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中华医学杂志(英文版) 2025年第04期

作者： Zhang Luyang Chu Yunhui Chen Man Tang Yue Pang Xiaowei Zhou Luoqi Yang Sheng dong minghao Xiao Jun Shang Ke Deng Gang Wang Wei Qin Chuan Tian Daishi Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and Technology Wuhan Hubei China Key Laboratory of Vascular Aging Ministry of Education Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China

Responses of soil microbial metabolism,function and soil quality to long-term addition of organic materials with different carbon sources

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Biochar 2024年第1期6卷 1430-1449页

作者： minghao dong Hanjun Zhou Jing Wang Jiahao Yang Jiazheng Lai Yulu Chen Feng Sun Xiefeng Ye Yunjie Wu Key Laboratory of Tobacco Cultivation of Tobacco Industry National Tobacco Cultivation&Physiology&Biochemistry Research CentreTobacco Science College of Henan Agricultural UniversityZhengzhou 450002HenanChina. College of Natural Resources and Environment Northwest A&F UniversityYanglingXianyang 712199ShanxiChina.

Biochar and green manure have been widely applied in agricultural production and are important means to achieve sustainable ***,there is limited research systematically and comprehensively exploring the response of soil microbiota and the changes in soil metabolomics after the addition of two different carbon source amendments to the soil,and the differential mechanisms of soil metabolomics between them remain *** this study,a long-term field experiment(initiated in 2019)was conducted to investigate the effects of biochar and green manure application on soil nutrients and soil functions driven by soil *** to the pure fertilizer treatment,biochar increased soil total carbon by 14.54%to 27.04%and soil available potassium by 4.67%to 27.46%.Ryegrass significantly increased soil available phosphorus and organic *** different fertilization regimes,the ecological niches of soil microbes changed *** analysis revealed that long-term ryegrass returning reduced the complexity of soil microbial *** and biochar increased dispersal limitation in fungal assemblages(reaching 93.33%and 86.67%,respectively),with biochar particularly enhancing variable selection in bacterial assemblages(accounting for 53.33%).Variation partitioning analysis based on redundancy analysis indicated that humic substances had the highest explanatory power for microbial community variation,with humic substances explaining 38.49%of bacteria and 52.19%of fungi *** ryegrass treatment mainly changed the abundance of carbohydrates(CH),amines(AM),c(AH),and lipids(LP),while the BC treatment mainly altered the abundance of organic acids(AC),amines(AM),and carbohydrates(CH).Meanwhile,both treatments significantly reduced the bisphenol A,one of the soil *** incorporation significantly increased the abundance of genes related to soil C,N,P,and S cycling,especially genes involved in carbon decomposition,while biochar

关键词： Biochar Ryegrass Soil Metabolome Metagenome

Alteration mechanism and classification and mechanical properties of altered granite

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Journal of Earth Science 2025年

作者： dong Jinyu SHI Shang LIU Handong REN minghao LI Jianyong North China University of Water Resources and Electric Power College of Geosciences and Engineering， North China University of Water Resources and Electric Power

Altered rock， often encountered in major engineering projects， can seriously affect the stability of rocks and slopes surrounding deeply buried tunnels. This study addressed the alteration mechanism， alteration degree classification， and mechanical parameters of altered rock in engineering project areas using field testing， thin slice identification， X-ray diffraction， and major element testing. Results showed that the altered rock types in the areas of the Pingjiang Pumped Storage Power Station (Hunan Province) and a diversion tunnel in northern Xinjiang include biotite granodiorite， biotite monzogranite， and cataclastic granite， and that the main alteration mechanisms are chloritization of biotite and clayization of feldspar minerals. The altered rocks were classified as slightly， moderately， or strongly altered according to their apparent characteristics， rebound value， longitudinal wave velocity， metamorphic mineral content， and porosity. The bulk density， elastic modulus， cohesion， and internal friction angle (Poisson’s ratio) of the altered rocks decreased (increased) with increase in the degree of alteration. Numerical simulations showed that in altered rock slope areas， the zone of strong rock alteration and the moderate–strong alteration contact zone exhibit locally large deformations that represent certain hazard to engineering projects. These results provide valuable guidance and support for major projects in altered rock areas.

