检索结果-南通市图书馆

Application of single-cell RNA sequencing in head and neck squamous cell carcinoma

中国癌症研究:英文版 2023年第4期35卷 331-342页

作者： Zhaohong An Wan Liu Wenbin Li minghui wei Changming An Department of Head&Neck Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Head&Neck Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen CenterShenzhen 518000China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Single-cell RNA sequencing has been broadly applied to head and neck squamous cell carcinoma(HNSCC) for characterizing the heterogeneity and genomic mutations of HNSCC benefiting from the advantage of single-cell resolution. We summarized most of the current studies and aimed to explore their research methods and ideas, as well as how to transform them into clinical applications. Through single-cell RNA sequencing, we found the differences in tumor cells’ expression programs and differentiation tracks. The studies of immune microenvironment allowed us to distinguish immune cell subpopulations, the extensive expression of immune checkpoints, and the complex crosstalk network between immune cells and non-immune cells. For cancerassociated fibroblasts(CAFs), single-cell RNA sequencing had made an irreplaceable contribution to the exploration of their differentiation status, specific CAFs markers, and the interaction with tumor cells and immune cells. In addition, we demonstrated in detail how single-cell RNA sequencing explored the HNSCC epithelial-tomesenchymal transition(EMT) model and the mechanism of drug resistance, as well as its clinical value.

关键词： Single-cell RNA sequencing head and neck squamous cell carcinoma intra-tumoral heterogeneity immune infiltration epithelial-to-mesenchymal transition drug resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中医药院校大学生数字中医药创新创业教育方法探索

引用

中医教育 2024年第3期43卷 31-35页

作者：毛伯䶮韦名慧冯月北京中医药大学生命科学学院北京102488 北京大学第一医院医学装备处北京100034

为了做好大众创业万众创新的人才储备,也为了促进中医药现代化进程,推进中医药数字化转型,我国亟须从本科开始培养一批具备多学科交叉融合能力的数字中医药创新创业人才。通过分析数字中医药创新创业教育的必要性,提出中医药院校大学生... 详细信息

为了做好大众创业万众创新的人才储备,也为了促进中医药现代化进程,推进中医药数字化转型,我国亟须从本科开始培养一批具备多学科交叉融合能力的数字中医药创新创业人才。通过分析数字中医药创新创业教育的必要性,提出中医药院校大学生数字中医药创新创业教育的方法:将专业课程与创新创业教育相融合,设计符合数字中医药特点的项目式教学法,借助其他高校、企业、医院的力量完成“产学研医”相融合的创新创业教育;笔者团队对此进行实践的结果:学生在教师辅助下按照设计方案完成项目目标,并取得了一定的成效,可为其他中医药院校提供参考和借鉴。

关键词：数字中医药创新创业项目式教学中医药院校

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

兴凯湖西部土壤-植物系统中硒含量特征、成因来源及迁移转化主控因素

引用

地质通报 2024年第1期43卷 163-172页

作者：梁帅戴慧敏翟富荣郭常来高铁刘凯魏明辉张哲寰杜贯新中国地质调查局沈阳地质调查中心辽宁沈阳110034 自然资源部黑土地演化与生态效应重点实验室辽宁沈阳110034 辽宁省黑土地演化与生态效应重点实验室辽宁沈阳110034 辽宁省地质矿产研究院有限责任公司辽宁沈阳110034 中国地质调查局自然资源实物地质资料中心河北廊坊065220

硒及其有机化合物对生物体具有重要的生物活性和特殊的保健功能,开展富硒土壤硒成因来源和迁移转化研究,对富硒土地利用和富硒功能产品研发具有重要的科学和经济意义。基于区域地质特征、土壤数据和植物籽实数据,开展土壤硒空间分布和... 详细信息

