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面向结构光三维测量的高稳定映射拼接方法

光学学报 2014年第11期34卷 165-170页

作者：汤明辉程筱胜崔海华戴宁南京航空航天大学机电学院江苏南京210016

基于自由视角测量的三维拼接大大提高了测量的便捷性,为了提高视角间三维映射的稳健性,提出了一种改进的高稳定映射拼接方法。根据图像间匹配的特征点实现视角重合,利用结构光相位信息完成特征点三维映射和空间定位。针对特征点相位缺... 详细信息

基于自由视角测量的三维拼接大大提高了测量的便捷性,为了提高视角间三维映射的稳健性,提出了一种改进的高稳定映射拼接方法。根据图像间匹配的特征点实现视角重合,利用结构光相位信息完成特征点三维映射和空间定位。针对特征点相位缺失无法重建的普遍问题,提出利用邻域点插值恢复特征点方法,虚拟重建视角间有效映射点,通过四元数法实现视角间点云的刚性变换和拼接。实验表明,相较传统的方法,该方法平均能将有效特征点数量提升20%,有效提高了映射拼接的稳定性。

关键词：测量结构光映射拼接高稳定

SiW/ZrO_2/MCM-41催化苯甲醚酰化反应

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石油化工 2013年第7期42卷 787-794页

作者：汤明慧张波吴磊浙江工业大学化学工程与材料学院工业催化研究所浙江杭州310014

采用逐层浸渍法制备了MCM-41介孔分子筛负载ZrO2及硅钨酸(SiW)催化剂,考察了催化剂在以苯甲醚为原料、乙酸酐为酰化试剂的Friedel-Crafts酰化反应中的催化活性,同时对催化剂进行XRD、N2吸-脱附测试、DSC、FTIR、NH3-TPD等表征,研究了ZrO... 详细信息

采用逐层浸渍法制备了MCM-41介孔分子筛负载ZrO2及硅钨酸(SiW)催化剂,考察了催化剂在以苯甲醚为原料、乙酸酐为酰化试剂的Friedel-Crafts酰化反应中的催化活性,同时对催化剂进行XRD、N2吸-脱附测试、DSC、FTIR、NH3-TPD等表征,研究了ZrO2与SiW及载体之间的相互作用对催化剂活性的影响。实验结果表明,SiW直接负载到MCM-41后,SiW与载体发生相互作用使Keggin结构发生畸变,导致活性下降;但SiW通过ZrO2接枝负载到MCM-41后,SiW较好地分散在载体表面且保持了完整的Keggin结构,SiW与ZrO2间的相互作用增加了催化剂上强酸中心的数目,显著提高了催化活性。催化剂的最佳制备条件为:ZrO2负载量20%(w),SiW负载量60%(w),焙烧温度200℃;最佳反应条件为:反应时间4 h,反应温度110℃,催化剂用量为0.2 g(基于10 mmol乙酸酐),苯甲醚与乙酸酐的摩尔比10。

关键词：硅钨酸氧化锆 MCM-41介孔分子筛催化剂苯甲醚 Friedel-Crafts酰化反应

A seroepidemiological survey on schistosomiasis japonica.

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中国寄生虫学与寄生虫病杂志 1983年第S1期 41-42页

作者： Yang Qingzhang, CaiChunyong, Huang Desheng, tang minghui, Xu Huanwen, Ma Xingbao: Shanghai Municipal Institute for Schistosomiasis Control and Research

A seroepidemiological survey of schistosomiasis japonica was conducted in two

关键词： rate A seroepidemiological survey on schistosomiasis japonica

强西南急流背景下湘桂边界两次预报失败的暖区暴雨个例分析

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气象 2020年第8期46卷 1001-1014页

作者：付炜唐明晖叶成志湖南省永州市气象台永州425000 气象防灾减灾湖南省重点实验室长沙410007 湖南省气象台长沙410007

利用常规观测资料、FY-2G卫星黑体亮温(TBB)资料、多普勒天气雷达资料以及ERA-Interim再分析资料,对2016年5月5日(以下简称“16·5”过程)和2018年4月23日(以下简称“18·4”过程)两次强西南急流背景下的暖区暴雨预报失败案例进行对比... 详细信息