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基于无率码的信息与能量同传中继信道传输速率的优化与实现

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通信学报 2019年第5期40卷 98-107页

作者：雷维嘉董明昊重庆邮电大学通信与信息工程学院重庆400065

研究了信息与能量同传中继信道传输速率的优化与实现。系统模型为三节点两跳中继模型,中继采用解码转发协议进行转发。一个完整的传输分为2个阶段,第一阶段为源到中继的传输,为信息与能量同时传输,中继对接收到的信号进行功率分裂,一部... 详细信息

研究了信息与能量同传中继信道传输速率的优化与实现。系统模型为三节点两跳中继模型,中继采用解码转发协议进行转发。一个完整的传输分为2个阶段,第一阶段为源到中继的传输,为信息与能量同时传输,中继对接收到的信号进行功率分裂,一部分信号用于信息译码,另一部分信号转换为电能用作第二阶段的信息转发;第二阶段为中继采用译码转发方式转发信息。采用两跳不等时长,在传输信息量一定的条件下,以最小化两跳传输总时间为目标对功率分裂因子进行优化。在优化结果的基础上,采用Raptor码和不同调制方式的组合实现两跳不同的传输速率,最大化地利用两跳不同的信道容量,给出了Raptor码码长和调制方式的选择机制。仿真证明,两跳不等时长的安排可以获得更高的吞吐量,而采用Raptor码可实现对信道容量的充分利用和信息高效而可靠的传输。

关键词：无线信息与能量同传无率码中继 Raptor码调制

Establishment and verification of anthropogenic speciated VOCs emission inventory of Central China

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Journal of Environmental Sciences 2025年第3期149卷 406-418页

作者： Xuan Lu dong Zhang Lanxin Wang Shefang Wang Xinran Zhang Yali Liu Keying Chen Xinshuai Song Shasha Yin Ruiqin Zhang Shanshan Wang minghao Yuan College of Chemistry Zhengzhou UniversityZhengzhou 450001China Research Institute of Environmental Sciences Zhengzhou UniversityZhengzhou 450001China School of Ecology and Environment Zhengzhou UniversityZhengzhou 450001China Zhengzhou Ecological Environment Monitoring Center of Henan Province Zhengzhou 450000China

Improving the accuracy of anthropogenic volatile organic compounds(VOCs)emission inventory is crucial for reducing atmospheric pollution and formulating control policy of air *** this study,an anthropogenic speciated VOCs emission inventory was established for Central China represented by Henan Province at a 3 km×3 km spatial resolution based on the emission *** 2019 VOCs emission in Henan Provincewas 1003.5 Gg,while industrial process source(33.7%)was the highest emission source,Zhengzhou(17.9%)was the city with highest emission and April and August were the months with the more *** VOCs emission regions were concentrated in downtown areas and industrial *** and aromatic hydrocarbons were the main VOCs contribution *** species composition,source contribution and spatial distribution were verified and evaluated through tracer ratio method(TR),Positive Matrix Factorization Model(PMF)and remote sensing inversion(RSI).Results show that both the emission results by emission inventory(EI)(15.7 Gg)and by TRmethod(13.6 Gg)and source contribution by EI and PMF are *** spatial distribution of HCHO primary emission based on RSI is basically consistent with that of HCHO emission based on EI with a R-value of *** verification results show that the VOCs emission inventory and speciated emission inventory established in this study are relatively reliable.