硒及其有机化合物对生物体具有重要的生物活性和特殊的保健功能,开展富硒土壤硒成因来源和迁移转化研究,对富硒土地利用和富硒功能产品研发具有重要的科学和经济意义。基于区域地质特征、土壤数据和植物籽实数据,开展土壤硒空间分布和成因来源研究,运用地统计学、相关性、生物富集系数等方法探讨硒在土壤-植物系统中的迁移转化主控因素。土壤Se含量为0.11~0.70 mg/kg,均值为0.37 mg/kg,含量特征及空间分布主要受成土母质控制;富锦组黑色岩系是形成富硒土壤的物质基础和Se元素的最初来源,后期有利的古气候环境演化促进了黑色岩系的持续风化,为土壤提供了丰富的硒源;植物富集能力BCF水稻/土壤>BCF玉米/土壤,籽实Se平均含量为Se水稻>Se玉米,含量与土壤理化指标相关性揭示,硒在土壤-植物系统中迁移转化受土壤矿物组成及土壤环境等因素制约。土壤硒主要来源于富锦组黑色岩系及其风化物,硒在土壤-植物系统中迁移转化主控因素为粘土矿物的吸附/解析作用;划定天然富硒土地6550.68 hm^(2),为富硒土地科学利用和富硒功能产品开发提供地学依据,有效支撑服务地方经济发展和疾病预防。

关键词：黑土地硒迁移转化主控因素环境地质调查工程兴凯湖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

益气活血法对慢性心力衰竭大鼠心肌能量代谢及炎性因子的影响

引用

中西医结合心脑血管病杂志 2024年第10期22卷 1773-1776页

作者：魏明慧张瑶刘璐菲叶婷赵海燕黑龙江中医药大学附属第二医院哈尔滨150001 浙江大学医学院附属儿童医院国家儿童健康与疾病临床医学研究中心黑龙江中医药大学

目的:基于益气活血法探讨全真一气汤合补阳还五汤对慢性心力衰竭(CHF)大鼠心肌能量代谢及炎性因子的影响。方法:将30只健康雄性SD大鼠随机分为对照组、模型组和中药组,每组10只。采用腹腔注射阿霉素制备CHF模型,中药组给予全真一气汤合... 详细信息

目的:基于益气活血法探讨全真一气汤合补阳还五汤对慢性心力衰竭(CHF)大鼠心肌能量代谢及炎性因子的影响。方法:将30只健康雄性SD大鼠随机分为对照组、模型组和中药组,每组10只。采用腹腔注射阿霉素制备CHF模型,中药组给予全真一气汤合补阳还五汤干预。采用酶联免疫吸附法(ELISA)检测三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、一磷酸腺苷(AMP)、白细胞介素6(IL-6)、N末端脑钠肽前体(NT-proBNP)水平;采用逆转录定量聚合酶链式反应(qRT-PCR)检测miR-21水平。结果:与对照组比较,模型组ATP、ADP、AMP降低(P<0.05),IL-6、NT-proBNP、miR-21表达均升高(P<0.05);与模型组比较,中药组ATP、ADP、AMP均升高(P<0.05),IL-6、NT-proBNP、miR-21表达均降低(P<0.05)。结论:益气活血法治疗可提高CHF大鼠心肌能量供应,减轻炎症反应,改善心功能。

关键词：慢性心力衰竭益气活血法心肌能量代谢炎症大鼠实验研究

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

储气库建设中数字化平台的构建——以S储气库为例

引用

石油工程建设 2024年第4期50卷 76-80页

作者：魏晓峰李思彤魏铭辉禚月平黄剑华辽河油田(盘锦)储气库有限公司辽宁盘锦124200 辽宁辽河泰利达石油技术有限公司辽宁盘锦124010

随着储气库业务的快速发展,对工程建设期数据信息的采集、归档与应用提出了更高的要求。S储气库一期工程从建设与运营的角度构建了数字化平台,内容涵盖数据资产管理系统、三维模型、管道可视化管理、数字化移交四个方面,实现了工程建设... 详细信息

