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How psychiatrists coordinate treatment for COVID-19: a retrospective study and experience from China

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General Psychiatry 2020年第4期33卷 174-178页

作者： Ling Yue Jingyi Wang mingliang Ju Yi zhu Lianghu Chen Lin Shi Bohai Shi Jun Chen Yifeng Shen Department of Psychiatry Shanghai Jiao Tong University School of MedicineAffiliated Shanghai Mental Health CenterShanghaiChina Department of Social Medicine School of Public HealthFudan UniversityShanghaiChina Department of Population Science and Experimental Medicine University College LondonLondonUK Department of Psychiatry Nanhui Mental Health Center of Pudong New AreaShanghaiChina Department of General Adult Psychiatry Xuhui District Mental Health CenterShanghaiChina Department of Psychiatry Hongkou District Mental Health CenterShanghaiChina

Background Patients with C0VID-19 are at high risk of developing mental health problems;however,the prevalence and management of mental disorders and how psychiatrists coordinate the treatment are *** We aimed to investigate the mental health problems of patients infected with C0VID-19 and to identify the role of psychiatrists in the clinical treatment team during the *** also share the experience of psychiatric consultations of patients with COVID-19 in Shanghai,*** We analysed data from the psychiatric medical records of 329 patients with COVID-19 in the Shanghai Public Health Clinical Center from 20 January to 8 March *** collected information including sociodemographic characteristics,whether patients received psychiatric consultation,mental health symptoms,psychiatric diagnoses,psychiatric treatments and severity level of *** Psychiatric consultations were received by 84(25.5%)patients with *** most common symptoms of mental health problems were sleep disorders(75%),anxiety(58.3%)and depressive symptoms(11.9%).The psychiatric consultation rate was highest in critically ill patients(69.2%),with affective symptoms or disturbed behaviour as their main mental health *** diagnoses for patients who received consultation included acute stress reaction(39.3%),sleep disorders(33.3%),anxiety(15.5%),depression(7.1%)and delirium(4.8%).In terms of psychiatric treatments,86.9%of patients who received psychiatric consultation were treated with psychotropic medications,including non-benzodiazepine sedative-hypnotic agents(54.8%),antidepressants(26.2%),benzodiazepines(22.6%)and antipsychotics(10.7%).Among the 76 patients who were discharged from the hospital,79%had recovered from mental health problems and were not prescribed any psychotropic *** symptoms of the remaining 21%of patients had improved and they were prescribed medications to continue the *** This is the first study

关键词： treatment coordinate prescribed

A soybean NAC homolog contributes to resistance to Phytophthora sojae mediated by dirigent proteins

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The Crop Journal 2022年第2期10卷 332-341页

作者： Guolong Yu Jianan Zou Jinhui Wang Rongsheng zhu Zhaoming Qi Hongwei Jiang Zhenbang Hu mingliang Yang Ying Zhao Xiaoxia Wu Chunyan Liu Candong Li Xue Yang Zhendong zhu Qingshan Chen Yongfu Fu Dawei Xin Key Laboratory of Soybean Biology of MOE Key Laboratory of Soybean Biology and Breeding/Genetics of MOACollege of AgricultureNortheast Agricultural UniversityHarbin 150030HeilongjiangChina bMOA Key Lab of Soybean Biology(Beijing) National Key Facility of Crop Gene Resource and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Soybean Research Institute Jilin Academy of Agricultural ScienceChangchun 130033JilinChina School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Jiamusi Branch Academy of Heilongjiang Academy of Agricultural Sciences Jiamusi 154007HeilongjiangChina Collaboration Centre to Russia of Institute of Grass Industry Heilongjiang Academy of Agricultural SciencesHarbin 150000HeilongjiangChina

Phytophthora sojae infection severely impairs soybean production. We previously identified a dirigent protein, Gm DRR1(Glycine max Disease Resistant Response 1), that increases soybean resistance to ***. However, the molecular basis of Gm DRR1 function remained largely uncharacterized. In the present study, analysis of Gm DRR1-RNAi, Gm DRR1-overexpressing, and CRISPR/Cas9-derived Gmdrr1 mutant lines revealed that Gm DRR1 expression significantly restricted P. sojae growth. Combining coimmunoprecipitation with liquid chromatography–tandem mass spectrometry revealed a Gm DRR1-interacting protein, Gm DRR2, which is homologous to Gm DRR1. An E-coniferyl alcohol coupling assay indicated that Gm DRR1 promotes the synthesis of(+)-pinoresinol, which helps to protect plants from P. sojae. The Gm NAC1(Glyma.05 G025500) transcription factor bound to the Gm DRR1 promoter both in vitro and in vivo to upregulate Gm DRR1 expression. Soybean resistance to P. sojae was increased by overexpression of Gm NAC1. Our findings suggest a novel signaling pathway involving a NAC transcription factor that mediates soybean resistance to P. sojae. Specifically, Gm NAC1 directly induces Gm DRR1 expression to increase resistance of soybean plants to P. sojae.

