检索结果-南通市图书馆

Insights into the underlying mechanisms and clinical management of microscopic colitis in relation to other gastrointestinal disorders

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2022年第1期10卷 37-53页

作者： Yuanbin Liu mingkai chen Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhanHubeiP.R.China

Microscopic colitis(MC)is a chronic inflammatory disease of the large intestine and as a relatively late recognized condition,its relationship with other disorders of the gastrointestinal tract is gradually being understood and *** a multifactorial disease,MC interacts with inflammatory bowel disease,celiac disease,and irritable bowel syndrome through genetic overlap,immunological factors,and gut *** risk of colorectal cancer was significantly lower in MC,gastrointestinal infections increased the risk of developing MC,and there was an inverse association between Helicobacter pylori infection and MC.A variety of associations are found between MC and other gastrointestinal disorders,where aspects such as genetic effects,resemblance of immunological profiles,and intestinal microecology are potential mechanisms behind the *** should be aware of these connections to achieve a better understanding and management of MC.

关键词： microscopic colitis inflammatory bowel disease celiac disease irritable bowel syndrome management

Multimodal fusion recognition for digital twin

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第2期10卷 337-346页

作者： Tianzhe Zhou Xuguang Zhang Bing Kang mingkai chen Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing210003China

The digital twin is the concept of transcending reality,which is the reverse feedback from the real physical space to the virtual digital *** hold great prospects for this emerging *** order to realize the upgrading of the digital twin industrial chain,it is urgent to introduce more modalities,such as vision,haptics,hearing and smell,into the virtual digital space,which assists physical entities and virtual objects in creating a closer ***,perceptual understanding and object recognition have become an urgent hot topic in the digital *** surface material classification schemes often achieve recognition through machine learning or deep learning in a single modality,ignoring the complementarity between multiple *** order to overcome this dilemma,we propose a multimodal fusion network in our article that combines two modalities,visual and haptic,for surface material *** the one hand,the network makes full use of the potential correlations between multiple modalities to deeply mine the modal semantics and complete the data *** the other hand,the network is extensible and can be used as a universal architecture to include more *** show that the constructed multimodal fusion network can achieve 99.42%classification accuracy while reducing complexity.

关键词： Digital twin Multimodal fusion Object recognition Deep learning Transfer learning

Atom engineering-regulated in situ transition of Cu(Ⅰ)-Cu(Ⅱ)for efficiently overcoming cancer drug resistance

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2022年第10期65卷 1879-1884页

作者： Yuequn Zhang mingkai chen Junping Wang Fei Cai Li Ma Tianfeng chen Department of Chemistry Jinan UniversityGuangzhou 510632China

The search of highly efficient drugs for overcoming cancer drug resistance continues to be a challenge for *** a metal drug based in situ oxidation-state transition system to disturb the redox balance in cancer cells is a promising approach for overcoming cancer drug *** by natural redox-active copper enzyme centers,we developed a Cu(Ⅰ)-Cu(Ⅱ) in situ transition system in this *** atom engineering,we fine-tuned the thermodynamic stability of this system to investigate its anticancer *** results indicated that the synthetic Cu(Ⅰ)-Cu(Ⅱ) system could under-go in situ transition in vitro and in vivo,to disrupt the intracellular redox balance and trigger mitochondrial dysfunction and G2/M arrest,leading to apoptosis and overcoming cancer drug *** study presents a feasible way to overcome cancer drug resistance by designing an in situ oxidation-state transition metal drug system.

关键词： cancer drug resistance Cu(Ⅰ)-Cu(Ⅱ)in situ transition atom engineering entatic state redox balance

A new method for coseismic offset detection from GPS coordinate time series

在线全文

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2023年第6期14卷 551-558页

作者： Zhiwei Yang Guangyu Xu Tengxu Zhang mingkai chen FeiWu Zhiping chen School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China Key Laboratory of Mine Environmental Monitoring and Improving around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China Key Laboratory for Digital Land and Resources of Jiangxi Province East China University of TechnologyNanchang 330013China Hubei Luojia Laboratory Wuhan 430079China College of Resources and Environmental Science and Engineering Hubei University of Science and TechnologyXianning 437100China

Currently,the extraction of coseismic offset signals primarily relies on earthquake catalog data to determine the occurrence time of *** is followed by the process of differencing the average GPS coordinate time series data,with a time interval of 3 to 5 days before and after the *** the face of the huge amount of GPS coordinate time series data today,the conventional approach of relying on earthquake catalog data to assist in obtaining coseismic offset signals has become increasingly *** address this problem,we propose a new method for automatically detecting coseismic offset signals in GPS coordinate time series without an extra earthquake catalog for ***,we pre-process the GPS coordinate time series data for filtering out stations with significant observations missing and detecting and removing ***,we eliminate other signals and errors in the GPS coordinate time series,such as trend and seasonal signals,leaving the coseismic offset signals as the primary *** resulting coordinate time series is then modeled using the first-order difference and data stacking *** modeling method enables automatic detection of the coseismic offset signals in the GPS coordinate time *** aforementioned method is applied to automatically detect coseismic offset signals using simulated data and the Searles Valley GPS data in California,*** results demonstrate the efficacy of our proposed method,successfully detecting coseismic offsets from vast amounts of GPS coordinate time series data.

