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Wide-spectrum optical synthetic aperture imaging via spatial intensity interferometry

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Opto-Electronic Advances 2023年第12期6卷 27-35页

作者： Chunyan Chu Zhentao Liu mingliang Chen Xuehui Shao Guohai Situ Yuejin Zhao Shensheng han Beijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology Beijing 100081China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China National Laboratory of Aerospace Intelligent Control Technology Beijing 100089China hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China.

High resolution imaging is achieved using increasingly larger apertures and successively shorter *** aperture synthesis is an important high-resolution imaging technology used in *** long baseline amplitude interferometry is susceptible to uncontrollable phase fluctuations,and the technical difficulty increases rapidly as the wavelength *** intensity interferometry inspired by HBT experiment is essentially insensitive to phase fluctuations,but suffers from a narrow spectral bandwidth which results in a lack of effective *** this study,we propose optical synthetic aperture imaging based on spatial intensity *** not only realizes diffraction-limited optical aperture synthesis in a single shot,but also enables imaging with a wide spectral bandwidth,which greatly improves the optical energy efficiency of intensity *** this method is insensitive to the optical path difference between the *** and experiments present optical aperture synthesis diffraction-limited imaging through spatial intensity interferometry in a 100 nm spectral width of visible light,whose maximum optical path difference between the sub-apertures reaches 69λ.This technique is expected to provide a solution for optical aperture synthesis over kilometer-long baselines at optical wavelengths.

关键词： optical synthetic aperture imaging ghost imaging intensity interferometry

关节镜下复位联合骨科机器人导航置钉治疗SandersⅡ、Ⅲ型跟骨骨折效果的随机对照研究

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中华解剖与临床杂志 2024年第8期29卷 503-509页

作者：徐明亮陈国梁袁罕黎仁龙李林陈景石荣剑徐州仁慈医院足踝外科徐州221004

目的:探讨关节镜下复位联合骨科机器人导航置钉治疗SandersⅡ、Ⅲ型跟骨骨折的临床疗效。方法:前瞻性随机对照研究。纳入2019年9月—2022年1月徐州仁慈医院足踝外科SandersⅡ、Ⅲ型跟骨骨折患者60例,其中男47例、女13例,年龄15~58(39.3... 详细信息

目的:探讨关节镜下复位联合骨科机器人导航置钉治疗SandersⅡ、Ⅲ型跟骨骨折的临床疗效。方法:前瞻性随机对照研究。纳入2019年9月—2022年1月徐州仁慈医院足踝外科SandersⅡ、Ⅲ型跟骨骨折患者60例,其中男47例、女13例,年龄15~58(39.3±10.8)岁;左足31例、右足29例。按数字表法随机分为2组:观察组30例采用关节镜下跟骨关节内骨折复位、机器人导航置入空心钉,对照组30例采用传统的跟骨外侧“L”形切口,跟骨骨折复位钢板内固定。比较2组患者手术住院时间、切口长度、术中出血量、骨折愈合时间、手术时间、术前及末次随访时跟骨Gissane角和Bohler角、美国足踝外科协会(AOFAS)踝-后足功能评分、疼痛视觉模拟评分法(VAS)评分及术后并发症发生率等差异。结果:60例患者手术顺利,术后均获随访12~16(13.63±1.26)个月。2组患者年龄、随访时间、性别、损伤侧别、致伤原因、Bohler角和Gissane角等基线资料比较,差异均无统计学意义(P值均>0.05)。观察组住院时间、切口长度、术中出血量、VAS评分、并发症发生率等观察指标分别为5.5(5.0,6.0)d、39(35,40)mm、20(15,25)mL、0(0,1)分、13.3%(4/30),均小于对照组的9.0(8.0,10.5)d、120.00(115,125)mm、45(35,50)mL、2(1,2)分、36.7%(11/30);观察组手术时间、AOFAS评分分别为90(80,95)min、92.0(90.0,93.0)分,均大于对照组的60(50,75)min、90.0(89.7,91.3)分:2组比较差异均有统计学意义(Z=6.61、6.70、6.69、4.88,χ^(2)=4.35,Z=8.51、2.77,P值均0.05)。观察组患者切口均一期愈合,其中2例患者术后3个月出现距下关节疼痛、2例患者术后2个月出现腓骨肌激惹症状;对照组中,切口一期愈合25例,二期愈合5例(2例患者术后1周皮肤切口坏死、3例患者术后第3日切口皮缘坏死),另有3例患者术后第1日出现足背外侧麻、3例患者术后3个月出现距下关节疼痛。结论:关节镜下复位联合骨科机器人导航置钉与跟骨外侧“L”形切口钢板内固定治疗SandersⅡ、Ⅲ型跟骨骨折,均能获得良好的效果,但前者具有手术切口小、出血少、骨折复位可视化、置钉精准化、并发症少等优势。

