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ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling

Journal of Clinical and Translational Hepatology 2024年第2期12卷 134-150页

作者： Shanshou Liu Jiangang Xie Chujun Duan Xiaojun Zhao Zhusheng Feng Zheng Dai Xu Luo Yu Li minghe yang Ran Zhuang Junjie Li Wen Yin Emergency Department Xijing HospitalFourth Military Medical UniversityXi’anShaanxiChina Emergency Department Tangdu HospitalFourth Military Medical UniversityXi’anShaanxiChina Third Student Brigade School of Basic Medical ScienceFourth Military Medical UniversityXi’anShaanxiChina Department of Immunology Fourth Military Medical UniversityXi’anShaanxiChina

apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ *** previously reported that adenosine deaminases acting on RNA-1(ADAR1)reduced intestinal and splenic inflammatory damage during ***,the roles and mechanism of ADAR1 in sepsis-induced liver injury remain ***:We performed transcriptome and single-cell RNA sequencing of peripheral blood mononuclear cells(PBMCs)from patients with sepsis to investigate the effects of ADAR1 on immune cell *** also employed a cecal ligation and puncture(CLP)sepsis mouse model to evaluate the roles of ADAR1 in sepsisinduced liver ***,we treated murine RAW 264.7 macrophages with lipopolysaccharide to explore the underlying ADAR1-mediated mechanisms in ***:PBMCs from patients with sepsis had obvious apoptotic morphological ***-cell RNA sequencing indicated that apoptosis-related pathways were enriched in monocytes,with significantly elevated ADAR1 and BCL2A1 expression in severe ***-induced septic mice had aggravated liver injury and Kupffer cell apoptosis that were largely alleviated by ADAR1 ***1 directly bound to premiR-122 to modulate miR-122 ***-122 was an upstream regulator of ***,ADAR1 also reduced macrophage apoptosis in mice with CLP-induced sepsis through the miR-122/BCL2A1 signaling pathway and protected against sepsis-induced liver ***:The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling *** study provides novel insights into the development of therapeutic interventions in sepsis.

关键词： Sepsis Macrophage ADAR1 microRNA122 BCL2A1 Apoptosis

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财政补偿政策对两级公立医院竞争策略选择的影响:基于演化博弈分析

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中国卫生经济 2024年第2期43卷 10-15页

作者：杨名赫洪学智安倩男李冬梅肖路阳北京中医药大学北京100000

目的:研究财政补偿政策对两级公立医院竞争策略选择的影响。方法:基于公立医院“质量策略”和“成本策略”选择框架,建立二级公立医院和三级公立医院的策略选择演化博弈模型,通过matlab模拟仿真分析不同财政补偿政策对公立医院竞争策略... 详细信息

目的:研究财政补偿政策对两级公立医院竞争策略选择的影响。方法:基于公立医院“质量策略”和“成本策略”选择框架,建立二级公立医院和三级公立医院的策略选择演化博弈模型,通过matlab模拟仿真分析不同财政补偿政策对公立医院竞争策略选择的影响。结果:公立医院选择最优策略占比越多,越快到达最优策略的演化稳定状态;相同单位财政补偿,更能改变二级医院的竞争策略选择倾向;无论是三级公立医院还是二级公立医院,补偿“质量策略”的影响都大于补偿成本政策,但过度补偿“质量策略”会导致二三级医院偏离最优策略。医院竞争成本对二级公立医院的影响远大于三级公立医院。结论:从政策上明确二三级医院的定位和策略;从财政上增加三级公立医院质量的建设投入,加大二级医院管理水平的建设投入;加强监督管理,引导医院合理竞争。

关键词：公立医院财政补偿竞争策略演化博弈分析

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KH550-SiO_(2)/polyimide insulating paper preparation and characterisation

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High Voltage 2024年第2期9卷 466-473页

作者： minghe Chi Xue Sun Xiaorui Zhang Jiahao Shi Ling Weng yang Yu School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbinChina Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinChina School of Materials Science and Engineering Harbin University of Science and TechnologyHarbinChina

Oil-paper insulation material is an essential component for oil-filled transformers,and polyimide(PI)insulation paper is a novel material in the field of *** improvement of insulation class for insulation paper has gained significant attention in recent *** this study,SiO_(2)nanoparticles were modified with a silane coupling agent(KH550),and the KH550-SiO_(2)was added to the fibre membrane through in situ *** chemical composition and microcosmic characteristics of the PI porous fibre membrane were characterised using FT-IR and SEM FT-IR and ***-quently,the dielectric constant of the composite paper was reduced to 2.3 upon adding 3 wt%of KH550-SiO_(2),and the dielectric strength reached its maximum value of 85 kV/*** results demonstrate that the insulation performance of the KH550-SiO_(2)/PI composite was significantly improved due to the incorporation of nano-SiO_(2).This establishes an efficient approach for achieving excellent electrical and thermal properties in practical applications using the KH550-SiO_(2)/PI fibre membrane.

