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B.t.微胶囊的喷雾干燥制备工艺优化及性能评价

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农药 2024年第7期63卷 494-499,531页

作者：陈蔚燕高明惠陈泳汀辛露露郑桂玲徐晓庆曲田丽张保华青岛农业大学化学与药学院山东青岛266109 青岛农业大学植物医学学院山东青岛266109 乳山韩威生物科技有限公司山东威海264500

[目的]为保证苏云金芽孢杆菌Bacillus thuringiensis(B.t.)制剂的储藏稳定性和抗逆性,从而充分发挥其杀虫作用、延长田间存活能力,制备了B.t.微胶囊。[方法]以B.t新菌株(B-Y7-1)为研究对象,采用喷雾干燥技术制备B.t.微胶囊,通过单因素... 详细信息

[目的]为保证苏云金芽孢杆菌Bacillus thuringiensis(B.t.)制剂的储藏稳定性和抗逆性,从而充分发挥其杀虫作用、延长田间存活能力,制备了B.t.微胶囊。[方法]以B.t新菌株(B-Y7-1)为研究对象,采用喷雾干燥技术制备B.t.微胶囊,通过单因素筛选及正交优化试验确定了喷雾干燥法的最佳制备工艺,并对其性能和活性进行了表征和评价。[结果]B.t.微胶囊喷雾干燥法的最佳工艺为:3%海藻酸钠为壁材,进口温度180℃、物料流速14 mL/min,微胶囊产率为76.45%±1.35%,活菌率为93.11%±2.03%;54℃下热储14 d后,喷雾干燥法制备的微胶囊囊内的芽孢存活率为71.23%,远高于B.t.菌粉的存活率8.08%;B.t.微胶囊在水中的释放符合一级动力学模型,在土壤中释放符合Ritger-Peppas模型,属于Fick扩散。生物活性测定表明,B.t.微胶囊对蛴螬的持效杀虫效果高于未包埋的B.t.菌液。[结论]实验结果说明B.t.微胶囊化可以改善其稳定性,并具有缓释特性。

关键词：苏云金芽孢杆菌微胶囊喷雾干燥性能

Hydrogenation of furfuryl alcohol to tetrahydrofurfuryl alcohol on NiB/SiO_(2) amorphous alloy catalyst

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Frontiers of Chemical Science and Engineering 2007年第2期1卷 151-154页

作者： SONG Yun LI Wei ZHANG minghui TAO Keyi Institute of New Catalytic Material Science College of ChemistryNankai UniversityTianjin 300071China

NiB/SiO2 amorphous alloy catalyst was prepared by power electroless plating method and characterized by induction coupled plasma(ICP),Brunauer–Emmett–Teller method(BET),transmission electron microscope(TEM)and X-ray diffraction(XRD)*** catalytic perfor-mance of NiB/SiO2 was investigated for the hydrogenation of furfuryl alcohol(FA)to tetrahydrofurfuryl alcohol(THFA).The effects of operational conditions,such as reaction tem-perature,pressure,and stirring rate were carefully *** proper conditions were determined as the following:pressure 2.0 MPa,temperature 120°C and stirring rate 550 r/min.A typical result with FA conversion of 99%and THFA selectivity of 100%was obtained under such conditions,which was close to that over Raney Ni.

关键词： amorphous alloy NiB/SiO2 hydrogenation furfuryl alcohol(FA) tetrahydrofurfuryl alcohol(THFA)

KR法脱硫中搅拌工艺与桨叶尺寸对脱硫剂分散行为的影响

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安徽工业大学学报（自然科学版） 2024年第4期41卷 457-465页

作者：程功操瑞宏廖建军钟巍李明晖王海军安徽工业大学冶金工程学院安徽马鞍山243032 新余钢铁股份有限公司硅钢薄板事业部江西新余338001

根据相似理论,按模型与原型尺寸的1:5建立铁水包物理模型,用于进行固液两相流实验,研究搅拌桨插入深度与转速对铁水包内粒子分散行为的影响;在此基础上,采用Fluent软件中的流体体积(VOF)模型与离散相模型(DPM)模拟分析桨叶尺寸对铁水包... 详细信息

