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Review on Optical Fiber Sensors With Sensitive Thin Films

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Photonic Sensors 2012年第1期2卷 14-28页

作者： minghong yang jixiang dai National Engineering Laboratory for Optical Fiber Sensing Technologies Wuhan University of Technology Wuhan 430070 China

The combination of fiber optics with nano-structure technologies and sensitive thin films offers great potential for the realization of novel sensor concepts. Miniatured optical fiber sensors with thin films as sensitive elements could open new fields for optical fiber sensor applications. Thin films work as sensitive elements and transducer to get response and feedback from environments, in which optical fibers are employed to work as signal carrier. This article presents some research work conducted at the National Engineering Laboratory for Optical Fiber Sensing Technologies in recent years. Concrete examples are： Pd/WO3 co-sputtered coating as sensing material for optical hydrogen sensors shows robust mechanical stability and meanwhile good sensing performance; TbDyFe magnetostrictive coating directly deposited on fiber Bragg grating （FBG） demonstrates its possibility of miniature optical magnetic field/current sensors, and 40-pm shift of the FBG wavelength happens at a magnetic field order of 50 mT.

关键词： Fiber Bragg grating sensitive thin film magnetron sputtering

High-performance single-component white light-emitting diodes based on donor-acceptor integrated carbon nitride

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Science China Chemistry 2025年第3期 1136-1143页

作者： Ning Wu Fangxu dai Kunpeng Wang Yunhu Wang Xinyi Wang Kai Zhang Mingming Zhang Kang Liu jixiang Xu Lei Wang Jun Xing Key Laboratory of Eco-chemical Engineering Ministry of EducationCollege of Chemistry and Molecular EngineeringQingdao University of Science & Technology School of Pharmacy Jining Medical University College of Sino-German Science and Technology Qingdao University of Science & Technology

White light-emitting diodes（WLEDs） as energy-saving light sources are widely used to alleviate the rising electric *** commercial WLEDs are blue/yellow-mixed emitting devices,which have some disadvantages,such as physiological damages of rich blue light,complex device structure and color *** is essential to develop single-component WLEDs with quasi-solar spectrum to overcome these *** we demonstrate a high-performance single-component WLED based on donor-acceptor integrated carbon nitride（DACN） *** donor-acceptor simultaneously increases the photoluminescence efficiency and the carrier mobility of graphitic carbon nitride（g-CN）,hence,the DACN-based WLED reaches a milestone in maximum luminance of 2,045 cdm-2and maximum external quantum efficiency of 2.2%,which are one order of magnitude higher than pristine g-CN-based ***,the DACN-based WLED emits broadband white light with color coordinates of（0.34,0.44） and a color temperature of 5,163 *** works open a way to boost optoelectronic properties of g-CN materials and show their promising application in single-component WLEDs.

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Fabrication and mechanical properties of self-toughening ZrB2–SiC composites from in-situ reaction

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Journal of Advanced Ceramics 2019年第4期8卷 527-536页

作者： Zhaofu ZHANG Jianjun SHA Yufei ZU jixiang dai Yingjun LIU State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology

Self-toughening ZrB2–SiC based composites are fabricated by in-situ reactive hot *** effect of sintering additive content on the microstructure and mechanical properties of the composites is *** observation found that the in-situ reactive hot pressing could promote the anisotropic growth of ZrB2 grains and the formation of interlocking *** microstructure could improve the mechanical properties,especially,for the fracture *** improved mechanical properties could be attributed to the self-toughening structure related to the ZrB2 platelets and the formed interlocking microstructure,which could trigger various toughening mechanisms such as grain pull-out,crack bridging,crack deflection,and crack branching,providing the main contribution to the high fracture toughness.

