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Leucine-rich repeats containing 4 protein(LRRC4)in memory,psychoneurosis,and glioblastoma

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Chinese Medical Journal 2023年第1期136卷 4-12页

作者： Kun Deng minghua wu Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangshaHunan 410013China NHC Key Laboratory of Carcinogenesis Xiangya HospitalCentral South UniversityChangshaHunan 410008China Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research InstituteCentral South UniversityChangshaHunan 410008China

Leucine-rich repeats containing 4(LRRC4,also named netrin-G ligand 2[NGL-2])is a member of the NetrinGs ligands(NGLs)family.As a gene with relatively high and specific expression in brain,it is a member of the leucine-rich repeat superfamily and has been proven to be a suppressor gene for gliomas,thus being involved in gliomagenesis.LRRC4 is the core of microRNA-dependent multi-phase regulatory loops that inhibit the proliferation and invasion of glioblastoma(GB)cells,including LRRC4/NGL2-activator protein 2(AP2)-microRNA(miR)182-LRRC4 and LRRC4-miR185-DNA methyltransferase 1(DNMT1)-LRRC4/specific protein 1(SP1)-DNMT1-LRRC4.In this review,we demonstrated LRRC4 as a new member of the partitioning-defective protein(PAR)polarity complex that promotes axon differentiation,mediates the formation and plasticity of synapses,and assists information input to the hippocampus and storage of memory.As an important synapse regulator,aberrant expression of LRRC4 has been detected in autism,spinal injury and GBs.LRRC4 is a candidate susceptibility gene for autism and a neuro-protective factor in spinal nerve damage.In GBs,LRRC4 is a novel inhibitor of autophagy,and an inhibitor of protein–protein interactions involving in temozolomide resistance,tumor immune microenvironment,and formation of circular RNA.

关键词： Netrin G Excitatory synapses Long-term potentiation Autism Multiple sclerosis Glioblastoma

Pattern recognition receptors in health and diseases

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2650-2673页

作者： Danyang Li minghua wu Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School Central South UniversityChangshaHunanChina The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of EducationCancer Research InstituteCentral South UniversityChangshaHunanChina

Pattern recognition receptors(PRRs)are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens,apoptotic host cells,and damaged senescent cells.PRRs bridge nonspecific immunity and specific immunity.Through the recognition and binding of ligands,PRRs can produce nonspecific anti-infection,antitumor,and other immunoprotective effects.Most PRRs in the innate immune system of vertebrates can be classified into the following five types based on protein domain homology:Toll-like receptors(TLRs),nucleotide oligomerization domain(NOD)-like receptors(NLRs),retinoic acid-inducible gene-1(RIG-1)-like receptors(RLRs),C-type lectin receptors(CLRs),and absent in melanoma-2(AIM2)-like receptors(ALRs).PRRs are basically composed of ligand recognition domains,intermediate domains,and effector domains.PRRs recognize and bind their respective ligands and recruit adaptor molecules with the same structure through their effector domains,initiating downstream signaling pathways to exert effects.In recent years,the increased researches on the recognition and binding of PRRs and their ligands have greatly promoted the understanding of different PRRs signaling pathways and provided ideas for the treatment of immune-related diseases and even tumors.This review describes in detail the history,the structural characteristics,ligand recognition mechanism,the signaling pathway,the related disease,new drugs in clinical trials and clinical therapy of different types of PRRs,and discusses the significance of the research on pattern recognition mechanism for the treatment of PRR-related diseases.

关键词： Pattern diseases protective

Ultrastable MOF-based foams for versatile applications

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Nano Research 2022年第4期15卷 2961-2970页

作者： Qian Hu Licong Xu Kaixing Fu Feichao Zhu Taoyu Yang Tao Yang Jinming Luo minghua wu Deyou Yu Engineering Research Center for Eco-Dyeing and Finishing of Textiles Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018China Brook Byers Institute for Sustainable Systems School of Civil and Environmental EngineeringGeorgia Institute of TechnologyAtlanta 30332USA School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China Institute for Nanomaterials Advanced Technologies and InnovationTechnical University of LiberecLiberec 46117Czech Republic Zheijiang Sci-Tech University Tongxiang Research Institute Tongxiang 345000China

