检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

论斯蒂格勒技术哲学的神话结构

太原师范学院学报（社会科学版） 2023年第1期22卷 11-17页

作者：陈明宽西北大学哲学学院陕西西安710127

斯蒂格勒的技术哲学由从三则神话演绎出的三项原则支撑建构起来。第一项原则为爱比米修斯原则,表示人类天生缺乏足以维持其生存的任何本能,必须借助于外在的技术而生存,技术就是人类的本质和存在方式。第二项原则为普罗米修斯原则,表示... 详细信息

斯蒂格勒的技术哲学由从三则神话演绎出的三项原则支撑建构起来。第一项原则为爱比米修斯原则,表示人类天生缺乏足以维持其生存的任何本能,必须借助于外在的技术而生存,技术就是人类的本质和存在方式。第二项原则为普罗米修斯原则,表示由于人类是后种系生成的物种,人类的进化就是技术的进化,其进化的动力在于人类死亡的超前性。第三项原则为潘多拉原则,表示技术即为欲望,二者对立而统一,既是使人类社会进化的解药,也是造成人类社会各种问题的毒药。这三项原则共同建构起了斯蒂格勒技术哲学的神话结构。斯蒂格勒技术哲学为我们理解技术以及当代技术现象提供了一种全新的视野。

关键词：斯蒂格勒技术后种系生成无产阶级化欲望

技术替补与技术文码化——斯蒂格勒技术哲学中的文码化思想分析

在线全文

学校读者我要写书评

暂无评论

自然辩证法通讯 2018年第6期40卷 128-134页

作者：陈明宽同济大学人文学院上海200092

斯蒂格勒技术哲学中的文码化概念是其描述分析技术之更新迭代的核心概念。文码化是指对连续而混沌的流程的离散化。斯蒂格勒所说的文码化就是德里达所说的延异。延异是替补不断生成的过程。在斯蒂格勒看来,技术文码化是人类的延异。因... 详细信息

斯蒂格勒技术哲学中的文码化概念是其描述分析技术之更新迭代的核心概念。文码化是指对连续而混沌的流程的离散化。斯蒂格勒所说的文码化就是德里达所说的延异。延异是替补不断生成的过程。在斯蒂格勒看来,技术文码化是人类的延异。因为人类在起源处一无所有,技术就成了人类的本质和存在方式,技术是人类之无本质的替补。人类生命的生成过程是与纯粹生命生成的断裂,其生成是技术的生成。在人类进化历程中,已经出现了三次技术文码化革命,分别是:书写技术文码化革命,印刷技术文码化革命和科学技术文码化革命。当今时代正是科学技术文码化时代。

关键词：斯蒂格勒技术文码化替补离散化

Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

在线全文

学校读者我要写书评

暂无评论

Internalized Cryptococcus neoformans Activates the Canonical...

改进高斯过程的客车侧风工况下气动造型优化研究

第十届全国免疫学学术大会

作者： Guangxun Meng mingkuan chen Yue Xing Wanqing Liao Key Laboratory of Molecular Virology & Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai Key Laboratory of Molecular Medical Mycology Changzheng Hospital

Cryptococcus neoformans(***)is an opportunistic fungal pathogen which causes Cryptococccosis in immunocompromised patients as well as immunocompetent *** cell surface receptors that recognize *** have been widely ***,intracellular sensing of this pathogen is still poorly *** previous studies have demonstrated that both biofilm and acapsular mutant of *** are able to activate the NLRP3 *** the current study,it was found that opsonization mediated internalization of encapsular *** also activated the canonical NLRP3-ASC-caspase-1 *** addition,the internalized *** activated the noncanonical NLRP3-ASC-caspase-8 inflammasome as well,which resulted in robust IL-1βsecretion and cell death from caspase-1 deficient primary dendritic ***,we found that caspase-1was inhibitory for the activation of caspase-8 in dendritic cells upon *** *** mechanistic studies showed that both of the phagolysosome membrane permeabilization and potassium efflux were responsible for *** induced activation of either the canonical NLRP3-ASC-caspase-1 inflammasome or the noncanonical NLRP3-ASC-caspase-8 ***,infection with Candida albicans or challenge with zymosan also led to the activation of the noncanonical NLRP3-ASC-caspase-8 inflammasome in cells absent for ***,these findings uncover a number of novel signaling pathways for the innate immune response of host cells to *** infection,and suggest that manipulating NLRP3 signaling may help to control fungal challenge.