关键词： ultrahigh temperature ceramic in-situ reaction interlocking microstructure mechanical property

Gene dysregulation analysis builds a mechanistic signature for prognosis and therapeutic benefit in colorectal cancer

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Journal of Molecular Cell Biology 2020年第11期12卷 881-893页

作者： Quanxue Li Wentao dai jixiang Liu Qingqing Sang Yi-Xue Li Yuan-Yuan Li School of Biotechnology East China University of Science and TechnologyShanghai 200237China Shanghai Center for Bioinformation Technology Shanghai 201203China Department of Surgery Shanghai Key Laboratory of Gastric NeoplasmsShanghai Institute of Digestive SurgeryRuijin HospitalShanghai jiao Tong University School of MedicineShanghai 200025China CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Shanghai Engineering Research Center of Pharmaceutical Translation and Shanghai Industrial Technology Institute Shanghai 201203China

The implementation of cancer precision medicine requires biomarkers or signatures for predicting prognosis and therapeutic *** of current efforts in this field are paying much more attention to predictive accuracy than to molecular mechanistic ***-driven strategy has recently emerged,aiming to build signatures with both predictive power and explanatory *** by this strategy,we developed a robust gene dysregulation analysis framework with machine learning algorithms,which is capable of exploring gene dysregulations underlying carcinogenesis from high-dimensional data with cooperativity and synergy between regulators and several other transcriptional regulation rules taken into *** then applied the framework to a colorectal cancer(CRC)cohort from The Cancer Genome *** identified CRC-related dysregulations significantly covered known carcinogenic processes and exhibited good prognostic *** choosing dysregulations with greedy strategy,we built a four-dysregulation(4-DysReg)signature,which has the capability of predicting prognosis and adjuvant chemotherapy benefit.4-DysReg has the potential to explain carcinogenesis in terms of dysfunctional transcriptional *** results demonstrate that our gene dysregulation analysis framework could be used to develop predictive signature with mechanistic interpretability for cancer precision medicine,and furthermore,elucidate the mechanisms of carcinogenesis.

关键词： gene dysregulation analysis mechanistic signature cancer precision medicine prognosis chemotherapy benefit colorectal cancer

A comparison of next-generation sequencing analysis methods for cancer xenograft samples

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Journal of Genetics and Genomics 2018年第7期45卷 345-350页

作者： Wentao dai jixiang Liu Quanxue Li Wei Liu Yi-Xue Li Yuan-Yuan Li shanghai center for bioinformation technology Shanghai 201203China shanghai engineering research center of pharmaceutical translation&shanghai industrial technology institute Shanghai 201203China school of biotechnology east china university of science and technologyShanghai 201203China shanghai industrial technology institute Shanghai 200237China

The application of next-generation sequencing （NGS） technology in cancer is influenced by the quality and purity of tissue samples. This issue is especially critical for patient-derived xenograft （PDX） models, which have proven to be by far the best preclinical tool for investigating human tumor biology, because the sensitivity and specificity of NGS analysis in xenograft samples would be compromised by the contamination of mouse DNA and RNA. This definitely affects downstream analyses by causing inaccurate mutation calling and gene expression estimates. The reliability of NGS data analysis for cancer xenograft samples is therefore highly dependent on whether the sequencing reads derived from the xenograft could be distinguished from those originated from the host. That is, each sequence read needs to be accurately assigned to its original species. Here, we review currently available methodologies in this field, including Xenome, Disambiguate, bamcmp and pdxBlacklist, and provide guidelines for users.

关键词： Patient-derived xenograft Next-generation sequencing Host contamination control Alignment

程序性死亡受体1抑制剂在胃癌新辅助治疗及转化治疗中应用的研究进展

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中华胃肠外科杂志 2025年第02期28卷 217-224页

作者：唐宇凡周柏全戴思孟文兵兵刘吉祥李路遥范瑞芳甘肃中医药大学第一临床医学院兰州联勤保障部队第九四〇医院普通外科兰州西北民族大学兰州兰州大学第二临床医学院兰州

胃癌是中国最常见的消化系统恶性肿瘤之一。随着免疫治疗的研究进展, 程序性死亡受体-1(PD-1)抑制剂为基础的免疫联合疗法为进展期胃癌的治疗提供了新思路。近年来, 随着免疫治疗在进展期胃癌治疗中的地位不断提升, 国内外越来越多的临... 详细信息