Metal-organic frameworks(MOFs)are attractive for promising applications but plagued by difficult recovery and deployment due to their intrinsic nano/micro powder nature.Although significant efforts have been made to develop separable solid matrixes for MOF supporting,the poor loading stability and durability of MOFs still challenge their engineering applications.Here,we present a facile and effective approach to fabricate MOF-based melamine foams(MFs)(denoted as MOFiths)with ultrahigh loading stability and operation stability,easy separation,and high-efficient performance for versatile robust applications.By adopting our approach,numbers of typical fragile MOFs characterized with wide ranges of particle size(from~nm to~μm)can be precisely incorporated into MFs with controllable loading ratios(up to~1,600%).Particularly,the produced MOFiths show excellent capacities for the highly effective and durable water purifications and acetalization reactions.100%of organic pollutants can be rapidly destructed within 10 min by MOFiths initiated Fenton or catalytic ozonation processes under five successive cycles while the maximum adsorption capacity of MOFiths toward Pb(II),Cd(II),and Cu(II)reaches to 422,222,and 105 mg·g^(-1),respectively.This study provides a critical solution to substantially facilitate the engineering applications of MOFs for long-term use in practice.

关键词： metal-organic framework melamine foam ultrastability versatile applications long-term use

OPTIMAL RISK CONTROL POLICIES FOR DIFFUSION MODELS WITH NON-CHEAP PROPORTIONAL REINSURANCE AND BANKRUPTCY VALUE

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Journal of Systems Science & Complexity 2011年第5期24卷 892-906页

作者： minghua wu Rong wu Aimin ZHOU School of Economics Nankai University Tianjin 3（}0071 China. School of Mathematical Sciences and LPMC Nankai University Tianjin 300071 China School of Economics Nankai University Tianjin 300071 China

这份报纸在散开模型的背景关于比例的再保险的优化考虑这个问题。作者同时考虑非便宜的比例的再保险和破产价值。目的是发现最大化总数的风险控制政策打折保守和破产值。结果表演，最佳的风险控制政策和函数改变的相应最佳的回来，两个... 详细信息

这份报纸在散开模型的背景关于比例的再保险的优化考虑这个问题。作者同时考虑非便宜的比例的再保险和破产价值。目的是发现最大化总数的风险控制政策打折保守和破产值。结果表演，最佳的风险控制政策和函数改变的相应最佳的回来，两个都取决于在保险和再保险的高级的率之间的破产价值和关系的范围。

关键词：保险费率风险控制扩散模型价值破产比例廉价优化问题

FLIM as a Promising Tool for Cancer Diagnosis and Treatment Monitoring

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Nano-Micro Letters 2021年第9期13卷 48-74页

作者： Yuzhen Ouyang Yanping Liu Zhiming MWang Zongwen Liu minghua wu Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School Central South UniversityChangsha 410013HunanPeople’s Republic of China School of Physics and Electronics Hunan Key Laboratory for Super-Microstructure and Ultrafast ProcessCentral South University932 South Lushan RoadChangsha 410083HunanPeople’s Republic of China The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of EducationCancer Research InstituteCentral South UniversityChangsha 410008HunanPeople’s Republic of China Shenzhen Research Institute of Central South University A510aVirtual University BuildingNanshan DistrictSouthern DistrictHigh-tech Industrial ParkYuehai StreetShenzhenPeople’s Republic of China State Key Laboratory of High-Performance Complex Manufacturing Central South University932 South Lushan RoadChangsha 410083HunanPeople’s Republic of China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054SichuanPeople’s Republic of China School of Chemical and Biomolecular Engineering The University of SydneySydneyNSW 2006Australia

Fluorescence lifetime imaging microscopy(FLIM)has been rapidly developed over the past 30 years and widely applied in biomedical engineering.Recent progress in fluorophore-dyed probe design has widened the application prospects of fluorescence.Because fluorescence lifetime is sensitive to microenvironments and molecule alterations,FLIM is promising for the detection of pathological conditions.Current cancer-related FLIM applications can be divided into three main categories:(i)FLIM with autofluorescence molecules in or out of a cell,especially with reduced form of nicotinamide adenine dinucleotide,and flavin adenine dinucleotide for cellular metabolism research;(ii)FLIM with Förster resonance energy transfer for monitoring protein interactions;and(iii)FLIM with fluorophore-dyed probes for specific aberration detection.Advancements in nanomaterial production and efficient calculation systems,as well as novel cancer biomarker discoveries,have promoted FLIM optimization,offering more opportunities for medical research and applications to cancer diagnosis and treatment monitoring.This review summarizes cutting-edge researches from 2015 to 2020 on cancer-related FLIM applications and the potential of FLIM for future cancer diagnosis methods and anti-cancer therapy development.We also highlight current challenges and provide perspectives for further investigation.

