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Daratumumab improves the hematological response and kidney function of patients with light chain deposition disease

中华医学杂志(英文版) 2025年第2期138卷 2024 Nov 13页

作者： Zhang Xin Yu Xiaojuan Wang Suxia Dong Yujun zhao minghui Zhou Fude Renal Division Department of Medicine Peking University First Hospital Beijing China Institute of Nephrology Peking University Beijing China Key Laboratory of Renal Disease Ministry of Health of China Beijing China Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases Chinese Academy of Medical Sciences Beijing China Laboratory of Electron Microscopy Pathological Centre Peking University First Hospital Beijing China Hematological Division Department of Medicine Peking University First Hospital Beijing China Peking-Tsinghua Center for Life Science Academy for Advanced Interdisciplinary Studies Peking University Beijing China

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A Parameterization of the Canonical Bases of Affine Modified Quantized Enveloping Algebras

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 235-258页

作者： Jie XIAO minghui zhao Department of Mathematical Sciences Tsinghua University College of Science Beijing Forestry University

For a symmetrizable Kac-Moody Lie algebra g, Lusztig introduced the corresponding modified quantized enveloping algebra˙U and its canonical basis˙B given by Lusztig in 1992. In this paper, in the case that g is a symmetric Kac-Moody Lie algebra of finite or affine type, the authors define a set M which depends only on the root category R and prove that there is a bijection between M and ˙B, where R is the T^2-orbit category of the bounded derived category of the corresponding Dynkin or tame quiver. The method in this paper is based on a result of Lin, Xiao and Zhang in 2011, which gives a PBW-type basis of U^+.

关键词： Ringel-Hall algebras Root categories Modified quantized enveloping algebras Canonical bases

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Intermingled fates of the South China Sea and Philippine Sea plate

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National Science Review 2019年第5期6卷 886-890页

作者： minghui zhao Jean-Claude Sibuet Jonny Wu Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of Sciences Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of Sciences Department of Earth and Atmospheric Sciences University of Houston

Recent studies have shown the extent and nature of the South China Sea (SCS) at the end of spreading by unfolding (*** restoring) the Manila slab,which is the subducted part of the SCS,and by identifying the nature of... 详细信息

关键词： SCS domain Intermingled fates of the South China Sea and Philippine Sea plate China

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叶黄素乳液凝胶3D打印间隔多层结构的构建及释放特性研究

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食品工业科技 2025年第3期46卷 133-142页

作者：邓帅赵明慧郝春雪李鸣李大婧冯蕾张钟元徐亚元江苏大学食品与生物工程学院江苏镇江212000 江苏省农业科学院农产品加工研究所江苏南京210014 东北林业大学生命科学学院黑龙江哈尔滨150040

通过流变特性和3D打印特性评估,筛选叶黄素负载层和空载层乳液凝胶的制备参数,运用双喷头3D打印技术将叶黄素负载层与空载层间隔交错打印,构建不同间隔多层结构的3D打印凝胶体系,探究间隔多层结构的间隔层数和空载层定位对叶黄素的释放... 详细信息

通过流变特性和3D打印特性评估,筛选叶黄素负载层和空载层乳液凝胶的制备参数,运用双喷头3D打印技术将叶黄素负载层与空载层间隔交错打印,构建不同间隔多层结构的3D打印凝胶体系,探究间隔多层结构的间隔层数和空载层定位对叶黄素的释放特性和生物可及性的影响。结果表明,通过提升油相体积分数、分离乳清蛋白(Whey Protein Isolate,WPI)浓度以及叶黄素载量,可以有效地提高叶黄素乳液凝胶的表观黏度、储能模量和损耗模量,同时降低蠕变恢复应变,增强叶黄素乳液凝胶的黏弹性和抵抗形变的能力,从而显著提升了叶黄素乳液凝胶的打印精确度和稳定性;当油相体积分数为15%、WPI浓度为10%和叶黄素载量为1.5%时,叶黄素乳液凝胶的3D打印效果最佳,打印精确性和稳定性分别为96.94%和97.60%。经体外模拟消化发现,间隔多层结构设计可有效改变叶黄素的释放行为,显著降低了叶黄素在胃消化阶段的释放率,从21.61%最低降至7.26%,使叶黄素在肠消化阶段表现出一定的时滞性,并显著提高叶黄素的生物可及性,最高达到了47.97%。本研究将为解决叶黄素生物可及性低的问题和运载工具的设计提供新的思路和理论依据。

关键词：叶黄素乳液凝胶间隔多层结构释放特性生物可及性

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基于DEA-Malmquist的天津市16家保健定点医院运营效率评价

