检索结果-南通市图书馆

酪酸梭菌对RSV感染加重的哮喘小鼠气道炎症的影响

在线全文

学校读者我要写书评

暂无评论

中国医药科学 2017年第15期7卷 31-35,45页

作者：郭颖张娟曾明华吴海霞李秋红孙新第四军医大学西京医院儿科陕西西安710032

目的酪酸梭菌对RSV感染的哮喘小鼠模型气道的炎症反应的影响。方法 6~8周龄雄性BALB/c小鼠36只,随机分为对照组(NC)、模型组(PC)、酪酸梭菌治疗组(LS),每组12只。除对照组(NC)以外,其余各组均采用卵清蛋白腹腔注射致敏和雾化吸入激发,... 详细信息

目的酪酸梭菌对RSV感染的哮喘小鼠模型气道的炎症反应的影响。方法 6~8周龄雄性BALB/c小鼠36只,随机分为对照组(NC)、模型组(PC)、酪酸梭菌治疗组(LS),每组12只。除对照组(NC)以外,其余各组均采用卵清蛋白腹腔注射致敏和雾化吸入激发,建立小鼠哮喘模型,在哮喘模型建立后第二日用RSV隔日滴鼻,连续3次,复制急性病毒感染哮喘模型。对照组(NC)采用生理盐水替代卵清蛋白和RSV。酪酸梭菌组(LS)于0~33天给予酪酸梭菌灌喂,每日1次,第34天计数支气管肺泡灌洗液(BALF)中的白细胞数目;制作肺组织的病理切片,进行HE染色和Masson染色,观察肺组织病理变化;酶联免疫吸附法(ELISA)检测BALF与血清中细胞因子IFN-γ、BALF中IL-12、IL-5及血清中嗜酸性粒细胞趋化因子。结果与模型组(PC)相比,酪酸梭菌组(LS)小鼠BALF中白细胞总数明显降低(P<0.01),BALF及血清中细胞因子IFN-γ、IL-12的水平升高(P<0.01),嗜酸性粒细胞趋化因子、IL-5水平降低(P<0.01)。结论酪酸梭菌可减轻RSV感染的哮喘小鼠气道炎症,酪酸梭菌对于RSV感染的哮喘小鼠具有一定的治疗作用。

关键词：酪酸梭菌支气管哮喘卵清蛋白小鼠

Changes in Global Vegetation Distribution and Carbon Fluxes in Response to Global Warming:Simulated Results from IAP-DGVM in CAS-ESM2

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2022年第8期39卷 1285-1298,I0002-I0010页

作者： Xiaofei GAO Jiawen ZHU Xiaodong zeng minghua ZHANG Yongjiu DAI Duoying JI He ZHANG International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Marine and Atmospheric Sciences Stony Brook UniversityNY 11790USA School of Atmospheric Sciences Sun Yat-Sen UniversityGuangzhou 510275China College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100875China

Terrestrial ecosystems are an important part of Earth systems,and they are undergoing remarkable changes in response to global *** study investigates the response of the terrestrial vegetation distribution and carbon fluxes to global warming by using the new dynamic global vegetation model in the second version of the Chinese Academy of Sciences(CAS)Earth System Model(CAS-ESM2).We conducted two sets of simulations,a present-day simulation and a future simulation,which were forced by the present-day climate during 1981-2000 and the future climate during 2081-2100,respectively,as derived from RCP8.5 outputs in ***_(2)concentration is kept constant in all simulations to isolate CO_(2)-fertilization *** results show an overall increase in vegetation coverage in response to global warming,which is the net result of the greening in the mid-high latitudes and the browning in the *** results also show an enhancement in carbon fluxes in response to global warming,including gross primary productivity,net primary productivity,and autotrophic *** found that the changes in vegetation coverage were significantly correlated with changes in surface air temperature,reflecting the dominant role of temperature,while the changes in carbon fluxes were caused by the combined effects of leaf area index,temperature,and *** study applies the CAS-ESM2 to investigate the response of terrestrial ecosystems to climate *** though the interpretation of the results is limited by isolating CO_(2)-fertilization effects,this application is still beneficial for adding to our understanding of vegetation processes and to further improve upon model parameterizations.

