great influence on the Mei-yu Period’s Precipitation in the

关键词： On the structure of the summer monsoon regime of East Asia high

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

ON INFLUENCE OF CHARACTERISTICS OF FLOW FIELDS AND THERMAL FACTORS ON MOTION OF TYPHOONS

引用

Science in China,Ser.B 1983年第5期26卷 524-537页

作者：黄士松汤明敏陆森娥 Department of Meteorology Nanjing University

This paper mainly aims at studying the influence of the characteristics of flow fields and thermal factors on the motion of typhoons, Results show that the northward (or southward) component of typhoon motion shows up when the southerly maximum wind on the east periphery of a typhoon is stronger (or weaker) than the northerly one to the west. A westward (or eastward) component appears when the westerly maximum wind to the south is weaker (or stronger and exceeds a certain value) than the easterly one to the north. The speeds of motion differ from each other depending on the different flow patterns. Counterclockwise rotation occurs when two typhoons are close to such an extent that they interact on each other. A typhoon also has the tendency of moving towards the stronger heating and more unstable areas, as well as in the direction of the gradient of temperature variation. In addition, the impact of the variation of subtropical high on typhoon motion is also discussed.

关键词： ON INFLUENCE OF CHARACTERISTICS OF FLOW FIELDS AND THERMAL FACTORS ON MOTION OF TYPHOONS

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于多特征参量的回转支承智能健康状态评估

引用

南京工业大学学报（自然科学版） 2014年第2期36卷 101-106页

作者：汤明敏王华黄筱调南京工业大学机械与动力工程学院江苏南京210009

为了提高回转支承运行可靠性,及时发现其潜在的失效,实施良好的设备维护与管理,有必要对其进行健康状态评估。选取表征回转支承健康状态的温度和扭矩作为特征参量,建立了一种采用遗传算法优化动态递归Elman神经网络的回转支承多参量健... 详细信息

为了提高回转支承运行可靠性,及时发现其潜在的失效,实施良好的设备维护与管理,有必要对其进行健康状态评估。选取表征回转支承健康状态的温度和扭矩作为特征参量,建立了一种采用遗传算法优化动态递归Elman神经网络的回转支承多参量健康状态评估模型,并利用3 MW变桨回转支承疲劳寿命实验数据对该模型进行了网络训练和测试。结果表明,该模型评估结果与实验值相符,可准确地对回转支承进行健康状态评估。

关键词：多特征参量健康评估 Elman网络遗传算法回转支承

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于EMS的分布式地县电网AVC控制策略

引用

电力系统保护与控制 2017年第6期45卷 137-141页

作者：苏志朋宋铭敏汤大伟赵晓莉国网芜湖供电公司安徽芜湖241000 国网南陵县供电公司安徽芜湖241300 上海电力学院电气工程学院上海200090

针对地、县电网垂直耦合紧密,县网规模较小,提出一种新型分布式地县电网AVC控制策略。该策略基于EMS地县一体化自动化系统,首先在地调、县调自动化系统中分别部署AVC应用,地调和县调的AVC可运行在联调、解列两种模式下。其次建立分布式... 详细信息

针对地、县电网垂直耦合紧密,县网规模较小,提出一种新型分布式地县电网AVC控制策略。该策略基于EMS地县一体化自动化系统,首先在地调、县调自动化系统中分别部署AVC应用,地调和县调的AVC可运行在联调、解列两种模式下。其次建立分布式AVC系统优化控制模型,并对优化目标函数引入计算因子,使得该模型同时适用于地调AVC和县调AVC,简化了计算算法。最后现场运行效果表明,该策略可实现从整个地区电网的角度进行区域电网无功优化,进一步提高地调、县调电压合格率。

关键词：电压自动控制电压质量网损电压稳定无功

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

非布司他治疗慢性肾脏病伴发高尿酸血症的疗效及预后影响因素

引用

中华临床医师杂志（电子版） 2023年第3期17卷 279-284页

作者：李昌艳顾芳刘娟唐明敏成都市第五人民医院肾内科四川成都611130

目的探讨非布司他治疗慢性肾脏病(CKD)伴发高尿酸血症(HUA)的疗效及预后影响因素。方法本研究为前瞻性研究。选取2019年7月至2020年7月诊治的152例CKD伴发HUA的患者作为研究对象,采用配额抽样法分为观察组(予以非布司他治疗,n=101)与对... 详细信息

目的探讨非布司他治疗慢性肾脏病(CKD)伴发高尿酸血症(HUA)的疗效及预后影响因素。方法本研究为前瞻性研究。选取2019年7月至2020年7月诊治的152例CKD伴发HUA的患者作为研究对象,采用配额抽样法分为观察组(予以非布司他治疗,n=101)与对照组(予以碳酸氢钠治疗,n=51),对比疗效、SUA、Scr、BUN、24 h尿蛋白、eGFR及不良反应、SUA未达标率;且根据观察组患者SUA是否达标分为预后良好组(SUA0.05);而在CKD分期、饮酒史、痛风史、高血压及基础24 h尿蛋白、eGFR、Scr、SUA、BUN比较中,具有统计学意义(P<0.05)。二元Logistic回归分析显示,CKD5期、痛风史及基础24 h尿蛋白、Scr、SUA升高和eGFR降低是影响观察组患者预后的独立危险因素(P<0.05)。结论非布司他治疗CKD伴发HUA疗效较为理想,但CKD5期、痛风史及基础24 h尿蛋白、Scr、SUA升高和eGFR降低会对患者预后产生影响。

关键词：非布司他慢性肾脏病高尿酸血症疗效预后

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

硅钢生产发展的探讨

引用

武钢技术 1999年第5期37卷 43-47页

作者：唐明民章荣德经济技术研究中心

通过对硅钢片厂技术改造和生产能力变化的调研，以及对冷轧硅钢市场需求的分析和预测，提出了解决生产工序中“瓶颈”的方案。

关键词：硅钢片厂硅钢冷轧取向技术改造

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

引用

Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：