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Pseudo-chromosome–length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation

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Science China(Life Sciences) 2023年第6期66卷 1379-1391页

作者： Jie Chen Honghui Zeng Wenqi Lv Ning Sun Cheng Wang Wenjie xu mingliang Hu Xiaoni Gan Lisheng He Shunping He Chengchi Fang Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanya572000China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan430072China University of Chinese Academy of Sciences Beijing100049China School for Ecological and Environmental Sciences Northwestern Polytechnical UniversityXi’an710072China

High hydrostatic pressure,low temperature,and scarce food supply are the major factors that limit the survival of vertebrates in extreme deep-sea environments.Here,we constructed a high-quality genome of the deep-sea Muddy arrowtooth eel(MAE,Ilyophis brunneus,captured below a depth of 3,500 m)by using Illumina,Pac Bio,and Hi-C sequencing.We compare it against those of shallow-water eel and other outgroups to explore the genetic basis that underlies the adaptive evolution to deep-sea biomes.The MAE genome was estimated to be 1.47 Gb and assembled into 14 pseudo-chromosomes.Phylogenetic analyses indicated that MAE diverged from its closely related shallow-sea species,European eel,~111.9 Mya and experienced a rapid evolution.The genome evolutionary analyses primarily revealed the following:(i)under high hydrostatic pressure,the positively selected gene TUBGCP3 and the expanded family MLC1 may improve the cytoskeleton stability;ACOX1 may enhance the fluidity of cell membrane and maintain transport activity;the expansion of ABCC12 gene family may enhance the integrity of DNA;(ii)positively selected HARS likely maintain the transcription ability at low temperatures;and(iii)energy metabolism under a food-limited environment may be increased by expanded and positively selected genes in AMPK and m TOR signaling pathways.

关键词： Ilyophis brunneus genome evolution deep sea adaption high hydrostatic pressure

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基于JAK2/STAT3信号通路的乌鸡肽营养素配方治疗贫血功效研究

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食品与发酵工业 2024年第3期50卷 80-85页

作者：张卓然廖群冯志远刘丹李明亮李诒光任杰许锦珍刘文颖谷瑞增刘文君中国食品发酵工业研究院有限公司北京市蛋白功能肽工程技术研究中心北京100015 江中药业股份有限公司江西南昌330096

乌鸡是我国特有的鸡种,具有很好的补血功能,利用乌鸡开发新的补血产品具有很大优势。该研究通过对贫血小鼠灌喂添加营养素(EDTAFeNa和维生素)的乌鸡肽配方样品,测试对其造血能力的恢复功效并通过探究信号通路研究造血作用机制。实验通... 详细信息

乌鸡是我国特有的鸡种,具有很好的补血功能,利用乌鸡开发新的补血产品具有很大优势。该研究通过对贫血小鼠灌喂添加营养素(EDTAFeNa和维生素)的乌鸡肽配方样品,测试对其造血能力的恢复功效并通过探究信号通路研究造血作用机制。实验通过使用环磷酰胺和乙酰苯肼制造小鼠贫血模型,并检测外周血象、骨髓病理学观察、间接胆红素含量、ATP酶活力、造血因子水平以及JAK2/STAT3信号通路。结果表明乌鸡肽营养素配方可以显著恢复外周血细胞和骨髓造血干细胞数量;减少间接胆红素含量,提高ATP酶活力从而保护红细胞免受破裂损伤;通过分泌促红细胞生成素(erythropoietin,EPO)、重组巨噬细胞粒细胞集落刺激因子(human granulocyte-macrophage colony stimulating factor,GM-CSF)和白细胞介素-3(interleukin-3,IL-3)造血因子促进造血细胞恢复,并通过JAK2/STAT3信号通路调控造血细胞增殖分化。该研究为乌鸡肽的开发和利用提供了指导。

关键词：乌鸡肽贫血环磷酰胺乙酰苯肼 JAK2/STAT3信号通路造血能力

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Sign-reversed anomalous Nernst effect in the ferromagnetic Weyl-semimetal Fe_(3-δ)GeTe_(2): the role of Fe vacancies