关键词： global warming vegetation distribution carbon flux leaf area index surface air temperature

Telomere-to-telomere genome assembly of melon(Cucumis melo ***)provides a high-quality reference for meta-QTL analysis of important traits

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2023年第10期10卷 202-214页

作者： minghua Wei Ying Huang Changjuan Mo Haiyan Wang Qingguo zeng Wenli Yang Jihao Chen Xuejun Zhang Qiusheng Kong National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Hami-melon Research Center Xinjiang Academy of Agricultural SciencesUrumqi 830091China Hainan Sanya Experimental Center for Crop Breeding Xinjiang Academy of Agricultural SciencesSanya 572014China

Melon is an important horticultural crop with extensive diversity in many horticultural *** explore its genomic diversity,it is necessary to assemble more high-quality complete genomes from different melon ***,a large number of QTLs have been mapped in several *** of the published QTLs onto a complete genome can provide more accurate information for candidate gene *** address these problems,a telomere-to-telomere(T2T)genome of the elite melon landrace Kuizilikjiz(Cucumis melo ***)was de novo assembled and all the published QTLs were projected onto it in this *** results showed that a high-quality Kuizilikjiz genome with the size of 379.2 Mb and N50 of 31.7 Mb was de novo assembled using the combination of short reads,PacBio high-fidelity long reads,Hi-C data,and a high-density genetic *** chromosome contained the centromere and telomeres at both ends.A large number of structural variations were observed between Kuizilikjiz and the other published genomes.A total of 1294 QTLs published in 67 studies were collected and projected onto the T2T *** clustered,co-localized,and overlapped QTLs were ***,20 stable meta-QTLs were identified,which significantly reduced the mapping intervals of the initial QTLs and greatly facilitated identification of the candidate ***,the T2T genome assembly together with the numerous projected QTLs will not only broaden the high-quality genome resources but also provide valuable and abundant QTL information for cloning the genes controlling important traits in melon.

关键词： Cucumis elite traits

Evaluation of the New Dynamic Global Vegetation Model in CAS-ESM

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2018年第6期35卷 659-670页

作者： Jiawen ZHU Xiaodong zeng minghua ZHANG Yongjiu DAI Duoying JI Fang LI Qian ZHANG He ZHANG Xiang SONG International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology School of Marine and Atmospheric Sciences Stony Brook University School of Atmospheric Sciences Sun Yat-Sen University College of Global Change and Earth System Science Beijing Normal University

In the past several decades, dynamic global vegetation models（DGVMs） have been the most widely used and appropriate tool at the global scale to investigate vegetation-climate interactions. At the Institute of Atmospheric Physics, a new version of DGVM（IAP-DGVM） has been developed and coupled to the Common Land Model（CoLM） within the framework of the Chinese Academy of Sciences＇ Earth System Model（CAS-ESM）. This work reports the performance of IAP-DGVM through comparisons with that of the default DGVM of CoLM（CoLM-DGVM） and observations. With respect to CoLMDGVM, IAP-DGVM simulated fewer tropical trees, more ＂needleleaf evergreen boreal tree＂ and ＂broadleaf deciduous boreal shrub＂, and a better representation of grasses. These contributed to a more realistic vegetation distribution in IAP-DGVM,including spatial patterns, total areas, and compositions. Moreover, IAP-DGVM also produced more accurate carbon fluxes than CoLM-DGVM when compared with observational estimates. Gross primary productivity and net primary production in IAP-DGVM were in better agreement with observations than those of CoLM-DGVM, and the tropical pattern of fire carbon emissions in IAP-DGVM was much more consistent with the observation than that in CoLM-DGVM. The leaf area index simulated by IAP-DGVM was closer to the observation than that of CoLM-DGVM; however, both simulated values about twice as large as in the observation. This evaluation provides valuable information for the application of CAS-ESM, as well as for other model communities in terms of a comparative benchmark.

关键词： vegetation dynamics dynamic global vegetation model vegetation distribution carbon flux leaf area index

宁乡市主要农作物上的农药使用情况调查与分析评价

在线全文

学校读者我要写书评

暂无评论

世界农药 2024年第6期46卷 16-22,33页

作者：卢小舟喻明华徐灵超曾晓玲金亮亮宁乡市农业技术推广中心湖南宁乡410600 宁乡市植保植检站湖南宁乡410600 宁乡市农业农村局湖南宁乡410600

全面系统调查了湖南省宁乡市2023年水稻、蔬菜、玉米等各大类作物的农药使用情况,从农药使用量、用药成本、用药次数、农药类型、农药来源、农药毒性、农药成分等多个维度对比分析了各类作物在农药使用上的特点和差异,并重点从农药减量... 详细信息