关键词：跟骨骨折骨折固定术内关节镜检查机器人导航置钉微创手术

神经内镜下微血管减压术治疗面肌痉挛患者的效果及对术后康复、复发的影响

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中外医学研究 2024年第16期22卷 34-37页

作者：邓明亮张辉翟红洁韩冠达李磊董小辉娄飞云蚌埠医科大学第一附属医院安徽蚌埠233000

目的:分析神经内镜下微血管减压术治疗面肌痉挛患者的效果,探讨其对术后康复及复发的影响。方法:选取2020年1月—2023年1月蚌埠医科大学第一附属医院神经外科收治的80例面肌痉挛患者作为研究对象,随机分为对照组和观察组,各40例。对照... 详细信息

目的:分析神经内镜下微血管减压术治疗面肌痉挛患者的效果,探讨其对术后康复及复发的影响。方法:选取2020年1月—2023年1月蚌埠医科大学第一附属医院神经外科收治的80例面肌痉挛患者作为研究对象,随机分为对照组和观察组,各40例。对照组采取常规微血管减压术治疗,观察组采取神经内镜下微血管减压术治疗,比较两组手术指标、治疗效果、术后并发症、复发情况等。结果:观察组手术时间、住院时间短于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组,而术后并发症发生率及术后1年复发率低于对照组,差异有统计学意义(P<0.05)。结论:常规微血管减压术、神经内镜下微血管减压术都是治疗面肌痉挛的方法,而神经内镜下微血管减压术是在微血管减压术的基础上利用神经内镜辅助观察和操作,进一步提高了手术视野清晰度,不仅有利于缩短手术时间,还能减少并发症风险,从而提高手术效果和术后康复速度,有效缩短住院时间,随访1年复发率也明显更低。

关键词：面肌痉挛显微手术微血管减压术神经内镜复发控制治疗效果

Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4378-4389页

作者： Dongrong Yi Quanjie Li han Wang Kai Lv Ling Ma Yujia Wang Jing Wang Yongxin Zhang mingliang Liu Xiaoyu Li Jianxun Qi Yi Shi George F.Gao Shan Cen Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100050China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal BiotechnologyPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100050China

Ebola virus(EBOV)infection leads to staggeringly high mortality *** and low-cost treatments are urgently needed to control frequent EBOV outbreaks in *** this study,we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and in *** work further showed that berbamine hydrochloride acts by directly binding to the cleaved EBOV glycoprotein(GPcl),disrupting GPcl interaction with viral receptor Niemann-Pick C1,thus blocking the fusion of viral and cellular *** data support the probability of developing anti-EBOV small molecule drugs by targeting viral *** importantly,since berbamine hydrochloride has been used in clinic to treat leukopenia,it holds great promise of being quickly repurposed as an anti-EBOV drug.

关键词： Ebola virus Drug repositioning Entry inhibitor Primed glycoprotein Structure-based virtual screening Protein-protein interaction Berbamine hydrochloride Natural compound

Ghost imaging for an axially moving target with an unknown constant speed

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Photonics Research 2015年第4期3卷 153-157页

作者： Xiaohui Li Chenjin Deng mingliang Chen Wenlin Gong Shensheng han Key Laboratory for Quantum Optics and Center for Cold Atom Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences

The influence of the axial relative motion between the target and the source on ghost imaging(GI) is *** the analytical and experimental results show that the transverse resolution of GI is reduced as the deviation of the target’s center position from the optical axis or the axial motion range increases. To overcome the motion blur,we propose a deblurring method based on speckle-resizing and speed retrieval, and we experimentally validate its effectiveness for an axially moving target with an unknown constant speed. The results demonstrated here will be very useful to forward-looking GI remote sensing.