胃癌是中国最常见的消化系统恶性肿瘤之一。随着免疫治疗的研究进展, 程序性死亡受体-1(PD-1)抑制剂为基础的免疫联合疗法为进展期胃癌的治疗提供了新思路。近年来, 随着免疫治疗在进展期胃癌治疗中的地位不断提升, 国内外越来越多的临床研究表明, 免疫治疗应用于进展期胃癌患者的新辅助治疗和转化治疗可以取得较好的疗效。因此, 本文就目前PD-1抑制剂在胃癌新辅助治疗及转化治疗中应用的研究进展进行综述。

关键词：胃肿瘤, 进展期 PD-1抑制剂新辅助治疗转化治疗

TGPred:a tumor gene prediction webserver for analyzing structural and functional impacts of variants

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Journal of Molecular Cell Biology 2020年第7期12卷 556-558页

作者： jixiang Liu Wei Liu Xue-Ling Li Quanxue Li Wentao dai Yuan-Yuan Li Shanghai Center for Bioinformation Technology&Shanghai Engineering Research Center of Pharmaceutical Translation Shanghai Industrial Technology InstituteShanghai 201203China Department of Surgery Shanghai Key Laboratory of Gastric NeoplasmsShanghai Institute of Digestive SurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China National Engineering Research Center for Nanotechnology Shanghai University of Medicine and Health SciencesShanghai 201318China School of Biotechnology East China University of Science and TechnologyShanghai 200237China

With the increasing use of high-throughput sequencing technology in tumor research,a large number of somatic variations are being identified and some of them have proved to be responsible for tumorigenesis(Cancer Genome Atlas Research Network et al.,2013).Investigating structural and functional impacts of tumor somatic variants would greatly help to identify causal variations,understand the mechanisms of carcinogenesis,and develop novel anti-tumor ***,many efforts have recently been made to map genomic variations to 3D protein structure,such as G23D(Solomon et al.,2016)and G2S(Wang et al.,2018).

关键词： al. Cancer structural

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氮化硅透明陶瓷光学薄膜的制备与特性分析

材料导报 2013年第2期27卷 31-34页

作者：程芸杨明红代吉祥杨志武汉理工大学光纤传感技术国家工程实验室武汉430070

采用射频磁控反应溅射法在不同工艺下制备微米级厚度的氮化硅薄膜,并利用椭圆偏振仪、分光光度计、X射线衍射仪、电子探针显微分析仪以及红外光谱仪对薄膜的光学性能、微观结构及化学成分进行了表征。测试结果表明,当N2和Ar的流量为1∶... 详细信息

采用射频磁控反应溅射法在不同工艺下制备微米级厚度的氮化硅薄膜,并利用椭圆偏振仪、分光光度计、X射线衍射仪、电子探针显微分析仪以及红外光谱仪对薄膜的光学性能、微观结构及化学成分进行了表征。测试结果表明,当N2和Ar的流量为1∶1时所制备样品为非晶态结构的高折射率富氮氮化硅薄膜;低温热处理对薄膜折射率有一定的改善作用;透过率随溅射气压的增加而升高、随功率的增大而降低;N-Si键的强度随溅射气压的升高而降低。

关键词：氮化硅薄膜射频溅射光学性能 FT-IR EPMA

Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury

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Science China(Life Sciences) 2022年第2期65卷 295-308页

作者： Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen jixiang Zhang Ya Shi Yaming yang Falong Lu Jianwu dai State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100080China University of the Chinese Academy of Sciences Beijing 100101China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangsha 410008China

Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal ***,the ependyma function as NSCs after SCI is still under *** used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after *** demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after *** study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future.

关键词： neural stem cell Nestin scRNA-seq Smart-seq2 ependymal cell