全面系统调查了湖南省宁乡市2023年水稻、蔬菜、玉米等各大类作物的农药使用情况,从农药使用量、用药成本、用药次数、农药类型、农药来源、农药毒性、农药成分等多个维度对比分析了各类作物在农药使用上的特点和差异,并重点从农药减量的角度给出了相关的评价和建议,为农药科学安全使用和农药减量增效提供参考。

关键词：农作物农药调查农药用量评价及建议

基于“MLT”原则采用扩张皮瓣整复面颈部瘢痕的方法及其临床效果

在线全文

学校读者我要写书评

暂无评论

中华烧伤与创面修复杂志 2024年第7期40卷 657-664页

作者：陶明秋黄覛韬梁鹏飞张明华张丕红何志友曾纪章周捷崔旭郭乐周思拓杨燕谢庭鸿黄晓元中南大学湘雅医院烧伤整形科长沙410008

目的探讨基于“MLT”原则采用扩张皮瓣整复面颈部瘢痕的方法及其临床效果。方法该研究为回顾性观察性研究。2019年1月-2022年5月,中南大学湘雅医院收治74例符合入选标准的烧创伤后面颈部瘢痕患者,其中男38例、女36例,年龄5~58岁,单纯面... 详细信息

目的探讨基于“MLT”原则采用扩张皮瓣整复面颈部瘢痕的方法及其临床效果。方法该研究为回顾性观察性研究。2019年1月-2022年5月,中南大学湘雅医院收治74例符合入选标准的烧创伤后面颈部瘢痕患者,其中男38例、女36例,年龄5~58岁,单纯面部受累者24例、单纯颈部受累者24例、面部和颈部均受累者26例,瘢痕面积12~145 cm^(2)。遵循色泽、质地与面部相似;皮瓣面积足够大以修复整个缺损;皮肤组织足够薄,能传递表情,以利于面部形态和五官的塑形的“MLT”原则,Ⅰ期行皮肤软组织扩张器(以下简称扩张器)置入术,Ⅱ期行扩张器取出+瘢痕切除+皮瓣移植术修复继发创面,将皮瓣供区创面直接缝合。术后采用硅凝胶制剂、激光治疗等抗瘢痕增生。观察并记录扩张器扩张倍数、扩张周期,皮肤软组织扩张术并发症发生情况,以及采用的皮瓣类型、Ⅱ期术后皮瓣成活情况。术后随访,评估患者面颈部远期整复效果和皮瓣供、受区恢复情况。结果135个扩张器扩张倍数为1.36~3.00倍,扩张周期为6~14个月。行皮肤软组织扩张术期间,8例患者出现扩张器置入后切口愈合不良、7例患者出现扩张器破裂、5例患者出现扩张器置入后切口感染、3例患者出现扩张器外露、2例患者出现注射壶注水困难、1例患者出现注射壶漏水。8例患者采用颈横动脉与旋肩胛动脉双血供肩背部扩张皮瓣,11例患者采用颈横动脉前穿支扩张皮瓣,12例患者采用胸廓内动脉穿支扩张皮瓣,16例患者采用上胸部及颈部串联扩张皮瓣,5例患者采用胸背动脉穿支扩张皮瓣,22例患者采用邻近旋转推进扩张皮瓣。Ⅱ期术后,71例患者皮瓣完全成活;1例患者皮瓣出现血运障碍,经高压氧治疗后成活;2例患者皮瓣末端出现坏死,经换药后愈合。术后对42例患者随访3~24个月,皮瓣颜色、质地、厚度均佳,与受区周围正常皮肤组织相近,面颈部外形及功能明显改善,皮瓣供、受区创面位置隐蔽且瘢痕形成较轻。结论整复面颈部瘢痕时,遵循“MLT”原则,在术前精心设计扩张皮瓣,Ⅱ期手术时重建亚单位内局部美学特征,术后积极采取规范的抗瘢痕治疗措施,整复后可使皮瓣颜色、质地、厚度与面颈部正常皮肤接近,面颈部外形及功能改善明显,遗留线性瘢痕较轻,有利于提升治疗效果。

关键词：瘢痕外科皮瓣烧伤面部颈扩张术创面修复

Ocean Response to a Climate Change Heat-Flux Perturbation in an Ocean Model and Its Corresponding Coupled Model