关键词： Cryptococcus neoformans Inflammasome NLRP3 Caspase-8 Caspase-1

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

重庆理工大学学报（自然科学） 2024年第4期38卷 15-23页

作者：王婷婷姚铭宽邵旭秦东晨陈江义郑州大学机械与动力工程学院郑州450000

高速客车的行驶安全性受侧风影响较大,为改善高速客车的气动特性和行驶稳定性,提出了一种改进的高斯过程回归模型对客车进行气动造型优化。该模型中,使用一种自动核构造算法,根据数据特征自动构造核函数,采用基于万有引力加速机理的自... 详细信息

高速客车的行驶安全性受侧风影响较大,为改善高速客车的气动特性和行驶稳定性,提出了一种改进的高斯过程回归模型对客车进行气动造型优化。该模型中,使用一种自动核构造算法,根据数据特征自动构造核函数,采用基于万有引力加速机理的自适应遗传算法对超参数进行优化,克服了传统近似模型精度低的问题。结果表明:改进高斯过程回归模型的预测值均位于95%置信区间,精度较高,实际应用中能够减少仿真和实验的次数,具有较好的工程实用价值。基于协同优化的思想对客车气动造型进行优化,客车的气动升力系数降低了22.56%,侧向力系数降低了18.53%,气动阻力系数降低了4.51%。

关键词：客车稳态侧风气动造型高斯过程回归遗传算法

An Essential Role for the NLRP3 Inflammasome in Host Defense against Cryptococcus neoformans infection

在线全文

学校读者我要写书评

暂无评论

An Essential Role for the NLRP3 Inflammasome in Host Defense...

The S267F variant of sodium taurocholate co-transporting polypeptide is strongly associated with resistance to chronic hepatitis B and high level of serum total bile acids

第八届全国免疫学学术大会

作者： mingkuan chen Guowei Lei Hua Li Shuxian Wu Junling Niu Liming Mao Ailing Lu Hongbin Wang Wei chen Guiwen Yang Liguo An Cunshuan Xu Qibin Leng Liping Zhu Guangxun Meng Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiShanghai Institutes for Biological Sciences Graduate University of Chinese Academy of Sciences College of Life Science Shandong Normal University College of Life Science Henan Normal University Department of Infectious Diseases Hua Shan HospitalFudan Unversity

Background:Innate immune system plays an important role in fighting against pathogen invasion through certain mechanisms such as phagocytosis and secretion of inhibitory *** an important component of the innate immune system, inflammasomes are multi-protein complexes which can convert pro-caspase-1 into its active form, the latter process pro-IL-1β into its mature ***3 inflammasome, one of the most studied inflammasomes, has been found to be involved in response to various pathogenic fungi, such as Candida albicans and Aspergillus *** neoformans is an opportunistic fungal pathogen, frequently causing fatal meningoencephalitis in AIDS ***:Here we explore the role of NLRP3 inflammasome in response to *** infection with human monocytic cell line and inflammasome component deficient mice by the method of immunoblot, ELISA, and Real-time ***:*** induced IL-1β secretion in THP-1 monocytes, this process was Nlrp3 inflammasome dependent and involved ROS production as well as Cathepsin B *** found that Dectin-1-- SYK signaling pathway was required for *** activation of the NLRP3 *** vivo, deficiency of the Nlrp3 inflammasome components led to increased mortality and fungi load in mice after *** ***:Our data thus revealed that the NLRP3 inflammasome was an important host factor for control of *** infection, and suggested that manipulating NLRP3 signaling may help to oppose *** infection.

关键词： Innate Immunity Inflammasome NLRP3 Cryptococcus neoformans

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Liver Research 2022年第3期6卷 186-190页

作者： Jiancheng Huang mingkuan Su Hongbin chen Shuiqing Wu Zongyun chen Department of Laboratory Medicine Mindong Hospital Affiliated to Fujian Medical UniversityFuanFujianChina Department of Gastroenterology Mindong Hospital Affiliated to Fujian Medical UniversityFuanFujianChina

Background and aims:The sodium taurocholate co-transporting polypeptide(NTCP)is a functional receptor for the hepatitis B virus(HBV),and it is critical for bile acid *** studies of the association between the S267F variant and chronic hepatitis B(CHB)have generated conflicting *** study analyzed the correlation between the NTCP S267F variant and CHB susceptibility by using a large sample of participants classified by gender and age,and this study also analyzed the relationship between this variant and the level of serum total bile ***:In total,543 patients with CHB and 429 control subjects underwent S267F variant genotyping using SNaPshot *** regression was utilized to evaluate any association of the NTCP S267F variant with CHB ***:The S267F variant was inversely correlated with the risk of chronic HBV infection in both the dominant model(GG genotype *** genotype:odds ratio(OR)=0.46,95%confidence interval(CI)0.30 -0.71,P<0.001)and the allele model(G allele vs.A allele:OR=0.50,95%CI 0.33-0.76,P=0.001),and this correlation was not affected by gender and age *** carriers of the heterozygous NTCP variant exhibited higher total bile acids levels than the carriers of wild-type NTCP,regardless of whether they were control subjects or patients with *** carriers exhibited reduced hepatitis B e antigen(HBeAg)-positivity rates and had lower ALT,AST,and lg DNA concentrations compared with wild-type carriers in patients with ***:The S267F variant of NTCP is a protective factor that reduces the risk of chronic HBV infection and exhibits a higher total bile acids *** with CHB who carry this variant may have a better prognosis than those carrying wild-type NTCP.

