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NIR-Ⅱ fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis

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Nano Research 2022年第10期15卷 9183-9191页

作者： Siyu Lu Liru Xue Meng Yang Jingjing Wang Yang Li Yuxin Jiang Xuechuan Hong mingfu wu Yuling Xiao State Key Laboratory of Virology Department GynecologyCancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Ultrasound State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China College of Science Research Center for EcologyLaboratory of Extreme Environmental Biological Resources and Adaptive EvolutionTibet UniversityLhasa 850000China Shenzhen Institute of wuhan University Shenzhen 518057China

Ovarian cancer is a global problem,and is typically diagnosed in the middle or late stages,with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic ***-modal near-infrared Ⅱ(NIR-Ⅱ,1,000–1,700 nm)fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep ***,we report a novel organic NIR-Ⅱ dye(H10)with excellent aggregation-induced-emission(AIE)characteristics(I/I0>1.6)utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole(ST)-based building ***,water-soluble and biocompatible H10@follicle-stimulating hormone(H10@FSH)dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were ***,for the first time,in vivo dual-mode NIR-Ⅱ fluorescent/photoacoustic(PA)imaging and image-guided surgery of patient-derived tumor xenograft(PDTX)and micro-metastatic abdominal ovarian cancer lesions were *** novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.

关键词： ovarian cancer peritoneal metastasis near-infraredⅡ(NIR-Ⅱ,1,000-1,700 nm)fluorescence/photoacoustic dual-modal imaging early detection

Optical molecular imaging in cancer research:current impact and future prospect

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维普期刊数据库

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Oncology and Translational Medicine 2024年第5期10卷 212-222页

作者： Yinuo Li Zihan Li Yuting Li Xiaofan Gao Tian Wang Xiangyi Ma mingfu wu National Clinical Research Center for Obstetrical and Gynecological Diseases Department of GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Cancer Invasion and Metastasis Ministry of EducationWuhanChina

Cancer has long been amajor threat to human *** advancements inmolecular imaging have revolutionized cancer research by enabling early and precise disease localization,essential for effective *** particular,optical molecular imaging is an invaluable cancer detection tool in preoperative planning,intraoperative guidance,and postoperative monitoring owing to its noninvasive nature,rapid turnover,safety,and ease of *** tumor microenvironment and cells within it express distinct *** imaging technology leverages these markers to differentiate tumor tissues from surrounding tissues and capture real-time images with high ***,a robust understanding of these cancer-relatedmolecules and their dynamic changes is crucial for effectivelymanaging *** advancements in opticalmolecular imaging technologies offer novel approaches for cancer investigation in research and *** review investigates themodern opticalmolecular imaging techniques employed in both preclinical and clinical research,including bioluminescence,fluorescence,chemiluminescence,photoacoustic imaging,and Raman *** explore the current paradigm of optical molecular imaging modalities,their current status in preclinical cancer research and clinical applications,and future perspectives in the fields of cancer research and treatment.

关键词： Cancer Opticalmolecular imaging Bioluminescence imaging Fluorescence Chemiluminescence Photoacoustic imaging Raman spectroscopy

Transient Expression of BVDV N^(pro) Gene in vitro and Distribution of Fusion Protein in Cells

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Journal of Northeast Agricultural University(English Edition) 2011年第1期18卷 52-55页

作者： HUO Hui wu mingfu WANG Junwei Collage of Veterinary Medicine Northeast Agricultural University Harbin 150030 China

The gene encoding nonstructural protein Npro of BVDV was amplified by PCR,then was inserted into pEGFP-C1 *** 293 cells were transfected in vitro with recombinant plasmid by ***-EGFP fusion protein was viewed directly with fluorensce microscope and mRNA expression of Npro was detected by reverse transcription-polymerase chain reaction（RT-PCR）.Results showed that recombinant plasmid was confirmed to be constructed correctly by PCR,restriction enzyme digestion and DNA sequencing;meanwhile,the gene carried was expressed in 293 *** fusion protein had properties of both the two Npro and enhanced green fluorescent proteins（EGFP） and distributed in the *** research lays a foundation for further researches which explored Npro gene function in the process of viral replication and synthesis.