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Science China(Physics,Mechanics & Astronomy) 2022年第11期65卷 125-131页

作者： Haiyang Yang Qi Wang Junwu Huang Zhouliang Wang Keqi Xia Chao Cao mingliang Tian Zhuan xu Jianhui Dai Yuke Li School of Physics and Hangzhou Key Laboratory of Quantum Matters Hangzhou Normal UniversityHangzhou 311121China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChineseAcademyof SciencesHefei 230031China Departmentof Physics Zhejiang UniversityHangzhou 310058China Zhejiang Province Key Laboratory of Quantum Technology and Device Zhejiang UniversityHangzhou 310027China

Anomalous Nernst effect, as a thermal partner of anomalous Hall effect, is particularly sensitive to the Berry curvature anomaly near the Fermi level, and has been used to probe the topological nature of quantum materials. In this work, we report the observation of both effects in the ferromagnetic Weyl-semimetal Fe_(3-δ)GeTe_(2) with tunable Fe vacancies. With decreasing Fe vacancies,the anomalous Hall conductivity evolves as a function of the longitudinal conductivity from the hopping region to the region where the intrinsic Berry curvature contribution dominates. Concomitant evolutions in the anomalous Nernst signal and the anomalous off-diagonal thermoelectric coefficient are observed below the Curie temperature, displaying a unique sign change caused by the Fe vacancies. Combining these results with first-principles calculations, we argue that the Fe-vacancy concentration plays a unique role in simultaneously tuning the chemical potential and ferromagnetism, which in turn controls the Berry curvature contribution in this family of ferromagnetic topological semimetals.

关键词： thermoelectronic effect Hall effect quantum transport topological Weyl semimetal

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Phase Regulation and Defect Passivation Enabled by Phosphoryl Chloride Molecules for Efficient Quasi‑2D Perovskite Light‑Emitting Diodes

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Nano-Micro Letters 2023年第8期15卷 181-191页

作者： mingliang Li Yaping Zhao Jia Guo Xiangqian Qin Qin Zhang Chengbo Tian Peng xu Yuqing Li Wanjia Tian Xiaojia Zheng Guichuan Xing Wen‑Hua Zhang Zhanhua Wei Sichuan Research Center of New Materials Institute of Chemical MaterialsChina Academy of Engineering PhysicsChengdu 610200People’s Republic of China Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021People’s Republic of China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoTaipaMacao 999078People’s Republic of China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005People’s Republic of China School of Materials and Energy Yunnan UniversityKunming 650050People’s Republic of China

Quasi-2D perovskites have attracted tremendous interest for application as lightemission layers in light-emitting diodes(LEDs).However,the heterogeneous n phase and non-uniform distribution still severely limit the further development of quasi-2D perovskite LEDs(Pero-LEDs).Meanwhile,the increased defect density caused by the reduced dimension and grain size induces non-radiative recombination and further deteriorates the device performance.Here,we found that a series of molecules containing phosphoryl chloride functional groups have noticeable enhancement effects on the device performance of quasi-2D Pero-LEDs.Then,we studied the modification mechanism by focusing on the bis(2-oxo-3-oxazolidinyl)phosphinic chloride(BOPCl).It is concluded that the BOPCl can not only regulate the phase distribution by decreasing the crystallization rate but also remain in the grain boundaries and passivate the defects.As a result,the corresponding quasi-2D Pero-LEDs obtained a maximum external quantum efficiency(EQE_(max))of 20.82%and an average EQE(EQE_(ave))of around 20%on the optimal 50 devices,proving excellent reproducibility.Our work provides a new selection of molecular types for regulating the crystallization and passivating the defects of quasi-2D perovskite films.