关键词： Bile acid Chronic hepatitis B(CHB) Hepatitis B virus(HBV) Sodium taurocholate co-transporting polypeptide(NTCP)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NLRP3炎症小体在流感病毒感染中的作用

中国细胞生物学学报 2015年第4期37卷 547-552页

作者：牛俊领陈明宽吴淑娴孟广勋徐存拴卢爱灵河南师范大学生命科学学院新乡453007 中国科学院分子病毒与免疫学重点实验室中国科学院上海巴斯德研究所上海200031 河南省–科技部共建细胞分化调控重点实验室培育基地新乡453007

NLRP3(NOD-,LRR,and pyrin domain-containing 3)炎症小体能够对多种病原体保守结构和内源性危险信号应答而活化Caspase-1,介导促炎症细胞因子前体Pro-IL-1β和Pro-IL-18的成熟与分泌,启动免疫防御,在抗微生物感染中发挥着重要作用。该... 详细信息

NLRP3(NOD-,LRR,and pyrin domain-containing 3)炎症小体能够对多种病原体保守结构和内源性危险信号应答而活化Caspase-1,介导促炎症细胞因子前体Pro-IL-1β和Pro-IL-18的成熟与分泌,启动免疫防御,在抗微生物感染中发挥着重要作用。该文总结了流感病毒的结构与变异、细胞对流感病毒的识别、流感病毒感染过程中NLRP3炎症小体的活化与功能、流感病毒对免疫识别的逃逸等内容。

关键词：流感病毒 NLRP3 炎症小体感染炎症

化学遗传学技术在抑郁症神经环路研究中的应用

在线全文

学校读者我要写书评

暂无评论

中华行为医学与脑科学杂志 2024年第6期33卷 554-559页

作者：李绍炜李节惠张明宽张浩胡明会陈丹徐凯勇李自发耿希文魏盛山东中医药大学中医学院济南250355 胜利油田中心医院东营257000 山东中医药大学中医药经典理论教育部重点实验室山东中医药大学中医药与脑科学交叉学科研究平台济南250355

化学遗传学技术是一种通过改变受体特异性和亲和力来调节细胞活性与功能的受体-配体系统的技术,其通过特异性地调控神经元及神经环路精准调控神经。目前,该技术在神经环路研究中应用十分广泛。本文主要简述化学遗传学技术在抑郁症神经... 详细信息

化学遗传学技术是一种通过改变受体特异性和亲和力来调节细胞活性与功能的受体-配体系统的技术,其通过特异性地调控神经元及神经环路精准调控神经。目前,该技术在神经环路研究中应用十分广泛。本文主要简述化学遗传学技术在抑郁症神经环路研究中的应用与进展,梳理该技术在腹侧被盖区、伏隔核、前额叶皮质、海马、外侧缰核等几个与抑郁症发生密切相关的脑区中的应用,讨论化学遗传学技术作为一种精准调控神经活动的技术在未来研究中的潜力和挑战,以期为化学遗传学技术在抑郁症神经环路研究提供可靠的思路和方向。

关键词：化学遗传学技术神经环路抑郁症神经调控

A Theoretical Insight into the Mechanism of Cu（I）-Catalyzed C--N Coupling between Aryl Halides and Aqueous Ammonia

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2015年第8期33卷 961-966页

作者： Ting chen mingkuan Yan Chao Zheng Jie Yuan Shen Xu Runfeng chen Wei Huang Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advaneed Materials Nanjing University of Posts & Telecommunications Nanjing Jiangsu 210023 China Key Laboratory of Flexible Electronics & Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced Materials Nanjing Tech University Nanjing Jiangsu 211816 China

Computational investigations of Cu（I）-catalyzed C--N coupling between aryl halides and aqueous ammonia without addition of any base or ligand were reported. Density functional theory calculations were performed to re- veal the mechanism of the ligand-free amination reaction for the preparation of primary aromatic amines. Through systematic evaluation of the relative concentrations of possible Cu species in solution, we propose that the active catalyst is the neutral Cu（I） complexes rather than the Cu（I） cations; oxidative addition of aryl bromide is a facile step of the catalytic cycle; reactant （NH3） and solvent molecule （NMP） can act as ligands of Cu species to help re- duce the activation energy of the forward reaction and increase the activation energy of the reverse reaction; except for Pathway B, the deprotonation step is irreversible due to the extreme exothermic feature; the elimination of H20 is kinetically favored, while that of HBr is thermodynamically preferred. These findings should be valuable for the mechanism understandings of the ligand-free Cu-catalyzed C--N cross-coupling reactions and for the further de- velopment of highly efficient amination catalyst systems.

关键词： amination C-N cross coupling Cu(I)-catalyzed coupling DFT catalytic mechanism