关键词： BVDV A^pro gene pEGFP-Cl vector 293 cells gene transfer technique

Experimental study of core and edge fluctuations by reflectometry on EAST tokamak

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Plasma Science and Technology 2021年第7期23卷 8-14页

作者： Zhen ZHOU Tao ZHANG mingfu wu Kaixuan YE Fubin ZHONG Jia HUANG Kangning GENG Yukai LIU Gongshun LI Haoming XIANG Yumin WANG Fei WEN Sanqiu LIU Jiangxi Province Key Laboratory of Fusion and Information Control Institute of Fusion Energy and Plasma ApplicationDepartment of PhysicsNanchang UniversityNanchang 330031People’s Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060People’s Republic of China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 5180602People’s Republic of China

An eight-channel poloidal correlation reflectometer(PCR)with O-mode polarization has been installed in the EAST tokamak to measure the fluctuations from core to *** PCR launches eight different frequency microwaves(20.4,24.8,33,40,42.4,48,52.6,57.2 GHz)into the plasma from the low field side and two poloidally separated antennae are used to receive the reflected *** a result,the diagnostic can measure fluctuations in eight(radial)×two(poloidal)spatial *** diagnostic has been applied to study the core and edge pedestal fluctuations during an inter-ELM phase in H-mode *** inter-ELM phase can be divided into two *** the first stage,a low frequency(<50 kHz)broadband fluctuation dominates in the pedestal gradient *** the second stage,this fluctuation is strongly suppressed and quasi-coherent fluctuations(QCFs)*** QCF’s amplitude increases with the pedestal density gradient,implying density gradient driven *** the core fluctuations inside the pedestal show no evident changes during the inter-ELM phase.

关键词： core fluctuation edge fluctuation reflectometry

Experimental investigation of scrape-off layer blob high density transition in L-mode plasmas on EAST

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Plasma Science and Technology 2022年第7期24卷 129-136页

作者： Ping WANG Guanghai HU Ning YAN Guosheng XU Lingyi MENG Zhikang LU Lin YU Manni JIA Yifeng WANG Liang CHEN Heng LAN Xiang LIU mingfu wu Liang WANG Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060People's Republic of China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060People's Republic of China Institute of Energy Hefei Comprehensive National Science CentreHefei 230031People's Republic of China

Lithium Beam Emission Spectroscopy systems in the outer midplane and divertor Langmuir probe arrays embedded in the divertor target plates,are utilized to investigate the scrape-off layer(SOL)blob transition and its relation with divertor detachment on *** blob transition in the near SOL is observed during the density ramp-up *** the plasma density,normalized to the Greenwald density limit,exceeds a threshold of f_(GW)~0.5,the blob size and lifetime increases by 2–3 times,while the blob detection rate decreases by about 2 *** addition,a weak density shoulder is observed in the near SOL region at the same density *** analysis indicates that the divertor detachment is highly correlated with the blob transition,and the density threshold of blob transition is consistent with that of the access to the outer divertor *** potential physical mechanisms are *** results could be useful for the understanding of plasma-wall interaction issues in future devices that will operate under a detached divertor and high density conditions(over the blob transition threshold).

关键词： blobs divertor detachment L-mode EAST

Feasibility of applying the lower cut-off frequency for the density radial coverage extension in EAST reﬂectometry measurement

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Plasma Science and Technology 2022年第5期24卷 112-117页

作者： Jia HUANG Xiang HAN Kaixuan YE Tao ZHANG Fei WEN mingfu wu Kangning GENG Gongshun LI Fubin ZHONG Yukai LIU Haoming XIANG Shuqi YANG Shoubiao ZHANG Xiang GAO Ge ZHUANG the EAST Team University of Science and Technology of China Hefei 230026People's Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060People's Republic of China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People's Republic of China

The extraordinary mode(X-mode)lower cut-off frequency is proposed for use in the reflectometry diagnostic on ITER for the electron density profile measurement,which is a trade-off between extreme plasma parameters and the accessible probing *** contemporary experiments,the lower cutoff frequency can be identified at the probing frequency below the electron cyclotron frequency(f_(ce)) under certain plasma *** provide here,for the first time,the experimental validation of the use of the lower cut-off frequency for the density profiles via the reflectometry measurement on *** corresponding group delay of the lower cut-off frequency evolves continuously with the upper one,revealing a reasonable radial coverage extension of reflectometry measurement toward the plasma *** is concluded that the lower cut-off frequency can be used as a supplement to the upper one in the density profile inversion process,which is of particular interest in the high magnetic field and/or density discharge to extend the radial coverage of reflectometry measurement.