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中国卫生标准管理 2025年第1期16卷 48-51页

作者：赵明辉孙宁刘洁天津医科大学总医院干部保健处天津300052 天津医科大学总医院智慧医学信息分析中心天津300052

目的分析干部保健定点医院运营效率,为进一步提升保健医院综合实力提供依据。方法采用数据包络分析(data envelopment analysis,DEA)方法和动态Malmquist指数模型,获取2017—2021年16家保健医院医疗指标,计算全要素生产率指数、生产技... 详细信息

目的分析干部保健定点医院运营效率,为进一步提升保健医院综合实力提供依据。方法采用数据包络分析(data envelopment analysis,DEA)方法和动态Malmquist指数模型,获取2017—2021年16家保健医院医疗指标,计算全要素生产率指数、生产技术变动指数和技术效率指数,研究医院运营管理效率。结果2017—2021年,只有3家保健医院的全要素生产率呈上升趋势,即第6、第10和第12家医院的均值>1.000,其余医院变化均值均<1.000。全要素生产率均值为0.977,生产技术变动指数为0.983,技术效率变动指数为0.994,运营效率仍有进一步提升空间。结论医院运营效率的下降与生产技术的关系密切,天津市保健医院在2017—2021年的全要素生产率呈下降趋势,这表明生产技术变动和技术效率变动是影响运营效率的主要因素。建议采取加强技术创新投入、人才培养与引进、优化资源配置等措施提高医院运营效率。保健行政部门应做好统筹规划,保证保健医院的有序投入。

关键词：数据包络分析医疗指标保健定点医院卫生资源运营效率 Malmquist指数模型

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Connotation and Determinants of Web Collective Intelligence

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Journal of Systems Science and Information 2022年第6期10卷 633-644页

作者： Lingling ZHANG Hanbin TANG minghui zhao School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China MOE Social Science Laboratory of Digital Economic Forecasts and Policy Simulation at UCAS Beijing 100190China

With continuous development of network technology, users in network community are promoted to interact deeply, and remarkable web collective intelligence emerges in the process. As a relatively new concept, the connotation of web collective intelligence is preliminarily explored in this paper, where the network community is taken as the environment, expert users as the subject, and web comments as the carrier. Meanwhile, taking Wikipedia as an example, by means of questionnaire survey and structural equation model, a more systematic index system is constructed from the perspective of user characteristics to explore determinants of web collective intelligence quality, and potential influence of user attributes on user behavior.

关键词： web collective intelligence connotation determinants

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Fault-controlled regional magmatism and mineral deposition in central Cathaysia——Evidence from ambient noise tomography

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Science China Earth Sciences 2022年第9期65卷 1715-1735页

作者： Lingmin CAO Huaiyu YUAN Liang zhao minghui zhao Haibo HUANG Tianyao HAO Xuelin QIU Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511438China ARC Centre of Excellence for Core to Crust Fluid Systems Department of Earth and Environmental SciencesMacquarie UniversityNorth RydeNSW 2109Australia Centre for Exploration Targeting University of Western AustraliaCrawley PerthWA 6009Australia State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100029China Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Submarine Geosciences Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China

Guangdong Province in the central Cathaysian Block has two world-class metallogenic belts, namely, the Nanling and Southeastern Coastal Metallogenic Belts(NLMB and SCMB), which are spatially coincide with the major regional Ganjiang and Zhenghe-Dapu Fault Zones(GJFZ and ZDFZ). However, what roles the faults played in mineral deposition and magmatism is unclear. Using ambient noise tomography, we obtain a 3-D whole-crust shear wave velocity model. By combining available regional geophysical models, we characterize the architecture of the regional shallow lithosphere and infer its possible tectonic connection to magmatic sources, pathways and surface deposition. The results show that the study area is loosely divided by the two major faults, the GJFZ and ZDFZ, into distinct velocity domains. In the north high Vand low V/Vcrust in the NLMB imply crustal remelting, which leads to the general felsic composition. In the coastal area, the lower crustal high Vanomaly is attributed to upwelling melts associated with Cretaceous magmatic activity. Between mineral belts, a swath of crustal lowvelocity zones extend into the uppermost mantle, manifesting partial melting related to upwelling magmas that may hint at a deep origin of magma from subcrustal lithosphere and likely feed surface mineral deposits through major faults. Secondary NW-trending faults coincide with low velocities and facilitated magmatic migration. A correlation between coastward extension of low velocities and younging of the Jurassic and Cretaceous magmatism is suggestive of a combined effect of slab rollback and a change in the direction of the Paleo-Pacific subduction system. We speculate a regional fault-control model in the central Cathaysian Block for the spatial-temporal evolution of regional deformation and magmatism during the middle Mesozoic.