随着储气库业务的快速发展,对工程建设期数据信息的采集、归档与应用提出了更高的要求。S储气库一期工程从建设与运营的角度构建了数字化平台,内容涵盖数据资产管理系统、三维模型、管道可视化管理、数字化移交四个方面,实现了工程建设与数字化建设同步,促进了数字化技术在储气库建设领域的应用与发展,为未来实现智能化储气库奠定了基础。系统介绍了数字化交付平台的功能,平台部署方式、系统架构和技术构架,简要介绍了阶段性成果,归纳总结了平台技术创新点,最后提出数字化交付中应关注的问题。

关键词：储气库数字化交付组成三维模型数据基础

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel approach towards the selection of regenerators for optimal Stirling engine performance based on energy and exergy analyses

引用

Science China(Technological Sciences) 2024年第1期67卷 295-310页

作者： YU MinJie ZHANG minghui XU Lei CUI HaiChuan LIU ZhiChun LIU wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China

Regenerators play a vital role in enhancing the overall performance of Stirling ***,this paper performed an energy and exergy analysis to elucidate the significance of regenerator characteristics concerning system performance,contributing to the optimal regenerator’s design and *** relationship between regenerator structure,regenerator exergy destruction,and output power,thermal efficiency,and exergy efficiency for Stirling engines was established by integrating the thermal model of Stirling engines with a mathematical model of *** contrast to cross-flow and parallel-flow regenerators,a novel concept of inclined-flow regenerators,featuring a matrix surface inclined in the direction of gas flow,was developed to achieve higher and more balanced engine output power and energy utilization efficiency.A comprehensive investigation was conducted into the effects of matrix structure types and regenerator geometries on the performance of both regenerators and *** results reveal that,following structural optimization,Stirling engines equipped with the inclined-flow regenerator demonstrate a substantial 16.6%,38.3%,and 37.2%increase in power output,thermal efficiency,and exergy efficiency,respectively,compared to those equipped with cross-flow *** contrast,when compared to engines fitted with parallel-flow regenerators,they experience a 13.5%reduction in power output but achieve remarkable enhancements of 45.4%and 36.7%in thermal and exergy efficiency,*** study introduces new insights into selecting regenerator structures for enhancing the output performance of Stirling engines.

关键词： Stirling engine inclined-flow regenerator adiabatic model exergy analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Torque Limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

引用

Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： wei Gu Zaiyu Chen Qun Li minghui Yin Qiang Li Yun Zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TLIC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial ***,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TLIC power is no longer in the step ***,the maximum point of the frequency response component(FRC)contributed by TLIC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately ***,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TLIC and load *** this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TLIC method based on delayed support is ***,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of post heat treatment on microstructure, mechanical property and corrosion behavior of AlSi10Mg alloy fabricated by selective laser melting

引用

Progress in Natural Science:Materials International 2024年第1期34卷 89-101页

作者： Yang Zheng Zihao Zhao Ruize Xiong Guochun Ren minghui Yao wei Liu Libin Zang School of Aeronautics and Astronautics Tiangong University School of Mechanical Engineering Tiangong University 3D Printing Research&Engineering Technology Center AECC Beijing Institute of Aeronautical Materials Tianjin Institute of Aerospace Mechanical and Electrical Equipment

The microstructure, mechanical property and corrosion behavior of the AlSi10Mg alloy fabricated by selective laser melting(SLMed-AlSi10Mg) after different post heat treatment(PHT) of direct aging(DA), solid solution(T4)and solid solution + aging(T6) were investigated. The microstructural characterization revealed that the porosity of the SLMed-AlSi10Mg was increased from 0.41 ± 0.04 % to 3.09 ± 0.11 % with increasing temperature. The Asbuilt and DA-treated samples exhibited a microstructure of α-Al matrix surrounded with continuous Si networks,whereas the T4-treated and T6-treated samples presented a microstructure of α-Al matrix surrounded with discrete Si particles. The microhardness, strength and work hardening rate of the SLMed-AlSi10Mg increased in the order of T4-treated sample < T6-treated sample < As-built sample < DA-treated sample(a reverse order was found for the elongation), which was due to the precipitation of nanoscale Si particles after DA treatment and the softening of α-Al matrix after T4 and T6 treatments. The corrosion resistance of the SLMed-AlSi10Mg was obviously deteriorated after T4 and T6 treatments compared with DA treatment, which was caused by the changes in Si morphology, residual stress and porosity.