关键词： VOCs verification Species composition Tracer ratio PMF Remote sensing inversion

Early stage of radiological expertise modulates resting-state local coherence in the inferior temporal lobe

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Psychoradiology 2022年第4期2卷 199-206页

作者： minghao dong Peiming Zhang Weilu Chai Xiaoyan Zhang Bihong TChen Hongmei Wang Jia Wu Chao Chen Yi Niu Jimin Liang Guangming Shi Chenwang Jin Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education School of Life Science and TechnologyXidian UniversityXi’an CityShaanxi 710071China Xian Key Laboratory of Intelligent Sensing and Regulation of tran-Scale Life Information Xi’an CityShaanxi 710071China Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education School of Artificial IntelligenceXidian UniversityXi’an CityShaanxi 710071China City of Hope Medical Center Duarte CityCalifornia 91010USA Department of Medical Imaging First Affiliated Hospital of Medical CollegeXi’an Jiaotong UniversityXi’an CityShaanxi 710000China School of Foreign Languages Northwestern Polytechnical UniversityXi’an CityShaanxi 710071China PLA Funding Payment Center Beijing 100000China School of Electronics and Engineering Xidian UniversityXi’an CityShaanxi 710071China

Background The visual system and its inherent functions undergo experience-dependent changes through the lifespan,enabling acquisition of new *** fMRI studies using tasks reported increased specialization in a number of cortical regions subserving visual *** ample studies focused on representation of long-term visual expertise in the brain,*** terms of year,monthly-based early-stage representation of visual expertise remains *** that spontaneous neuronal oscillations actively encode previous experience,we propose brain representations in the resting state is fundamentally *** The current study aimed to investigate how monthly-based early-stage visual expertise are represented in the resting state using the expertise model of *** In particular,we investigated the altered local clustering pattern of spontaneous brain activity using regional homogeneity(ReHo).A cohort group of radiology interns(n=22)after one-month training in X-ray department and matched laypersons(n=22)were recruited after rigorous behavioral *** The results showed higher ReHo in the right hippocampus(HIP)and the right ventral anterior temporal lobe(vATL)(corrected by Alphasim correction,P<0.05).Moreover,ReHo in the right HIP correlated with the number of cases reviewed during intern radiologists’training(corrected by Alphasim correction,P<0.05).Conclusions In sum,our results demonstrated that the early stage of visual expertise is more concerned with stabilizing visual feature and domain-specific knowledge into long-term *** results provided novel evidence regarding how early-stage visual expertise is represented in the resting brain,which help further elaborate how human visual expertise is *** propose that our current study may provide novel ideas for developing new training protocols in medical schools.

关键词： visual expertise resting state fMRI radiologists inferior temporal cortex

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论全面依法治国视域下的大学生法治教育

思想理论教育导刊 2022年第7期 65-70页

作者：李牧董明皓武汉理工大学法学与人文社会学院武汉理工大学马克思主义学院

推进全面依法治国需要加强法治教育,大学生是推进全面依法治国的重要生力军,开展大学生法治教育是高校培养和提高大学生法治意识、促进大学生健康成长成才的重要途径。当前高校开展大学生法治教育尚存在一些误区,教育的针对性和实效性... 详细信息

推进全面依法治国需要加强法治教育,大学生是推进全面依法治国的重要生力军,开展大学生法治教育是高校培养和提高大学生法治意识、促进大学生健康成长成才的重要途径。当前高校开展大学生法治教育尚存在一些误区,教育的针对性和实效性有待进一步增强、法治实践教育尚需进一步拓展。为此,开展大学生法治教育应把握好思想政治理论课教育教学这个主渠道,以习近平法治思想为指导思想,采取灵活多样的课堂教学方法,提高教育教学质量,为大学生提供参与法治实践教育的多种途径,在真实情境中加深他们对法治知识的认识,提升大学生的法治实践能力和法治素养,使他们成为中国特色社会主义法治道路的忠实信仰者、坚定捍卫者与模范践行者。

关键词：全面依法治国法治教育习近平法治思想

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论基层应急法治能力提升的三重向度

学术交流 2022年第9期 42-51,191页

作者：李牧董明皓武汉理工大学法学与人文社会学院武汉430070 武汉理工大学马克思主义学院武汉430070

基层应急法治能力提升,是加快推进基层治理体系和治理能力现代化建设的重要目标,需从理念引领、主体塑造、预案规约三向度协同推进方能提升。理念引领上,将基层党建引领与以人民为中心理念内化为在法治轨道上推进基层应急管理的行动指南... 详细信息