关键词： Phytophthora sojae Soybean GmNAC1 Dirigent Lignin

Government Regulations on the Lottery Industry

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Social Sciences in China 2007年第3期28卷 178-180页

作者： zhu Xinli Tang mingliang Song Jun(译) the Law School of Zhejiang University the Institute of Law of Zhejiang Academy of Social Sciences 不详

While China’s lottery has been very successful, there now exist serious problems. Firstly, the rights of lottery buyers are seriously infringed

关键词：彩票工业中国政府调节行业管理

Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica

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Chinese Herbal Medicines 2023年第3期15卷 457-462页

作者： Yang Wang Fanyu Shi Zihan Lu mingliang Zhang Zekun Zhang Fangfang Jia Beibei Zhang Lishan Ouyang Zhixiang zhu Shepo Shi Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102401China Gaoping Chinese Medicine Hospital Gaoping 048400China

Objective:To study the chemical constituents of the roots of Angelica dahurica,a well-known Chinese herbal medicine named Baizhi in ***:Compounds were separated by various chromatographies,and the structures of new compounds were elucidated based on the analysis of their spectroscopic and spectrometric data(1D,2D NMR,HRESI MS,IR,and UV).The absolute configurations of new compounds were determined by the calculated electronic circular dichroism and chemical *** inhibitory activities of all isolates against nitric oxide(NO)production were evaluated using lipopolysaccharide-activated RAW 264.7macrophage ***:Seven new 3,4-dihydro-furanocoumarin derivatives(1a/1b,2a/2b,3a/3b,4)together with a known furanocoumarin(5)were isolated from the roots of *** new compounds included three pairs of enantiomers,(4S,2’’R)-angelicadin A(1a)/(4R,2’’S)-angelicadin A(1b),(4S,2’’S)-angelicadin A(2a)/(4R,2’’R)-angelicadin A(2b),and(4S,2’’S)-secoangelicadin A(3a)/(4R,2’’R)-secoangelicadin A(3b),together with(4R,2’’R)-secoangelicadin A methyl ester(4).The known xanthotoxol(5)inhibited the NO production with the half-maximal inhibitory concentration(IC50)value of(32.8±0.8)μmol/L,but all the new compounds showed no inhibitory activities at the concentration of100μmol/***:This is the first report of the discovery of 3,4-dihydro-furanocoumarins from *** results are not only meaningful for the understanding of the chemical constituents of ***,but also enrich the reservoir of natural products.

关键词： Angelica dahurica(Fisch.ex Hoffm.)Benth.et Hook.f. anti-inflammation coumarin 3,4-dihydro-furanocoumarin enantiomers(4S,2R)-angelicadin A (4R,2S)-angelicadin A (4S,2S)-angelicadin A (4R,2R)-angelicadin A (4S,2S)-secoangelicadin A (4R,2R)-secoangelicadin A (4R,2R)-secoangelicadin A methyl ester

Contactless Microwave Detection of Shubnikov–De Haas Oscillations in Three-Dimensional Dirac Semimetal ZrTe_5

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Chinese Physics Letters 2019年第6期36卷 49-52页

作者： Min Wu Hongwei Zhang Xiangde zhu Jianwei Lu Guolin Zheng Wenshuai Gao Yuvan Han Jianhui Zhou Wei Ning mingliang Tian Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory Chinese Academy of Sciences Department of Physics University of Science and Technology of China Department of Physics Shaanxi University of Science and Technology School of Science RMIT University Department of Physics School of Physics and Materials Science Anhui University

We report Shubnikov–de Haas(SdH)oscillations of a three-dimensional(3D) Dirac semimetal candidate of layered material ZrTe_5 single crystals through contactless electron spin resonance(ESR)measurements with the magnetic field up to 1.4 *** ESR signals manifest remarkably anisotropic characteristics with respect to the direction of the magnetic field,indicating an anisotropic Fermi surface in ZrTe_*** experiments demonstrate that the ZrTe_5 single crystals have the signature of massless Dirac fermions with nontrivialBerry phase,key evidence for 3D Dirac/Weyl ***,the onset of quantum oscillation of our ZrTe_5 crystals revealed by the ESR can be derived down to 0.2 T,much smaller than the onset of SdH oscillation determined by conventional magnetoresistance ***,ESR measurement is a powerful tool to study the topologically nontrivial electronic structure in Dirac/Weyl semimetals and other topological materials with low bulk carrier density.

关键词： Dirac Microwave Haas ESR spin down tool our

A strategy with label-free quantification of the targeted peptides for quantitative peptidome analysis of human serum

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Science China Chemistry 2010年第4期53卷 759-767页

作者： zhu Jun, WANG FangJun, DONG XiaoLi, YE mingliang & ZOU HanFa Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic Research and Analysis Center Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China Key Laboratory of Separation Sciences for Analytical Chemistry Chinese Academy of Sciences Dalian China National Chromatographic Research and Analysis Center Chinese Academy of Sciences Dalian China Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China