关键词： GI Ghost imaging for an axially moving target with an unknown constant speed

Contactless Microwave Detection of Shubnikov–De Haas Oscillations in Three-Dimensional Dirac Semimetal ZrTe_5

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Chinese Physics Letters 2019年第6期36卷 49-52页

作者： Min Wu Hongwei Zhang Xiangde Zhu Jianwei Lu Guolin Zheng Wenshuai Gao Yuvan han Jianhui Zhou Wei Ning mingliang Tian Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory Chinese Academy of Sciences Department of Physics University of Science and Technology of China Department of Physics Shaanxi University of Science and Technology School of Science RMIT University Department of Physics School of Physics and Materials Science Anhui University

We report Shubnikov–de Haas(SdH)oscillations of a three-dimensional(3D) Dirac semimetal candidate of layered material ZrTe_5 single crystals through contactless electron spin resonance(ESR)measurements with the magnetic field up to 1.4 *** ESR signals manifest remarkably anisotropic characteristics with respect to the direction of the magnetic field,indicating an anisotropic Fermi surface in ZrTe_*** experiments demonstrate that the ZrTe_5 single crystals have the signature of massless Dirac fermions with nontrivialBerry phase,key evidence for 3D Dirac/Weyl ***,the onset of quantum oscillation of our ZrTe_5 crystals revealed by the ESR can be derived down to 0.2 T,much smaller than the onset of SdH oscillation determined by conventional magnetoresistance ***,ESR measurement is a powerful tool to study the topologically nontrivial electronic structure in Dirac/Weyl semimetals and other topological materials with low bulk carrier density.

关键词： Dirac Microwave Haas ESR spin down tool our

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

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Bioactive Materials 2022年第3期7卷 77-91页

作者： Yi han Lu Jiang Huihui Shi Chenfang Xu Minting Liu Qingjian Li Lan Zheng Hong Chi Mingyue Wang Zuguo Liu mingliang You Xian Jun Loh Yun-Long Wu Zibiao Li Cheng Li Fujian Provincial Key Laboratory of Ophthalmology and Visual Science&Ocular Surface and Corneal Diseases Eye Institute&Affiliated Xiamen Eye CenterSchool of MedicineXiamen UniversityXiamen361102China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore138634Singapore School of Chemical Sciences University of Chinese Academy of ScienceBeijing100049China Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of ScienceNingbo315201China Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen361102China hangzhou Cancer Institute Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou Cancer HospitalZhejiang University School of MedicineHangzhou310002China Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Pharmaceutical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan250353China Department of Materials Science and Engineering National University of SingaporeSingapore117575Singapore

Dry eye is a common ocular disease that results in discomfort and impaired vision,impacting an individual’s quality of life.A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface,which limits their therapeutic ***,it is imperative to design a novel drug delivery system that not only improves the water solubility of the drug but also prolongs its retention time on the ocular ***,we develop a copolymer from mono-functional POSS,PEG,and PPG(MPOSS-PEG-PPG,MPEP)that exhibits temperature-sensitive sol-gel transition *** thermo-responsive hydrogel improves the water solubility of FK506 and simultaneously provides a mucoadhesive,long-acting ocular delivery *** addition,the FK506-loaded POSS hydrogel possesses good biocompatibility and significantly improves adhesion to the ocular *** comparison with other FK506 formulations and the PEG-PPG-FK506(F127-FK506)hydrogel,this novel MPOSS-PEG-PPG-FK506(MPEP-FK506)hydrogel is a more effective treatment of dry eye in the murine dry eye ***,delivery of FK506 in this POSS hydrogel has the potential to prolong drug retention time on the ocular surface,which will improve its therapeutic efficacy in the management of dry eye.