根据相似理论,按模型与原型尺寸的1:5建立铁水包物理模型,用于进行固液两相流实验,研究搅拌桨插入深度与转速对铁水包内粒子分散行为的影响;在此基础上,采用Fluent软件中的流体体积(VOF)模型与离散相模型(DPM)模拟分析桨叶尺寸对铁水包流场及脱硫剂分散效果的影响。结果表明:搅拌桨插入深度为95~125 mm时,随插入深度的增加,铁水包底部的粒子数先增后减;插入深度在105~115 mm区间粒子分散效果较好。转速为112~180 r/min时,随转速的增加,铁水包底部的粒子数先明显增多后略有减少;转速大于180 r/min时,底部粒子数基本不受转速影响,粒子混合效果较好的物理模拟工况为搅拌桨插入深度115 mm、转速147 r/min。旋转桨叶下方存在弱流区,流场速度低于0.4 m·s^(-1),增加桨叶直径,流场整体速度增加,漩涡深度加深,弱流区有减小趋势;桨叶直径超过1440 mm时,弱流区基本不变,同时随桨叶直径的增加,铁水包底部区域脱硫剂含量增加,有利于提高脱硫剂利用率,节约成本;桨叶直径为1540 mm时,搅拌桨上表面中心部分裸露,桨叶直径过大易出现卷吸空气的现象,降低铁的收得率;桨叶距离铁水包包壁较近,会增大流体对铁水包壁面的冲刷作用,有损铁水包的工作寿命。综合搅拌效果与脱硫剂分散程度,搅拌桨直径1440 mm时粒子混合与脱硫剂分散效果较好,搅拌桨桨叶与铁水包最优直径比为0.401。

关键词： KR脱硫脱硫剂分散行为桨叶数值模拟硅钢新能源

5G远程控制骨科机器人辅助骨盆髋臼骨折经皮通道螺钉置入的安全性和有效性分析

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创伤外科杂志 2024年第7期26卷 501-505页

作者：韩波侯秀秀李运美杨明辉邢宝瑞河北省沧州中西医结合医院骨盆髋部创伤科河北沧州061000 首都医科大学附属北京积水潭医院创伤骨科北京102208

目的评价5G远程控制骨科机器人辅助经皮螺钉内固定治疗骨盆髋臼骨折手术的安全性和有效性。方法回顾性分析2023年3月—8月由北京积水潭医院创伤骨科医师在国家骨科医学中心5G+骨科远程手术中心,通过控制河北省沧州中西医结合医院骨科... 详细信息

目的评价5G远程控制骨科机器人辅助经皮螺钉内固定治疗骨盆髋臼骨折手术的安全性和有效性。方法回顾性分析2023年3月—8月由北京积水潭医院创伤骨科医师在国家骨科医学中心5G+骨科远程手术中心,通过控制河北省沧州中西医结合医院骨科机器人共治疗骨盆髋臼骨折患者33例,男性21例,女性12例;年龄18~78岁,平均50.1岁。致伤原因:道路交通伤13例,高处坠落伤15例,水平地面摔伤3例,重物砸伤2例。其中骨盆骨折19例,髋臼骨折14例。共置入通道螺钉76枚。评价指标包括螺钉置入准确性、术中不良事件发生率、螺钉规划时间和螺钉置入时间以及术后1周内并发症发生率。结果置钉位置评价优69枚(90.8%),良7枚(9.2%),无螺钉穿透皮质骨。螺钉采集图像后至规划完成时间为3~8 min,平均5.3 min;螺钉置入时间2~7 min,平均3.5 min。手术操作中未发生任何不良事件。患者术后1周内均未出现伤口感染、血肿、内固定松动或断裂、术后再骨折、血管神经损伤等并发症。患者均对手术效果表示满意。结论 5G远程控制骨科机器人技术通过高速、低延迟的5G网络连接手术室与远程控制中心,允许外科医师在不同地点精确操控机器人进行手术操作,在提高手术精度和安全性方面具有明显优势。