利用常规观测资料、FY-2G卫星黑体亮温(TBB)资料、多普勒天气雷达资料以及ERA-Interim再分析资料,对2016年5月5日(以下简称“16·5”过程)和2018年4月23日(以下简称“18·4”过程)两次强西南急流背景下的暖区暴雨预报失败案例进行对比分析。结果表明:两次暖区暴雨过程的水汽分别来源于925 hPa西南急流和显著西南风,“16·5”过程的水汽辐合强度及范围较“18·4”过程更强、更广,导致暴雨出现的范围更广;超低空急流断裂处的辐合区叠加在湘桂边界南岭山脉特殊地形上,动力抬升触发及维持作用更加明显。大气层结稳定度对暖区暴雨的发生具有重要指示作用,“16·5”过程大气不稳定度更大导致了更强的暖区暴雨;两次暖区暴雨的湿层厚度较锋面暴雨浅薄,中低层的显著湿区导致了暴雨或大暴雨的出现;“16·5”暖区暴雨发生过程中能量长时间的维持,是西南低空急流暖湿输送导致高温、高湿、高能的对流不稳定层结反复重建的结果,最终导致强降水持续,进而导致了更大的总降水量。“18·4”过程冷锋前100 km外相对较弱的水汽辐合区,是暖区暴雨的一个重要预报指标;两次过程中高空槽的经向度是决定暖区暴雨范围大小的重要因子。地形在两次暖区暴雨过程中的降水增幅作用明显,降水中心主要出现在山谷或盆地的迎风坡位置;两次暖区暴雨与边界层的动力辐合、水汽供应关系密切,边界层辐合抬升和地形的作用明显,短期预报需重点关注边界层辐合区及特殊地形位置,对数值预报进行适当订正。雷达风廓线资料揭示了两次暖区暴雨过程西南风厚度的差异对降水强度的影响;垂直风切变的增强、环境风偏弱特征在这两次过程中分别提供了强降水持续维持的信息,对暴雨的预报预警的升级有一定的指示作用。

关键词：暖区暴雨强西南急流地形作用边界层辐合

Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

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ANIMAL MODELS AND EXPERIMENTAL MEDICINE 2024年第4期7卷 584-590页

作者： Xu, Jing Ren, Jilong Xu, Kai Fang, minghui Ka, Meina Xu, Fei Wang, Xin Wang, Jing Han, Zhiqiang Feng, Guihai Zhang, Ying Hai, tang Li, Wei Hu, Zheng Chinese Acad Sci State Key Lab Stem Cell & Reprod Biol Inst Zool Beijing 100101 Peoples R China Chinese Acad Sci Key Lab Organ Regenerat & Reconstruct Beijing Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Beijing Inst Stem Cell & Regenerat Med Beijing Peoples R China Chinese Acad Sci Beijing Farm Anim Res Ctr Inst Zool Beijing 100101 Peoples R China Jilin Univ Hosp 1 Key Lab Organ Regenerat & Transplantat Minist Educ Changchun 10061 Peoples R China

Background: Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic, while immunogenic genes need to be eliminated to improve the immune compatibility between humans and pigs. Current knockout strategies are mainly aimed at the genes causing hyperacute immune rejection (HAR) that occurs in the first few hours while adaptive immune reactions orchestrated by CD4 T cell thereafter also cause graft failure, in which process the MHC II molecule plays critical roles. Methods: Thus, we generate a 4-gene (GGTA1, CMAH, beta 4GalNT2, and CIITA) knockout pig by CRISPR/Cas9 and somatic cell nuclear transfer to compromise HAR and CD4 T cell reactions simultaneously. Results: We successfully obtained 4KO piglets with deficiency in all alleles of genes, and at cellular and tissue levels. Additionally, the safety of our animals after gene editing was verified by using whole-genome sequencing and karyotyping. Piglets have survived for more than one year in the barrier, and also survived for more than 3 months in the conventional environment, suggesting that the piglets without MHC II can be raised in the barrier and then gradually mated in the conventional environment. Conclusions: 4KO piglets have lower immunogenicity, are safe in genomic level, and are easier to breed than the model with both MHC I and II deletion.