关键词： X-mode reflectometry density profile EAST lower cut-off frequency

Experimental study of double tearing mode on EAST tokamak

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Plasma Science and Technology 2020年第2期22卷 47-53页

作者： mingfu wu Zixi LIU Tao ZHANG Fubin ZHONG Gongshun LI Haoming XIANG Kangning GENG Kaixuan YE Jia HUANG Fei WEN Yumin WANG Xiang HAN Shoubiao ZHANG Haiqing LIU Guoqiang LI Ge ZHUANG Xiang GAO University of Science and Technology of China Hefei 230026People's Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China Advanced Energy Research Center Shenzhen UniversityShenzhen 518060People’s Republic of China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People's Republic of China

The double tearing mode(DTM)in a high βN(βN>1.5)discharge with internal transport barrier on EAST was investigated.A 15 kHz tearing mode(TM)(m≥3,n=3)appears at outer q=2 surface at first,which is stable in the highβN *** a 2 kHz TM(m=2,n=1)occurs at inner q=2 *** after,high βN collapsed with the crash of ELM,and DTM formed during the collapse of β*** positions of the two islands of the DTM are consistent with the q=2 *** temperature fluctuations are the strongest between the two magnetic islands.A statistical analysis of high βN discharges operating with the reversed magnetic shear configuration in the EAST 2015-2018 campaign revealed the existence of the DTM in many *** the DTM phase,all βN are reduced by 10%-30% within 0.1 ***,there are two different βN behaviors thereafter-with and without βN *** the physical mechanism of βN recovery during the DTM phase will benefit steady-state operation with reversed shear configurations in the future.

关键词： highβN βN collapse EAST double tearing mode

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带模浇筑地下连续墙成墙技术探讨

北方建筑 2018年第2期3卷 53-56页

作者：吴明付中铁十六局集团北京轨道交通工程建设有限公司北京通州101100

由于素填土、砾质粘土、砂性土及强风化岩层等地层地下连续墙在施工中,成墙后墙表面平整度较差,甚至出现局部墙体夹泥、渗水、露筋、混凝土超方等现象,给地铁车站基坑基面处理带来很多不便。针对此类情况,本文提出了带模浇筑地下连续墙... 详细信息

由于素填土、砾质粘土、砂性土及强风化岩层等地层地下连续墙在施工中,成墙后墙表面平整度较差,甚至出现局部墙体夹泥、渗水、露筋、混凝土超方等现象,给地铁车站基坑基面处理带来很多不便。针对此类情况,本文提出了带模浇筑地下连续墙的方法。采用在地连墙钢筋笼外表面安装一层镀锌铁皮,以解决地下连续墙成墙缺陷问题。

关键词：地铁车站连续墙成墙技术带模浇筑成墙缺陷

大孔径钻孔炮眼法二次爆破大块岩石技术在神山露天煤矿的应用

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河南科技 2018年第25期37卷 87-89页

作者：吴明福陕西神延煤炭有限责任公司西湾露天煤矿

为了解决大块岩石爆破效率低、成本高等问题, 提高露天煤矿爆破岩石的效率, 推进工作面的施工,神山露天煤矿爆破技术人员探索出了一套大孔径炮眼法二次爆破大块岩石的技术.实践证明, 该技术不仅取得了良好的爆破效果, 而且提高了大块... 详细信息

为了解决大块岩石爆破效率低、成本高等问题, 提高露天煤矿爆破岩石的效率, 推进工作面的施工,神山露天煤矿爆破技术人员探索出了一套大孔径炮眼法二次爆破大块岩石的技术.实践证明, 该技术不仅取得了良好的爆破效果, 而且提高了大块破碎效率与经济效益.

关键词：大孔径钻孔炮眼法二次爆破大块岩石