关键词：骨盆骨折髋臼骨折远程医学机器人手术 5G

短链脂肪酸对小鼠缺血再灌注肾损伤的炎症及纤维化影响和作用机制研究

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中华肾病研究电子杂志 2024年第4期13卷 181-187页

作者：孙婧婷李娜罗明辉高瑶瑶白义行朱国贞山西医科大学公共卫生学院太原030000 山西医科大学第二医院肾内科太原030001 山西医科大学太原030000

目的探讨短链脂肪酸(SCFAs)对小鼠肾损伤后炎症及纤维化的影响及其作用机制。方法采用双侧肾动脉夹闭25 min诱导缺血再灌注(I/R)肾损伤建立小鼠肾脏纤维化模型后,小鼠随机分为缺血再灌注组(I/R组)、短链脂肪酸组(I/R+SCFAs组)和短链脂... 详细信息

目的探讨短链脂肪酸(SCFAs)对小鼠肾损伤后炎症及纤维化的影响及其作用机制。方法采用双侧肾动脉夹闭25 min诱导缺血再灌注(I/R)肾损伤建立小鼠肾脏纤维化模型后,小鼠随机分为缺血再灌注组(I/R组)、短链脂肪酸组(I/R+SCFAs组)和短链脂肪酸合并抗CD25单克隆抗体组(I/R+SCFAs+anti-CD25组),并设假手术组(Sham组),每组6只。I/R+SCFAs组和I/R+SCFAs+anti-CD25组小鼠在术前1周连续饮用SCFAs溶液,且I/R+SCFAs+anti-CD25组小鼠在术前2 d和手术当天给予腹腔注射anti-CD25;Sham组小鼠只分离肾动脉不进行夹闭。建模28 d后收集各组小鼠肾组织,进行病理学检测,免疫组织化学检测CD68、肿瘤坏死因子-α(TNF-α)、细胞间黏附分子-1(ICAM-1)、叉头盒转录因子P3(Foxp3)和转录因子维甲酸相关孤儿受体γt(RORγt)的表达,Western印迹检测各组肾组织中Toll样受体4(TLR4)、髓样分化因子88(MyD88)和核转录因子κB p65(NF-κB p65)及α-平滑肌肌动蛋白(α-SMA)等蛋白表达水平。结果与Sham组相比,I/R组小鼠病理损伤较重,肾小管间质纤维化增多,免疫组织化学检测显示肾组织CD68、TNF-α、ICAM-1表达显著升高(P均<0.05),Western印迹检测TLR4、MyD88、NF-κB p65、α-SMA蛋白表达水平显著增多(P均<0.05)。与I/R组相比,I/R+SCFAs组小鼠肾纤维化程度减轻,肾组织的CD68、TNF-α、ICAM-1表达降低,而且TLR4、MyD88、NF-κB p65、α-SMA蛋白表达水平亦降低(P均<0.05)。与I/R+SCFAs组相比,I/R+SCFAs+anti-CD25组病理损伤加重,Foxp3表达减少,而TNF-α、ICAM-1、RORγt表达升高(P均<0.05),TLR4、MyD88、NF-κB p65、α-SMA蛋白表达水平有所升高。结论SCFAs可能通过TLR4/MyD88/NF-κB通路抑制炎症因子产生,从而减轻肾脏炎症反应和肾纤维化。

关键词：炎症肾纤维化短链脂肪酸 Toll样受体4 调节性T细胞

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

Risk HLA class Ⅱ alleles and amino acid residues in MPO-ANCA associated vasculitis

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Risk HLA class Ⅱ alleles and amino acid residues in MPO-ANC...