关键词： GPS Coordinate time series Coseismic offset Signal detection

Substituent-regulated highly X-ray sensitive Os(Ⅵ)nitrido complex for low-toxicity radiotherapy

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第1期32卷 158-161页

作者： mingkai chen Xiaoting Huang Jie Lai Li Ma Tianfeng chen Department of Chemistry Jinan UniversityGuangzhou 510632China

A high efficiency and low toxicity radiosensitizer,OsN(PhenOH)Cl_3,was designed and synthesized through substituent *** the best of our knowledge,this is the first osmium-based coordination complex *** experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.

关键词： Os(Ⅵ)nitrido Complex Radiotherapy Radiosensitizer G2/M cell cycle arrest

Progress in the Clinical Features and Pathogenesis of Abnormal Liver Enzymes in Coronavirus Disease 2019

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2021年第2期9卷 239-246页

作者： Haiyan Wu Shuzhong Liu Hesheng Luo mingkai chen Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhanHubeiChina

With the rapid development of research on coronavirus disease 2019(COVID-19),more and more attention has been drawn to its damage to extrapulmonary *** are increasing lines of evidence showing that liver injury is closely related to the severity of COVID-19,which may have an adverse impact on the progression and prognosis of the *** is more,severe acute respiratory syndrome coronavirus-2 infection,cytokine storm,ischemia/hypoxia reperfusion injury,aggravation of the primary liver disease and drug-induced liver injury may all contribute to the hepatic damage in COVID-19 patients;although,the drug-induced liver injury,especially idiosyncratic drug-induced liver injury,requires further causality confirmation by the updated Roussel Uclaf Causality Assessment Method published in *** to now,there is no specific regimen for COVID-19,and COVID-19-related liver injury is mainly controlled by symptomatic and supportive ***,we review the clinical features of abnormal liver enzymes in COVID-19 and pathogenesis of COVID-19-related liver injury based on the current evidence,which may provide help for clinicians and researchers in exploring the pathogenesis and developing treatment strategies.

关键词： Coronavirus disease 2019 Abnormal liver enzymes Liver injury Idiosyncratic drug-induced liver injury Roussel Uclaf Causality Assessment Method Clinical characteristics

Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2023年第4期16卷 5169-5175页

作者： Liwen Zhu Leung Chan Junping Wang mingkai chen Fei Cai Yuan Tian Li Ma Tianfeng chen Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China

Radiotherapy is one of the main therapeutic methods for cancers;however,nonselective killing of normal cells and tumor cells by X-ray inevitably results in toxicity and side *** low-toxicity and high-efficiency radiosensitizers to reduce the practical dose of X-ray is a promising approach to overcoming these side ***,we report the use of carboxylatecontaining organic ligands to construct one-dimensional high-Z lanthanide chains for efficient response to *** onedimensional lanthanide chains are stacked through weak interactions to form coordination nanoframeworks in the presence of polyethylenimine(PEI).The morphology and activity of the synthesized nanoframeworks can be regulated through selenium atom *** study presents a promising approach for effective radiotherapy through selenium-engineering stable lanthanide nanoframeworks with precise coordination structures as radiosensitizers to mitigate X-ray side effects.

关键词： selenium lanthanide coordination nanoframeworks radiotherapy radiosensitizers

Task-Oriented Semantic Communication with Foundation Models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第7期21卷 65-77页

作者： chen mingkai Liu Minghao Zhang Zhe Xu Zhiping Wang Lei Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China School of Ocean Information Engineering Jimei UniversityXiamen 361021China Key Laboratory of Underwater Acoustic Communication and Marine Information Technology(Xiamen University) Ministry EducationXiamen 361005China

In the future development direction of the sixth generation(6G)mobile communication,several communication models are proposed to face the growing challenges of the *** rapid development of artificial intelligence(AI)foundation models provides significant support for efficient and intelligent communication *** this paper,we propose an innovative semantic communication paradigm called task-oriented semantic communication system with foundation ***,we segment the image by using task prompts based on the segment anything model(SAM)and contrastive language-image pretraining(CLIP).Meanwhile,we adopt Bezier curve to enhance the mask to improve the segmentation ***,we have differentiated semantic compression and transmission approaches for segmented ***,we fuse different semantic information based on the conditional diffusion model to generate high-quality images that satisfy the users'specific task ***,the experimental results show that the proposed system compresses the semantic information effectively and improves the robustness of semantic communication.

关键词： diffusion model foundation model joint source-channel coding task-oriented semantic communication

High-dimensional zinc porphyrin nanoframeworks as efficient radiosensitizers for cervical cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第7期34卷 182-185页

作者： Fei Cai Kun Ye mingkai chen Yuan Tian Peicong chen Hao Lin Tianfeng chen Li Ma Department of Chemistry Jinan UniversityGuangzhou 510632China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001China

Radiotherapy is widely used clinically, but the toxic and side effects of nonselective killing of high-energy radiation limit its application. Finding biocompatible materials to assemble radiotherapy sensitizers and studying their sensitization patterns are of great significance for the clinical application. Here, biocompatible zinc porphyrin was chosen as sub-unit to construct various dimensional coordination frameworks. By employing top-down approach, suitable nanoframeworks with various dimensional zinc porphyrin were synthesized as radiosensitizers. The experimental data showed that high-dimensional zinc porphyrin nanoframeworks exhibit higher X-ray response performance.

关键词： Zinc porphyrin frameworks Nanoframeworks Radiosensitizer Apoptosis