关键词： CD4 T cell genetically edited pig immune rejection major histocompatibility complex II xenotransplantation SWINE LEUKOCYTE ANTIGEN CLASS-II MICE LACKING CELLS

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中国儒家传统金融伦理思想初探

管子学刊 2007年第2期 101-104页

作者：唐名辉丁瑞莲中南大学法学院社会学系湖南长沙410075 中南大学行政学院湖南长沙410075

本文试图探讨儒家的金融伦理思想。文章认为:儒家由人性自利的基础出发,强调金融合理的自然主义立场;由此进一步导出仁义为本的民本主义;智勇兼重的理性精神;礼让为先的合作精神等主要金融伦理原则。这些原则与诚信原则、互利互惠原则... 详细信息

本文试图探讨儒家的金融伦理思想。文章认为:儒家由人性自利的基础出发,强调金融合理的自然主义立场;由此进一步导出仁义为本的民本主义;智勇兼重的理性精神;礼让为先的合作精神等主要金融伦理原则。这些原则与诚信原则、互利互惠原则、节俭原则等一起构造了中国古代金融伦理体系。我们应该积极有效地从这些资源中吸取养料,在改造发展的原则下为建设适应社会主义市场经济制度的崭新的金融体系而努力。

关键词：儒家金融伦理自然主义民本主义理性精神合作精神

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment

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Neuroscience Bulletin 2024年第8期40卷 1076-1092页

作者： Zongyao Ren Haiyan tang Wendiao Zhang minghui Guo Jingjie Cui Hua Wang Bin Xie Jing Yu Yonghao Chen Ming Zhang Cong Han Tianyao Chu Qiuman Liang Shunan Zhao Yingjie Huang Xuelian He Kefu Liu Chunyu Liu Chao Chen Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life Sciencesand Department of PsychiatryThe Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center on Mental Disorders The Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410011China Furong Laboratory Changsha 410000China Department of Psychiatry SUNY Upstate Medical UniversitySyracuseNY 13210USA Precision Medical Center Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430014China Department of Medical Genetics Hunan Children's HospitalChangsha 410007China

Intellectual disability(ID)is a condition characterized by cognitive impairment and difficulties in adaptive *** our research,we identified two de novo mutations(c.955C>T and c.732C>A)at the KDM2A locus in individuals with varying degrees of *** addition,by using the Gene4Denovo database,we discovered five additional cases of de novo mutations in *** mutations we identified significantly decreased the expression of the KDM2A *** investigate the role of KDM2A in neural development,we used both 2D neural stem cell models and 3D cerebral *** findings demonstrated that the reduced expression of KDM2A impairs the proliferation of neural progenitor cells(NPCs),increases apoptosis,induces premature neuronal differentiation,and affects synapse *** ChIP-Seq analysis,we found that KDM2A exhibited binding to the transcription start site regions of genes involved in *** addition,the knockdown of KDM2A hindered H3K36me2 binding to the downstream regulatory elements of *** integrating ChIP-Seq and RNA-Seq data,we made a significant discovery of the core genes'remarkable enrichment in the MAPK signaling ***,this enrichment was specifically linked to the p38 MAPK ***,disease enrichment analysis linked the differentially-expressed genes identified from RNA-Seq of NPCs and cerebral organoids to neurodevelopmental disorders such as ID,autism spectrum disorder,and ***,our findings suggest that KDM2A plays a crucial role in regulating the H3K36me2 modification of downstream genes,thereby modulating the MAPK signaling pathway and potentially impacting early brain development.

关键词： Intellectual disability KDM2A Neurodevelopmental disorder Cerebral organoids