关键词： Quasi-2D perovskite Phosphoryl chloride functional group Crystallization control N phase control Passivation

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Inconel 617镍基合金电弧增材制造微观组织与力学性能

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焊接 2024年第2期 31-35页

作者：张旭万金初朱亮吉明亮杨宗辉南京工程学院江苏省先进结构材料与应用技术重点实验室南京211167

电弧增材制造技术基于分散累加原理,可实现镍基高温合金复杂结构快速无模加工,是一种广受关注的先进加工技术。该研究以高温耐蚀合金Inconel 617增材制造块体为研究对象,采用OM,SEM及万能拉伸试验机等手段分析了增材制造镍基合金块体微... 详细信息

电弧增材制造技术基于分散累加原理,可实现镍基高温合金复杂结构快速无模加工,是一种广受关注的先进加工技术。该研究以高温耐蚀合金Inconel 617增材制造块体为研究对象,采用OM,SEM及万能拉伸试验机等手段分析了增材制造镍基合金块体微观组织及力学性能。研究结果表明,Mo元素在柱状枝晶间偏析,促使大尺寸的Laves相沿枝晶析出。在拉伸应力下,Laves相由于脆性较高,易发生断裂,诱发裂纹萌生。由于裂纹扩展路径在不同方向拉伸时存在显著差异,导致增材制造构件沿沉积方向强度(900 MPa)显著高于垂直沉积方向强度(700 MPa)。该研究为电弧增材制造镍基合金的组织性能调控奠定了一定基础,为进一步推动电弧增材制造镍基合金构件的应用进行了有益探索。

关键词：镍基合金增材制造微观组织力学性能各向异性

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Dipeptides VL increase protein accumulation in C2C12 cells by activating the Akt-mTOR pathway and inhibiting the NF-κB pathway

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Food Bioscience 2022年第1期45卷 122-130页

作者： mingliang Li Ying Wei Zhiyuan Feng Muyi Cai Yaguang xu Ruizeng Gu Yongqing Ma Xingchang Pan Beijing Engineering Research Center of Protein&Functional Peptides China National Research Institute of Food and Fermentation IndustriesBeijing 100015PR China

The Akt-mTOR signaling pathway plays a central role in regulating intracellular protein metabolism,and the NF-κB signaling pathway plays a vital role in developing skeletal muscle atrophy.In this study,we took the three dipeptides Val-Leu(VL),Leu-Leu(LL),and Leu-Gln(LQ)identified from corn peptides as the research objects and proved that peptides could promote C2C12 cell differentiation and protein synthesis by activating the Akt-mTOR signaling pathway.On the other hand,the dipeptides also inhibited the classical pathway of the NF-κB signaling pathway,down-regulated the expression of two E3 ubiquitin ligases MAFbx and MURF-1,attenuated apoptosis induced by TNF-α,and thus inhibited protein degradation in cells.In conclusion,the dipeptides isolated from corn peptides showed the effect of increasing protein accumulation in skeletal muscle,suggesting the application potential of corn peptides in promoting the growth of skeletal muscle mass.In addition,this experiment compared the different characteristics of the effects of the dipeptide VL and its corresponding amino acid mixture on the Akt-mTOR signaling pathway.

关键词： VL C2C12 Akt-mTOR NF-κB Skeletal muscle

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磁分离水处理技术专利分析

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自动化应用 2024年第7期65卷 272-274页

作者：倪明亮吉青青郑旭刘琴邱明全任钦毅中建环能科技股份有限公司四川成都610045

基于智慧芽专利数据库,对磁分离水处理技术的公开专利进行了系统检索和分析。通过关键词、分类号的组合检索以及采用人工去噪、补检等手段得到相关专利集。从专利的申请趋势、主要申请人、申请人国别、IPC分布、专利布局情况等多个维度... 详细信息

基于智慧芽专利数据库,对磁分离水处理技术的公开专利进行了系统检索和分析。通过关键词、分类号的组合检索以及采用人工去噪、补检等手段得到相关专利集。从专利的申请趋势、主要申请人、申请人国别、IPC分布、专利布局情况等多个维度进行分析并得出结论,以期为技术研发、市场布局等提供参考。