关键词： Ambient noise tomography Crustal Vs structure Ganjiang Fault Zone Zhenghe-Dapu Fault Zone Mesozoic magmatism

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Seismic phases from the Moho and its implication on the ultraslow spreading ridge

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Acta Oceanologica Sinica 2013年第12期32卷 75-86页

作者： ZHANG Jiazheng zhao minghui QIU Xuelin LI Jiabiao RUAN Aiguo Key Laboratory of Marginal Sea Geology of Chinese Academy of Sciences South China Sea Institute of OceanologyChinese Academy of Sciences University of Academy of Sciences The Second Institute of Oceanography State Oceanic Administration

The Moho interface provides critical evidence for crustal thickness and the mode of oceanic crust accretion. The seismic Moho interface has not been identified yet at the magma-rich segments （46°-52°E） of the ultra- slow spreading Southwestern Indian Ridge （SWIR）. This paper firstly deduces the characteristics and do- mains of seismic phases based on a theoretical oceanic crust model. Then, topographic correction is carried out for the OBS record sections along Profile Y3Y4 using the latest OBS data acquired from the detailed 3D seismic survey at the SWIR in 2010. Seismic phases are identified and analyzed, especially for the reflected and refracted seismic phases from the Moho. A 2D crustal model is finally established using the ray tracing and travel-time simulation method. The presence of reflected seismic phases at Segment 28 shows that the crustal rocks have been separated from the mantle by cooling and the Moho interface has already formed at zero age. The 2D seismic velocity structure across the axis of Segment 28 indicates that detachment faults play a key role during the processes of asymmetric oceanic crust accretion.

关键词： Moho interface seismic phases ultra-slow spreading ridge 2D crustal structure SouthwesternIndian Ridge (SWIR)

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Characteristics of PmP phases from earthquakes and their role in crustal tomography:An active volcanic area example,northeastern Japan

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Science China Earth Sciences 2011年第5期54卷 640-646页

作者： XIA ShaoHong QIU XueLin XU HuiLong zhao minghui SHI XiaoBin Chinese Academy of Sciences Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China

Later earthquake-sourced PmP phases have the potential to significantly improve ray coverage and resolution of crustal tomography methods,as their trajectories are quite different from those of shallower P *** paper analyzes the characteristics of later PmP arrival times from earthquakes with different focal *** results show that PmP arrival time differences from earthquakes at a range of focal depths are gradually lowered with increasing *** found that where the first recorded P-wave phase was the intra-crustal refraction phase(Pg),the differences in arrival time between Pg and PmP phases decreased with increasing focal depth at an offset of less than 120 *** the first P-wave phase is the upper mantle refraction phase(Pn),the difference in arrival times between Pn and PmP phases became larger with an increase in focal depth at an offset of more than 150 km.A total of 394 PmP phases and 3356 first P phases were picked from seismograms in the active volcanic area of northeastern Japan,according to the characteristics of calculated arrival times,amplitudes and particle *** were used to investigate the role of PmP phases in crustal tomography beneath an active volcanic *** of the detailed resolution analysis show that the addition of PmP data can improve significantly the resolution of the lower crustal structure in tomographic *** the PmP data were included in the tomographic inversion,the path of upwelling magma,along which a series of low-frequency microearthquakes is clearly distributed,was better *** results suggest that the PmP phase has an important role in detailed crustal tomography.

关键词： PmP phase crustal structure tomography earthquake active volcanoes

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The South China Sea is not a mini-Atlantic: plate-edge rifting vs intra-plate rifting

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National Science Review 2019年第5期6卷 902-913页

作者： Pinxian Wang Chi-Yue Huang Jian Lin Zhimin Jian Zhen Sun minghui zhao State Key Laboratory of Marine Geology Tongji University Department of Earth Sciences Cheng Kung University Department of Geology and Geophysics Woods Hole Oceanographic Institution Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences

The South China Sea, as ‘a non-volcanic passive margin basin’ in the Pacific, has often been considered as a small-scale analogue of the *** recent ocean drilling in the northern South China Sea margin found, however, that the Iberian model of non-volcanic rifted margin from the Atlantic does not apply to the South China *** this paper, we review a variety of rifted basins and propose to discriminate two types of rifting basins: plate-edge type such as the South China Sea and intra-plate type like the *** not only differ from each other in structure, formation process, lifespan and geographic size, but also occur at different stages of the Wilson *** intra-plate rifting occurred in the Mesozoic and gave rise to large oceans, whereas the plate-edge rifting took place mainly in the mid-Cenozoic, with three-quarters of the basins concentrated in the Western *** a member of the Western Pacific system of marginal seas, the South China Sea should be studied not in isolation on its origin and evolution, but in a systematic context to include also its neighboring counterparts.

关键词： rifting marginal basin passive margin South China Sea Western Pacific subduction

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