关键词： Fluorescence lifetime imaging microscopy Förster resonance energy transfer Reduced form of nicotinamide adenine dinucleotide Biosensors Cancer

通脑饮治疗急性脑梗死的临床疗效及作用机制研究:基于网络药理学和分子对接技术

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中国全科医学 2024年第23期27卷 2904-2912页

作者：张林高锦吴明华王广梅南京中医药大学附属南京市中西医结合医院神经内科江苏省南京市210000 南京中医药大学江苏省南京市210000 南京中医药大学附属医院江苏省中医院神经内科江苏省南京市210000 南京中医药大学附属南京市中西医结合医院药剂科江苏省南京市210000

背景脑梗死是由各种原因引起的局部脑组织区域供血障碍,通脑饮为江苏省中医院治疗脑梗死的协定方,但具体作用机制尚不清楚。目的本研究旨在通过网络药理学和临床试验,解释通脑饮治疗脑梗死的机制。方法选取2019年1月—2020年6月江苏省... 详细信息

背景脑梗死是由各种原因引起的局部脑组织区域供血障碍,通脑饮为江苏省中医院治疗脑梗死的协定方,但具体作用机制尚不清楚。目的本研究旨在通过网络药理学和临床试验,解释通脑饮治疗脑梗死的机制。方法选取2019年1月—2020年6月江苏省中医院收治的199例脑梗死患者。根据随机数字表法,将患者分为对照组(97例)和试验组(102例)。两组均接受稳定型脑梗死的标准化治疗,试验组加用通脑饮治疗。治疗前和治疗2周时,两组均采用美国国立卫生研究院卒中量表(NIHSS)评估卒中引起的功能损害程度,采用改良Rankin量表(mRS)评估神经功能的恢复情况。从TCMSP和文献中筛选通脑饮的化学成分,选择生物利用度(OB)≥30%和药物相似性(DL)≥0.18要求的成分寻找该处方的有效成分。利用OMIM和GeneCards数据库分析通脑饮治疗脑梗死的分子靶点。在筛选出共同靶点后,用Cytoscape软件、String数据库分别绘制化合物和靶蛋白的网络图、构建蛋白相互作用(PPI)网络和基因本体论(GO)功能及京都基因和基因组百科全书(KEGG)信号通路富集分析。最后,进行分子对接实验,确定通脑饮治疗脑梗死的主要活性成分。结果治疗后,试验组NIHSS、mRS评分均低于对照组(P<0.05)。最终得到通脑饮活性成分60个,潜在靶点147个,疾病相关靶点5167个,药物与疾病的交集靶点121个。KEGG信号通路富集分析获得前列腺癌症、神经活性配体-受体相互作用、白介素(IL)-17信号通路、催乳素信号通路、PI3K-Akt信号通路、钙信号通路等。分子对接显示,通脑饮治疗脑卒中的主要活性成分β谷甾醇、山柰酚和胡萝卜素与核心蛋白雄激素受体(AR)有较好的结合性。结论通脑饮可能通过激活AR来治疗脑梗死。IL-17信号通路、PI3K-Akt信号通路和催乳素信号通路也是潜在的机制。

关键词：脑梗死通脑饮网络药理学炎症分子对接

中青年冠心病患者冠状动脉多支病变的影响因素分析

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中国医药科学 2024年第10期14卷 128-131页

作者：吴明华江西省九江市柴桑区人民医院心内科江西九江332100

目的探讨中青年冠心病患者冠状动脉多支病变的影响因素。方法连续性选取2020年1月至2022年12月在九江市柴桑区人民医院心内科住院的60岁以下冠心病患者400例为研究对象。研究对象分为冠状动脉单支病变组和多支病变组,采用logistic回... 详细信息