关键词： Ocular adhesive Polyhedral oligomeric silsesquioxane FK506 Dry eye

从记者到“新闻官”:国民党新闻管理者的职业抉择和职业悲剧——以董显光、曾虚白、马星野为中心的探讨

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国际新闻界 2015年第10期37卷 127-148页

作者：王明亮秦汉暨南大学新闻与传播学院中国人民大学新闻学院美国加利福尼亚大学圣地亚哥分校传播学院

本研究着眼于阐释以董显光、曾虚白、马星野等为代表的原新闻从业者,在国难日深、民族危亡的大时代里,自觉投身体制,成为管理者之后,左右于"自由/民主"和"国家/道统"的内心矛盾和纠结。研究发现,这些浸染过"自由主义"底色的国民党新闻... 详细信息

本研究着眼于阐释以董显光、曾虚白、马星野等为代表的原新闻从业者,在国难日深、民族危亡的大时代里,自觉投身体制,成为管理者之后,左右于"自由/民主"和"国家/道统"的内心矛盾和纠结。研究发现,这些浸染过"自由主义"底色的国民党新闻管理者,都不同程度地存在着角色的冲突和矛盾。早年的教育背景和记者从业经历,使他们在内心深处认同和向往自由主义的新闻事业;但他们自小又大多接受了良好的儒家传统教育,继承了中国传统文人"忠君爱国"、"先天下之忧而忧"的秉性,面对着内忧外患的国家现状,他们不约而同地做出了"救亡压倒一切,甚至是牺牲自由"的选择,毅然加入国民党宣传机关,做起了新闻官。但这也使得他们在面对党员/报人、党纪/职业伦理等诸多互为矛盾的角色和抉择时,进退失据。而真诚地拥抱权力和体制则使他们丧失了知识分子"议政参政"的土壤条件,最终沦落为国民党党政科层体制中的"事务性技术官僚"。

关键词：国民党新闻管理者角色困惑职业抉择

四川地区藏族人群血小板计数与血栓弹力图参数相关性研究

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标记免疫分析与临床 2024年第5期31卷 872-876页

作者：潘明亮周卫东张林李广权邓容钟培英三六三医院输血科四川成都610041 三六三医院检验科四川成都610041

目的探讨四川地区藏族人群血小板(platelet,PLT)计数与血栓弹力图(thrombelastogram,TEG)参数之间的相关性。方法回顾性分析2022年1月至2022年12月本院收治的2056名进行了血栓弹力图及血常规检测的藏族患者。根据PLT水平分为4组,PLT降低... 详细信息

目的探讨四川地区藏族人群血小板(platelet,PLT)计数与血栓弹力图(thrombelastogram,TEG)参数之间的相关性。方法回顾性分析2022年1月至2022年12月本院收治的2056名进行了血栓弹力图及血常规检测的藏族患者。根据PLT水平分为4组,PLT降低组(PLT300×10^(9)/L,n=322)。对比4组TEG参数结果,探讨四川地区藏族人群TEG参数与PLT计数之间的关系。同时选取同时间段2056名本地区汉族人群,比较藏族与汉族TEG参数与PLT计数之间的关系是否有差异。结果四川地区藏族人群中,弹力图最大切角(Angle)、凝血综合指数(CI)、血凝块最大振幅(MA)与PLT计数呈正相关,相关系数r分别为0.401、0.418、0.419(P<0.001);血凝块形成时间(K)、反应时间(R)与PLT计数呈负相关,相关系数r分别为-0.393、-0.138(P<0.001)。四川地区汉族人群中,Angle、CI、MA与PLT计数呈正相关,相关系数r分别为0.271、0.273、0.333(P<0.001);K与PLT计数呈负相关,相关系数r为-0.248(P<0.001),R与PLT计数无相关性。藏族PLT降低组、PLT正常高值组PLT计数与Angle、CI、MA呈正相关,与K呈负相关;藏族PLT正常低值组、藏族PLT升高组PLT计数与Angle、CI、MA呈正相关,与K、R呈负相关。结论四川地区藏族人群PLT计数与TEG参数间有密切的相关性,与本地区汉族人群有差异。

关键词：血栓弹力图血小板藏族相关性研究