Peptidomics draws more and more attention in discovering useful biomarkers for early diagnosis of disease. However, there is lack of efficient quantification strategy in peptidome analysis. In this study, a strategy with label-free quantification of the targeted endogenous peptides based on peak intensity using μUPLC-Q-TOF-MS/MS was developed for quantitative peptidome analysis of human serum. Different amounts of standard BSA tryptic digesting peptides were added into the same serum extracts for evaluation of the developed strategy, and it was observed that the average relative error of the targeted peptides was 6.42%, which was superior to the result obtained directly by commercially available software PLGS. It was also demonstrated that this quantification strategy could obviously increase the detection sensitivity of the peptide by DDA analysis. Then, this strategy was applied to comparatively analyze the peptides extracted from the serum of HCC or breast cancer patients and healthy individuals, respectively. Peptides with charge states up to 5 and molecular weight over 4000 can be reliably identified and quantified. This quantitative analysis method based on μUPLC-Q-TOF-MS/MS exhibited superior sensitivity than that by MALDI-TOF-MS commonly used in peptidome analysis. Finally, some interesting endogenous peptides related to corresponding diseases were successfully obtained.

关键词： peptidomics label-free quantification hepatocellular carcinoma breast cancer human serum

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人文地理学的“神经转向”研究进展及启示

地理科学进展 2020年第7期39卷 1182-1195页

作者：王敏林铭亮朱竑华南师范大学地理科学学院广州510631 华东师范大学城市与区域科学学院上海200241 广州大学华南人文地理与城市发展研究中心广州510006

"神经转向"是在后现代语境下提出的,运用神经机制诠释人的心智与空间的关系,超越"社会文化"与"生物神经"的边界,强调情感、身体、"非理性"等的主体特征,为人文地理学研究提供了新的认识论和方法论。同时,人文地理学研究的"空间传统"有... 详细信息

"神经转向"是在后现代语境下提出的,运用神经机制诠释人的心智与空间的关系,超越"社会文化"与"生物神经"的边界,强调情感、身体、"非理性"等的主体特征,为人文地理学研究提供了新的认识论和方法论。同时,人文地理学研究的"空间传统"有益于对批判神经科学关于"心智—大脑—环境"的理解产生知识溢出,实现学科交叉的良性循环。论文梳理了国内外涉及神经科学理论与方法的人文地理学研究,基于具身认知和非表征理论分析人文地理学中"神经转向"研究的理论基础,并围绕空间感知、情感认知、行为实践等主题进行介绍。另外,神经科学技术手段为人文地理学研究提供了新的方法,大脑成像、眼动追踪技术已经在地理学科中得到应用,呈现可期的未来愿景。最后,论文提出"神经转向"对中国人文地理学研究的理论创新和实践路径的启示。

关键词：神经科学非表征理论具身认知心智行为人文地理学

Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3013-3028页

作者： Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying zhu Jianbo Pan Wei Jiang Zengxia Li mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang Key Laboratory of Metabolism and Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesShanghai Medical CollegeFudan University200032ShanghaiChina CAS Key Lab of Separation Sciences for Analytical Chemistry National Chromatographic Research and Analysis CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences116023DalianChina The Chemical Proteomics Center and State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences201203ShanghaiChina University of Chinese Academy of Sciences 100049BeijingChina Department of Urology Zhongshan HospitalFudan University200032ShanghaiChina Department of Urology Zhongshan Hospital Wusong BranchFudan University200032ShanghaiChina Center for Novel Target and Therapeutic Intervention Chongqing Medical University400016ChongqingChina Department of Urology Huashan HospitalFudan University200040ShanghaiChina

Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for ***,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical *** multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in *** the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary *** further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug ***,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft *** integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies.

关键词： drug PC3 diagnosis operative

昆虫信息化学物质在害虫大量诱杀防治中的应用

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内蒙古林业调查设计 2024年第2期47卷 31-34,54页

作者：李秀华董文信周德宝包长岁祝军陈国发张明亮王金芝内蒙古赤峰市敖汉旗林业和草原局内蒙古敖汉024300 内蒙古大兴安岭森林病虫害防治(种子)总站内蒙古牙克石022150 内蒙古阿尔山森林工业有限公司内蒙古阿尔山127421 辽宁省兴城市自然资源事务服务中心辽宁兴城125100 国家林业和草原局生物灾害防控中心沈阳110034 内蒙古赤峰市敖汉旗大黑山林场内蒙古敖汉024319

昆虫信息化学物质已成为控制森林害虫的主要措施,其在大量诱杀防治技术中发挥了重要作用。文章综述了昆虫信息化学物质研究进展,分析了信息化学物质组分的配比与剂量、诱捕器的类型、颜色、设置高度和距离对害虫诱捕的影响,旨在为利用... 详细信息

昆虫信息化学物质已成为控制森林害虫的主要措施,其在大量诱杀防治技术中发挥了重要作用。文章综述了昆虫信息化学物质研究进展,分析了信息化学物质组分的配比与剂量、诱捕器的类型、颜色、设置高度和距离对害虫诱捕的影响,旨在为利用昆虫信息化学物质对害虫大量诱杀防治工作提供借鉴,为实现高效、环保、无公害害虫防治提供科学参考。

关键词：昆虫信息化学物质大量诱杀防治应用