目的探讨中青年冠心病患者冠状动脉多支病变的影响因素。方法连续性选取2020年1月至2022年12月在九江市柴桑区人民医院心内科住院的60岁以下冠心病患者400例为研究对象。研究对象分为冠状动脉单支病变组和多支病变组,采用logistic回归分析多支病变的影响因素。结果与冠状动脉单支病变组比较,多支病变组中高血压、糖尿病、血脂异常、吸烟、肥胖者较多,同型半胱氨酸、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、促甲状腺生成素、游离三碘甲状腺素原、天冬氨基酸转移酶、红细胞分布宽度均较高(P <0.05)。高血压、糖尿病、血脂异常、吸烟、肥胖及较高的红细胞分布宽度是中青年冠心病患者冠状动脉多支病变的独立危险因素(P <0.05)。结论中青年冠心病患者应加强危险因素评估,降低冠状动脉多支病变的发生风险。

关键词：冠心病多支病变中青年影响因素

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Phenolic rigid organic filler/isotactic polypropylene composites.I.Preparation

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Frontiers of Chemical Science and Engineering 2008年第3期2卷 236-241页

作者： Dongming QI Lei YANG minghua wu Heming LIN Kohhei NITTA Key Laboratory of Advanced Textile Materials and Manufacturing Technology Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018China Graduate School of Natural Science&Technology Kanazawa UniversityKanazawaIshikawa920-1192Japan

A novel phenolic rigid organic filler(KT)was melt-mixed with an isotactic polypropylene(iPP)to prepare a series of PP/KT composites,with or without maleic anhydride grafted polypropylene(MAPP)as compatilizer.The evolution of filler morphology during melt-mixing and melt-pressure processes was monitored by scanning electron microscope(SEM)and polarized optical microscope(POM).The influences of shear force,pressure time,filler content and MAPP concentration on the final filler dispersion were studied.We found that this rigid organic filler readily melted and dispersed homogenously into the iPP matrix through a fission-fusion process during the melt-mixing process.Thus a balanced dispersion,which was closely related to shear force and MAPP concentration,can be achieved.During the meltpressure process,parts of the filler particles combined gradually through a coalescence process.However,the incorporation of MAPP can effectively inhibit the tendency to coalesce and refine the filler particles sizes into nanoscale.Thus,a series of PP/KT composites with controllable filler particles size and narrow size distribution can be obtained just by adjusting process conditions and MAPP concentration.In addition,due to the in-situ formation mechanism,the filler phase possessed a typical solid true-spherical shape.

关键词： rigid organic filler polypropylene dispersion in-situ formation

Dispersion of“guava-like”silica/polyacrylate nanocomposite particles in polyacrylate matrix

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Frontiers of Chemical Science and Engineering 2008年第2期2卷 127-134页

作者： Dongming QI minghua wu Lei YANG Jianzhong SHAO Yongzhong BAO Key Laboratory of Advanced Textile Materials and Manufacturing Technology Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Chemical Engineering Zhejiang UniversityHangzhou 310027China

A series of“guava-like”silica/polyacrylate nanocomposite particles with close silica content and different grafting degrees were prepared via mini-emulsion polymerization using 3-(trimethoxysilyl)propyl methacrylate(TSPM)modified silica/acrylate dispersion.The silica/polyacrylate composite particles were melt-mixed with unfilled polyacrylate(PA)resin to prepare corresponding silica/polyacrylate molded composites and the dispersion mechanism of these silica particles from the“guava-like”composite particles into polyacrylate matrix was studied.It was calculated that about 110 silica particles were accumulated in the bulk of every silica/polyacrylate composite latex particle.Both the solubility tests of silica/polyacrylate composite latex particles in tetrahydrofuran(THF)and the section transmission electron microscope(TEM)micrographs of silica/polyacrylate molded composites indicated that the grafting degree of silica particles played a crucial role in the dispersion of silica/polyacrylate composite particles into the polyacrylate matrix.When the grafting degree of polyacrylate onto silica was in a moderate range(ca.20%-70%),almost all of silica particles in these“guava-like”composite particles were dispersed into the polyacrylate matrix in a primaryparticle-level.However,at a lower grafting degree,massive silica aggregations were found in molded composites because of the lack of steric protection.At a greater grafting degree(i.e.,200%),a cross-linked network was formed in the silica/polyacrylate composite particles,which prevented the dispersion of composite particles in THF and polyacrylate matrix as primary particles.

关键词： silica polyacrylate nanocomposite dispersion