关键词： composite insulation fibre

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The Sasa-Satsuma equation with high-order discrete spectra in space-time solitonic regions:soliton resolution via the mixed■-Riemann-Hilbert problem

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Communications in Theoretical Physics 2024年第6期76卷 13-25页

作者： minghe Zhang Zhenya Yan KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

In this paper,we investigate the Cauchy problem of the Sasa-Satsuma(SS)equation with initial data belonging to the Schwartz *** SS equation is one of the integrable higher-order extensions of the nonlinear Schrödinger equation and admits a 3×3 Lax *** the aid of the■nonlinear steepest descent method of the mixed■-Riemann-Hilbert problem,we give the soliton resolution and long-time asymptotics for the Cauchy problem of the SS equation with the existence of second-order discrete spectra in the space-time solitonic regions.

关键词： Sasa-Satsuma equation inverse scattering ■-Riemann-Hilbert problem ■steepest descent method soliton resolution

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A probabilistic generative model for tracking multi-knowledge concept mastery probability

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Frontiers of Computer Science 2024年第3期18卷 155-170页

作者： Hengyu LIU Tiancheng ZHANG Fan LI minghe YU Ge YU School of Computer Science and Engineering Northeastern UniversityShenyang 110169China Software College Northeastern UniversityShenyang 110169China

Knowledge tracing aims to track students’knowledge status over time to predict students’future performance *** a real environment,teachers expect knowledge tracing models to provide the interpretable result of knowledge *** chain-based knowledge tracing(MCKT)models,such as Bayesian Knowledge Tracing,can track knowledge concept mastery probability over ***,as the number of tracked knowledge concepts increases,the time complexity of MCKT predicting student performance increases exponentially(also called explaining away problem).When the number of tracked knowledge concepts is large,we cannot utilize MCKT to track knowledge concept mastery probability over *** addition,the existing MCKT models only consider the relationship between students’knowledge status and problems when modeling students’responses but ignore the relationship between knowledge concepts in the same *** address these challenges,we propose an inTerpretable pRobAbilistiC gEnerative moDel(TRACED),which can track students’numerous knowledge concepts mastery probabilities over *** solve explain away problem,we design long and short-term memory(LSTM)-based networks to approximate the posterior distribution,predict students’future performance,and propose a heuristic algorithm to train LSTMs and probabilistic graphical model *** better model students’exercise responses,we proposed a logarithmic linear model with three interactive strategies,which models students’exercise responses by considering the relationship among students’knowledge status,knowledge concept,and *** conduct experiments with four real-world datasets in three knowledge-driven *** experimental results show that TRACED outperforms existing knowledge tracing methods in predicting students’future performance and can learn the relationship among students,knowledge concepts,and problems from students’exercise *** also conduct several case *** case studies show that

关键词： probabilistic graphical model deep learning knowledge tracing learner modeling

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The impact of the COVID-19 prevention and economic interventions on express delivery industry:Evidence from China

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Journal of Management Science and Engineering 2024年第1期9卷 16-37页

作者： Juan Liu Jiafu Tang minghe Sun School of Economics Dongbei University of Finance&Economics(DUFE)Dalian116025China School of Management Science&Engineering Dongbei University of Finance&Economics(DUFE)Dalian116025China Department of Management Science and Statistics College of BusinessThe University of Texas at San AntonioSan AntonioUSA

As a fundamental logistics service,the express delivery(ED)industry provides production and consumption activities to maintain efficient supply chain *** plays an important role in promoting industrial development and maintaining daily life and *** study examined the effects of COVID-19 on the ED industry using ED package delivery data from 31 provinces(autonomous regions and municipalities)in *** a difference-in-differences method,the COVID-19 outbreak was found to have a positive effect and epidemic prevention and control(EPC)policies were found to have negative effects on the development of the ED *** addition to EPC policies,the Chinese government has implemented other short-term economic interventions(SEI),such as the resumption of work and production(RWP),policies to balance economic growth,and epidemic *** study divided the pandemic period into three stages to analyze the different impacts of EPC and SEI policy changes on the ED *** RWP policies adopted during the pandemic positively impacted the volume and income of packages delivered to the ED *** conclusions of this study are significant for the ED industry in addressing public health emergencies and for the Chinese government to formulate EPC and SEI policies during epidemic periods.