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2022年第1期39卷 55-66页

作者： Jiangbo JIN Xiao DONG Juanxiong HE Yi YU Hailong LIU minghua ZHANG Qingcun zeng He ZHANG Xin GAO Guangqing ZHOU Yaqi WANG International Center for climate and Environment Sciences(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100049China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China School of Marine and Atmospheric Sciences Stony Brook UniversityStony BrookNew YorkNY 11790USA

State-of-the-art coupled general circulation models(CGCMs)are used to predict ocean heat uptake(OHU)and sealevel change under global ***,the projections of different models vary,resulting in high *** of the inter-model spread is driven by responses to surface heat *** study mainly focuses on the response of the ocean to a surface heat flux perturbation F,as prescribed by the Flux-Anomaly-Forced Model Intercomparison Project(FAFMIP).The results of ocean model were compared with those of a CGCM with the same ocean *** the global scale,the changes in global mean temperature,ocean heat content(OHC),and steric sea level(SSL)simulated in the OGCM are generally consistent with CGCM *** in changes in ocean temperature,OHC,and SSL between the two models primarily occur in the Arctic and Atlantic Oceans(AA)and the Southern Ocean(SO)*** addition to the differences in surface heat flux anomalies between the two models,differences in heat exchange between basins also play an important role in the inconsistencies in ocean climate changes in the AA and SO *** discrepancies are largely due to both the larger initial value and the greater weakening change of the Atlantic meridional overturning circulation(AMOC)in *** greater weakening of the AMOC in the CGCM is associated with the atmosphere–ocean feedback and the lack of a restoring salinity boundary ***,differences in surface salinity boundary conditions between the two models contribute to discrepancies in SSL changes.

关键词： ocean heat uptake Atlantic meridional overturning circulation ocean general circulation model coupled general circulation model

西藏羊和白-藏杂交羊外周血IFN-α、IgG和IL-2的研究

在线全文

学校读者我要写书评

暂无评论

草学 2024年第1期 69-73页

作者：庞倩曾洁杜丹陈明华杨平贵周明亮四川省草原科学研究院四川红原624400

为了解西藏羊和白萨福克羊与西藏羊的杂交后代羊生长发育中免疫因子的分泌特点和免疫学特征,以西藏羊和白-藏杂交羊为研究对象,应用ELISA方法检测0.5、1和1.5岁外周血中干扰素(IFN-α)、免疫球蛋白G(IgG)和白细胞介素-2(IL-2)的质量浓度... 详细信息

为了解西藏羊和白萨福克羊与西藏羊的杂交后代羊生长发育中免疫因子的分泌特点和免疫学特征,以西藏羊和白-藏杂交羊为研究对象,应用ELISA方法检测0.5、1和1.5岁外周血中干扰素(IFN-α)、免疫球蛋白G(IgG)和白细胞介素-2(IL-2)的质量浓度,分析其变化规律。结果表明:随年龄的增长,藏公羊IL-2呈逐渐降低的趋势,而藏母羊呈逐渐升高的趋势(P<0.05);藏杂交公羊和藏母羊IgG含量都呈逐渐降低趋势,藏公羊下降较明显(P<0.05);藏公羊IFN-α的含量逐渐降低,0.5岁与1岁之间下降趋势明显(P<0.05),而藏母羊变化不大。随年龄的增长,白-藏杂交羊公羊和母羊IL-2含量先降低再升高;白-藏杂交羊公羊IgG含量变化不大,母羊则是先升高后下降趋势,且1岁和1.5岁之间下降明显(P<0.05);白-藏杂交羊公羊IFN-α的含量逐渐降低,而母羊是先升高后下降。

关键词：西藏羊白-藏杂交羊 α干扰素免疫球蛋白G 白细胞介素-2

在线全文

学校读者我要写书评

暂无评论

低碱高硅率高铁水泥的研发与生产实践

水泥工程 2024年第3期 34-36,44页

作者：曹勤肖明华刘帅明曾江波朱璟肖凤林江西安福南方水泥有限公司江西安福343200 吉安市质量技术监督检测中心江西吉安343000

通过优选碱含量低的原材料、采用高硅率生料配料、改进熟料煅烧工艺操作、合理控制水泥粉磨指标,研发生产了水泥碱含量小于0.40%、熟料硅率为3.5的低碱高硅率高铁水泥,满足了国家重点工程高铁建设项目需要。

关键词：低碱高硅率高铁水泥