关键词：磁分离水处理专利分析

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射流引风空调匀温性能及其影响因素的仿真研究

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洁净与空调技术 2024年第1期 38-41页

作者：李龙斌顾明亮李婧田志强徐新魏伟青岛海尔智能技术研发有限公司

采用STAR CCM+软件对立式空调流场进行数值模拟,根据计算结果,分析讨论了射流引风的机理,并对其影响因素进行研究,对比了不同气流形态、风量以及引风通道宽度的引风性能。结果表明,双股气流形式的引风效果明显,提高风量可以提升引风量,... 详细信息

采用STAR CCM+软件对立式空调流场进行数值模拟,根据计算结果,分析讨论了射流引风的机理,并对其影响因素进行研究,对比了不同气流形态、风量以及引风通道宽度的引风性能。结果表明,双股气流形式的引风效果明显,提高风量可以提升引风量,但引风量占比在达到一定数值后反而会有所降低,引风通道宽度过大和过小都会减弱射流引风的匀温性能。

关键词：空调射流引风数值模拟风量人体舒适性

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High-throughput“read-on-ski”automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第7期23卷 564-577页

作者： Qizheng WANG Jun LU Ke FAN Yiwei xu Yucui XIONG Zhiyong SUN Man ZHAI Zhizhong ZHANG Sheng ZHANG Yan SONG Jianzhong LUO mingliang YOU Meijin GUO Xiao ZHANG State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou510320China Hangzhou Cancer Institute Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou Cancer HospitalZhejiang University School of MedicineHangzhou310002China

Organoid models are used to study kidney physiology,such as the assessment of nephrotoxicity and underlying disease processes.Personalized human pluripotent stem cell-derived kidney organoids are ideal models for compound toxicity studies,but there is a need to accelerate basic and translational research in the field.Here,we developed an automated continuous imaging setup with the“read-on-ski”law of control to maximize temporal resolution with minimum culture plate vibration.High-accuracy performance was achieved:organoid screening and imaging were performed at a spatial resolution of 1.1µm for the entire multi-well plate under 3 min.We used the in-house developed multi-well spinning device and cisplatin-induced nephrotoxicity model to evaluate the toxicity in kidney organoids using this system.The acquired images were processed via machine learning-based classification and segmentation algorithms,and the toxicity in kidney organoids was determined with 95%accuracy.The results obtained by the automated“read-on-ski”imaging device,combined with label-free and non-invasive algorithms for detection,were verified using conventional biological procedures.Taking advantage of the close-to-in vivo-kidney organoid model,this new development opens the door for further application of scaled-up screening using organoids in basic research and drug discovery.

关键词： Kidney organoid High-throughput microscopy Nephrotoxicity Machine learning

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现代产业学院建设模式研究与探索——以德肯汽车产业学院为例

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时代汽车 2024年第10期 69-72页

作者：唐涛李明亮汤宝许志鹏黄晶晶刘鸿远盐城工业职业技术学院汽车与交通学院江苏盐城224005

产业学院是适应现代产业发展、深化协同育人的有效形式,是高校落实产教融合的重要载体,是构建行业产教融合共同体的坚实基础。目前我校与盐城德肯汽车有限公司合作建立德肯汽车产业学院,通过健全管理体制和运行机制、创新人才培养模式... 详细信息

产业学院是适应现代产业发展、深化协同育人的有效形式,是高校落实产教融合的重要载体,是构建行业产教融合共同体的坚实基础。目前我校与盐城德肯汽车有限公司合作建立德肯汽车产业学院,通过健全管理体制和运行机制、创新人才培养模式、建设教师队伍、建立实习实训基地、搭建产学研合作平台等方式,构建集人才培养、科学研究、技术创新、学生创业等功能于一体的人才培养实体,探索现代产业学院的建设模式,解决人才培养与产业需求的结构性矛盾,打造高效产教融合的示范区,实现现代产业学院可持续、内涵式创新发展。

关键词：产业学院协同育人产教融合行业产教融合共同体人才培养建设模式

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