基层应急法治能力提升,是加快推进基层治理体系和治理能力现代化建设的重要目标,需从理念引领、主体塑造、预案规约三向度协同推进方能提升。理念引领上,将基层党建引领与以人民为中心理念内化为在法治轨道上推进基层应急管理的行动指南,从而强化党建在基层应急管理的政治引领功能,也为基层应急管理广聚人民力量;主体塑造上,在强化应急法治知识认知积累中培育基层党员群众的法治素养,提升运用法治预防与应对突发事件的能力;预案规约上,编制与村规民约同质的基层应急预案为基层党员群众依法应对突发事件提供具体方案,构建契合基层需求的应急演练机制,从而提升基层党员群众应急法治能力之执行力。

关键词：基层治理应急法治能力三重向度

Dawn of CAR-T cell therapy in autoimmune diseases

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Chinese Medical Journal 2024年第10期137卷 1140-1150页

作者： Yuxin Liu minghao dong Yunhui Chu Luoqi Zhou Yunfan You Xiaowei Pang Sheng Yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang Chuan Qin Daishi Tian Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhanHubei 430030China

Chimeric antigen receptor(CAR)-T cell therapy has achieved remarkable success in the treatment of hematological *** on the immunomodulatory capability of CAR-T cells,efforts have turned toward exploring their potential in treating autoimmune *** analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases,covering a range of subtypes such as systemic lupus erythematosus,multiple sclerosis,among ***-T therapy holds promise in mitigating several shortcomings,including the indiscriminate suppression of the immune system by traditional immunosuppressants,and non-sustaining therapeutic levels of monoclonal antibodies due to inherent pharmacokinetic *** persisting and proliferating in vivo,CAR-T cells can offer a tailored and precise *** paper reviewed preclinical experiments and clinical trials involving CAR-T and CAR-related therapies in various autoimmune diseases,incorporating innovations well-studied in the field of hematological tumors,aiming to explore a safe and effective therapeutic option for relapsed/refractory autoimmune diseases.

关键词： CAR-T cell therapy Autoimmune disease Immunotherapy Multiple sclerosis Neuromyelitis optica spectrum disorder Systemic lupus erythematosus

N6-腺苷酸甲基化修饰在肿瘤发生发展中的作用

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中华实验外科杂志 2020年第9期37卷 1770-1774页

作者：董明皓张霓何锋华中科技大学同济医学院第二临床学院武汉430030 华中科技大学同济医学院附属同济医院胸外科武汉430030

N6-腺苷酸甲基化(m^6A)是大多数真核生物的信使RNA(mRNA)中最常见的修饰之一,它动态可逆地参与RNA生命周期的各个阶段,从RNA加工、出核、翻译到RNA降解。这种修饰是由甲基化酶(writers)安装,可以被去甲基化酶(erasers)逆转,以及被识别蛋... 详细信息

N6-腺苷酸甲基化(m^6A)是大多数真核生物的信使RNA(mRNA)中最常见的修饰之一,它动态可逆地参与RNA生命周期的各个阶段,从RNA加工、出核、翻译到RNA降解。这种修饰是由甲基化酶(writers)安装,可以被去甲基化酶(erasers)逆转,以及被识别蛋白(readers)读取,受到它们的共同调控。随着m^6A修饰的检测和测序技术的发展以及单碱基分辨率等新兴技术的兴起,多种m6A相关蛋白陆续被鉴定出来,它们共同调控基因表达的机制已得到了更深入的解析。在此基础上,m^6A在肿瘤增殖、迁移、侵袭等过程中发挥的作用日益凸显,相关机制的阐明对肿瘤的诊断与预后表现着极为重要的作用。

关键词： N6-腺苷酸甲基化肿瘤检测技术 RNA生物学功能