关键词： COVID-19 Epidemic prevention and control policy Resumption of work and production Express delivery industry Quasi-experiment Difference-in-differences

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Preparation and Photostriction Properties of BiFeO_(3)-BaTiO_(3)Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1079-1086页

作者： ZHENG Zewei ZHANG Liqiang CHEN Chen CAO minghe YI Zhiguo LIU Hanxing School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China School of Microelectronics Shanghai UniversityShanghai 200444China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Under illumination by 405,520 and 655 nm monochromatic visible light(light intensity of 30 kW/m^(2)),large photostriction(ΔL/L)of 0.19%,0.13%and 0.26%for 67BiFeO_(3)-33BaTiO_(3)(67BF-33BT)lead-free ferroelectric ceramics are obtained,*** studying the ferroelectric and photoelectric properties in conjunction with in situ Raman spectroscopy,it is found that the photostrictive effect of 67BF-33BT is not caused by the electrical strain induced by abnormal photovoltaic voltage,but related to the optical induced oxygen octahedral *** 67BF-33BT lead-free ferroelectric material with excellent photostrictive response in the visible light region is expected to play an important role in the field of optical drive electromechanical devices.

关键词： ferroelectric ceramics photostrictive effect visible light response

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分形理论在钻头选型中的应用

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钻采工艺 2007年第2期30卷 34-36页

作者：杨明合中国石油大学石油天然气工程学院

在介绍分形基本理论的基础上,指出该理论可以用来描述具有自相似特征的沉积地层的序列。根据常规的测井资料数据,给出了一种使用多变量计算关联维数的方法。同时建立了地层关联维数和钻头工作效益标度之间的统计关系,根据这种统计得出... 详细信息

在介绍分形基本理论的基础上,指出该理论可以用来描述具有自相似特征的沉积地层的序列。根据常规的测井资料数据,给出了一种使用多变量计算关联维数的方法。同时建立了地层关联维数和钻头工作效益标度之间的统计关系,根据这种统计得出的关系式,论文最后给出了使用关联维数进行钻头优选的新方法。通过实例结算表明,该方法切实可行。

关键词：分形理论关联维数钻头选型

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利用分形理论评价地层可钻性

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石油学报 2010年第1期31卷 124-128页

作者：张旭翟应虎李祖光杨明合中国石油大学石油工程教育部重点实验室北京102249 长江大学石油工程学院湖北荆州434023

利用分形理论研究了大庆徐家围子地区火山岩地层可钻性的评价方法。根据现场声波测井资料及岩心资料,通过室内实验和回归分析建立了声波测井资料与地层可钻性解释模型,结合变尺度分析法分析了该地区声波测井资料的分形特征及长程相关性... 详细信息

利用分形理论研究了大庆徐家围子地区火山岩地层可钻性的评价方法。根据现场声波测井资料及岩心资料,通过室内实验和回归分析建立了声波测井资料与地层可钻性解释模型,结合变尺度分析法分析了该地区声波测井资料的分形特征及长程相关性。依据传统一维、二维随机中点分形插值理论,提出了加权改进随机中点插值法,并结合地层对比技术及深度归一化方法,构建了声波时差测井参数分布场,根据已建立的可钻性解释模型得到地层可钻性分布场。研究结果表明:声波测井资料与地层可钻性之间具有相关关系,且具有很好的分形特征及长程相关性。分形理论可以定量确定地层可钻性分布场。该方法精度高,推广能力强,预测结果符合实际地层变化规律。

关键词：地层可钻性声波测井资料分形理论数据插值解释模型模拟计算

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Neoadjuvant chemotherapy with capecitabine combined with oxaliplatin for mid-low locally advanced rectal cancer with negative mesorectal fascia:Long-term outcomes of a prospective trial(PKUCH-R03 trial)

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Chinese Journal of Cancer Research 2024年第4期36卷 410-420页

作者： Nan Chen minghe Zhao Yunfeng Yao Lin Wang Yifan Peng Tingting Sun Tiancheng Zhan Jun Zhao Aiwen Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterUnit IIIPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterUnit IIIPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:To evaluate the safety and efficacy of neoadjuvant chemotherapy(NCT)in mid-low locally advanced rectal cancer with negative mesorectal fascia(MRF).Methods:This prospective,single-arm phaseⅡtrial was designed and conducted at Peking University Cancer *** patients who provided consent received 3 months of NCT(capecitabine and oxaliplatin,CapOX)followed by total mesorectal excision(TME).The primary endpoint was the rate of pathological complete response(pCR).Results:From January 2019 through December 2021,a total of 53 patients were enrolled,7.5%of whom experienced grade 3-4 adverse events during *** pCR rate was 17.0%for the entire cohort,and the overall rate of postoperative complications was 37.7%(1.9%of gradeⅢa patients).The 3-year disease-free survival rate was 91.4%,and 23.5%(12/51)of the patients suffered from major low anterior resection syndrome(LARS).Postoperative complications were independently associated with major ***:For patients with mid-low rectal cancer with negative MRF,3 months of NCT were found to yield a favorable tumor response with acceptable *** fair long-term survival,the NCT regimen could be associated with low rates of perioperative complications as well as acceptable anal function.

关键词： Neoadjuvant chemotherapy rectal cancer mesorectal fascia disease-free survival anal function

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