关键词： Selective laser melting AlSi10Mg alloy Post heat treatment Microstructure Mechanical property Corrosion behavior

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于时机理论的出院计划在老年髋关节置换病人主要照顾者中的应用研究

引用

骨科 2024年第2期15卷 164-168页

作者：金梦杰李思琦张梦珂魏铭慧史凌云新疆医科大学护理学院乌鲁木齐830017 新疆医科大学第一附属医院护理部乌鲁木齐830054

目的探讨基于时机理论的出院计划在老年髋关节置换病人主要照顾者中的应用效果,为制订规范化的出院计划提供参考。方法采用便利抽样法,选取2023年4月至8月在新疆医科大学第一附属医院行髋关节置换的68例老年病人的主要照顾者为研究对... 详细信息

目的探讨基于时机理论的出院计划在老年髋关节置换病人主要照顾者中的应用效果,为制订规范化的出院计划提供参考。方法采用便利抽样法,选取2023年4月至8月在新疆医科大学第一附属医院行髋关节置换的68例老年病人的主要照顾者为研究对象,根据病人入院时间分为对照组和观察组,每组34例。对照组实施常规护理,观察组在常规护理的基础上实施基于时机理论的出院计划。观察两组病人主要照顾者干预前后的准备度、照顾能力及疾病获益感得分情况。结果干预后,观察组主要照顾者的准备度高于对照组,差异有统计学意义(P<0.001)。广义估计方程结果显示:出院1个月、3个月,两组主要照顾者照顾能力的组间效应有统计学意义(Wald χ^(2)组间=29.79,P组间<0.001),交互效应无统计学意义(Wald χ^(2)交互=2.20,P交互=0.14);疾病获益感的组间效应、交互效应均有统计学意义(Wald χ^(2)组间=232.91,P组间<0.001;Wald χ^(2)交互=113.42,P交互<0.001)。结论基于时机理论的出院计划可以提高照顾者准备度及照顾能力,减轻出院照护压力,提升照顾者疾病获益感。

关键词：时机理论出院计划髋关节置换术照顾者

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preferentially selective extraction of lithium from spent LiCoO_(2)cathodes by medium-temperature carbon reduction roasting

引用

International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 315-322页

作者： Daixiang wei wei Wang Longjin Jiang Zhidong Chang Hualei Zhou Bin Dong Dekun Gao minghui Zhang Chaofan Wu School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Anhui Chaoyue Environmental Protection Technology Co. LtdChuzhou 239060China Anhui Huihong Technology Co. LtdChuzhou 239060China

Lithium recovery from spent lithium-ion batteries(LIBs)have attracted extensive attention due to the skyrocketing price of *** medium-temperature carbon reduction roasting was proposed to preferential selective extraction of lithium from spent Li-CoO_(2)(LCO)cathodes to overcome the incomplete recovery and loss of lithium during the recycling *** LCO layered structure was destroyed and lithium was completely converted into water-soluble Li2CO_(3)under a suitable temperature to control the reduced state of the cobalt *** Co metal agglomerates generated during medium-temperature carbon reduction roasting were broken by wet grinding and ultrasonic crushing to release the entrained *** results showed that 99.10%of the whole lithium could be recovered as Li2CO_(3)with a purity of 99.55%.This work provided a new perspective on the preferentially selective extraction of lithium from spent lithium batteries.

关键词： spent LiCoO_(2)cathodes medium-temperature carbon reduction lithium extraction priority crystal transformation macro-scopic transport resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：