第十三届全国免疫学学术大会

作者： Huaiyu Wang Zhao Cui Sufang Chen Li Zhu min Chen minghui Zhao Peking University First Hospital

Background: GWAS indicated that patients with MPO-ANCA associated vasculitis(AAV) were associated with HLA-DQ, while the susceptible alleles in these loci were under-investigated. Methods and Findings: We genotyped 258 Chinese MPO-AAV patients and 597 healthy controls, for four-digit resolution of HLA DRB1, DQA1, DQB1 and DPB1, and extracted the encoded amino acid sequences from IMGT/HLA database. T cell epitopes of MPO were predicted and were docked with the HLA molecules. We found DQA1*0302(OR=2.30, 95%CI 1.73-3.05, P=3.90×10) and DQB1*0303(OR=1.84, 95%CI 1.42-2.38, P=3.63×10) were significantly risk alleles for MPO-AAV. They were in overt linkage disequilibrium(r=0.69) and the haplotype DQA1*0302-DQB1*0303 was risk to the disease(haplotype score=6.39, P=1.61×10). Aspartate on DQ α chain, encoded by DQA1*0302 and showed significantly risk effect(OR=2.11, 95%CI 1.64-2.72, P=4.59×10) to MPO-AAV, formats salt bridge with DQ β chain and stabilizes the homodimerizing of HLA molecules. Isoleucine on DQ β chain, encoded by DQB1*0303, increased the susceptibility of MPO-AAV(OR=1.72, 95%CI 1.37-2.16, P=2.20×10), and may involve in antigen presentation by impacting HLA-DM and-DQ interaction. DQB1*0201(OR=0.29, 95%CI 0.18-0.48, P=4.54×10) and DQA1*0501(OR=0.28, 95%CI 0.16-0.50, P=3.61×10) showed negative associations with the disease. Molecular docking revealed that the predicted epitopes of MPO could be presented by the susceptible HLA ***: We identified two risk alleles of HLA II genes and their encoding amino acids which confer susceptibility to MPO-AAV. It provides clues for the further investigations on MPO epitope presentation, which is one of the key events in the pathogenesis of AAV.

关键词： HLA MPO-ANCA susceptibility

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小血管炎肾损害

中国实用内科杂志 2006年第3期26卷 333-336页

作者：赵明辉陈旻北京大学第一医院肾内科北京100034

系统性血管炎是指以血管壁的炎症和纤维素样坏死为病理特征的一组系统性疾病，可分为原发性和继发性．继发性是指继发于其他疾病，例如感染、系统性红斑狼疮等，原发性是指目前病因不明者。根据受累血管的大小将系统性血管炎分为3类，... 详细信息

系统性血管炎是指以血管壁的炎症和纤维素样坏死为病理特征的一组系统性疾病，可分为原发性和继发性．继发性是指继发于其他疾病，例如感染、系统性红斑狼疮等，原发性是指目前病因不明者。根据受累血管的大小将系统性血管炎分为3类，部夫血管炎、中等血管炎和小血管炎。在原发性小血管炎中，部分疾病与抗中性粒细胞胞浆抗体（anti—neutrophil cytoplasmic antibodies，ANCA）密切相关，后者是其特异性的血清学诊断工具，因而称之为ANCA相关小血管炎（ANCA—associated systemic vascu—lifts，AASV），是本文论述的重点，它包括韦格纳肉芽肿病（Wegener＇s granulomatosis，WG）、显微镜下型多血管炎（microscopic polyangiitis，MPA）、变应性肉芽肿性血管炎（churg—strauss syndrome，css）和局灶节段坏死性肾小球肾炎。

关键词：原发性小血管炎局灶节段坏死性肾小球肾炎抗中性粒细胞胞浆抗体变应性肉芽肿性血管炎肾损害显微镜下型多血管炎 systemic syndrome 系统性血管炎系统性红斑狼疮

Myeloperoxidase influences the complement regulatory activity of complement factor H

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Myeloperoxidase influences the complement regulatory activit...